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Dermatology and Therapy OnlineFirst articles

Open Access 20.01.2023 | Review

Advances in Photodynamic Therapy for the Treatment of Actinic Keratosis and Nonmelanoma Skin Cancer: A Narrative Review

Photodynamic therapy (PDT) with photosensitization using 5-aminolevulinic acid (ALA) [including a nanoemulsion (BF-200 ALA)] is approved in the USA for the treatment of actinic keratoses (AKs); another derivative, methyl aminolevulinate, is not …

verfasst von:
Aaron S. Farberg, Justin W. Marson, Teo Soleymani

Open Access 17.01.2023 | Original Research

Bimekizumab Efficacy and Safety in Japanese Patients with Plaque Psoriasis in BE VIVID: A Phase 3, Ustekinumab and Placebo-Controlled Study

This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.1007/s13555-022-00883-y .

verfasst von:
Akihiko Asahina, Yukari Okubo, Akimichi Morita, Yayoi Tada, Atsuyuki Igarashi, Richard G. Langley, Delphine Deherder, Mizuho Matano, Veerle Vanvoorden, Maggie Wang, Mamitaro Ohtsuki, Hidemi Nakagawa

Open Access 13.01.2023 | Review

Generalized Pustular Psoriasis: A Review on Clinical Characteristics, Diagnosis, and Treatment

Generalized pustular psoriasis (GPP) is a rare, chronic, and severe inflammatory skin disorder characterized by sudden eruption of sterile pustules, often accompanied by systemic inflammation. GPP flares can be life-threatening if untreated, owing …

verfasst von:
Raquel Rivera-Díaz, Esteban Daudén, José Manuel Carrascosa, Pablo de la Cueva, Luis Puig

Open Access 13.01.2023 | Case Report

Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib—A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata

Alopecia areata (AA) is a cell-mediated autoimmune disease in which a cytotoxic T-cell response against hair follicles occurs. AA has been demonstrated to frequently co-exist with atopic dermatitis (AD), and the coincidence of atopy predisposes to …

verfasst von:
Kinga Kołcz, Magdalena Żychowska, Edyta Sawińska, Adam Reich

Open Access 12.01.2023 | Original Research

Clinical Factors Affecting the Effectiveness of 1550-nm Erbium-Doped Fractional Photothermolysis Laser for Individual Atrophic Acne Scar Types

Atrophic acne scars are the most common type of acne scars and cause significant physical and psychological distress [ 1 ]. They usually develop as a result of abnormal collagen formation and degradation during wound healing after inflammatory …

verfasst von:
Soo Ran Lee, Soyun Cho

Open Access 10.01.2023 | Review

Hyperhidrosis: A Central Nervous Dysfunction of Sweat Secretion

Hyperhidrosis (HH) is a central nervous dysfunction characterized by abnormally increased sweating due to a central dysregulation of sweat secretion. HH significantly affects the quality of life of patients in their private, social and …

verfasst von:
Johannes Wohlrab, Falk G. Bechara, Christoph Schick, Markus Naumann

Open Access 09.01.2023 | Brief Report

Real-Life Effectiveness and Safety of Upadacitinib in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: A Single-Center 16-Week Study

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases, affecting up to 4.9% of the adult population worldwide [ 1 ]. From a clinical point of view, atopic dermatitis is characterized by recurrent eczematous skin lesions …

verfasst von:
Luigi Gargiulo, Luciano Ibba, Andrea Cortese, Jessica Avagliano, Mario Valenti, Antonio Costanzo, Alessandra Narcisi

Open Access 06.01.2023 | Review

Apremilast in Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review and Meta-analysis

Palmoplantar psoriasis (PP) is a chronic, debilitating, inflammatory skin disease of the palms and/or soles, with reported incidence of 2.8–40.9% in patients with psoriasis [ 1 ]. Despite the surface area of the palms and soles representing less …

verfasst von:
Riley K. Spencer, Kareem G. Elhage, Joy Q. Jin, Mitchell S. Davis, Marwa Hakimi, Tina Bhutani, Wilson Liao

Open Access 06.01.2023 | Brief Report

Clinical Features and Survival of Multiple Primary Melanoma: A Belgian Single Center Cohort

Cutaneous melanoma (CM) represents a significant health burden, especially in fair-skinned populations [ 1 ]. The incidence of CM is steadily increasing throughout the world [ 2 ]. In Belgium, CM represents the fourth and sixth most frequent cancer …

verfasst von:
G. Absil, P. Collins, L. Seidel, T. Damsin, A. F. Nikkels

Open Access 02.01.2023 | Original Research

Risankizumab in Patients with Moderate-to-Severe Atopic Dermatitis: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study

Atopic dermatitis (AD) is a common chronic inflammatory skin condition that affects an estimated 14% of children and 7% of adults in the United States [ 1 ] and 1–3% of adults worldwide [ 2 ], with large variations across countries and ethnicities …

verfasst von:
Stephen K. Tyring, Phoebe Rich, Yayoi Tada, Stefan Beeck, Izabella Messina, Jie Liu, Xiaohong Huang, Stephen Shumack

Open Access 02.01.2023 | Review

Novel Therapies in Plaque Psoriasis: A Review of Tyrosine Kinase 2 Inhibitors

Plaque psoriasis is a systemic immune-mediated disease driven by interleukin-17 producing cells under the regulation of interleukin-23. Interleukin-23 signaling is mediated by the intracellular kinase tyrosine kinase 2, a Janus kinase family …

verfasst von:
George Martin

Open Access 31.12.2022 | Original Research

Real-World Findings on the Characteristics and Treatment Exposures of Patients with Hidradenitis Suppurativa from US Claims Data

