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Zeitschrift

Journal of Experimental & Clinical Cancer Research

Journal of Experimental & Clinical Cancer Research 1/2018

Ausgabe 1/2018

Inhaltsverzeichnis ( 327 Artikel )

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

Zike Yang, Yanxia Qi, Nan Lai, Jiahe Zhang, Zehong Chen, Mingyu Liu, Wan Zhang, Rongcheng Luo, Shijun Kang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Relevance of 3d culture systems to study osteosarcoma environment

Angela De Luca, Lavinia Raimondi, Francesca Salamanna, Valeria Carina, Viviana Costa, Daniele Bellavia, Riccardo Alessandro, Milena Fini, Gianluca Giavaresi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

EZH2 promotes hepatocellular carcinoma progression through modulating miR-22/galectin-9 axis

Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang, Hang Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance

Ji-Hyun Lee, Seul-Ki Kim, Iftikhar Ali Khawar, Su-Yeong Jeong, Seok Chung, Hyo-Jeong Kuh

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Role of the nervous system in cancer metastasis

Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos, Kulmira Nurgali

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Stress-inducible Protein-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway

Linlin Huang, Ertao Zhai, Shirong Cai, Yi Lin, Junbin Liao, Huilin Jin, Sui Peng, Lixia Xu, Minhu Chen, Zhirong Zeng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells

Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li, Wenhua Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia

Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing, Ling Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li, Jingang Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence

Mingyu Liu, Qiaoting Hu, Mengxian Tu, Xinyi Wang, Zike Yang, Guoxiong Yang, Rongcheng Luo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms

Jessica Wagner, C. Leah Kline, Lanlan Zhou, Vladimir Khazak, Wafik S. El-Deiry

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia

Yiran Chen, Xiaoling Xie, Anqin Wu, Lei Wang, Yuxing Hu, Honghao Zhang, Yuhua Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Over-expression of oncigenic pesudogene DUXAP10 promotes cell proliferation and invasion by regulating LATS1 and β-catenin in gastric cancer

Yongcan Xu, Xiang Yu, Chenchen Wei, Fengqi Nie, Mingde Huang, Ming Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-3928v is induced by HBx via NF-κB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3

Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li, Hua Tang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma

Leilei Zhang, Xiaoyu He, Fang Li, Hui Pan, Xiaolin Huang, Xuyang Wen, He Zhang, Bin Li, Shengfang Ge, Xiaofang Xu, Renbing Jia, Xianqun Fan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum DNA integrity index as a potential molecular biomarker in endometrial cancer

Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio, Lucia Cicchillitti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability

Zhikun Lin, Ruiping He, Haifeng Luo, Chang Lu, Zhen Ning, Yuanhang Wu, Chuanchun Han, Guang Tan, Zhongyu Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MicroRNA-150 enhances radiosensitivity by inhibiting the AKT pathway in NK/T cell lymphoma

Shao Jie Wu, Jun Chen, BingYi Wu, Yu Jue Wang, Kun Yuan Guo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-302a-5p/367-3p-HMGA2 axis regulates malignant processes during endometrial cancer development

Jian Ma, Da Li, Fan-Fei Kong, Di Yang, Hui Yang, Xiao-Xin Ma

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Fate of Antibody-Drug Conjugates in Cancer Cells

Cécile Chalouni, Sophia Doll

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway

Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou, Dan Xie

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1

Mengmeng Zhang, Fei Miao, Rong Huang, Wenjie Liu, Yuechao Zhao, Tao Jiao, Yalan Lu, Fan Wu, Xiaojuan Wang, Han Wang, Hong Zhao, Hongge Ju, Shiying Miao, Linfang Wang, Wei Song

01.12.2018 | Research | Ausgabe 1/2018 Open Access

14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling

Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang, Jian-Hua Zhu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells

Huijie Yang, Na Yu, Juntao Xu, Xiaosheng Ding, Wei Deng, Guojin Wu, Xin Li, Yingxiang Hou, Zhenhua Liu, Yan Zhao, Min Xue, Sifan Yu, Beibei Wang, Xiumin Li, Gang Niu, Hui Wang, Jian Zhu, Ting Zhuang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings

Chi Fang, Chen-yun Dai, Zhu Mei, Ming-jie Jiang, Dian-na Gu, Qian Huang, Ling Tian

