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Ophthalmology and Therapy OnlineFirst articles

Open Access 08.04.2024 | ORIGINAL RESEARCH

Bilateral Pattern Electroretinogram Abnormalities in Patients with Herpes Zoster Keratitis and Conjunctivitis

Herpes zoster ophthalmicus (HZO) is secondary to reactivation of varicella zoster virus (VZV) in the ophthalmic division of the trigeminal nerve, which accounts for 10–20% of all herpes zoster cases [ 15 , 19 ]. As VZV replicates, the inflammation …

verfasst von:
Jingyi Li, Yuexin Wang, Xin Xie, Weizhen Zeng, Shiying Li, Rupesh Agrawal, Yun Feng

Open Access 08.04.2024 | ORIGINAL RESEARCH

Additional Guidance on the Use of the PRESERFLO™ MicroShunt in the Treatment of Glaucoma: Insights from a Second Delphi Consensus Panel

This article is published with digital features, including videos, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/10.6084/m9.figshare.25055621 .

verfasst von:
Anthony P. Khawaja, Luís Abegão Pinto, Ingeborg Stalmans, Florent Aptel, Anna Barkander, Keith Barton, Henny Beckers, Milko Iliev, Thomas Klink, Giorgio Marchini, Jose Martínez de la Casa, Karin R. Pillunat, Jan H. Simonsen, Clemens Vass

Open Access 08.04.2024 | ORIGINAL RESEARCH

Rate and Predictors of Misclassification of Active Diabetic Macular Edema as Detected by an Automated Retinal Image Analysis System

Individuals with diabetes mellitus (DM) are prone to various health complications, which can significantly impact their quality of life and increase mortality rates [ 1 ]. One of the major threats to vision in patients with uncontrolled or …

verfasst von:
Lamberto La Franca, Carola Rutigliani, Lisa Checchin, Rosangela Lattanzio, Francesco Bandello, Maria Vittoria Cicinelli

Open Access 08.04.2024 | REVIEW

Transient Monocular Visual Loss (Amaurosis Fugax): How Does Age Impact Diagnosis?

Transient monocular visual loss (TMVL), also known as transient monocular blindness or amaurosis fugax (“fleeting blindness”), is a temporary loss of vision often due to ischemia to the retina. While acute TMVL should be considered an emergency …

verfasst von:
Vivian Paraskevi Douglas, Sruti S. Rachapudi, Pamela Davila-Siliezar, Noor A. R. Laylani, Andrew G. Lee

Open Access 08.04.2024 | ORIGINAL RESEARCH

The PRAMOS Study: PRostaglandin Analogues Monotherapy—Awareness Survey on Ocular Surface Involvement

Glaucoma is a chronic progressive optic neuropathy that causes progressive loss of retinal ganglion cells and retinal nerve fiber layers and can ultimately lead to blindness if left untreated. All currently available therapeutical options aim at …

verfasst von:
Paul Bastelica, Jean Paul Renard, Florent Aptel, Antoine Labbé, Cédric Schweitzer, Muriel Poli, Antoine Rousseau, Cédric Lamirel, Christophe Baudouin

Open Access 06.04.2024 | ORIGINAL RESEARCH

Swiss Multicenter Ab Interno XEN45 Gel Stent Study: 2-Year Real-World Data

Glaucoma is the primary cause for irreversible complete loss of vision worldwide [ 1 , 2 ]. Its progression is multifactorial [ 3 , 4 ]; however, the intraocular pressure (IOP) is the only proven risk factor that can be adjusted to slow disease …

verfasst von:
Anthia Papazoglou, René Höhn, Megir Schawkat, Christoph Tappeiner, Milko Iliev, Konstantin Gugleta, Giulia Saletta, Andrea Wiencierz, Barbara Wagels, Margarita G. Todorova, Iwona Krzyzanowska, Marc Töteberg-Harms, Markus Tschopp

Open Access 06.04.2024 | ORIGINAL RESEARCH

An Appraisal of the Preventive Effect of Statins on the Development of Graves’ Ophthalmopathy: A Hospital-Based Cohort Study

Graves’ disease (GD) is the most common cause of hyperthyroidism, with an annual incidence of 20 cases per 100,000 persons and a female to male ratio ranging from 4:1 to 5:1 [ 1 , 2 ]. GD pathogenesis occurs via the stimulation of thyrotropin …

verfasst von:
Grace Chia-Yen Hsu, Shyang-Rong Shih, Fang-Yu Chang, Shu-Lang Liao, Yi-Hsuan Wei

