Osteoporosis International OnlineFirst articles

Open Access 16.04.2024 | Original Article

Clinical features, treatment, and follow-up of OPPG and high-bone-mass disorders: LRP5 is a key regulator of bone mass

Low-density lipoprotein receptor-related protein 5 (LRP5) is a type I transmembrane receptor belonging to the LDL receptor family, composed of an extracellular domain, a membrane-spanning domain, and an intracellular domain [ 1 ]. The extracellular …

verfasst von:: Na Ren, Shanshan Lv, Xiang Li, Chong Shao, Ziyuan Wang, Yazhao Mei, Wendi Yang, Wenzhen Fu, Yunqiu Hu, Ling Sha, Weiwei Hu, Zhenlin Zhang, Chun Wang

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15.04.2024 | Review

Family/caregiver influence on osteoporosis management for older people: an integrative review

An integrative literature review was conducted to understand family/caregiver influence on osteoporosis management for older people. Findings include caregivers’ overprotection, caregivers’ risks for fragility fractures due to caregiving role …

verfasst von:: Paula Zubick, Sherry Dahlke

15.04.2024 | Original Article

The cost-effectiveness of osteoporosis medications for preventing periprosthetic fractures following femoral neck fracture indicated hip arthroplasty: a break-even analysis

For each decade of life after the age of 50, the risk of hip fracture doubles [ 1 ]. Due to the aging population, the volume of worldwide hip fractures was projected to increase from 1.7 million in 1990 to 6.3 million in 2050 [ 2 ]. Although they …

verfasst von:: Amil R. Agarwal, Matthew J. Kinnard, Christopher Murdock, Amy Y. Zhao, Uzoma Ahiarakwe, Jordan S. Cohen, Kendall F. Moseley, Gregory J. Golladay, Savyasachi C. Thakkar

Open Access 13.04.2024 | Case Report

Delayed and significant hypercalcaemia due to teriparatide therapy: a case report and review

Teriparatide is recombinant human parathyroid hormone (1–34) and is indicated for the treatment of patients with osteoporosis at high risk of fracture, including steroid induced osteoporosis [ 1 ]. It is the first anabolic therapy developed and has …

verfasst von:: K. McCarroll, T. Carroll, M. Neville, D. Fitzpatrick, R. Lannon

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12.04.2024 | Original Article

Higher prevalence of thyroid-specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007–2010

Osteoporosis is a common health problem characterized by decreased bone density and strength. Weakened bone microarchitecture leads to osteoporotic fractures. Apart from aging-related and estrogen deficiency-related bone loss, other diseases, such …

verfasst von:: Jialu Wu, Jian Li, Zhe Yan, Xijie Yu, Hui Huang

08.04.2024 | Original Article

Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study

Bone fracture and 30-year BMI trajectories

Osteoporotic fracture in adults is a major health problem in the United States and worldwide [ 1 ]. For older adults, the fracture risk is greater than that for most younger individuals—often due to underlying comorbidities, such as bone fragility …

verfasst von:: Zihao Xin, Hanfei Xu, Xiaoyu Zhang, Elizabeth J. Samelson, Douglas P. Kiel, Ching-Ti Liu

Open Access 08.04.2024 | Review

Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review

A recent fracture is a powerful risk factor for a subsequent fracture [ 1 ]. Therefore, it is imperative that osteoporosis treatment be initiated very soon after an incident fracture to decrease imminent fracture risk. However, a theoretical …

verfasst von:: M. Chandran, K. E. Akesson, M. K. Javaid, N. Harvey, R. D. Blank, M. L. Brandi, T. Chevalley, P. Cinelli, C. Cooper, W. Lems, G. P. Lyritis, P. Makras, J. Paccou, D. D. Pierroz, M. Sosa, T. Thomas, S. Silverman, Fracture Working Group of the Committee of Scientific Advisors of the International Osteoporosis Foundation, on behalf of the International Osteoporosis Foundation, Société Internationale de Chirurgie Orthopédique et de Traumatologie

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06.04.2024 | Editorial

Follow-up in Fracture Liaisons Services: the involvement of general practitioners and fracture nurses is urgently needed

verfasst von:: Willem F. Lems, Joop P. van den Bergh, Piet Geusens

Open Access 04.04.2024 | Original Article

Romosozumab in patients who experienced an on-study fracture: post hoc analyses of the FRAME and ARCH phase 3 trials

A previous fracture is well-documented as a strong risk factor for the occurrence of future fracture [ 1 – 4 ]. The risk for subsequent fracture is at its greatest immediately following a fracture [ 3 , 5 , 6 ]; incidence of fracture after a prior …

verfasst von:: J. Lane, B. Langdahl, M. Stone, A. Kurth, M. Oates, J. Timoshanko, Z. Wang, C. Libanati, F. Cosman

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Open Access 02.04.2024 | Original Article

Cost-effectiveness of romosozumab for the treatment of postmenopausal women with osteoporosis at high risk of fracture in Belgium

