Type 2 diabetes (T2D) is a chronic metabolic disorder characterized by insulin resistance and eventual functional failure of pancreatic beta cells [ 1 ]. Over the last few decades, the prevalence of T2D has increased globally, rising from 3.9 to …
verfasst von:
Paolo Angelo Cortesi, Ippazio Cosimo Antonazzo, Pasquale Palladino, Marco Gnesi, Silvia Mele, Marco D’Amelio, Elena Zanzottera Ferrari, Giampiero Mazzaglia, Lorenzo Giovanni Mantovani
Insulin resistance is a common pathogenic ground for many highly prevalent diseases. These include atherogenic dyslipidemia [ 1 ], type 2 diabetes, obesity, hypertension [ 1 ], and closely related cardiovascular disease and renal dysfunction [ 1 …
verfasst von:
Vincenzo Trischitta, Alessandra Antonucci, Claudia Menzaghi, Antonella Marucci, Rosa Di Paola
Diabetes mellitus (DM) is a global systemic chronic condition. Diabetic retinopathy (DR) is a common microvascular complication of DM [ 1 ]. It will affect approximately 50% of patients with type 1 or type 2 diabetes [ 2 ]. If treatment is not …
Subjects with type 1 diabetes (T1D) are routinely screened for celiac disease (CD), and the importance of diagnosis and treating CD lies with the potential complications: osteoporosis, iron-deficiency anemia, lymphoma, small-bowel cancer, and …
Obesity is characterized by the accumulation of excess body fat, primarily resulting from an imbalance between energy intake and expenditure [ 1 ]. Obesity has emerged as a significant public health concern, affecting approximately 700 million …
Metabolic health (MH) refers to the comprehensive risk assessment of multiple diseases, including cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), which is characterized by healthy blood …
Total hemoglobin mass, the absolute mass of hemoglobin contained in red blood cells, determines oxygen transport capacity and strongly correlates to maximal oxygen consumption [ 1 ]. Patients with type 2 diabetes exhibit on average a 20% decline in …
verfasst von:
Frank Wojan, Sten Stray-Gundersen, Jiahui Zhao, Sophie Lalande
The incidence and prevalence of chronic limb-threatening ischemia (CLTI) are dramatically increasing among patients with diabetes [ 1 ]. CLTI is characterized by the presence of rest pain, gangrene, or lower limb ulceration > 2 weeks duration [ 1 …
verfasst von:
Matteo Monami, Antonio Silverii, Cesare Miranda, Luca Monge, Luigi Uccioli, Germano Scevola, Eugenio Stabile, Mauro Gargiulo, Alessia Scatena, Benedetta Ragghianti, Cristiana Vermigli, for the Panel of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome and on behalf of SID and AMD
Matteo Monami, Alessia Scatena, Cesare Miranda, Luca Monge, Alessandro De Cassai, Antonio Volpe, Rodolfo Tramonta, Gerardo Medea, Corrado Bordieri, Marco Falcone, Laura Stefanon, Andrea Bernetti, Cristina Cappella, Mauro Gargiulo, Valentina Lorenzoni, Germano Scevola, Eugenio Stabile, Benedetta Ragghianti, Giovanni Antonio Silverii, Roberto da Ros, Marco Meloni, Laura Giurato, Giuseppe Murdolo, Eleonora Bianchini, Francesco Gaggia, Carlotta Gauna, Francesco Romeo, Matteo Apicella, Michele Mantuano, Luigi Uccioli, Cristiana Vermigli, for the Panel of the Italian Guidelines for the treatment of Diabetic Foot Syndrome and on behalf of SID and AMD
Maturity-onset diabetes of the young (MODY) is the prevalent form of monogenic diabetes with autosomal dominant inheritance, which consists of a heterogeneous group with 14 distinct types [ 1 – 3 ]. The estimated prevalence of the disease in …
verfasst von:
Cemal Çavdarlı, Gönül Büyükyılmaz, Büşranur Çavdarlı, Sebile Çomçalı, Pınar Topçu Yılmaz, Mehmet Numan Alp
As one of the common chronic diseases, diabetes is a global public health problem, which brings great challenges to human health. Diabetic nephropathy, one of the chronic microvascular complications of diabetes, causes a great impact on the …
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by insulin secretion destruction. Islet insult, usually affected by factors such as viral infection, inflammation, and toxic chemicals, initiates the abnormal islet β …
verfasst von:
Tong Wang, Tong Zhang, Ning Dong, Yao Tan, Xia Li, Yuting Xie, Liang Li, Yandan Zhou, Pu Zhang, Ming Li, Qianxin Li, Ruixuan Wang, Ronghan Wu, Ling Gao
DME is a major adverse outcome of diabetes mellitus and is a leading cause of vision impairment in adults of working age worldwide [ 1 ]. It arises due to the leakage of fluid from damaged blood vessels into the macula, an area in the centre of the …
Gestational diabetes mellitus (GDM) is the most common metabolic complication of pregnancy, affecting up to 4–8% of pregnancies. The incidence of GDM in twin pregnancies is higher compared to singleton pregnancies [ 1 ]. The pathogenesis of GDM …
verfasst von:
Angela Silvano, Oumaima Ammar, Noemi Strambi, Giovanni Sisti, Astrid Parenti, Viola Seravalli, Mariarosaria Di Tommaso
The transplantation of kidneys is the preferred treatment for patients with end-stage renal disease, offering superior kidney replacement compared to dialysis. It not only enhances patients' quality of life but also reduces mortality risk and …
verfasst von:
Qiufeng Du, Tao Li, Xiaodong Yi, Shuang Song, Jing Kang, Yunlan Jiang
Type 2 Diabetes mellitus (T2DM) is a chronic disease characterized by glucose metabolism disorder. The incidence of this disease has been going up on a global scale. It is reported that the global prevalence of diabetes in 2019 is estimated to be …
verfasst von:
Yun-Yun He, Mei-Ling Jin, Xiang-Yang Fang, Xiao-Juan Wang
In 2019, the Advanced Technologies and Treatment for Diabetes (ATTD) set forth consensus recommendations for continuous glucose monitoring (CGM)-based glucose control in which glucose levels between 70 and 180 mg/dL were proposed as the treatment …
Ischemic stroke (IS) is one of the most common types of cerebrovascular disease, accounting for about 70% of all cerebrovascular diseases and 85% of strokes [ 1 – 3 ], with high rates of disability and death [ 4 ], especially in critically ill …
verfasst von:
Haowei Pan, Yiqun Xiong, Yanming Huang, Jie Zhao, Haifang Wan
