Diabetes Therapy OnlineFirst articles

Open Access 24.04.2024 | Case Report

Exogenous Insulin Antibody Syndrome (EIAS) Presenting in an Elderly, Long-Term Patient with Type 1 Diabetes Mellitus that Resolved with Low-Cost Outpatient Therapy with Mycophenolate Mofetil and Regular Insulin by Pump

Exogenous insulin antibody syndrome (EIAS) has until recently been a rarely described complication of exogenous insulin therapy. EIAS results not only in hyperglycemia, but also in hypoglycemia and occasionally in ketoacidosis (DKA). The incidence …

verfasst von:: Terri Jerkins, Katherine Stockham, David S. H. Bell

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Open Access 24.04.2024 | Original Research

Effect of Luseogliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, and Dipeptidyl-Peptidase 4 Inhibitors on the Quality-of-Life and Treatment Satisfaction of Patients With Type 2 Diabetes Mellitus: A Subanalysis of a Multicenter, Open-Label, Randomized-Controlled Trial (J-SELECT Study)

Quality of life (QOL) of patients is an important factor in continuing diabetes management. Current Japanese guidelines recommend pharmacotherapy to maintain patients’ QOL in addition to the consideration of appropriate targets for glucose …

verfasst von:: Masahiro Fukuda, Ichiro Sakuma, Yutaka Wakasa, Hideaki Funayama, Akira Kondo, Naoki Itabashi, Yasuyuki Maruyama, Takashi Kamiyama, Yasunori Utsunomiya, Akira Yamauchi, Hidenori Yoshii, Hirokazu Yamada, Koichi Mochizuki, Masahiro Sugawara, on behalf of the J-SELECT study investigators

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Open Access 24.04.2024 | Study Protocol

The IDEAL (Insulin therapy DE-intensificAtion with iglarLixi) Randomised Controlled Trial—Study Design and Protocol

Multiple daily injection insulin regimen (MDI), also referred to as intensive insulin therapy (IIT), represents the most complex type of insulin regimen used in the management of people with type 2 diabetes (PwT2D). Correspondingly, MDI regimen …

verfasst von:: Peter Novodvorský, Lenka Thieme, Ivana Laňková, Miloš Mráz, Zoltán J. Taybani, Balázs Bótyik, Péter Stella, Miroslav Vytasil, Felipe Lauand, Mireille Bonnemaire, Martin Haluzík

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Open Access 22.04.2024 | Correction

Correction to: Effect of Neo-Policaptil Gel Retard on Liver Fat Content and Fibrosis in Adults with Metabolic Syndrome and Type 2 Diabetes: A Non-invasive Approach to MAFLD

verfasst von:: Giuseppina Guarino, Felice Strollo, Teresa Della Corte, Ersilia Satta, Sandro Gentile

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Open Access 20.04.2024 | Original Research

Real-World Effectiveness of the Gla-300 + Cap + App Program in Adult Users Living with Type 2 Diabetes in Taiwan

The International Diabetes Federation (IDF) Atlas reported that in 2021, 537 million people had diabetes globally; of these, type 2 diabetes is estimated to account for over 90% of cases [ 1 , 2 ]. This number is predicted to increase by 46% to 783 …

verfasst von:: Chih-Yuan Wang, Fang L. Zhou, Aakash B. Gandhi, Tsung-Ying Lee, Nancy Cui, Jiuo-Shan Mao, Jung-Fu Chen

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Open Access 20.04.2024 | Original Research

Effects of Two COVID-19 Lockdowns on HbA1c Levels in Patients with Type 1 Diabetes and Associations with Digital Treatment, Health Literacy, and Diabetes Self-Management: A Multicenter, Observational Cohort Study Over 3 Years

During the recent coronavirus disease 2019 (COVID-19) pandemic, nationwide lockdowns were imposed in most countries to contain the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 1 – 4 ]. Patients with diabetes mellitus …

verfasst von:: Daniel Tajdar, Dagmar Lühmann, Laura Walther, Lasse Bittner, Martin Scherer, Ingmar Schäfer

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Open Access 20.04.2024 | Original Research

Basal Insulinotherapy in Patients Living with Diabetes in France: The EF-BI Study

