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Journal of Neural Transmission OnlineFirst articles

16.03.2024 | Editorial

Editorial for Emeritus Professor Yoshikuni Mizuno

verfasst von:
Nobutaka Hattori

16.03.2024 | Editorial

Neuroscience and addiction research: current advances and perspectives

verfasst von:
Emmanuel Darcq, Brigitte L. Kieffer

13.03.2024 | Neurology and Preclinical Neurological Studies - Original Article

Pathogenesis of Parkinson’s disease: from hints from monogenic familial PD to biomarkers

Twenty-five years have passed since the causative gene for familial Parkinson's disease (PD), Parkin (now PRKN), was identified in 1998; PRKN is the most common causative gene in young-onset PD. Parkin encodes a ubiquitin-protein ligase, and …

verfasst von:
Nobutaka Hattori, Manabu Funayama, Yuzuru Imai, Taku Hatano

08.03.2024 | Neurology and Preclinical Neurological Studies - Original Article

Somatosensory evoked potentials recorded from DBS electrodes: the origin of subcortical N18

The different peaks of somatosensory-evoked potentials (SEP) originate from a variety of anatomical sites in the central nervous system. The origin of the median nerve subcortical N18 SEP has been studied under various conditions, but the exact …

verfasst von:
Arif Abdulbaki, Johannes C. Wöhrle, Christian Blahak, Ralf Weigel, Katja Kollewe, H. Holger Capelle, Hansjörg Bäzner, Joachim K. Krauss

04.03.2024 | Psychiatry and Preclinical Psychiatric Studies - Short communication

Genetic mouse models in opioid research: current status and future directions

Synthetic and semi-synthetic opioids are prescribed for the management of severe pain conditions, but their long-term use is often leading to physical dependence and addiction disorders. Understanding the complex neurobiology of the opioid system …

verfasst von:
Monserrat Avila-Zozaya, Venetia Zachariou

02.03.2024 | Neurology and Preclinical Neurological Studies - Original Article

Differential patterns of functional connectivity in tremor dominant Parkinson’s disease and essential tremor plus

Tremor dominant Parkinson’s disease (TDPD) and essential tremor plus (ETP) syndrome are commonly encountered tremor dominant neurological disorders. Although the basal ganglia thalamocortical (BGTC) and cerebello thalamocortical (CTC) networks are …

verfasst von:
Shweta Prasad, Jitender Saini, Rose Dawn Bharath, Pramod Kumar Pal

Open Access 01.03.2024 | Psychiatry and Preclinical Psychiatric Studies - Original Article

More than fear? Brain activation patterns of dental phobic patients before and after an exposure-based treatment

Hyperactivation of brain networks conferring defensive mobilization is assumed to underlie inappropriate defensive-preparation in patients with Specific Phobia. However, studies targeting Dental Phobia (DP) yielded quite heterogeneous results and …

verfasst von:
André Wannemueller, Jürgen Margraf, Martin Busch, Hans-Peter Jöhren, Boris Suchan

Open Access 28.02.2024 | Neurology and Preclinical Neurological Studies - Original Article

Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes

In Parkinson’s disease (PD), impaired gait and cognition affect daily activities, particularly in the more advanced stages of the disease. This study investigated the relationship between gait parameters, cognitive performance, and brain …

verfasst von:
Radim Krupička, Christiane Malá, Slávka Neťuková, Tereza Hubená, Filip Havlík, Ondrej Bezdicek, Petr Dušek, Evžen Růžička

28.02.2024 | Neurology and Preclinical Neurological Studies - Original Article

NFKB1 variants were associated with the risk of Parkinson´s disease in male

The NF-κB pathway is involved in the pathogenesis of neurological disorders that have inflammation as a hallmark, including Parkinson’s disease (PD). Our objective was to determine whether common functional variants in the NFKB1, NFKBIA and NFKBIZ …

verfasst von:
Sergio Perez-Oliveira, Daniel Vazquez-Coto, Sara Pardo, Marta Blázquez-Estrada, Manuel Menéndez-González, Pablo Siso, Esther Suárez, Ciara García-Fernández, Beatriz de la Casa Fages, Eliecer Coto, Victoria Álvarez

28.02.2024 | Neurology and Preclinical Neurological Studies - Original Article

Headache patterns in patent foramen ovale patients: beyond migraine with aura

Patent foramen ovale (PFO) is a common cardiac anomaly linked with cryptogenic strokes and migraine, particularly migraine with aura. This study aims to explore the spectrum of headache disorders in PFO patients, focusing on identifying patterns …

verfasst von:
Raluca Ștefania Badea, N. Grecu, A. C. Ribigan, F. Antochi, C. Tiu, B. O. Popescu

Open Access 24.02.2024 | Psychiatry and Preclinical Psychiatric Studies - Review Article

It is not just about transcription: involvement of brain RNA splicing in substance use disorders

Alternative splicing is a co-transcriptional process that significantly contributes to the molecular landscape of the cell. It plays a multifaceted role in shaping gene transcription, protein diversity, and functional adaptability in response to …

verfasst von:
Luana Carvalho, Amy W. Lasek

20.02.2024 | Neurology and Preclinical Neurological Studies - Original Article

Does thyroid diseases contribute to the natural history of idiopathic adult-onset dystonia? Data from the Italian Dystonia Registry

