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Diabetology International OnlineFirst articles

27.03.2024 | Mini-Review

Advances in the clinical measurement of glucagon: from diagnosis to therapy

Glucagon has many functions: it promotes glucose production, fatty acid oxidation, thermogenesis, energy consumption, lipolysis, and myocardial contraction, and suppresses lipogenesis, appetite, and gastrointestinal motility. Which of these …

verfasst von:
Tadahiro Kitamura, Masaki Kobayashi

25.03.2024 | Original Article

Impact of early-morning administration of rapid-acting insulin on the increase in blood glucose levels related to the dawn phenomenon in individuals with type 1 diabetes

The dawn phenomenon, first described by Schmidt and colleagues in 1981, is characterized by a pronounced rise in blood glucose levels during the early morning that has been attributed to suboptimal fulfillment of insulin requirements in …

verfasst von:
Tomofumi Takayoshi, Yushi Hirota, Akane Yamamoto, Kai Yoshimura, Seiji Nishikage, Mariko Ueda, Wataru Ogawa

23.03.2024 | Mini-Review

Advances in clinical research on glucagon

We are now celebrating the 100th anniversary of the discovery of an important pancreatic hormone, glucagon. Glucagon is historically described as a diabetogenic hormone elevating glucose levels via increases in insulin resistance and hepatic …

verfasst von:
Ichiro Horie, Norio Abiru

12.03.2024 | Case Report

Pregnancy-associated fulminant type 1 diabetes: a case report and review of the literature

Pregnancy-associated fulminant type 1 diabetes (PF) has received high clinical attention because of its low incidence and poor prognosis. It poses a great threat to the lives of mothers and infants; therefore, it is imperative to understand its …

verfasst von:
Hikari Nebashi, Hitoshi Matsui, Chika Tei, Masanori Hasebe, Hiroko Takanashi

12.03.2024 | Original Article

Association between erectile dysfunction and subjective well-being in primary care patients with type 2 diabetes

Diabetes mellitus (DM) is a global health issue that affects 9.8% of adults (20–79 years) worldwide. However, 20.9% of adults had DM in Egypt. Globally, type 2 diabetes mellitus (T2DM) accounts for about ninety percent of all diabetes estimates [ 1 …]. Living with T2DM has a significant association with lower subjective well-being (SWB) compared with general population [

verfasst von:
Hazem A. Sayed Ahmed, Ehaab Mahmoud Abdallah, Mohamed Abd Elwahed Mohamed, Tamis Mohamed Aboelfotoh, Hebatallah Nour-Eldein, Ahmed Mahmoud Fouad

11.03.2024 | Case Report

A case of rapidly progressive insulin-dependent diabetes mellitus without islet autoantibodies developed over two years after the first dose of nivolumab

The case was an 80-year-old Japanese man. He was diagnosed with right renal cell carcinoma when he was 74. After laparoscopic radical nephrectomy, the patient received interferon, sorafenib, axitinib, and nivolumab therapy. The patient developed …

verfasst von:
Kota Nishihama, Yuko Okano, Chisa Inoue, Kanako Maki, Kazuhito Eguchi, Soichiro Tanaka, Atsuro Takeshita, Mei Uemura, Taro Yasuma, Toshinari Suzuki, Esteban C. Gabazza, Yutaka Yano

07.03.2024 | Correction

Correction: New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes in Japan Diabetes Society (English version)

verfasst von:
Akira Shimada, Eiji Kawasaki, Norio Abiru, Takuya Awata, Yoichi Oikawa, Haruhiko Osawa, Hiroshi Kajio, Junji Kozawa, Kazuma Takahashi, Daisuke Chujo, Shinsuke Noso, Tomoyasu Fukui, Junnosuke Miura, Kazuki Yasuda, Hisafumi Yasuda, Akihisa Imagawa, Hiroshi Ikegami

29.02.2024 | Case Report

Type 1 diabetes mellitus following COVID-19 vaccination: a report of two cases and review of literature

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection, which led to the coronavirus 2019 (COVID-19) pandemic, has promoted the development of novel therapeutic agents and vaccines to combat the global spread of the virus. While …

verfasst von:
Shota Mochizuki, Junnosuke Miura, Kiwako Ucida, Ryo Kubota, Hirona Fujikawa, Satoshi Takagi, Naoshi Yoshida, Sachiko Ootake, Chika Fujimori, Akihito Shinohara, Junji Tanaka, Tetsuya Babazono

29.02.2024 | Mini-Review

Monogenic diabetes

Diseases in which genetic factors contribute to nearly 100% of the causation by single-gene mutations are referred to as monogenic disorders or Mendelian genetic diseases. These include neonatal diabetes mellitus (NDM), presenting within the first …

verfasst von:
Yukio Horikawa, Kazuyoshi Hosomichi, Daisuke Yabe

26.02.2024 | Mini-Review

Advances in basic research on glucagon and alpha cells

The regulation of plasma amino acid levels by glucagon in humans first attracted the attention of researchers in the 1980s. Recent basic research using animal models of glucagon deficiency suggested that a major physiological role of glucagon is …

verfasst von:
Yoshitaka Hayashi

26.02.2024 | Original Article

Impact of inpatient management of hyperglycemia on peripheral T cell markers in patients with type 2 diabetes

Immune cell function is impaired in hyperglycemic patients with diabetes but thought to improve with normalization of blood glucose levels. In this study, we hypothesized that this improvement might involve changes in T cell function. We compared …

verfasst von:
Tomohisa Kunii, Isao Usui, Teruo Jojima, Masanori Shimizu, Masato Kase, Shintaro Sakurai, Takuya Tomaru, Toshie Iijima, Yoshimasa Aso

24.02.2024 | Original Article

Incidence of overt diabetes in pregnancy among women with 50-g glucose challenge test ≥ 200 mg/dL

Gestational diabetes (GDM) is defined as any degree of glucose intolerance that was first recognized during pregnancy. [ 1 – 4 ] However, the diagnosis is made regardless of the degree of hyperglycemia so women with a more severe degree of …

verfasst von:
Dittakarn Boriboonhirunsarn, Amporn Robkhonburi, Dawrueng Gusonkhum

20.02.2024 | Short Communication

Current status of screening and management of gestational diabetes in early pregnancy: a questionnaire survey in Japan

Our aim is to investigate the obstetric practices in Japan regarding the screening and management of gestational diabetes mellitus (GDM) diagnosed before 20 weeks of gestation (early-GDM). A web-based questionnaire survey was administered to 991 …

verfasst von:
Maki Yokoyama, Kei Miyakoshi, Sayuri Nakanishi, Noriyuki Iwama, Shigeru Aoki, Ichiro Yasuhi, Takashi Sugiyama

15.02.2024 | Original Article

Predictors of the effectiveness of isCGM usage in adults with type 1 diabetes mellitus: post-hoc analysis of the ISCHIA study

The use of continuous glucose monitoring is becoming common especially among patients with type 1 diabetes (T1D). The function of intermittent-scanning continuous glucose monitoring (isCGM) is limited compared to real-time continuous glucose …

verfasst von:
Takashi Murata, Yushi Hirota, Kiminori Hosoda, Ken Kato, Kunichi Kouyama, Ryuji Kouyama, Akio Kuroda, Yuka Matoba, Munehide Matsuhisa, Shu Meguro, Junnosuke Miura, Kunihiro Nishimura, Naoki Sakane, Akira Shimada, Shota Suzuki, Atsuhito Tone, Masao Toyoda, The ISCHIA Study Group

12.02.2024 | Original Article

Exosomal UMOD gene expression and urinary uromodulin level as early noninvasive diagnostic biomarkers for diabetic nephropathy in type 2 diabetic patients

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes and most frequently results in end-stage renal disease (ESRD). DN is characterized pathophysiologically by an early phase of glomerular hypertrophy …

verfasst von:
Shaimaa I. Barr, Sahar S. Bessa, Tarek M. Mohamed, Eman M. Abd El-Azeem

10.02.2024 | Original Article

Changes in serum levels of liver-related parameters, uric acid, and hemoglobin in patients with type 2 diabetes mellitus under treatment with tofogliflozin—a post-hoc analysis of the UTOPIA study

Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a class of anti-diabetic agents, not only improve hyperglycemia but also exhibit beneficial effects on other cardiorenal risk factors, including body weight, visceral adiposity, hyperinsulinemia …

verfasst von:
Naoto Katakami, Tomoya Mita, Yasunori Sato, Hirotaka Watada, Iichiro Shimomura

16.10.2019 | Review Article

Islet autoantibodies in disease prediction and pathogenesis

Type 1 diabetes (T1D) is now predictable by measuring specific islet autoantibodies (IAbs). Almost all children who developed multiple IAbs will progress to T1D with time, while individuals with single IAb have a very low risk although it is an …

verfasst von:
Xiaofan Jia, Yong Gu, Hilary High, Liping Yu

14.08.2019 | Original Article

Incidence and causes of mildly to moderately elevated aminotransferase in Japanese patients with type 2 diabetes

Alanine aminotransferase (ALT) is an enzyme found mostly in liver and kidney cells that influences hepatic metabolism. Serum ALT activity is elevated in diseases that cause hepatocellular injury, making it a reliable and sensitive marker of liver …

verfasst von:
Chia-Hsien Chang, Motonobu Sakaguchi

17.06.2019 | Original Article

Prospective study on clinical characteristics of Japanese diabetic patients with chronic limb-threatening ischemia presenting Fontaine stage IV

The aim of this prospective cross-sectional study was to reveal clinical characteristics of Japanese diabetic patients with chronic limb-threatening ischemia (CLTI) presenting ischemic unhealed ulcer/gangrene (Fontaine stage IV) in the real-world …

verfasst von:
Mitsuyoshi Takahara, Shota Okuno, Izumi Nakamura, Osamu Iida, Takuya Tsujimura, Yosuke Hata, Yukihiro Fujita, Masakazu Haneda

11.04.2019 | Original Article

Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy

Over the last few decades, the prevalence of cardiovascular disease (CVD), chronic kidney disease (CKD), and diabetes, leading causes of death globally and regionally [ 1 ], has increased considerably [ 2 ], while interaction between these …

verfasst von:
Sahar Ghavidel Darestani, Mihoko Kurano, Atsushi Shinnakasu, Kiyoaki Yamamoto, Yukari Dochi, Kayo Uemura, Yuko Ikeda, Aiko Arimura, Hiroshi Arimura, Akira Kikuchi, Hiroshi Hashiguchi, Takahisa Deguchi, Yoshihiko Nishio