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Graefe's Archive for Clinical and Experimental Ophthalmology OnlineFirst articles

21.04.2024 | Retinal Disorders

Long-term follow-up of the cognitive function in children after intravitreal ranibizumab for retinopathy of prematurity

Retinopathy of prematurity (ROP) is a devastating neurovascular disease of the immature retinal vascularization process that occurs in premature infants and is one of the leading causes of childhood blindness worldwide [ 1 , 2 ]. The treatment fo r … ROP aims to stop the neovascularization progression by inhibiting the abnormal increase of vascular endothelial growth factor (VEGF) levels in the eyes [

verfasst von:
Ya Tian, Zixin Fan, Xianlu Zeng, Zhen Yu, Xiaofeng Lu, Xinyu Zhao, Zhenquan Wu, Honghui He, Jian Zeng, Lei Zheng, Linlin Zhang, Victor S. M. C. Correa, Guishuang Ying, Shaochong Zhang, Guoming Zhang

21.04.2024 | Oculoplastics and Orbit

Is topical antibiotic use necessary to prevent surgical site infection following oculoplastic surgery?

Guidelines for routine prophylactic antibiotic use in oculoplastic surgery vary widely throughout the world and most oculoplastic surgeons prescribe systemic and/or topical antibiotics perioperatively in oculoplasty [ 1 ]. Since two decades, major …

verfasst von:
Robin Dupré, Stéphanie Baillif, Romain Lotte, Raymond Ruimy, Jacques Lagier, Yasmina Berrouane, Tamer Gawdat, Mehdi Fendri, Arnaud Martel

21.04.2024 | Cataract

Effect of decentration and tilt on the in vitro optical quality of monofocal and trifocal intraocular lenses

Intraocular lenses (IOLs) of different focal designs cater to varying ranges of vision. Monofocal IOLs offer exceptional distance vision but require the use of glasses for near and intermediate visual tasks. Trifocal IOLs offer visual acuity at …

verfasst von:
Ruo-Lin Pan, Qing-Qing Tan, Xuan Liao, Li-Xuan Xie, Su-Yun Qin, Yu-Ling Tang, Chang-Jun Lan

Open Access 19.04.2024 | Miscellaneous

Search engine optimization and its association with readability and accessibility of diabetic retinopathy websites

Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults in the USA [ 1 ]. However, the risk of vision loss from DR can be reduced through early detection and management of blood sugar and blood pressure levels, as well as …

verfasst von:
Matthew R. Lam, Garrett N. Manion, Benjamin K. Young

19.04.2024 | Oculoplastics and Orbit

Teprotumumab improves light sensitivity in patients with thyroid eye disease

Teprotumumab, a monoclonal antibody that blocks the insulin-like growth factor-1 receptor (IGF-1R) has been approved in 2020 by the US Food and Drug Administration for the treatment of thyroid eye disease (TED). The overexpression of IGF-1R and …

verfasst von:
Emanuil Parunakian, Shoaib Ugradar, Joseph Tolentino, Emil Malkhasyan, Pershanjit Raika, Joseph Ghaly, Chirag Bisht, Raymond S Douglas

Open Access 17.04.2024 | Retinal Disorders

Invivo generated autologous plasmin enzyme assisted vitrectomy, partial circumferential-oral retinotomy, silicone oil injection in patients with chronic retinal detachment without posterior vitreous detachment

Chronic retinal detachment can be described as retinal detachment which is present longer than three months, with clinical findings of pigmented demarcation line, retinal thinning, subretinal bands, intra-retinal cysts and subretinal crystalline …

verfasst von:
Cengiz Aras, Fevzi Senturk, Sevil Karaman Erdur, Mahmut Dogramaci, Mehmet Selim Kocabora, Ali Demircan, Yunus Emre Budak

16.04.2024 | Retinal Disorders

Influence of submacular hemorrhage at baseline on the long-term outcomes of aflibercept treatment for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

Submacular hemorrhage (SMH), a cause of severe visual loss in wet age-related macular degeneration (wAMD), has been reported to be observed in 7%–53% patients with wAMD at baseline [ 1 , 2 ]. Although a treatment strategy has not been established …

verfasst von:
Mio Morizane Hosokawa, Chihiro Ouchi, Yusuke Shiode, Shuhei Kimura, Ryo Matoba, Tetsuro Morita, Yuki Morizane

Open Access 16.04.2024 | Glaucoma

Histopathological findings of failed blebs after microinvasive bleb surgery with the XEN Gel Stent and Preserflo MicroShunt

Glaucoma is one of the most common causes of blindness worldwide and results in loss of retinal ganglion cells, eventually leading to relative and absolute scotomas and vision loss, if the condition is left untreated. In patients where topical …

verfasst von:
Jonas Neubauer, Daniela Suesskind, Caroline J. Gassel, Emil Nasyrov, Bogomil Voykov

Open Access 16.04.2024 | Pediatrics

Effects of cycloplegia on crystalline lens morphology and location in acute acquired concomitant esotropia

Acute acquired concomitant esotropia (AACE) is identified as a subtype of strabismus characterized by a sudden onset of concomitant esotropia with diplopia post-infancy [ 1 ], notably impacting the patients’ quality of life. Various etiologies …

verfasst von:
Weibin Chen, Jiawen Liu, Wei Dai, Jie Hao, Jiayu Chen, Jing Fu

Open Access 15.04.2024 | Cornea

Transepithelial phototherapeutic keratectomy for treatment-resistant recurrent corneal erosion syndrome