A few earlier observations and recent controlled studies pointed to the possible contribution of thyroid diseases in idiopathic adult-onset dystonia (IAOD). The aim of this study was to investigate the association between thyroid status and …

verfasst von:
Sarah Idrissi, Vittorio Velucci, Marcello Esposito, Assunta Trinchillo, Francesco Habestwallner, Daniele Belvisi, Giovanni Fabbrini, Gina Ferrazzano, Vincenzo Rizzo, Carmen Terranova, Paolo Girlanda, Roberta Pellicciari, Laura Avanzino, Francesca Di Biasio, Roberta Marchese, Francesco Bono, Giovanni Idone, Vincenzo Laterza, Christian Lettieri, Sara Rinaldo, Roberto Eleopra, Anna Castagna, Maria Concetta Altavista, Vincenzo Moschella, Roberto Erro, Paolo Barone, Pierangelo Barbero, Roberto Ceravolo, Sonia Mazzucchi, Marcello Mario Mascia, Tommaso Ercoli, Antonella Muroni, Maurizio Zibetti, Leonardo Lopiano, Cesa Lorella Maria Scaglione, Anna Rita Bentivoglio, Martina Petracca, Luca Magistrelli, Maria Sofia Cotelli, Giovanni Cossu, Giovanna Maddalena Squintani, Tiziana De Santis, Tommaso Schirinzi, Salvatore Misceo, Antonio Pisani, Alfredo Berardelli, Giovanni Defazio

Open Access 17.02.2024 | Neurology and Preclinical Neurological Studies - Original Article

Combined light and electron microscopy (CLEM) to quantify methamphetamine-induced alpha-synuclein-related pathology

Methamphetamine (METH) produces a cytopathology, which is rather specific within catecholamine neurons both in vitro and ex vivo, in animal models and chronic METH abusers. This led some authors to postulate a sort of parallelism between METH …

verfasst von:
Michela Ferrucci, Paola Lenzi, Gloria Lazzeri, Carla L. Busceti, Alessandro Frati, Stefano Puglisi-Allegra, Francesco Fornai

Open Access 16.02.2024 | Neurology and Preclinical Neurological Studies - Original Article

High-dose glucocorticoids in COVID-19 patients with acute encephalopathy: clinical and imaging findings in a retrospective cohort study

During the pandemic, acute encephalopathy (AE), in its most frequent clinical manifestation, delirium, affected up to 65% of hospitalized patients with COVID-19 (Helms et al. 2020 ) and was associated with a higher mortality (Mendes et al. 2021 ).

verfasst von:
Alexandra Rhally, Giulia Bommarito, Marjolaine Uginet, Gautier Breville, Patrick Stancu, Alice Accorroni, Frédéric Assal, Patrice H. Lalive, Karl-Olof Lövblad, Gilles Allali

13.02.2024 | Neurology and Preclinical Neurological Studies - Review Article

The pathobiology of depression in Huntington’s disease: an unresolved puzzle

Huntington’s disease (HD) is an autosomal-dominant progressive neurodegenerative disease that manifests with a triad of symptoms including motor dysfunctions, cognitive deficits, and prominent neuropsychiatric symptoms, the most common of which is …

verfasst von:
Kurt A. Jellinger

Open Access 27.01.2024 | Neurology and Preclinical Neurological Studies - Original Article

Validation of the Italian version of the Parkinson’s Disease- Cognitive Functional Rating Scale

A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson’s disease (PD) lies in the notable decrease in functioning due to cognitive impairment. The Parkinson’s Disease-Cognitive Functional Rating Scale …

verfasst von:
Michela Garon, Luca Weis, Antònia Siquier, Eleonora Fiorenzato, Francesca Pistonesi, Valeria Cianci, Margherita Canesi, Francesca Pesce, Elisa Reali, Beatrice Pozzi, Ioannis Ugo Isaias, Chiara Siri, Gabriella Santangelo, Sofia Cuoco, Paolo Barone, Jaime Kulisevsky, Angelo Antonini, Roberta Biundo

26.01.2024 | Psychiatry and Preclinical Psychiatric Studies - Original Article

The relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study

This study aimed to investigate the association between serum prolactin levels and psychiatric symptoms and cognitive function in drug-naïve schizophrenia patients. The study recruited 91 drug-naïve schizophrenia patients and 67 healthy controls.

verfasst von:
Guoshuai Luo, Fengfeng Bai, Xuehui Qu, Yifan Jing, Shuo Wang, Zaimina Xuekelaiti, Cong Yao, Meijuan Li, Jie Li

24.01.2024 | Neurology and Preclinical Neurological Studies - Review Article

Mild cognitive impairment in Huntington’s disease: challenges and outlooks

Although Huntington's disease (HD) has classically been viewed as an autosomal-dominant inherited neurodegenerative motor disorder, cognitive and/or behavioral changes are predominant and often an early manifestation of disease. About 40% of …

verfasst von:
Kurt A. Jellinger

Open Access 23.01.2024 | Neurology and Preclinical Neurological Studies - Original Article

Virus-induced brain pathology and the neuroinflammation-inflammation continuum: the neurochemists view

Fascinatingly, an abundance of recent studies has subscribed to the importance of cytotoxic immune mechanisms that appear to increase the risk/trigger for many progressive neurodegenerative disorders, including Parkinson’s disease (PD) …

verfasst von:
Jeswinder Sian-Hulsmann, Peter Riederer

22.01.2024 | Neurology and Preclinical Neurological Studies - Original Article

Association between autonomic dysfunction with motor and non-motor symptoms in patients with Parkinson's disease

To investigate the association between autonomic dysfunction (AutD) and motor as well as non-motor symptoms (NMS) in patients with Parkinson's disease (PD). Fifty-three PD patients were divided into two groups based on the number of domains …

verfasst von:
Yi Qin, De-Tao Meng, Zhao-Hui Jin, Wen-Jun Du, Bo-Yan Fang