Atherosclerotic cardiovascular disease (ASCVD) is a major cause of death among people with diabetes mellitus. This includes coronary artery disease, cerebrovascular disease, and peripheral vascular disease with an atherosclerotic origin.
The results of the recently concluded ULTIMATE-DAPT and T-PASS trials strongly support the emerging concept of antiplatelet monotherapy in patients at high bleeding risk undergoing percutaneous coronary intervention. Monotherapy with more potent …
Finerenone is a novel nonsteroidal mineralocorticoid receptor (MR) antagonist (MRA) with unique pharmacological properties that offer potent and selective blockade of the MR with a more favorable side effect profile than spironolactone and …
Patients are at high risk of major cardiovascular (CV) events a year after acute myocardial infarction (AMI), particularly those with ST-segment elevation myocardial infarction (STEMI), and with elderly patients being at even greater risk.
Prevalence of adult congenital heart disease (CHD) is increasing, owing to continued advances in congenital cardiac surgery and pediatric cardiology. Currently, > 90% of children diagnosed with complex CHD are expected to survive to adulthood [ 1 …
Within the spectrum of cardiovascular diseases, the main cause of morbidity and mortality worldwide, heart failure (HF) is considered one of the most common [ 1 ]. HF is a complex clinical syndrome with symptoms and signs that result from any …
In the past decade, it has been proven that the endothelium is not simply a passive inner layer of blood vessels but a highly active metabolic and endocrine organ. Vascular endothelial function (VEF) plays a vital role, not only in regulating …
Coronary artery disease (CAD) continues to be the primary cause of mortality worldwide. The adoption of primary percutaneous coronary intervention (PPCI) as the standard treatment for patients with ST-elevation myocardial infarction (STEMI) …
Around one-quarter of all patients undergoing cardiac procedures, particularly those on cardiopulmonary bypass, develop cardiac surgery-associated acute kidney injury (CSA-AKI). This complication increases the risk of several serious morbidities …
Amiodarone is an iodine-rich drug that is used to treat supraventricular and ventricular arrhythmias [ 1 ]. It has very low risk of pro-arrhythmia, making this drug beneficial for use in patients with left ventricular (LV) dysfunction [ 2 ].
Patients with hypertension are at an increased risk of cardiovascular disease and death. Resistant hypertension, or hypertension that is unsuccessfully treated with multiple antihypertensive medications, further exacerbates the complications and …
Left atrial strain (LAS) provides prognostic information regarding the occurrence of ischemic stroke, heart failure, and death in patients with atrial fibrillation (AF) [ 1 – 3 ]. Consequently, therapies that improve LAS might help reduce …
Nicotinamide adenine dinucleotide (NAD+) is a promising anti-aging molecule that plays a role in cellular energy metabolism and maintains redox homeostasis. Additionally, NAD+ is involved in regulating deacetylases, DNA repair enzymes …
Reducing low-density lipoprotein cholesterol (LDL-C) levels has been shown to reduce the risk of developing atherosclerotic cardiovascular disease (ASCVD). Statins are the foundation of LDL-C lowering therapy with other non-statin agents used in …
The American Heart Association (AHA) and American College of Cardiology (ACC) recommend intravenous (IV) morphine to relieve pain associated with acute coronary syndrome (ACS) [ 1 ]. The class IIa recommendation prioritizes patient comfort, but its …
Breast cancer (BC) is the most commonly diagnosed malignancy and the primary cause of cancer-related deaths among women worldwide [ 1 ]. Clinically, standardized diagnosis and treatment significantly enhance patient prognosis [ 2 , 3 ]. However …
Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiomyopathy, affecting up to one in 500 individuals worldwide [ 1 , 2 ]. Among patients with symptomatic HCM, nearly 30% of patients have an obstructive phenotype, marked by …
Heart failure (HF) is a heterogeneous syndrome affecting more than 60 million persons globally. Despite the benefits of quadruple guideline-directed medical therapy (GDMT) in improving outcomes for patients with HF, significant morbidity from HF …