The burden of osteoporosis is significant, both in economic and human terms. Globally, osteoporosis causes around 9 million new fractures each year, and this number is steadily increasing. It is projected to affect 200 million women worldwide …

verfasst von:: Evelien Gielen, Martina Aldvén, John A. Kanis, Fredrik Borgström, Emmanuelle Senior, Damon Willems

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02.04.2024 | Original Article

Demographics and medical burden of osteogenesis imperfecta: a nationwide database analysis

Osteogenesis Imperfecta (OI), often referred to as brittle bone disease, encompasses a variety of connective tissue disorders primarily characterized by a lifelong predisposition to fractures [ 1 ]. Some individuals with OI may also exhibit …

verfasst von:: Chien-An Shih, Chia-Chun Li, Yin-Fan Chang, Jawl-Shan Hwang, Meng-Che Tsai, Yen-Yin Chou, Chii-Jeng Lin, Ming-Tung Huang, Chih-Kai Hong, Ta-Wei Tai, Chih-Hsing Wu

Open Access 02.04.2024 | Review

The association of vasomotor symptoms with fracture risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis of observational studies

Vasomotor symptoms (VMS), mainly hot flushes and night sweats, are quite common in women entering menopause and adversely affect their quality of life [ 1 , 2 ]. An abrupt increase in VMS occurs during the first two years before the final menstrual …

verfasst von:: Panagiotis Anagnostis, Konstantinos Lallas, Anna Pappa, Georgios Avgeris, Kristina Beta, Dimitrios Damakis, Eirini Fountoukidou, Maria Zidrou, Irene Lambrinoudaki, Dimitrios G. Goulis

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01.04.2024 | Original Article

Periprosthetic fractures are osteoporotic fractures: missed opportunities for osteoporosis diagnosis

Approximately 7 million Americans are living with a total hip or total knee replacement [ 1 ]. The number of patients undergoing total hip and total knee arthroplasty procedures is projected to reach 4 million annually by 2030, representing an …

verfasst von:: Paul S. Whiting, Kristyn Hare, Diane Krueger, Gretta Borchardt, Kristina Parvanta-Johnson, James Bernatz, Neil Binkley, Paul A. Anderson

01.04.2024 | Correction

Correction to: Semi-automatic proximal humeral trabecular bone density assessment tool: technique application and clinical validation

verfasst von:: De-Ming Guo, Yuan-Zhi Weng, Ze-Hao Yu, Shi-Huai Li, Wen-Rui Qu, Xiao-Ning Liu, Huan Qi, Chi Ma, Xiong-Feng Tang, Rui-Yan Li, Qinghe Han, Hao Xu, Weijia William Lu, Yan-Guo Qin

29.03.2024 | Letter to the Editor

Factors influencing the measurement of sagittal spinopelvic alignment in patients with vertebral fractures

verfasst von:: Takaomi Kobayashi, Tadatsugu Morimoto, Masaaki Mawatari

29.03.2024 | Letter to the Editor

Letter to the editor

verfasst von:: Nicolas Plais, Jesus Gallego-Bustos, Ignacio Mahillo-Fernández, Felix Tomé-Bermejo, Charles Mengis, Luis Alvarez-Galovich

Open Access 27.03.2024 | Original Article

Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study

Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mass and the deterioration of bone microstructure, which leads to heightened bone fragility and an elevated risk of fracture [ 1 ]. Clinical diagnosis primarily …

verfasst von:: Yaotian Cai, Gao Jun, Xiaojie Zhuang

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Open Access 27.03.2024 | Review

Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis

To determine and appraise the certainty of fracture liaison service (FLS) in reducing the risk of secondary fragility fractures in older adults aged ≥ 50 years and to examine the nature of the FLS and the roles of various disciplines involved in …

verfasst von:: Musa Sani Danazumi, Nicol Lightbody, Gordana Dermody

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23.03.2024 | Original Article

The relationship between bone strain index, bone mass, microarchitecture and mechanical behavior in human vertebrae: an ex vivo study

Osteoporosis is a metabolic bone disease characterized by a reduction in bone strength that leads to an increase in fragility fractures risk [ 1 ]. Osteoporotic fractures are associated with substantial social, economic, and healthcare burdens.

verfasst von:: Jean-Paul Roux, François Duboeuf, Elisabeth Sornay-Rendu, Luca Rinaudo, Fabio Massimo Ulivieri, Julien Wegrzyn, Roland Chapurlat

Open Access 23.03.2024 | Original Article

The significance of recent fracture location for imminent risk of hip and vertebral fractures—a nationwide cohort study on older adults in Sweden

Fractures, particularly in the hip and spine, lead to considerable suffering, morbidity, and mortality, resulting in substantial societal and healthcare costs [ 1 , 2 ]. Upon reaching the age of fifty, women face a 50% lifetime risk of experiencing …

verfasst von:: Mattias Lorentzon, Henrik Litsne, Kristian F. Axelsson

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin