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Diabetes Therapy OnlineFirst articles

07.08.2020 | Brief Report Open Access

Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects

Reduced muscle strength is a risk factor for type 2 diabetes mellitus (T2DM) [ 1 ], and muscle strength is lower in patients with T2DM than in their non-diabetic counterparts [ 2 ]. In addition, reduced muscle strength predicts cardiovascular …

Yuki Someya, Yoshifumi Tamura, Kageumi Takeno, Saori Kakehi, Takashi Funayama, Yasuhiko Furukawa, Hiroaki Eshima, Keisuke Watanabe, Toshiyuki Kurihara, Toshio Yanagiya, Hideyoshi Kaga, Ruriko Suzuki, Daisuke Sugimoto, Satoshi Kadowaki, Ryuzo Kawamori, Hirotaka Watada

07.08.2020 | Letter Open Access

Letter to the Editor Regarding: Patient Preferences for GLP-1 Receptor Agonist Treatment of Type 2 Diabetes Mellitus in Japan: A Discrete Choice Experiment

Toshiyuki Iwahori

07.08.2020 | Letter Open Access

Response to “Letter to the Editor Regarding: Patient Preferences for Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Treatment of Type 2 Diabetes Mellitus in Japan: A Discrete Choice Experiment”

Anne B. Brooks, Jakob Langer, Tommi Tervonen, Mads Peter Hemmingsen, Kosei Eguchi, Elizabeth D. Bacci

05.08.2020 | Review Open Access

Insights into the Role of Renal Biopsy in Patients with T2DM: A Literature Review of Global Renal Biopsy Results

The number of persons with diabetes mellitus (DM) is increasing globally, especially type 2 DM (T2DM) [ 1 ]. In the USA, 23 million adults were diagnosed with diabetes in 2016, of whom 90.9% had T2DM and only 5.8% had type 1 diabetes (T1DM) [ 2 ].

Xue Tong, Qun Yu, Ghada Ankawi, Bo Pang, Bo Yang, Hongtao Yang

04.08.2020 | COVID-19 | Commentary Open Access

ACE2 and SARS-CoV-2 Infection: Might GLP-1 Receptor Agonists Play a Role?

Vincenzo M. Monda, Francesca Porcellati, Felice Strollo, Sandro Gentile

01.08.2020 | Original Research Open Access

Role of FTO and MC4R Polymorphisms in Escalating Obesity and Their Indirect Association With Risk of T2D in Indian Population

Obesity, a global phenomenon, is also known as corpulence or fatness. This leads to excessive accumulation of body fat, usually due to higher intake of calories than utilisation by the body. However, many other risk factors are involved in the …

Shahbaz Khan, Amit Kumar Verma, Vasiuddin Khan, Deepti Bhatt, Sahar Rafat, Mohammed A. Alsahli, Arshad Husain Rahmani, Babita Meena, Irshad Husain Naqvi, Kapil Dev

30.07.2020 | Original Research Open Access

Prescription of Sulphonylureas among Patients with Type 2 Diabetes Mellitus in Italy: Results from the Retrospective, Observational Multicentre Cross-Sectional SUSCIPE (Sulphonyl_UreaS_Correct_Internal_Prescription_Evaluation) Study

To date, despite the availability of several molecules and drug classes for the treatment of type 2 diabetes mellitus (T2DM), a large portion of patients still do not achieve optimal glycemic control and are therefore exposed to a higher long-term …

Carlo Bruno Giorda, Emanuela Orsi, Salvatore De Cosmo, Antonio Carlo Bossi, Catia Guerzoni, Stefania Cercone, Barbara Gilio, Franco Cavalot

30.07.2020 | Original Research Open Access

Subpopulation Differences in the Cardiovascular Efficacy of Long-Acting Glucagon-Like Peptide 1 Receptor Agonists in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis

Cardiovascular disease (CVD) is the leading cause of death among patients with type 2 diabetes mellitus (T2DM), who are characterized as having a high risk for CVD [ 1 ]. As popular antidiabetic agents for patients with T2DM [ 2 ], glucagon-like …

Liyun He, Na Yang, Lingling Xu, Fan Ping, Wei Li, Yuxiu Li, Huabing Zhang

29.07.2020 | Original Research Open Access

Ultra-Rapid Lispro Efficacy and Safety Compared to Humalog® in Japanese Patients With Type 2 Diabetes: PRONTO-T2D Subpopulation Analysis

The vast majority of people with diabetes have type 2 diabetes mellitus (T2DM), and the increasing global prevalence of T2DM represents a worldwide health burden [ 1 ]. Adequate blood glucose control is important for preventing diabetic …

Hideaki Jinnouchi, Makoto Imori, Hiroshi Nishiyama, Takeshi Imaoka

29.07.2020 | Original Research Open Access

Ultra-Rapid Lispro Efficacy and Safety Compared to Humalog® in Japanese Patients with Type 1 Diabetes: PRONTO-T1D Subpopulation Analysis

