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Naunyn-Schmiedeberg's Archives of Pharmacology OnlineFirst articles

The hepatoprotective role of piperazine ferulate against cisplatin-induced hepatotoxicity in rats: insights into the Keap1/Nrf-2/HO-1 signaling and inflammatory pathways

  • Research

Piperazine ferulate (PF) is a compound synthesized from the reaction between ferulic acid and piperazine hexahydrate. PF has demonstrated various antioxidative and anti-inflammatory properties, indicating its potential as a protective agent.

Combining anxiolytic activity of thymol and trans-ferulic acid: a potential GABAergic intervention

  • Research

Trans‐ferulic acid (TFA), a phenolic acid abundant in fruits and cereals, and thymol (THY), a monoterpenoid phenol from thyme oils, are bioactive natural compounds with notable neuropharmacological potential. This study evaluated the combined …

Novel cyclic heptapeptides as potential therapeutics against methicillin-resistant Staphylococcus aureus infections

  • Research

Novel therapeutic agents for methicillin-resistant Staphylococcus aureus (MRSA) need to be developed because of the growing antibacterial resistance against MRSA. This study aimed to design and develop novel cyclic heptapeptides as potential …

Targeting NMDA receptors in pain management: therapeutic innovations through piracetam repurposing

  • Review

The N-methyl-d-aspartate (NMDA) receptor plays a pivotal role in pain modulation, making it a key target for therapeutic interventions in chronic pain management. Traditionally known for its cognitive-enhancing effects, piracetam …

Evaluating adverse events of antibacterials in infants: insights from FDA adverse event reporting system (FAERS) data

  • Open Access
  • Research

This study addresses a significant gap in evaluations of the safety of antibacterial drugs in infants aged 0–1 year on the basis of a comprehensive pharmacovigilance analysis. We use data spanning the period from 2005Q1 to 2025Q1, which we obtain …

Biocompatible hydrogel eradicates pregnancy-associated genital warts

  • Research

Current treatments for pregnancy-associated genital warts (PGW) often fail to balance safety and efficacy, especially during gestation. In this study, we introduce GelPV-5-ALA-Matrine, a smart, photoresponsive hydrogel designed for localized …

Natural compounds naringin and nobiletin synergistically inhibit the PI3K/AKT/mTOR pathway in NSCLC: molecular docking and cytotoxicity studies

  • Research

Non-small-cell lung cancer (NSCLC) is the most common malignant type, and the present treatments do not offer the most effective outcomes for therapy. The capacity of tumor cells to proliferate and migrate is closely associated with the aberrant …

Clonidine attenuates chronic hypoxic stress-induced behavioral abnormalities in male Swiss mice through suppression of oxidative stress and pro-inflammatory cytokines

  • Research

Hypoxia is a potent stressor arising from insufficient oxygen delivery to the brain that can trigger neuronal damage and neurological complications. Oxidative stress (OS) and neuroinflammation have been implicated in hypoxia-induced …

In vivo and in silico approaches for evaluating nerolidol-β-cyclodextrin nanoparticles: Antioxidant potential and hormonal modulation in DMBA-induced mammary carcinoma

  • Research

The aim of this study is to investigate the chemopreventive effects of nerolidol-β-cyclodextrin nanoparticles (NER-βCD-NPs) on DMBA-induced oxidative stress, lipid, and hormonal disturbances in rats and to characterize their physicochemical …

Overexpression of histidine decarboxylase promotes cancer cell apoptosis and migration in HN5 cells

  • Research

This study aimed to assess the expression of histidine decarboxylase (HDC) in oral squamous cell carcinoma (OSCC) and investigate its functional role in patient prognosis as well as in apoptosis and migration of OSCC cells. A total of 58 …

An integrated approach combining computational analyses and experimental validation deciphers the mechanism and active substance basis of Huazhuo Ningfu decoction in treating psoriasis

  • Research

This study aims to elucidate the mechanism of HZD in treating psoriasis and identify its active components through a comprehensive approach combining tandem mass tag (TMT)-based quantitative proteomics with machine learning and molecular docking …

Postmarketing pharmacovigilance study of levothyroxine based on FDA adverse event reporting system (FAERS) and Mendelian randomization

  • Research

This study utilizes adverse event records for levothyroxine from the FAERS database to explore and evaluate its post-marketing adverse events. Using levothyroxine adverse event records from the FAERS database, four methods—report ratio odds ratio …

Bisphenol A disrupts cartilage homeostasis through CYP2C19

  • Open Access
  • Research

Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical (EDC), disrupts hormonal signaling and induces inflammation, yet its role in osteoarthritis (OA) pathogenesis remains unclear, underscoring a critical environmental health research gap.

Chemical screening of Hibiscus rosa-sinensis for their phytochemicals and their in vitro/in silico evaluation as α-amylase inhibitors

  • Research

Since ancient times, flowers of Hibiscus rosa-sinensis have been a prominent ingredient of medicinal recipes. The understudied research article is a part of our experimental work to isolate bioactive molecules of flowers of Hibiscus rosa-sinensis …

Integrative bioinformatics and machine learning to explore the mechanism of Scutellaria baicalensis Georgi in TGF-β1-induced ASMCs proliferation during asthma airway remodeling

  • Research

Bronchial asthma is a complex disease characterized by chronic inflammation and airway hyperresponsiveness. As a traditional Chinese herb with anti-inflammatory and anti-allergic properties, Scutellaria baicalensis Georgi (SBG) has demonstrated …

Risedronate attenuates renal fibrosis by targeting prenylation-dependent RhoA/ROCK1 and ERK/NF-κB signaling

  • Research

Chronic kidney disease (CKD) is a global health concern with rising morbidity and mortality. The repurposing of drugs offers a valuable opportunity to accelerate therapeutic development in CKD. Risedronate (RIS), a nitrogen-containing …

UV-synthesized albumin-based doxorubicin nanoparticles induce apoptosis and modulate leukemia surface markers while overcoming drug resistance

  • Research

Although chemotherapeutic agents such as doxorubicin (DOX) are used to treat leukemia, their application is often limited by systemic toxicity, low specificity, and the development of drug resistance. The development of drug delivery systems can …