Photodynamic therapy (PDT) with photosensitization using 5-aminolevulinic acid (ALA) [including a nanoemulsion (BF-200 ALA)] is approved in the USA for the treatment of actinic keratoses (AKs); another derivative, methyl aminolevulinate, is not …
This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.1007/s13555-022-00883-y .
verfasst von:
Akihiko Asahina, Yukari Okubo, Akimichi Morita, Yayoi Tada, Atsuyuki Igarashi, Richard G. Langley, Delphine Deherder, Mizuho Matano, Veerle Vanvoorden, Maggie Wang, Mamitaro Ohtsuki, Hidemi Nakagawa
Generalized pustular psoriasis (GPP) is a rare, chronic, and severe inflammatory skin disorder characterized by sudden eruption of sterile pustules, often accompanied by systemic inflammation. GPP flares can be life-threatening if untreated, owing …
verfasst von:
Raquel Rivera-Díaz, Esteban Daudén, José Manuel Carrascosa, Pablo de la Cueva, Luis Puig
Alopecia areata (AA) is a cell-mediated autoimmune disease in which a cytotoxic T-cell response against hair follicles occurs. AA has been demonstrated to frequently co-exist with atopic dermatitis (AD), and the coincidence of atopy predisposes to …
verfasst von:
Kinga Kołcz, Magdalena Żychowska, Edyta Sawińska, Adam Reich
Atrophic acne scars are the most common type of acne scars and cause significant physical and psychological distress [ 1 ]. They usually develop as a result of abnormal collagen formation and degradation during wound healing after inflammatory …
Hyperhidrosis (HH) is a central nervous dysfunction characterized by abnormally increased sweating due to a central dysregulation of sweat secretion. HH significantly affects the quality of life of patients in their private, social and …
verfasst von:
Johannes Wohlrab, Falk G. Bechara, Christoph Schick, Markus Naumann
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases, affecting up to 4.9% of the adult population worldwide [ 1 ]. From a clinical point of view, atopic dermatitis is characterized by recurrent eczematous skin lesions …
verfasst von:
Luigi Gargiulo, Luciano Ibba, Andrea Cortese, Jessica Avagliano, Mario Valenti, Antonio Costanzo, Alessandra Narcisi
Palmoplantar psoriasis (PP) is a chronic, debilitating, inflammatory skin disease of the palms and/or soles, with reported incidence of 2.8–40.9% in patients with psoriasis [ 1 ]. Despite the surface area of the palms and soles representing less …
verfasst von:
Riley K. Spencer, Kareem G. Elhage, Joy Q. Jin, Mitchell S. Davis, Marwa Hakimi, Tina Bhutani, Wilson Liao
Cutaneous melanoma (CM) represents a significant health burden, especially in fair-skinned populations [ 1 ]. The incidence of CM is steadily increasing throughout the world [ 2 ]. In Belgium, CM represents the fourth and sixth most frequent cancer …
verfasst von:
G. Absil, P. Collins, L. Seidel, T. Damsin, A. F. Nikkels
Atopic dermatitis (AD) is a common chronic inflammatory skin condition that affects an estimated 14% of children and 7% of adults in the United States [ 1 ] and 1–3% of adults worldwide [ 2 ], with large variations across countries and ethnicities …
verfasst von:
Stephen K. Tyring, Phoebe Rich, Yayoi Tada, Stefan Beeck, Izabella Messina, Jie Liu, Xiaohong Huang, Stephen Shumack
Plaque psoriasis is a systemic immune-mediated disease driven by interleukin-17 producing cells under the regulation of interleukin-23. Interleukin-23 signaling is mediated by the intracellular kinase tyrosine kinase 2, a Janus kinase family …
This article is published with digital features, including an infographic to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.6084/m9.figshare.21656852 .
verfasst von:
Amit Garg, Haley B. Naik, Afsaneh Alavi, Paul Hazen, Jennifer L. Hsiao, Vivian Y. Shi, Jamie Weisman, Tanja Tran, Jan Rudnik, Adam Jedrzejczyk, Ingrid Pansar, Alexa B. Kimball
Guselkumab is a fully-human immunoglobulin G1λ antibody that selectively binds to the p19 subunit of interleukin-23 (IL-23), inhibiting its interaction with the IL-23 receptor [ 1 ]. In the pivotal phase III VOYAGE 1 (NCT02207231) and VOYAGE 2 …
verfasst von:
April W. Armstrong, Timothy Fitzgerald, Robert R. McLean, Amanda Teeple, Jonathan P. Uy, Mobolaji Olurinde, Katelyn Rowland, Lin Guo, Ying Shan, Kristina Callis Duffin
Melasma is a commonly acquired pigmentation disorder characterized by symmetrical brown macules and patches on the face with irregular borders, which has a negative effect on appearance and self-esteem of patients [ 1 – 3 ]. Its pathophysiology is …
verfasst von:
Lin Liu, Chen Liang, Yuzhou Xue, Tingqiao Chen, Yangmei Chen, Yufan Lan, Jiamei Wen, Xinyi Shao, Jin Chen
Psoriasis is a common chronic, recurrent, inflammatory skin disease that mainly affects young and middle-aged people [ 1 ]. There are more than 125 million patients with psoriasis worldwide, with a morbidity rate of 0.1–3%. The incidence rate in …
Psoriasis is a systemic immune-mediated, inflammatory disease involving the skin. In some patients, joint manifestations are also present and further contribute to the disease impact. A typical area affected by psoriasis is characterized by …
verfasst von:
Melinda Gooderham, Kim A. Papp, Charles Lynde, Isabelle Delorme, Jennifer Beecker, Lorne Albrecht, Ignacio Dei-Cas, Danielle Brassard, Vimal H. Prajapati, Antonio Vieira, Lenka Rihakova
Atopic dermatitis (AD) is a chronic, pruritic, multifactorial, and heterogeneous inflammatory skin disease involving genetic, immunological, and environmental factors, characterized by periods of exacerbation and remission. AD occurs predominantly …
verfasst von:
Jorge Sánchez, Iris-Selva Ale, Maria Valeria Angles, Guillermo Guidos Fogelbach, Angela Marie Jansen, Roberto Takaoka, Arturo Borzutzky
Skin aging was considered for years an aesthetic concern but with the increase in life expectancy, the functional impact of aging has been emphasized [ 1 , 2 ] …
verfasst von:
Lilia R. S. Guadanhim, Hélio A. Miot, Juliana L. M. Soares, Silas A. M. Silva, Gislaine R. Leonardi, Renato D. Lopes, Ediléia Bagatin
Although significant advancements have been made in developing targeted therapeutics for psoriasis, a large proportion of patients never achieve long-term, complete disease resolution on even the most effective biologic [ 1 ], and disease …
verfasst von:
Lauren M. Fahmy, Bradley D. Kwinta, Celine M. Schreidah, Laura K. Ferris, Larisa J. Geskin
The essential force that allows an epicutaneously applied drug to penetrate the skin is mediated by diffusion. The physicochemical properties of the skin tissue at the site of application and the concentration gradient of the dissolved drug …