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review

Jiang Jiang, Hailong Li, Eskandar Qaed, Jing Zhang, Yushu Song, Rong Wu, Xinmiao Bu, Qinyan Wang, Zeyao Tang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TFAP2C promotes stemness and chemotherapeutic resistance in colorectal cancer via inactivating hippo signaling pathway

Xu Wang, Di Sun, Jiandong Tai, Si Chen, Miao Yu, Dong Ren, Lei Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development

Xingwang Xie, Xueyan Wang, Weijia Liao, Ran Fei, Nan Wu, Xu Cong, Qian Chen, Lai Wei, Yu Wang, Hongsong Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Development and evaluation of novel tumor-targeting paclitaxel-loaded nano-carriers for ovarian cancer treatment: in vitro and in vivo

Shu Yao, Li Li, Xuan-tao Su, Kai Wang, Zai-jun Lu, Cun-zhong Yuan, Jin-bo Feng, Shi Yan, Bei-hua Kong, Kun Song

01.12.2018 | Review | Ausgabe 1/2018 Open Access

New therapeutic strategies to treat human cancers expressing mutant p53 proteins

Giovanni Blandino, Silvia Di Agostino

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo

Xiaoran Guo, Kenneth K. W. To, Zhen Chen, Xiaokun Wang, Jianye Zhang, Min Luo, Fang Wang, Shirong Yan, Liwu Fu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer

Huiling Lai, Xuejiao Zhao, Yu Qin, Yi Ding, Ruqi Chen, Guannan Li, Marilyne Labrie, Zhiyong Ding, Jianfeng Zhou, Junbo Hu, Ding Ma, Yong Fang, Qinglei Gao

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

The potential role of HGF-MET signaling and autophagy in the war of Alectinib versus Crizotinib against ALK-positive NSCLC

Xing Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling

Yuan-Yuan Qiang, Chang-Zhi Li, Rui Sun, Li-Sheng Zheng, Li-Xia Peng, Jun-Ping Yang, Dong-Fang Meng, Yan-Hong Lang, Yan Mei, Ping Xie, Liang Xu, Yun Cao, Wen-Wen Wei, Li Cao, Hao Hu, Qin Yang, Dong-Hua Luo, Ying-Ying Liang, Bi-Jun Huang, Chao-Nan Qian

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Serum DNA integrity index as a potential molecular biomarker in endometrial cancer

Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio, Lucia Cicchillitti

01.12.2018 | Review | Ausgabe 1/2018 Open Access

CDK9 inhibitors in acute myeloid leukemia

Silvia Boffo, Angela Damato, Luigi Alfano, Antonio Giordano

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition

Wanchun Wang, Ding Chen, Kewei Zhu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The viable circulating tumor cells with cancer stem cells feature, where is the way out?

Y. T. Luo, J. Cheng, X. Feng, S. J. He, Y. W. Wang, Q. Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation

Xiangrui Li, Zhijian Zhang, Yao Zhang, Yuxiang Cao, Huijun Wei, Zhihao Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Wilms’ tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability

Jingyuan Tang, Feng Wang, Gong Cheng, Shuhui Si, Xi Sun, Jie Han, Hao Yu, Wei Zhang, Qiang Lv, Ji-Fu Wei, Haiwei Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway

Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Efficient targeted tumor imaging and secreted endostatin gene delivery by anti-CD105 immunoliposomes

Huiqin Zhuo, Baoshi Zheng, Jianming Liu, Yong Huang, Huiling Wang, Duo Zheng, Naiquan Mao, Jinyu Meng, Sufang Zhou, Liping Zhong, Yongxiang Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

Jianjun Zhu, Mingpeng Jin, Jiaojiao Wang, Hui Zhang, Yousheng Wu, Deyang Li, Xiaoying Ji, Hushan Yang, Chun Yin, Tingting Ren, Jinliang Xing

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer

Jian-Feng Liu, Lei Wu, Lei-Lei Yang, Wei-Wei Deng, Liang Mao, Hao Wu, Wen-Feng Zhang, Zhi-Jun Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Downregulation of castor zinc finger 1 predicts poor prognosis and facilitates hepatocellular carcinoma progression via MAPK/ERK signaling

Ji-Long Wang, Meng-yuan Yang, Shuai Xiao, Bo Sun, Yi-Ming Li, Lian-Yue Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma

Dongliang Li, Yongjian Zhang, He Zhang, Chao Zhan, Xin Li, Tu Ba, Zini Qiu, Fang E, Guixiang Lv, Chendan Zou, Chuxuan Wang, Lining Si, Chaoxia Zou, Qiang Li, Xu Gao

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Tearing down the walls: FDA approves next generation sequencing (NGS) assays for actionable cancer genomic aberrations

Matteo Allegretti, Alessandra Fabi, Simonetta Buglioni, Aline Martayan, Laura Conti, Edoardo Pescarmona, Gennaro Ciliberto, Patrizio Giacomini

01.12.2018 | Meeting Report | Ausgabe 1/2018 Open Access

Reprogramming Tumor-Immune Cell Interface in Solid and Hematological Malignancies to Enhance Response to Therapy

Maria Teresa Di Martino, Francesca Zazzeroni, Massimo Donadelli, Claudia Chiodoni, Michele Caraglia, Katia Scotlandi, Stefania Meschini, Carlo Leonetti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma

Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu, Kangsheng Tu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling

Dong-dong Cheng, Shi-jie Li, Bin Zhu, Shu-min Zhou, Qing-cheng Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells

Shu-Guang Li, Qian-Wei Shi, Ling-yan Yuan, Li-ping Qin, Yan Wang, Yu-Qing Miao, Zhe Chen, Chang-Quan Ling, Wen-xing Qin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway

Xiao Fu, Mengjie Liu, Shengyang Qu, Jiequn Ma, Yamin Zhang, Tingting Shi, Hongqing Wen, Yujuan Yang, Shuhong Wang, Jing Wang, Kejun Nan, Yu Yao, Tao Tian

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway

Bao-Xia Li, Heng-Bang Wang, Miao-Zhen Qiu, Qiu-Yun Luo, Han-Jie Yi, Xiang-Lei Yan, Wen-Tao Pan, Lu-Ping Yuan, Yu-Xin Zhang, Jian-Hua Xu, Lin Zhang, Da-Jun Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN

Hui Ran, Yemin Zhu, Ruyuan Deng, Qi Zhang, Xisheng Liu, Ming Feng, Jie Zhong, Shuhai Lin, Xuemei Tong, Qing Su

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Monitoring the effect of first line treatment in RAS/RAF mutated metastatic colorectal cancer by serial analysis of tumor specific DNA in plasma

C. B. Thomsen, T. F. Hansen, R. F. Andersen, J. Lindebjerg, L. H. Jensen, A. Jakobsen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LncRNA-TUSC7/miR-224 affected chemotherapy resistance of esophageal squamous cell carcinoma by competitively regulating DESC1

Zhi-wei Chang, Yong-xu Jia, Wei-jie Zhang, Li-jie Song, Ming Gao, Ming-jun Li, Rui-hua Zhao, Jing Li, Ya-li Zhong, Qiao-zhi Sun, Yan-ru Qin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

Manuela Porru, Luca Pompili, Carla Caruso, Annamaria Biroccio, Carlo Leonetti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long non-coding RNA MIAT promotes gastric cancer growth and metastasis through regulation of miR-141/DDX5 pathway

Min Sha, Mei Lin, Jia Wang, Jun Ye, Jie Xu, Ning Xu, Junxing Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer

Chao-Hui Zheng, Jia-Bin Wang, Man-Qiang Lin, Peng-Yang Zhang, Li-Chao Liu, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Jian-Wei Xie, Ping Li, Chang-Ming Huang

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1

Mengmeng Zhang, Fei Miao, Rong Huang, Wenjie Liu, Yuechao Zhao, Tao Jiao, Yalan Lu, Fan Wu, Xiaojuan Wang, Han Wang, Hong Zhao, Hongge Ju, Shiying Miao, Linfang Wang, Wei Song

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance

Meng-Shih Weng, Jer-Hwa Chang, Wen-Yueh Hung, Yi-Chieh Yang, Ming-Hsien Chien

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang, Zhenglan Huang, Miao Gao, Zhenhong Luo, Fangzhu Zhou, Lin Liu, Qing Xiao, Xin Wang, Wenli Feng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

Yan Wang, Wenbin Xu, Zixun Yan, Weili Zhao, Jianqing Mi, Junmin Li, Hua Yan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141