Open Access 06.04.2024 | ORIGINAL RESEARCH

Accuracy of Toric Intraocular Lens Calculators with Predicted and Measured Posterior Corneal Astigmatism Across Different Types of Astigmatism

Astigmatism is a prevalent refractive error characterized by an uneven curvature of the cornea or lens, leading to distorted or blurred vision [ 1 ]. Among patients undergoing cataract surgery, around 40% exhibit corneal astigmatism of 1.0 diopter …

verfasst von:
Soonwon Yang, Jaehyun Park, Woong Joo Whang, Yong-Soo Byun, Hyun Seung Kim, So-Hyang Chung

Open Access 06.04.2024 | ORIGINAL RESEARCH

Dynamic Changes of Capsular-Intraocular Lens Adhesion in Plate-Haptic Hydrophilic and Loop-Haptic Hydrophobic Eyes

The dynamic process involving intraocular lenses (IOLs) and capsular bag is a critical factor affecting the optical performance and clinical outcomes following cataract surgery. Several studies have emphasized that the strong adhesion between the …

verfasst von:
Yinying Zhao, Zhewen Zhang, Fuman Yang, Pingjun Chang, Dandan Wang, Feng Huang, Yune Zhao

Open Access 30.03.2024 | ORIGINAL RESEARCH

Ocular Manifestations in Juvenile Behçet’s Disease: A Registry-Based Analysis from the AIDA Network

Ocular inflammation represents one of the three cardinal manifestations of Behçet’s disease (BD) along with recurrent oral and genital ulceration. The presence of uveitis, retinal vasculitis and related ocular complications is a significant …

verfasst von:
Carla Gaggiano, Abdurrahman Tufan, Silvana Guerriero, Gaafar Ragab, Jurgen Sota, Stefano Gentileschi, Stefania Costi, Ibrahim A. Almaghlouth, Andrea Hinojosa-Azaola, Samar Tharwat, Petros P. Sfikakis, Giuseppe Lopalco, Matteo Piga, Giovanni Conti, George Fragoulis, Angela Mauro, Ezgi D. Batu, Seza Ozen, Maria Tarsia, Francesco La Torre, Perla A. Kawakami-Campos, Antonio Vitale, Valeria Caggiano, Riza C. Kardaş, Gian Marco Tosi, Bruno Frediani, Tadej Avčin, José Hernández-Rodríguez, Luca Cantarini, Claudia Fabiani, the AIDA Network

Open Access 26.03.2024 | ORIGINAL RESEARCH

Efficacy, Safety and Immunogenicity of Sun’s Ranibizumab Biosimilar in Neovascular Age-Related Macular Degeneration: A Phase 3, Double-Blind Comparative Study

Age-related macular degeneration (AMD) is a neurodegenerative retinal disease which is progressive in nature, leading to vision impairment, and is a major cause of irreversible blindness in patients aged ≥ 50 years in the developed world [ 1 , 2 ].

verfasst von:
Asim K. Ghosh, Usha S. Nikumbh, Chaitanya K. Shukla, Rohit S. Laul, Abhishek Dixit, Santosh K. Mahapatra, Sameera Nayak, Urmil M. Shah, Sandeep Parwal, Narendran Venkatapathy, Natasha Radhakrishnan, Anup Kelgaonkar, Sandeep Saxena, Divyansh Mishra, Vivek Pravin Dave, Perwez Khan, Manojkumar R. Saswade, Malli S. Shantilal, Kim Ramasamy, Smitha Sreekanta, Mandodari Rajurkar, Maulik Doshi, Sapan Behera, Piyush Patel, Shilpi Dhawan, Lalit Lakhwani

Open Access 26.03.2024 | ORIGINAL RESEARCH

Enhancing Diabetic Macular Edema Treatment Outcomes: Exploring the ESASO Classification and Structural OCT Biomarkers

Diabetes mellitus continues to pose a significant global health challenge, with an alarming rise in the number of affected individuals. In 2019, the International Diabetes Federation reported that approximately 240 million people worldwide had …

verfasst von:
Giacomo Panozzo, Maria V. Cicinelli, Giulia Dalla Mura, Diana Giannarelli, Maria Vadalà, Vincenza Bonfiglio, Giovanni Bellisario, Francesco Bandello, the ESASO Study Group

Open Access 23.03.2024 | ORIGINAL RESEARCH

Real-World Safety Outcomes with Brolucizumab in Neovascular Age-Related Macular Degeneration: Findings from the IRIS® Registry

