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American Journal of Clinical Dermatology OnlineFirst articles

Open Access 25.03.2024 | Original Research Article

Early and Sustained Improvements in Symptoms and Quality of Life with Upadacitinib in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: 52-Week Results from Two Phase III Randomized Clinical Trials (Measure Up 1 and Measure Up 2)

Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by a combination of genetic, immune, and environmental factors [ 1 – 3 ]. The global prevalence of AD is estimated at 2960 per 100,000 persons, impacting up to 20% of children and …

verfasst von:
Jonathan I. Silverberg, Melinda J. Gooderham, Amy S. Paller, Mette Deleuran, Christopher G. Bunick, Linda F. Stein Gold, DirkJan Hijnen, Brian M. Calimlim, Wan-Ju Lee, Henrique D. Teixeira, Xiaofei Hu, Shiyu Zhang, Yang Yang, Ayman Grada, Andrew M. Platt, Diamant Thaçi

18.03.2024 | Review Article

Expert Panel Review of Skin and Hair Dermatophytoses in an Era of Antifungal Resistance

Dermatophytoses are fungal infections of the skin, hair, and nails that affect approximately 25% of the global population. Occlusive clothing, living in a hot humid environment, poor hygiene, proximity to animals, and crowded living conditions are …

verfasst von:
Rachel C. Hill, Avrom S. Caplan, Boni Elewski, Jeremy A. W. Gold, Shawn R. Lockhart, Dallas J. Smith, Shari R. Lipner

18.03.2024 | Original Research Article

Tree-Based Machine Learning to Identify Predictors of Psoriasis Incidence at the Neighborhood Level: A Populational Study from Quebec, Canada

Psoriasis is a chronic immune-mediated skin disease affecting ~60 million people worldwide with higher incidence in industrialized countries [ 1 , 2 ]. In 2013, the World Health Organization recognized psoriasis as a major global health problem and …

verfasst von:
Anastasiya Muntyanu, Raymond Milan, Mohammed Kaouache, Julien Ringuet, Wayne Gulliver, Irina Pivneva, Jimmy Royer, Max Leroux, Kathleen Chen, Qiuyan Yu, Ivan V. Litvinov, Christopher E. M. Griffiths, Darren M. Ashcroft, Elham Rahme, Elena Netchiporouk

07.03.2024 | Therapy in Practice

Management of Acne in Pregnancy

Acne is one of the most common dermatological conditions to affect women of childbearing age, so it is important to consider the safety of long-term acne treatments on women who could become pregnant. In this review article, we clarify what …

verfasst von:
Akash Rau, Jonette Keri, Jenny E. Murase

04.03.2024 | Systematic Review

Small-Molecule Inhibitors and Biologics for Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review and Network Meta-Analysis

Palmoplantar psoriasis (PP) is a distinct variant of psoriasis that predominantly affects the palms and soles. The prevalence of PP has been reported to be up to 40.9% in individuals with psoriasis [ 1 ]. PP is characterized by scaly erythematous …

verfasst von:
I-Hsin Huang, Po-Chien Wu, Hsien-Yi Chiu, Yu-Huei Huang

26.02.2024 | Review Article

Rapidly Evolving Pre- and Post-surgical Systemic Treatment of Melanoma

With the development of effective BRAF-targeted and immune-checkpoint immunotherapies for metastatic melanoma, clinical trials are moving these treatments into earlier adjuvant and perioperative settings. BRAF-targeted therapy is a standard of …

verfasst von:
Ryan C. Augustin, Jason J. Luke

16.02.2024 | Review Article

The Impact of Dermatologic Adverse Events on the Quality of Life of Oncology Patients: A Review of the Literature

Dermatologic adverse events resulting from oncologic therapy are common and negatively impact patients’ quality of life. Dermatologic adverse events include toxicity of the skin, oral mucosa, nails, and hair and are seen with cytotoxic …

verfasst von:
Annika Belzer, Jolanta J. Pach, Kailyn Valido, Jonathan S. Leventhal

13.02.2024 | Review Article

Field Cancerization Therapies for the Management of Actinic Keratosis: An Updated Review

Field cancerization theory highlights that the skin surrounding actinic keratoses (AK) is also at increased risk for possible malignant transformation; thus, field-directed treatments may both reduce the risk of AK recurrence and potentially …

verfasst von:
Ishita Aggarwal, Carolina Puyana, Neha Chandan, Nathan Jetter, Maria Tsoukas

Open Access 10.02.2024 | Correction

Correction to: OX40 in the Pathogenesis of Atopic Dermatitis—A New Therapeutic Target

verfasst von:
Michael Croft, Ehsanollah Esfandiari, Camilla Chong, Hailing Hsu, Kenji Kabashima, Greg Kricorian, Richard B. Warren, Andreas Wollenberg, Emma Guttman-Yassky

09.02.2024 | Original Research Article

Autoimmune, Autoinflammatory Disease and Cutaneous Malignancy Associations with Hidradenitis Suppurativa: A Cross-Sectional Study

Hidradenitis suppurativa (HS) is an idiopathic inflammatory disorder, primarily affecting intertriginous regions [ 1 ]. Clinically, HS is characterized by chronic nodules, abscesses, and sinus tracts, leading to ulceration and scarring in …

verfasst von:
Hilliard T. Brydges, Ogechukwu C. Onuh, Rebecca Friedman, Joy Barrett, Rebecca A. Betensky, Catherine P. Lu, Avrom S. Caplan, Afsaneh Alavi, Ernest S. Chiu

08.02.2024 | Review Article

Therapeutic Strategies in BRAF V600 Wild-Type Cutaneous Melanoma

There have been many recent advances in melanoma therapy. While 50% of melanomas have a BRAF mutation and are a target for BRAF inhibitors, the remaining 50% are BRAF wild-type. Immune checkpoint inhibitors targeting PD-1, cytotoxic …

verfasst von:
Alexandra Haugh, Adil I. Daud

Open Access 18.01.2024 | Review Article

OX40 in the Pathogenesis of Atopic Dermatitis—A New Therapeutic Target

Atopic dermatitis (AD) is a chronic, heterogeneous, inflammatory disease characterized by skin lesions, pruritus, and pain [ 1 , 2 ]. It is the most common inflammatory skin disease that affects nearly 20% of children, 15% of adolescents, and 10% …

verfasst von:
Michael Croft, Ehsanollah Esfandiari, Camilla Chong, Hailing Hsu, Kenji Kabashima, Greg Kricorian, Richard B. Warren, Andreas Wollenberg, Emma Guttman-Yassky