Yukun Liu, Ran Zhao, Yanmei Wei, Mengna Li, Heran Wang, Weihong Niu, Yao Zhou, Yuanzheng Qiu, Songqing Fan, Yihao Zhan, Wei Xiong, Yanhong Zhou, Xiaoling Li, Zheng Li, Guiyuan Li, Ming Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma

Yan Yang, Jian Zhu, Tiantian Zhang, Jing Liu, Yumei Li, Yue Zhu, Lingjie Xu, Rui Wang, Fang Su, Yurong Ou, Qiong Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells

Wei Lu, Yun Wan, Zhiqiang Li, Bin Zhu, Chunrong Yin, Haiyan Liu, Shaoxin Yang, Yuanmei Zhai, Yehua Yu, Yanyu Wei, Jun Shi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008

Helicia Paz, Eun Ji Joo, Chih-Hsing Chou, Fei Fei, Kevin H. Mayo, Hisham Abdel-Azim, Haike Ghazarian, John Groffen, Nora Heisterkamp

01.12.2018 | Research | Ausgabe 1/2018 Open Access

5′/ 3′ imbalance strategy to detect ALK fusion genes in circulating tumor RNA from patients with non-small cell lung cancer

Yongqing Tong, Zhijun Zhao, Bei Liu, Anyu Bao, Hongyun Zheng, Jian Gu, Mary McGrath, Ying Xia, Bihua Tan, Chunhua Song, Yan Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions

Zhengdong Jiang, Cancan Zhou, Liang Cheng, Bin Yan, Ke Chen, Xin Chen, Liang Zong, Jianjun Lei, Wanxing Duan, Qinhong Xu, Xuqi Li, Zheng Wang, Qingyong Ma, Jiguang Ma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway

Yen-Hsiu Yeh, Ho-Fu Hsiao, Yen-Cheng Yeh, Tien-Wen Chen, Tsai-Kun Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis

Xiaowei Li, Mingzuo Jiang, Di Chen, Bing Xu, Rui Wang, Yi Chu, Weijie Wang, Lin Zhou, Zhijie Lei, Yongzhan Nie, Daiming Fan, Yulong Shang, Kaichun Wu, Jie Liang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The anti-tumor efficacy of CDK4/6 inhibition is enhanced by the combination with PI3K/AKT/mTOR inhibitors through impairment of glucose metabolism in TNBC cells

Daniele Cretella, Andrea Ravelli, Claudia Fumarola, Silvia La Monica, Graziana Digiacomo, Andrea Cavazzoni, Roberta Alfieri, Alessandra Biondi, Daniele Generali, Mara Bonelli, Pier Giorgio Petronini

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT

Weiwei Liu, Xuchu Wang, Yiyun Wang, Yibei Dai, Yiyi Xie, Ying Ping, Binbin Yin, Pan Yu, Zhenping Liu, Xiuzhi Duan, Zhaoping Liao, Yuhua Chen, Chunhua Liu, Xiang Li, Zhihua Tao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mature and progenitor endothelial cells perform angiogenesis also under protease inhibition: the amoeboid angiogenesis

Anastasia Chillà, Francesca Margheri, Alessio Biagioni, Mario Del Rosso, Gabriella Fibbi, Anna Laurenzana

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lipid accumulation in human breast cancer cells injured by iron depletors

Maida De Bortoli, Elena Taverna, Elisa Maffioli, Patrizia Casalini, Francesco Crisafi, Vikas Kumar, Claudio Caccia, Dario Polli, Gabriella Tedeschi, Italia Bongarzone

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MiR-10a-5p targets TFAP2C to promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Guangbing Xiong, Hua Huang, Mengyu Feng, Gang Yang, Suli Zheng, Lei You, Lianfang Zheng, Ya Hu, Taiping Zhang, Yupei Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis

Xuelian Chen, Lirong Zhang, Yujie Jiang, Lian Song, Yanfang Liu, Fang Cheng, Xin Fan, Xiongfeng Cao, Aihua Gong, Dongqing Wang, Haitao Zhu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461

Guihong Li, Jing Shen, Junguo Cao, Guangtong Zhou, Ting Lei, Yuxue Sun, Haijun Gao, Yaonan Ding, Weidong Xu, Zhixin Zhan, Yong Chen, Haiyan Huang