Brolucizumab, an anti-vascular endothelial growth factor (VEGF) therapy, was approved for the treatment of neovascular (wet) age-related macular degeneration (nAMD) based on data from the pivotal phase 3 HAWK and HARRIER clinical trials [ 1 , 2 ].

verfasst von:
Marco A. Zarbin, Mathew W. MacCumber, Helene Karcher, Eser Adiguzel, Andrew Mayhook, Andrew LaPrise, Ver L. Bilano, Franklin Igwe, Michael S. Ip, Charles C. Wykoff

Open Access 23.03.2024 | GUIDELINES

Diabetic Disease of the Eye in Canada: Consensus Statements from a Retina Specialist Working Group

Despite advances in systemic care, diabetic disease of the eye (DDE) remains the leading cause of blindness worldwide. There is a critical gap of up-to-date, evidence-based guidance for ophthalmologists in Canada that includes evidence from recent …

verfasst von:
Amer Omar, R. Geoff Williams, James Whelan, Jason Noble, Michael H. Brent, Michel Giunta, Sébastien Olivier, Mustapha Lhor

Open Access 20.03.2024 | ORIGINAL RESEARCH

Evaluation of a Digital Amsler Grid (PocDoc) for Macular Disease Screening: A Comparative Analysis with the Conventional Method

Visual impairment (VI) is a major global health concern affecting approximately 596 million people in 2020 [ 1 ]. The main causes of VI are cataract, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy, and uncorrected refractive …

verfasst von:
Joewee Boon, William Rojas-Carabali, Yusra Asad, Jonathan Tzien Yih Lim, Rajesh Rajagopalan, Rupesh Agrawal

Open Access 20.03.2024 | ORIGINAL RESEARCH

Analytical and Functional Similarity of Aflibercept Biosimilar ABP 938 with Aflibercept Reference Product

Retinal diseases such as neovascular (wet) age-related macular degeneration (nAMD) are leading causes of severe vision impairment around the world [ 1 – 3 ]. The discovery that vascular endothelial growth factor (VEGF) is a key mediator involved in …

verfasst von:
Neungseon Seo, Xiaoyan Guan, Tian Wang, Hyo S. Helen Chung, Mats Wikström, Rupa Padaki, Kevin Kalenian, Scott Kuhns, Kelli Matthies, Jill Crouse-Zeineddini, Helen Y. Wong, Michael Ng, Ian N. Foltz, Shawn Cao, Jennifer Liu

Open Access 20.03.2024 | ORIGINAL RESEARCH

Clinical Characteristics and Treatment of Ophthalmic Sequelae of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis at a Tertiary Eyecare Centre in Hungary

Stevens–Johnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN), constitute a spectrum of diseases that are life-threatening immunologic dermatological disorders affecting the skin and mucous membranes [ 1 ]. The incidence of …

verfasst von:
Gábor Tóth, Andrea Lukács, Tanja Stachon, Frank Schirra, Gábor László Sándor, Zoltán Zsolt Nagy, Nóra Szentmáry

Open Access 20.03.2024 | ORIGINAL RESEARCH

Accuracy of Ten Intraocular Lens Formulas in Spherical Equivalent of Toric Intraocular Lens Power Calculation

Cataract surgery is regarded as a combined rehabilitative and refractive procedure. As modern surgical techniques advance, patients’ expectations for optimal postoperative vision continue to rise. The precision of the preoperative intraocular lens …

verfasst von:
Jingyi Shi, Zehui Zhu, Bin Hu, Shuyi Qian, Yalan Wang, Pingjun Chang, Yun-e Zhao

Open Access 18.03.2024 | ORIGINAL RESEARCH

The Efficacy of Adalimumab in Children with Chronic Non-infectious Posterior Uveitis and Panuveitis: A Retrospective Cohort Study

Pediatric uveitis is a severe inflammatory eye disease that results in vision loss in one-third of patients, eventually leading to permanent blindness [ 1 ]. More severe complications in idiopathic pediatric uveitis require special considerations [ …2

verfasst von:
Tianyu Tao, Shizhao Yang, Daquan He, Xuening Peng, Zhenyu Wang, Qi Jiang, Tianfu Wang, Wenru Su

Open Access 18.03.2024 | REVIEW

The Future of Checkpoint Inhibitors in Uveal Melanoma: A Narrative Review

Uveal melanoma (UM) is a rare form of melanoma that arises from melanocytes in the uvea. The incidence has ranged from < 1 to > 9 cases per million from 1970 to the 2010s, and varies by geography and race. In northern Europe and Oceania, the …

verfasst von:
Jinyu Wang, Zehua Li, Hongbo Yin