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Clinical Research in Cardiology OnlineFirst articles

31.07.2021 | Original Paper Open Access

Gender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities

Chronic obstructive lung disease (COPD) has a high prevalence worldwide [ 1 ] and is known to be associated with multiple comorbidities, in particular cardiovascular disorders [ 2 , 3 ]. Many studies have shown differences between males and females …

Franziska C. Trudzinski, Christina Kellerer, Rudolf A. Jörres, Peter Alter, Johanna I. Lutter, Frederik Trinkmann, Felix J. F. Herth, Marion Frankenberger, Henrik Watz, Claus F. Vogelmeier, Hans-Ulrich Kauczor, Tobias Welte, Jürgen Behr, Robert Bals, Kathrin Kahnert

31.07.2021 | Letter to the Editors Open Access

Occurrence of acute infarct-like myocarditis following COVID-19 vaccination: just an accidental co-incidence or rather vaccination-associated autoimmune myocarditis?

Bishwas Chamling, Volker Vehof, Stefanos Drakos, Mareike Weil, Philipp Stalling, Christian Vahlhaus, Patrick Mueller, Michael Bietenbeck, Holger Reinecke, Claudia Meier, Ali Yilmaz

27.07.2021 | Original Paper

Clinical outcomes of drug-coated balloon in coronary lesions: a real-world, all-comers study

Modern interventional cardiology was well established by the time balloon angioplasty for the treatment of coronary artery disease (CAD) was performed in 1977 [ 1 ]. Subsequently, in 1986, the first bare-metal stent (BMS) was introduced as a rescue …

Liang Pan, Wenjie Lu, Zhanying Han, Sancong Pan, Xi Wang, Yingguang Shan, Xule Wang, Xiaolin Zheng, Ran Li, Yanjun Zhou, Peng Qin, Qiangwei Shi, Shuai Zhou, Wencai Zhang, Sen Guo, Peisheng Zhang, Xiaofei Qin, Guoju Sun, Zhongsheng Qin, Zhenwen Huang, Chunguang Qiu

27.07.2021 | Original Paper Open Access

Complications and mortality after catheter ablation of ventricular arrhythmias: risk in VT ablation (RIVA) score

Catheter ablation of ventricular arrhythmias (VA) has proven to be an effective therapeutic option for secondary arrhythmia prophylaxis [ 1 – 4 ]. Recent ablation modalities diverge from pure endocardial approaches to combined epi- and endocardial …

Shibu Mathew, Thomas Fink, Sebastian Feickert, Osamu Inaba, Naotaka Hashiguchi, Michael Schlüter, Peter Wohlmuth, Erik Wissner, Roland Richard Tilz, Christian-Hendrik Heeger, Laura Rottner, Bruno Reissmann, Andreas Rillig, Andreas Metzner, Tilman Maurer, Karl-Heinz Kuck, Feifan Ouyang

23.07.2021 | Original Paper Open Access

Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation

The association of aortic valve stenosis (AS) and gastrointestinal bleeding (GIB) from angiodysplasia is known as Heyde syndrome (HS) [ 1 ]. The prevalence of GIB related to HS has been described as 1 to 3 percent of patients with aortic stenosis [ …2

Lara Waldschmidt, Andreas Drolz, Paula Heimburg, Alina Goßling, Sebastian Ludwig, Lisa Voigtländer, Matthias Linder, Niklas Schofer, Hermann Reichenspurner, Stefan Blankenberg, Dirk Westermann, Lenard Conradi, Johannes Kluwe, Moritz Seiffert

23.07.2021 | Original Paper Open Access

Activity of the adrenomedullin system to personalise post-discharge diuretic treatment in acute heart failure

Acute heart failure (AHF) is the most common cause of hospitalisation in patients 50 years or older, and it is still associated with unacceptably high mortality and morbidity [ 1 , 2 ], with up to 30% of patients dying within 1 year after hospital …

Nikola Kozhuharov, Leong Ng, Desiree Wussler, Ivo Strebel, Zaid Sabti, Oliver Hartmann, Mohamed Eltayeb, Iain Squire, Albina Nowak, Max Rieger, Jasmin Martin, Eleni Michou, Sabrina Stefanelli, Christian Puelacher, Samyut Shrestha, Maria Belkin, Tobias Zimmermann, Pedro Lopez-Ayala, Joachim Struck, Andreas Bergmann, Alexandre Mebazaa, Alice Blet, Danielle Menosi Gualandro, Tobias Breidthardt, Christian Mueller

19.07.2021 | COVID-19 | Original Paper Open Access

SARS-CoV-2, myocardial injury and inflammation: insights from a large clinical and autopsy study

Viruses are known as the most prevalent cause of myocarditis [ 1 ], and during previous viral outbreaks, which to date were mostly due to influenza A and B cases, autopsy series reported myocarditis prevalence ranging from 22 to 34% [ 2 , 3 ].