For people with diabetes, adequate blood glucose control is important for preventing diabetic complications and cardiovascular disease and for reducing the medical and public health burden [ 1 ]. Hemoglobin A1c (HbA1c) is the current standard for …

Junnosuke Miura, Makoto Imori, Hiroshi Nishiyama, Takeshi Imaoka

28.07.2020 | Review Open Access

A Review on Semaglutide: An Oral Glucagon-Like Peptide 1 Receptor Agonist in Management of Type 2 Diabetes Mellitus

Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are a well-established class of glucose-lowering drugs. GLP-1 RAs can be classified according to their structure, duration of action and mode of administration. This review describes the basic …

Sanjay Kalra, Rakesh Sahay

28.07.2020 | Original Research Open Access

Establishment of a Risk Prediction Model for Non-alcoholic Fatty Liver Disease in Type 2 Diabetes

Type 2 diabetes (T2DM) is a complex metabolic disorder that has become a major public health problem worldwide in the past three decades, with diabetes mellitus the ninth major cause of death. About one in 11 adults worldwide now have diabetes …

Yali Zhang, Rong Shi, Liang Yu, Liping Ji, Min Li, Fan Hu

27.07.2020 | Review Open Access

Effect of Sodium-Glucose Cotransporter-2 Inhibitors on Endothelial Function: A Systematic Review of Preclinical Studies

Diabetes is a major public health problem [ 1 ] with an increasing economic burden worldwide and a strong link to cardiovascular disease [ 2 ]. The insulin resistance associated with type 2 diabetes (T2D) contributes to hyperglycemia, dyslipidemia …

Afnan S. Alshnbari, Sophie A. Millar, Saoirse E. O’Sullivan, Iskandar Idris

25.07.2020 | Editorial Open Access

Diabetes Therapy Podcast: ATTD Conference Highlights

Sufyan Hussain, Tim Street

25.07.2020 | Review Open Access

Burden of Diabetes and Prediabetes in Nepal: A Systematic Review and Meta-Analysis

The burden of diabetes has posed insurmountable challenges in both low- and high-income countries [ 1 ]. In 2019, an estimated 463 million adults worldwide, aged 20–79 years, lived with diabetes, and the number is predicted to increase to 700 …

Nipun Shrestha, Shiva Raj Mishra, Saruna Ghimire, Bishal Gyawali, Suresh Mehata

24.07.2020 | Review Open Access

Are SGLT-2 Inhibitors the Future of Heart Failure Treatment? The EMPEROR-Preserved and EMPEROR-Reduced Trials

Heart failure is frequently associated with diabetes, and therapies which reduce mortality in people with heart failure and reduced ejection fraction (HFrEF) are often limited to drugs which modulate the renin–angiotensin–aldosterone system or …

David M. Williams, Marc Evans

22.07.2020 | Original Research Open Access

Long-Term Cost-Effectiveness Analyses of Empagliflozin Versus Oral Semaglutide, in Addition to Metformin, for the Treatment of Type 2 Diabetes in the UK

Management of type 2 diabetes mellitus (T2DM) is associated with considerable burden to the health care system in the UK, estimated to cost £10 billion each year [ 1 ]. Hypoglycaemic episodes, diabetes-related complications and comorbidities …

Mafalda Ramos, Michael H. Cummings, Anastasia Ustyugova, Syed I. Raza, Shamika U. de Silva, Mark Lamotte

21.07.2020 | Original Research Open Access

Relationship Between Estimated Glycosylated Hemoglobin Using Flash Glucose Monitoring and Actual Measured Glycosylated Hemoglobin in a Chinese Population

The FreeStyle Libre™ (Abbott Diabetes Care, Witney, UK) flash glucose monitoring (FGM) system is one of a new generation of glucose-testing devices. The FGM system has made glucose checks easier with its ability to scan a sensor for a glucose …

Yun Hu, Yun Shen, Rengna Yan, Fengfei Li, Bo Ding, Huiying Wang, Xiaofei Su, Jianhua Ma

21.07.2020 | Original Research Open Access

Clinical Efficacy of Quadruple Oral Therapy for Type 2 Diabetes in Real-World Practice: A Retrospective Observational Study

Type 2 diabetes (T2D) is a progressive disease that is characterized by a deterioration in pancreatic beta cell function and aggravation of insulin resistance [ 1 ]. As the disease progresses, several patients with T2D are eventually unable to …

Yun Kyung Cho, Jiwoo Lee, Hwi Seung Kim, Joong-Yeol Park, Chang Hee Jung, Woo Je Lee

18.07.2020 | COVID-19 | Practical Approach Open Access

Basal-Bolus Insulin Regimen for Hospitalised Patients with COVID-19 and Diabetes Mellitus: A Practical Approach

The coronavirus disease 2019 (COVID-19) pandemic has affected 213 countries worldwide, with more than 5.4 million confirmed cases and more than 340,000 deaths at the time of writing this paper [ 1 ]. The outbreak of this disease has resulted in an …

Bhawna Attri, Alpesh Goyal, Yashdeep Gupta, Nikhil Tandon