This article is published with digital features, including an infographic to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.6084/m9.figshare.21656852 .

verfasst von:
Amit Garg, Haley B. Naik, Afsaneh Alavi, Paul Hazen, Jennifer L. Hsiao, Vivian Y. Shi, Jamie Weisman, Tanja Tran, Jan Rudnik, Adam Jedrzejczyk, Ingrid Pansar, Alexa B. Kimball

Open Access 31.12.2022 | Brief Report

Real-World Effectiveness of 9–12 Months of Guselkumab Therapy among Patients with Moderate-to-Severe Plaque Psoriasis in the CorEvitas Psoriasis Registry

Guselkumab is a fully-human immunoglobulin G1λ antibody that selectively binds to the p19 subunit of interleukin-23 (IL-23), inhibiting its interaction with the IL-23 receptor [ 1 ]. In the pivotal phase III VOYAGE 1 (NCT02207231) and VOYAGE 2 …

verfasst von:
April W. Armstrong, Timothy Fitzgerald, Robert R. McLean, Amanda Teeple, Jonathan P. Uy, Mobolaji Olurinde, Katelyn Rowland, Lin Guo, Ying Shan, Kristina Callis Duffin

Open Access 28.12.2022 | Original Research

An Intelligent Diagnostic Model for Melasma Based on Deep Learning and Multimode Image Input

Melasma is a commonly acquired pigmentation disorder characterized by symmetrical brown macules and patches on the face with irregular borders, which has a negative effect on appearance and self-esteem of patients [ 1 – 3 ]. Its pathophysiology is …

verfasst von:
Lin Liu, Chen Liang, Yuzhou Xue, Tingqiao Chen, Yangmei Chen, Yufan Lan, Jiamei Wen, Xinyi Shao, Jin Chen

Open Access 24.12.2022 | Original Research

Efficacy, Safety and Pharmacokinetics of IL-17 Monoclonal Antibody Injection (AK111) in Patients with Moderate-to-Severe Plaque Psoriasis: A Randomized, Double-Blinded, Placebo-Controlled Phase Ib Multidose Escalation Clinical Study

Psoriasis is a common chronic, recurrent, inflammatory skin disease that mainly affects young and middle-aged people [ 1 ]. There are more than 125 million patients with psoriasis worldwide, with a morbidity rate of 0.1–3%. The incidence rate in …

verfasst von:
Congjun Jiang, Huan Zhou, Wanlu Zhang, Yu Xia, Baiyong Li, Xiang Ni, Guoqin Wang, Wenhui Zhang, Benchao Chen, Zhimei He, Min Zhang, Rui Chen, Hongzhong Jin, Liehua Deng

Open Access 23.12.2022 | Original Research

Sustained Effectiveness of Secukinumab Across Different Body Regions in Patients with Moderate-to-Severe Plaque Psoriasis from the PURE Registry

Psoriasis is a systemic immune-mediated, inflammatory disease involving the skin. In some patients, joint manifestations are also present and further contribute to the disease impact. A typical area affected by psoriasis is characterized by …

verfasst von:
Melinda Gooderham, Kim A. Papp, Charles Lynde, Isabelle Delorme, Jennifer Beecker, Lorne Albrecht, Ignacio Dei-Cas, Danielle Brassard, Vimal H. Prajapati, Antonio Vieira, Lenka Rihakova

Open Access 23.12.2022 | Review

Healthcare Disparities in Atopic Dermatitis in Latin America: A Narrative Review

Atopic dermatitis (AD) is a chronic, pruritic, multifactorial, and heterogeneous inflammatory skin disease involving genetic, immunological, and environmental factors, characterized by periods of exacerbation and remission. AD occurs predominantly …

verfasst von:
Jorge Sánchez, Iris-Selva Ale, Maria Valeria Angles, Guillermo Guidos Fogelbach, Angela Marie Jansen, Roberto Takaoka, Arturo Borzutzky

Open Access 22.12.2022 | Original Research

Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study

Skin aging was considered for years an aesthetic concern but with the increase in life expectancy, the functional impact of aging has been emphasized [ 1 , 2 ] …

verfasst von:
Lilia R. S. Guadanhim, Hélio A. Miot, Juliana L. M. Soares, Silas A. M. Silva, Gislaine R. Leonardi, Renato D. Lopes, Ediléia Bagatin

Open Access 21.12.2022 | Brief Report

Topical Mechlorethamine for the Treatment of Psoriasis: A Report of Two Cases and Literature Review

Although significant advancements have been made in developing targeted therapeutics for psoriasis, a large proportion of patients never achieve long-term, complete disease resolution on even the most effective biologic [ 1 ], and disease …

verfasst von:
Lauren M. Fahmy, Bradley D. Kwinta, Celine M. Schreidah, Laura K. Ferris, Larisa J. Geskin

Open Access 21.12.2022 | Review

Supersaturation as a Galenic Concept for Improving the Cutaneous Bioavailability of Drugs in Topical Therapy

The essential force that allows an epicutaneously applied drug to penetrate the skin is mediated by diffusion. The physicochemical properties of the skin tissue at the site of application and the concentration gradient of the dissolved drug …

verfasst von:
Johannes Wohlrab, Adina Eichner