Matteo Dal Ferro, Rossana Bussani, Alessia Paldino, Vincenzo Nuzzi, Chiara Collesi, Lorena Zentilin, Edoardo Schneider, Ricardo Correa, Fulvio Silvestri, Serena Zacchigna, Mauro Giacca, Marco Metra, Marco Merlo, Gianfranco Sinagra

16.07.2021 | Original Paper

Feasibility and effectiveness of a multidimensional post-discharge disease management programme for heart failure patients in clinical practice: the HerzMobil Tirol programme

Heart failure (HF) is a global health problem with increasing incidence and prevalence [ 1 ]. Hospitalization for acute HF, which either marks the onset of the disease or—more often—abruptly interrupts the course of the disease, is associated with …

G. Poelzl, T. Egelseer-Bruendl, B. Pfeifer, R. Modre-Osprian, S. Welte, B. Fetz, S. Krestan, B. Haselwanter, M. M. Zaruba, J. Doerler, C. Rissbacher, E. Ammenwerth, A. Bauer

16.07.2021 | Original Paper Open Access

Diastolic dysfunction in individuals with and without heart failure with preserved ejection fraction

Heart failure (HF) with preserved ejection fraction (HFpEF) is a widespread syndrome with increasing prevalence. It is characterized by clinical symptoms or signs, left ventricular ejection fraction ≥ 50%, and a pathological increase of cardiac …

Jan-Per Wenzel, Ramona Bei der Kellen, Christina Magnussen, Stefan Blankenberg, Benedikt Schrage, Renate Schnabel, Julius Nikorowitsch

13.07.2021 | Original Paper

Feasibility and safety of minimal-contrast IVUS-guided rotational atherectomy for complex calcified coronary artery disease

Chronic kidney disease (CKD) is associated with accelerated atherosclerosis and coronary artery calcification [ 1 ]. Percutaneous coronary intervention (PCI) of heavily calcified coronary lesions is technically challenging and usually associated …

Abdelhakim Allali, Hussein Traboulsi, Dmitriy S. Sulimov, Mohamed Abdel-Wahab, Felix Woitek, Norman Mangner, Rayyan Hemetsberger, Nader Mankerious, Karim Elbasha, Ralph Toelg, Gert Richardt

12.07.2021 | Original Paper Open Access

Quantitative flow ratio (QFR) identifies functional relevance of non-culprit lesions in coronary angiographies of patients with acute myocardial infarction

Acute myocardial infarction (MI) represents the acute presentation of coronary artery disease (CAD), and is defined as evidence of myocardial injury with abnormal biomarkers in the setting of acute myocardial ischemia [ 1 ]. Invasive coronary …

Andrea Milzi, Rosalia Dettori, Nikolaus Marx, Sebastian Reith, Mathias Burgmaier

12.07.2021 | Original Paper Open Access

Prognostic value of hepatorenal function following transcatheter edge-to-edge mitral valve repair

The cardiovascular system is in close relation to other organ systems, including the kidney and the liver, and impairment of cardiac function can lead to hepatic or renal dysfunction and vice versa [ 1 – 3 ]. The interactions of the heart with the …

Tetsu Tanaka, Refik Kavsur, Maximilian Spieker, Christos Iliadis, Clemens Metze, Patrick Horn, Atsushi Sugiura, Stephan Baldus, Malte Kelm, Georg Nickenig, Roman Pfister, Ralf Westenfeld, Marc Ulrich Becher

09.07.2021 | Trial Design Open Access

Rationale and design of the EPCHF trial: the early palliative care in heart failure trial (EPCHF)

The progressive nature of heart failure (HF) coupled with high mortality and poor quality-of-life (QoL) mandates greater attention to palliative care (PC) as a routine component of HF management. Limited evidence exists from randomized controlled …