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Iron-dependent cell death as executioner of cancer stem cells

Bin Zhao, Xin Li, Ye Wang, Peng Shang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2

Shan Li, Yan-Min Ma, Peng-Sheng Zheng, Ping Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma

Yi Xu, Yue Yao, Xingming Jiang, Xiangyu Zhong, Zhidong Wang, Chunlong Li, Pengcheng Kang, Kaiming Leng, Daolin Ji, Zhenglong Li, Lining Huang, Wei Qin, Yunfu Cui

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The phospholipase DDHD1 as a new target in colorectal cancer therapy

Stefania Raimondo, Marta Cristaldi, Simona Fontana, Laura Saieva, Francesca Monteleone, Giovanna Calabrese, Gianluca Giavaresi, Rosalba Parenti, Riccardo Alessandro

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling

Ling Cao, Yulin Liu, Dan Wang, Lan Huang, Feng Li, Jinbo Liu, Chaoqi Zhang, Zhibo Shen, Qun Gao, Weitang Yuan, Yi Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

Duarte Mendes Oliveira, Katia Grillone, Chiara Mignogna, Valentina De Falco, Carmelo Laudanna, Flavia Biamonte, Rosa Locane, Francesco Corcione, Massimiliano Fabozzi, Rosario Sacco, Giuseppe Viglietto, Donatella Malanga, Antonia Rizzuto

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3β/snail signalling

Wen-Ze Qiu, Hai-Bo Zhang, Wei-Xiong Xia, Liang-Ru Ke, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Tie-Bang Kang, Xiang Guo, Xing Lv

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The perfect personalized cancer therapy: cancer vaccines against neoantigens

Luigi Aurisicchio, Matteo Pallocca, Gennaro Ciliberto, Fabio Palombo

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Role of metabolism in cancer cell radioresistance and radiosensitization methods

Le Tang, Fang Wei, Yingfen Wu, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Hao Deng, Ke Cao, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

Branson Chen, Jong Bok Lee, Hyeonjeong Kang, Mark D. Minden, Li Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Attenuation of TGFBR2 expression and tumour progression in prostate cancer involve diverse hypoxia-regulated pathways

Hui Zhou, Guanqing Wu, Xueyou Ma, Jun Xiao, Gan Yu, Chunguang Yang, Nan Xu, Bao Zhang, Jun Zhou, Zhangqun Ye, Zhihua Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Androgen receptor and heat shock protein 27 co-regulate the malignant potential of molecular apocrine breast cancer

Xiaozhen Liu, Changyun Feng, Junjun Liu, Lu Cao, Guomin Xiang, Fang Liu, Shuling Wang, Jiao Jiao, Yun Niu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation

Yuan-Hua Wu, Wun-Syuan Wu, Li-Ching Lin, Chiang-Shin Liu, Sheng-Yow Ho, Bour-Jr Wang, Bu-Miin Huang, Ya-Ling Yeh, Hui-Wen Chiu, Wei-Lei Yang, Ying-Jan Wang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

Ruixia Huang, Einar K. Rofstad

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The dual blockade of MET and VEGFR2 signaling demonstrates pronounced inhibition on tumor growth and metastasis of hepatocellular carcinoma

Yu Zhang, Xiaomei Gao, Ying Zhu, Dhruba Kadel, Haoran Sun, Jing Chen, Qin Luo, Haoting Sun, Luyu Yang, Jing Yang, Yuanyuan Sheng, Yan Zheng, Kejin Zhu, Qiongzhu Dong, Lunxiu Qin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling

Maria Francesca Santolla, Rosamaria Lappano, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Anna Sebastiani, Sergio Abonante, Pierfrancesco Tassone, Pierosandro Tagliaferri, Maria Teresa Di Martino, Marcello Maggiolini, Adele Vivacqua

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum miR-22 as potential non-invasive predictor of poor clinical outcome in newly diagnosed, uniformly treated patients with diffuse large B-cell lymphoma: an explorative pilot study

Francesco Marchesi, Giulia Regazzo, Francesca Palombi, Irene Terrenato, Andrea Sacconi, Manuela Spagnuolo, Sara Donzelli, Mirella Marino, Cristiana Ercolani, Anna Di Benedetto, Giovanni Blandino, Gennaro Ciliberto, Andrea Mengarelli, Maria Giulia Rizzo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