Insulin therapy is a necessary step in achieving optimal glycemic targets in type 1 diabetes (T1DM), but also in most advanced patients with type 2 diabetes (T2DM) when oral antidiabetic agents and non-insulin injectable treatments have failed to …

verfasst von:: Pierre Gourdy, Patrice Darmon, Isabelle Borget, Corinne Emery, Isabelle Bureau, Bruno Detournay, Amar Bahloul, Noemie Allali, Aymeric Mahieu, Alfred Penfornis

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Open Access 20.04.2024 | Original Research

Psychosocial Self-efficacy and its Association with Selected Potential Factors Among Adults with Type 1 Diabetes: A Cross-Sectional Survey Study

Type 1 diabetes, currently remains a non-preventable chronic disease [ 1 ] despite various ongoing research like pharmacologically enhanced regulatory hematopoietic stem cells [ 2 ] and targeted delivery of immune therapeutics using nanoparticles [ …3

verfasst von:: Divya Anna Stephen, Anna Nordin, Unn-Britt Johansson, Jan Nilsson

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Open Access 18.04.2024 | Correction

Correction to: Use of IDegLira to Intensify, Simplify, and Increase Appropriateness of Type 2 Diabetes Therapy: A Real-Life Experience

verfasst von:: Isabella Romano, Rosalia Serra

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Open Access 16.04.2024 | Review

Barriers to the Use of Insulin Therapy and Potential Solutions: A Narrative Review of Perspectives from the Asia–Pacific Region

The rising prevalence of type 2 diabetes (T2D) is posing major challenges for the healthcare systems of many countries, particularly in the Asia–Pacific Region, in which T2D can present at younger ages and lower body mass index when compared with …

verfasst von:: Roger Chen, Azizul Hasan Aamir, Mohammod Feroz Amin, Pongamorn Bunnag, Siew Pheng Chan, Lixin Guo, Mohammad E. Khamseh, Viswanathan Mohan, Nemencio Nicodemus Jr., Anthony Roberts, Tri Juli Edi Tarigan, Kyu-Chang Won, Roopa Mehta

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Open Access 15.04.2024 | Original Research

Neutrophil Extracellular Traps (NETs) Are Associated with Type 2 Diabetes and Diabetic Foot Ulcer Related Amputation: A Prospective Cohort Study

Among the various complications associated with diabetes, diabetic foot ulcer (DFU) has emerged as a significant contributor to both disability and mortality. The prevalence of DFU among individuals aged 50 years and above in China is alarmingly …

verfasst von:: Irshat Ibrahim, Yilimire Nuermaimaiti, Gulijianaiti Maimaituxun, Xinling Luo, Mailudemu Maimaituxun, Azimat Akbar, Kahaer Tuerxun, Yuanquan Wu

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Open Access 11.04.2024 | Original Research

Effectiveness, Simplification and Persistence of IDegLira in Poorly Controlled People with Type 2 Diabetes: A 4-Year Follow-Up Real-World Study

Type 2 diabetes (T2D) is a chronic condition that requires progressive therapy intensification [ 1 ]. However, inertia in intensifying anti-hyperglycemic therapy, especially when insulin needs to be started, is a common barrier [ 2 ].

verfasst von:: Chiara Di Loreto, Roberta Celleno, Debora Pezzuto, Franca Ambrosi, Silvia Bellavita, Marinella Biagini, Monica Passeri, Paola Del Sindaco

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Open Access 10.04.2024 | Original Research

Associations Between HbA1c and Glucose Time in Range Using Continuous Glucose Monitoring in Type 1 Diabetes: Cross-Sectional Population-Based Study

The main objectives of treating diabetes mellitus are to optimize glucose levels to prevent hypo- and hyperglycemia, counteract the development of micro- and macrovascular diseases, and strive for a high quality of life. For over 40 years …

verfasst von:: Björn Eliasson, Elin Allansson Kjölhede, Sofia Salö, Nick Fabrin Nielsen, Katarina Eeg-Olofsson

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Open Access 05.04.2024 | Review

SGLT2 Inhibitors – The New Standard of Care for Cardiovascular, Renal and Metabolic Protection in Type 2 Diabetes: A Narrative Review