Marc Ulrich Becher, Mahmoud Balata, Michaela Hesse, Fabian Draht, Christian Zachoval, Birgitta Weltermann, Ralf Westenfeld, Martin Neukirchen, Roman Pfister, Thomas Standl, Lukas Radbruch, Georg Nickenig

03.07.2021 | Original Paper

Prevalence and clinical characteristics of prediabetes and diabetes mellitus in young patients with ST-segment elevation myocardial infarction

Diabetes mellitus (DM) is a known risk factor for coronary artery disease (CAD) and ST-segment elevation myocardial infarction (STEMI) [ 1 , 2 ]. Many clinical studies have previously shown that DM is more frequent in elderly populations with acute …

Luis Alberto Mata Marín, Johannes Schmucker, Andreas Fach, Rico Osteresch, Stephan Rühle, Daniela Garstka, Ingo Eitel, Rainer Hambrecht, Harm Wienbergen

03.07.2021 | Original Paper

Hypertension control and end-stage renal disease in atrial fibrillation: a nationwide population-based cohort study

Atrial fibrillation (AF) and chronic kidney disease (CKD) are closely inter-related. Patients with AF have a high risk of CKD and end-stage renal disease (ESRD), whereas patients with CKD show an increased risk of AF [ 1 – 3 ].

Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip

28.06.2021 | Letter to the Editors Open Access

The Heidelberg cardio-oncology unit (COUNT)—a possible blueprint for improved care of cardio-oncological patients

L. H. Lehmann, F. Stein, D. Jäger, N. Frey

25.06.2021 | Original Paper Open Access

Serum markers of fibrosis, cardiovascular and all-cause mortality in hemodialysis patients: the AURORA trial

Cardiovascular (CV) diseases are the leading cause of mortality in patients on dialysis. But for now, no therapeutic intervention was proven to improve CV outcomes [ 1 , 2 ].

Madonna Salib, Sophie Girerd, Nicolas Girerd, Winfried März, Hubert Scharnagl, Ziad A. Massy, Céline Leroy, Kévin Duarte, Hallvard Holdaas, Alan G. Jardine, Roland E. Schmieder, Bengt Fellström, Natalia López-Andrés, Patrick Rossignol, Faiez Zannad

24.06.2021 | Original Paper Open Access

Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study

Type 2 diabetes mellitus (T2DM) is the leading metabolic disease worldwide affecting approximately 422 million adults according to the World Health Organisation [ 1 ]. T2DM represents a well-established risk factor for cardiovascular disease (CVD) …

Volker H. Schmitt, Anja Leuschner, Claus Jünger, Antonio Pinto, Omar Hahad, Andreas Schulz, Natalie Arnold, Sven-Oliver Tröbs, Marina Panova-Noeva, Karsten Keller, Tanja Zeller, Manfred Beutel, Norbert Pfeiffer, Konstantin Strauch, Stefan Blankenberg, Karl J. Lackner, Jürgen H. Prochaska, Philipp S. Wild, Thomas Münzel

24.06.2021 | Original Paper Open Access

Factors associated with a high or low implantation of self-expanding devices in TAVR

Transcatheter aortic valve replacement (TAVR) has been established as the treatment of choice in high-risk patients with severe symptomatic aortic stenosis and has convincing benefits in intermediate- and low-risk patients [ 1 ]. Technological …

Verena Veulemans, Oliver Maier, Kerstin Piayda, Kira Lisanne Berning, Stephan Binnebößel, Amin Polzin, Shazia Afzal, Lisa Dannenberg, Patrick Horn, Christian Jung, Ralf Westenfeld, Malte Kelm, Tobias Zeus

22.06.2021 | Original Paper Open Access

Ten-year clinical outcomes of polymer-free versus durable polymer new-generation drug-eluting stent in patients with coronary artery disease with and without diabetes mellitus

Results of the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol- and Zotarolimus-Eluting Stents (ISAR-TEST 5) trial

Diabetes mellitus is associated with numerous acute and late complications affecting different organ systems. However, cardiovascular disease remains the leading cause of morbidity and mortality in this population. In this vein, myocardial …

Tobias Koch, Tobias Lenz, Michael Joner, Erion Xhepa, Tobias Koppara, Jens Wiebe, J. J. Coughlan, Alp Aytekin, Tareq Ibrahim, Thorsten Kessler, Salvatore Cassese, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Sebastian Kufner, for the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol-Eluting Versus Zotarolimus- Eluting Stents (ISAR-TEST 5) Investigators