NHERF1 and tumor microenvironment: a new scene in invasive breast carcinoma

Concetta Saponaro, Alessandro Vagheggini, Emanuela Scarpi, Matteo Centonze, Ivana Catacchio, Ondina Popescu, Maria Irene Pastena, Francesco Giotta, Nicola Silvestris, Anita Mangia

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

Hanjie Yi, Xianglei Yan, Qiuyun Luo, Luping Yuan, Baoxia Li, Wentao Pan, Lin Zhang, Haibo Chen, Jing Wang, Yubin Zhang, Yifan Zhai, Miao-Zhen Qiu, Da-Jun Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cyclizing-berberine A35 induces G2/M arrest and apoptosis by activating YAP phosphorylation (Ser127)

Wuli Zhao, Hong Liu, Junxia Wang, Mengyan Wang, Rongguang Shao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation

Sifan Wu, Qiongdan Zheng, Xiaoxia Xing, Yinying Dong, Yaohui Wang, Yang You, Rongxin Chen, Chao Hu, Jie Chen, Dongmei Gao, Yan Zhao, Zhiming Wang, Tongchun Xue, Zhenggang Ren, Jiefeng Cui

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SPIN1, negatively regulated by miR-148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer

Xu Chen, Ya-Wen Wang, Peng Gao

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The dysregulation of tRNAs and tRNA derivatives in cancer

Shi-qiong Huang, Bao Sun, Zong-ping Xiong, Yan Shu, Hong-hao Zhou, Wei Zhang, Jing Xiong, Qing Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma

Hsin-Pai Li, Chen-Ching Peng, Chih-Ching Wu, Chien-Hsun Chen, Meng-Jhe Shih, Mei-Yuan Huang, Yi-Ru Lai, Yung-Li Chen, Ting-Wen Chen, Petrus Tang, Yu-Sun Chang, Kai-Ping Chang, Cheng-Lung Hsu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Physical interaction of STAT1 isoforms with TGF-β receptors leads to functional crosstalk between two signaling pathways in epithelial ovarian cancer

Xiaoling Tian, Wencai Guan, Lingyun Zhang, Wenwen Sun, Daibing Zhou, Qunbo Lin, Weimin Ren, Lubna Nadeem, Guoxiong Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade

Cheng-fu Cai, Guo-dong Ye, Dong-yan Shen, Wei Zhang, Mao-li Chen, Xin-xin Chen, Da-xiong Han, Yan-jun Mi, Qi-cong Luo, Wang-yu Cai, Shu-yu Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LncMAPK6 drives MAPK6 expression and liver TIC self-renewal

Guanqun Huang, Hui Jiang, Yueming He, Ye Lin, Wuzheng Xia, Yuanwei Luo, Min Liang, Boyun Shi, Xinke Zhou, Zhixiang Jian

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LncRNA TUG1 promoted KIAA1199 expression via miR-600 to accelerate cell metastasis and epithelial-mesenchymal transition in colorectal cancer

Junfeng Sun, Jiyi Hu, Guojun Wang, Zhen Yang, Chunlin Zhao, Xiefu Zhang, Jiaxiang Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma

Hye Jeong Park, Jun Sang Bae, Kyoung Min Kim, Young Jae Moon, See-Hyoung Park, Sang Hoon Ha, Usama Khamis Hussein, Zhongkai Zhang, Ho Sung Park, Byung-Hyun Park, Woo Sung Moon, Jung Ryul Kim, Kyu Yun Jang

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway

Bao-Xia Li, Heng-Bang Wang, Miao-Zhen Qiu, Qiu-Yun Luo, Han-Jie Yi, Xiang-Lei Yan, Wen-Tao Pan, Lu-Ping Yuan, Yu-Xin Zhang, Jian-Hua Xu, Lin Zhang, Da-Jun Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma

Yeonhwa Song, Jin-Sun Kim, Se-Hyuk Kim, Yoon Kyung Park, Eunsil Yu, Ki-Hun Kim, Eul-Ju Seo, Heung-Bum Oh, Han Chu Lee, Kang Mo Kim, Haeng Ran Seo

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Immune checkpoint therapy in liver cancer

Feng Xu, Tianqiang Jin, Yuwen Zhu, Chaoliu Dai

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma

Xianglin Hao, Fei Han, Bangjin Ma, Ning Zhang, Hongqiang Chen, Xiao Jiang, Li Yin, Wenbin Liu, Lin Ao, Jia Cao, Jinyi Liu