A substantial evidence base supports the use of sodium-glucose cotransporter-2 inhibitors (SGLT2is) in the treatment of type 2 diabetes mellitus (T2DM). This class of medicines has demonstrated important benefits that extend beyond …

verfasst von:: Samuel Seidu, Vicki Alabraba, Sarah Davies, Philip Newland-Jones, Kevin Fernando, Stephen C. Bain, Jane Diggle, Marc Evans, June James, Naresh Kanumilli, Nicola Milne, Adie Viljoen, David C. Wheeler, John P. H. Wilding

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Open Access 05.04.2024 | Summary of Research

Summary of Research: Efficacy and Safety of the SGLT2 Inhibitor Empagliflozin Versus Placebo and the DPP-4 Inhibitor Linagliptin Versus Placebo in Young People with Type 2 Diabetes (DINAMO): A Multicentre, Randomised, Double-Blind, Parallel Group, Phase 3 Trial

The increasing occurrence of childhood overweight and obesity has been followed by a substantial increase in youth-onset type 2 diabetes (T2D). Pharmacological treatment options for youth-onset T2D remain limited, with a clear unmet need for …

verfasst von:: Lori M. Laffel

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Open Access 05.04.2024 | Original Research

Aberrant Brain Triple-Network Effective Connectivity Patterns in Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with an increasing prevalence worldwide. Varying degrees of insulin resistance, impairment of insulin secretion function, and rising production of glucose are the characteristics of …

verfasst von:: Yujie Zhang, Xiao Yin, Yu-Chen Chen, Huiyou Chen, Mingxu Jin, Yuehu Ma, Wei Yong, Vijaya Prakash Krishnan Muthaiah, Wenqing Xia, Xindao Yin

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Open Access 04.04.2024 | Original Research

An Obesity-Centric Approach with and Without Anti-Obesity Medications Compared to the Usual-Care Approach to Management of Patients with Obesity and Type 2 Diabetes in an Employer Setting: A Pragmatic Randomized Controlled Trial (EMPOWER-T2D)

This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/10.6084/m9.figshare.25334650 .

verfasst von:: Kevin M. Pantalone, Bruce Rogen, Patty Zirm, Huijun Xiao, James Bena, Gretchen Barnard, Elena Borukh, Seenia Peechakara, Marcio L. Griebeler, James B. Young, Bartolome Burguera

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Open Access 04.04.2024 | Review

Dual and Triple Incretin-Based Co-agonists: Novel Therapeutics for Obesity and Diabetes

The discovery of long-acting incretin receptor agonists represents a major stride forward in tackling the dual epidemic of obesity and diabetes. Here we outline the evolution of incretin-based pharmacotherapy, from exendin-4 to the discovery of …

verfasst von:: Robert M. Gutgesell, Rubén Nogueiras, Matthias H. Tschöp, Timo D. Müller

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Open Access 04.04.2024 | Review

The Current and Future Role of Insulin Therapy in the Management of Type 2 Diabetes: A Narrative Review

Early initiation of intensive insulin therapy has been demonstrated to be effective in controlling glycemia and possibly preserving beta-cell function. Innovations in insulin formulations and delivery systems continue. However, we have seen an …

verfasst von:: Janet B. McGill, Irl B. Hirsch, Christopher G. Parkin, Grazia Aleppo, Carol J. Levy, James R. Gavin III

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Open Access 04.04.2024 | Study Protocol

Effect of Luseogliflozin on Myocardial Flow Reserve in Patients with Type 2 Diabetes Mellitus (LUCENT-J Study)

Sodium–glucose cotransporter-2 (SGLT2) inhibitors act on the proximal renal tubules to reduce glucose, thereby lowering blood glucose. These drugs were initially developed as antihyperglycemic agents. However, the EMPA-REG trial demonstrated for …

verfasst von:: Tamiko Tamanaha, Hisashi Makino, Cheol Son, Ryo Koezuka, Mayu Tochiya, Yoko Omura-Ohata, Tatsuya Takekawa, Masaki Matsubara, Michio Noguchi, Tsutomu Tomita, Kyoko Honda-Kohmo, Miki Matsuo, Emi Tateishi, Tetsuya Fukuda, Yoshihiro Miyamoto, Satoshi Yasuda, Kiminori Hosoda

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Springer Medizin