Recurrent corneal erosion syndrome (RCES) is a painful eye condition characterized by abnormal epithelial adhesion to underlying basal lamina. The most common etiology of RCES is mechanical trauma (45–64%), followed by anterior basement membrane …

verfasst von:
Mukhtar Bizrah, Maheshver Shunmugam, Geoffrey Ching, Radhika P. Patel, Nizar Din, David T. C. Lin, Simon P. Holland

13.04.2024 | Cataract

Prevalence data for total corneal astigmatism in cataract patients

Cataract is the leading cause of global blindness, the sole remedy for which is surgical intervention. Thanks to the advancement of intraocular lenses (IOLs) - based refractive surgery [ 1 ], the objective of cataract surgery has shifted from …

verfasst von:
Linbo Bian, Baikai Ma, Zhengze Sun, Wenlong Li, Yiyun Liu, Rui Qin, Jiawei Chen, Yunke Ma, Lu Zhao, Hong Qi

12.04.2024 | Retinal Disorders

Short-term outcomes of intravitreal faricimab for refractory neovascular age-related macular degeneration

Age-related macular degeneration (AMD) is the most common cause of visual loss and blindness in the developed world in people over the age of 50 years. Currently, more than 200 million people are estimated to have AMD worldwide. This number is …

verfasst von:
Wissam Aljundi, Cristian Munteanu, Berthold Seitz, Alaa Din Abdin

11.04.2024 | Cataract

Efficacy and safety of the implantation of a single-piece angulated foldable IOL in the sulcus

Cataract surgery is the most common surgical procedure performed worldwide, whereby the crystalline lens is removed and replaced by an intraocular lens (IOL). Surgery is usually performed to treat age-related cataract formation. The average age at …

verfasst von:
Gauthier Blanckaert, Joachim Van Calster, Joyce Jansen, Joris Vander Mijnsbrugge, Ann-Laure Delbecq, Ivo De Clerck, Jean-François Fils, Peter Stalmans

Open Access 10.04.2024 | Cataract

Optical power profiles and aberrations of a non-diffractive wavefront-shaping extended depth of focus intraocular lens

Several optical designs of intraocular lenses (IOL) are currently available, aiming to provide the best solution for patients who wish to achieve independence from spectacles following cataract surgery. Monofocal IOLs provide clear vision, usually …

verfasst von:
Nuria Garzón, José Antonio Gómez-Pedrero, César Albarrán-Diego, Sara Fernández-Núñez, Sara Villanueva Gómez-Chacón, María García-Montero

10.04.2024 | Pediatrics

The impact of simultaneous correction of the V pattern on the results of surgical treatment in children with intermittent exotropia

In the last several years, numerous investigators have attempted to address some of the concerns related to unsatisfactory long-term results of intermittent exotropia (IXT) management [ 1 ]. Factors such as patient’s age at the time of the surgery …

verfasst von:
Malgorzata Kochana, Agnieszka Rosa, Piotr Loba

Open Access 09.04.2024 | Glaucoma

The retinal venous pressure at different levels of airway pressure measured with a new method

The measurement of retinal venous pressure (RVP) is required for correctly calculating ocular perfusion pressure (OPP = 2/3 mean arterial blood pressure minus RVP) [ 1 ]. A reduced perfusion pressure leads to impaired blood flow if the limits of …

verfasst von:
Johanna L. Baumgärtner, Richard Stodtmeister, René Mauer, Lutz E. Pillunat, Karin R. Pillunat

Open Access 08.04.2024 | Basic Science

Detection sensitivity of fluorescence lifetime imaging ophthalmoscopy for laser-induced selective damage of retinal pigment epithelium

A number of devices are currently in use to facilitate the detection and monitoring of disease in ophthalmology, and further development continues [ 1 ]. Autofluorescence (AF) [ 2 ], fluorescein angiography (FA) [ 3 , 4 ], optical coherence …

verfasst von:
Svenja Rebecca Sonntag, Maximilian Hamann, Eric Seifert, Salvatore Grisanti, Ralf Brinkmann, Yoko Miura

Open Access 08.04.2024 | Retinal Disorders

The time course of spontaneous closure of idiopathic full-thickness macular holes

An idiopathic full-thickness macular hole (iFTMH) is a vitreomacular interface disease with an opening of all neurosensory retinal layers in the fovea, leading to vision loss, metamorphopsia and central scotoma. It is more frequently observed in …

verfasst von:
Jonas Neubauer, Faik Gelisken, Taylan Ozturk, Karl-Ulrich Bartz-Schmidt, Spyridon Dimopoulos

08.04.2024 | Glaucoma

Correlation of retrobulbar perfusion deficits with glaucomatous visual field defects

Glaucoma, a major cause of permanent vision loss worldwide [ 1 ], presents a significant risk to human ocular health. In 2020, approximately 76 million individuals were affected by glaucoma, and by 2040, more than 111.8 million individuals will be …

verfasst von:
Zhiqing Wang, Xiaowei Zhong, Xi Lu, Jianing Shi, Weiyun Shi, Can Zhao, Ting Wang

06.04.2024 | Basic Science

MicroRNA expression profiling in tears and blood as predictive biomarkers for anti-VEGF treatment response in wet age-related macular degeneration

Age-related macular degeneration (AMD) is a prevalent cause of irreversible vision loss and blindness worldwide [ 1 , 2 ]. Wet AMD, characterized by choroidal neovascularization (CNV), is a particularly aggressive form of the disease and accounts …

verfasst von:
Chu-Yu Yen, Chi-Ming Chiu, I-Mo Fang