Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide, with surgery representing the cornerstone of curative treatment. Although surgical techniques and perioperative care have improved …

Connective tissue diseases (CTDs) are a heterogeneous group of disorders characterized by structural and functional impairment of the extracellular matrix, manifesting primarily as autoimmune, heritable or degenerative conditions such as systemic …

Overexpression of trophoblast cell surface antigen 2 (TROP2) has been identified in various malignancies. Antibody–drug conjugates (ADCs) targeting TROP2 with topoisomerase 1 inhibitor chemotherapy payloads are currently marketed in breast and …

Activating mutations in the epidermal growth factor receptor (EGFR) are a well-established oncogenic driver in non–small cell lung cancer (NSCLC) and several other solid tumours, predicting high initial response rates and progression-free survival …

Sarcopenia is a progressive loss of skeletal muscle mass and strength that significantly contributes to frailty and disability in older adults. Traditionally considered a consequence of myofiber atrophy and impaired protein turnover, recent …

Olfactory receptors (ORs), once considered peripheral to sensory biology, are now recognized as functionally important components of precision medicine. This review synthesizes genomic, structural, and translational evidence demonstrating that ORs …

Our study utilized patient-derived intestinal organoids (PDIOs) in a theranostic approach to assess the efficacy of CFTR modulator (CFTRm) drugs on eight rare CFTR variants. We employed the forskolin-induced swelling (FIS) assay and demonstrated …

In recent years, fibroblast activation protein (FAP) has demonstrated significant potential in oncology, and the development of FAP-targeted therapeutic agents has increasingly become a key research focus in the fields of molecular imaging and …

High-grade vulvar intraepithelial neoplasia (VIN) is the precursor lesion of vulvar squamous cell carcinoma (VSCC). Two distinct subtypes are recognized: human papillomavirus (HPV)-associated high-grade squamous intraepithelial lesion (HSIL) and …

Combination therapy, which involves the simultaneous use of two or more drugs within the same formulation, aims to broaden therapeutic activity, reduce the risk of resistance, and achieve synergistic or additive effects. This approach has gained …

Cancer is a complex and multifaceted disease characterized by the uncontrolled proliferation of abnormal cells that can invade and damage surrounding tissues, making it a major contributor to global mortality. According to data from the World …

Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections constituting nearly 8% of the human genome. Far from being inert genetic fossils, HERVs have co-evolved with their hosts, acquiring regulatory and functional roles …