Liver cirrhosis (LC) is the final stage of liver fibrosis, which leads to severe complications including ascites, encephalopathy, and hepatocellular carcinoma [ 1 ]. LC diagnosis can be confirmed through microscopic pathological examination of …
Metabolic-associated-dysfunction steatotic liver disease (MASLD) is currently the most common cause of chronic liver disease worldwide, affecting 25% of the general population and more than 50% and 90% of diabetic and obese patients, respectively.
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Javier Ampuero, Rocío Aller, Rocío Gallego-Durán, Javier Crespo, Jose Luis Calleja, Carmelo García-Monzón, Judith Gómez-Camarero, Joan Caballería, Oreste Lo Iacono, Luis Ibañez, Javier García-Samaniego, Agustín Albillos, Rubén Francés, Conrado Fernández-Rodríguez, Douglas Maya-Miles, Moisés Diago, Maria Poca, Raúl J. Andrade, Raquel Latorre, Francisco Jorquera, Rosa María Morillas, Desamparados Escudero, Manuel Hernández-Guerra, María Jesús Pareja-Megia, Jesús M. Banales, Patricia Aspichueta, Salvador Benlloch, José Miguel Rosales, Juan Turnes, Manuel Romero-Gómez, on behalf of HEPAmet Registry
The advent of safe and potent direct-acting antivirals (DAAs) has revolutionized the care of hepatitis C virus (HCV) infection. Currently, short-term treatment with pan-genotypic DAAs consistently achieves sustained virologic response (SVR 12 ) …
Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD), and ulcerative colitis (UC) are characterized by relentless chronic inflammation of the intestinal tract. Thiopurine medications, such as azathioprine (AZA) and 6-mercaptopurine …
Hepatocellular carcinoma (HCC) remains an important cause of cancer-related mortality, and in recent years, its incidence has continued to incline [ 1 ]. Most patients with HCC are diagnosed with stage B or C in the Barcelona Clinic Liver Cancer …
Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of liver disease in modern society, with a reported global incidence of 25–45% [ 1 ]. NAFLD is considered not only a risk factor for liver-related events (LREs), such as …
Over recent years, the prevalence of steatotic liver disease has substantially increased worldwide, and the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has become a pressing issue affecting populations across …
The therapeutic outcomes of colon cancer (CC) have improved in recent years, owing to advances in chemotherapy and the advent of molecular-targeted drugs. Nevertheless, research on novel biomarkers and molecular-targeted drugs is essential to …
The liver is a crucial organ for maintaining nutritional homeostasis in the body, and as the disease progresses from chronic liver disease (CLD) to cirrhosis, various metabolic disorders appear and increase the risk of complications [ 1 ]. Previous …
Nodular gastritis (NG) is a type of chronic gastritis characterized by marked lymphoid hyperplasia mainly in the gastric antrum, and is almost exclusively induced by Helicobacter pylori ( H . pylori ) infection [ 1 , 2 ]. NG in adults is strongly …
Globally, the incidence of colorectal cancer (CRC) ranked third with 1.80 million cases in 2020 [ 1 ]. Colonoscopy (CS) reduces incidence and mortality of CRC [ 2 , 3 ]. In the U.S., CS is recommended as a CRC screening option and national health …
The classification of malignant lymphomas has evolved to reveal distinct biological subtypes. In this era of immune-oncology, there is much interest in prognostic and predictive indicators for patients with diffuse large B-cell lymphoma (DLBCL) …
Altered intestinal microbial composition (dysbiosis) and metabolic products activate aggressive mucosal immune responses that mediate inflammatory bowel diseases (IBD). This dysbiosis impairs the function of regulatory immune cells, which normally …
Bile duct stones are a common disease, which can cause biliary complications including cholangitis, obstructive jaundice, and biliary pancreatitis [ 1 ]. The guidelines from various associations consistently recommend endoscopic retrograde …
According to the 2016 Comprehensive Survey of Living Conditions conducted by the Japanese Ministry of Health, Labour and Welfare, the prevalence of constipation ranges from 2 to 5% in Japan and it shows a higher frequency in females than males …