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

Duarte Mendes Oliveira, Katia Grillone, Chiara Mignogna, Valentina De Falco, Carmelo Laudanna, Flavia Biamonte, Rosa Locane, Francesco Corcione, Massimiliano Fabozzi, Rosario Sacco, Giuseppe Viglietto, Donatella Malanga, Antonia Rizzuto

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1α/VEGFA signalling in hepatocellular carcinoma

Jinduan Lin, Shunwang Cao, Yu Wang, Yanwei Hu, Hongwei Liu, Jiehua Li, Jing Chen, Pan Li, Jumei Liu, Qian Wang, Lei Zheng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy

Man Yu, Ting Liu, Yicheng Chen, Yafang Li, Wenhua Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Gastrin inhibits gastric cancer progression through activating the ERK-P65-miR23a/27a/24 axis

Li-Dong Zu, Xing-Chun Peng, Zhi Zeng, Jing-Long Wang, Li-Li Meng, Wei-Wei Shen, Chun-Ting Hu, Ye Yang, Guo-Hui Fu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A

Yi Zhang, Ran Tao, Shan-Shan Wu, Cui-Cui Xu, Jie-Ling Wang, Jie Chen, Yong-Sheng Yu, Zheng-Hao Tang, Xiao-Hua Chen, Guo-Qing Zang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion

Caiyun Liu, Like Qu, Chuanke Zhao, Chengchao Shou

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Emerging role of lipid metabolism alterations in Cancer stem cells

Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li, Bo Xiang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII

Antonietta Rosella Farina, Lucia Cappabianca, Pierdomenico Ruggeri, Luciana Gneo, Cristina Pellegrini, Maria-Concetta Fargnoli, Andrew Reay Mackay

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Long non-coding RNAs in ovarian cancer

Lei Zhan, Jun Li, Bing Wei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner

Guanqun Huang, Hui Jiang, Ye Lin, Wuzheng Xia, Yuanwei Luo, Yanpeng Wu, Weilong Cai, Xinke Zhou, Xianhan Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling

Fengchao Liu, Xiaoling Wu, Xin Jiang, Yanzhi Qian, Jian Gao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

ER-α36 mediates cisplatin resistance in breast cancer cells through EGFR/HER-2/ERK signaling pathway

Linlin Zhu, Jiao Zou, Yuanyin Zhao, Xiaomei Jiang, Yang Wang, Xiangwei Wang, Bin Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Liquid biopsy in mice bearing colorectal carcinoma xenografts: gateways regulating the levels of circulating tumor DNA (ctDNA) and miRNA (ctmiRNA)

Jessica Gasparello, Matteo Allegretti, Elisa Tremante, Enrica Fabbri, Carla Azzurra Amoreo, Paolo Romania, Elisa Melucci, Katia Messana, Monica Borgatti, Patrizio Giacomini, Roberto Gambari, Alessia Finotti

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, Carla Ijurko, Ángel Hernández-Hernández

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Reprogramming the murine colon cancer microenvironment using lentivectors encoding shRNA against IL-10 as a component of a potent DC-based chemoimmunotherapy

Joanna Rossowska, Natalia Anger, Agnieszka Szczygieł, Jagoda Mierzejewska, Elżbieta Pajtasz-Piasecka

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer

Jing Chen, Shunwang Cao, Bo Situ, Juan Zhong, Yanwei Hu, Shufen Li, Jinlan Huang, Jiasen Xu, Shiyang Wu, Jinduan Lin, Qianwen Zhao, Zhen Cai, Lei Zheng, Qian Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway

Xueran Chen, Shangrong Zhang, Zhen Wang, Fengsong Wang, Xinwang Cao, Quan Wu, Chenggang Zhao, Huihui Ma, Fang Ye, Hongzhi Wang, Zhiyou Fang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint

Xiaoting Lin, Dongshao Chen, Cheng Zhang, Xiaotian Zhang, Zhongwu Li, Bin Dong, Jing Gao, Lin Shen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4

Yue Fu, Xinchun Liu, Qiuyang Chen, Tongtai Liu, Cheng Lu, Jun Yu, Yi Miao, Jishu Wei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer

Haicheng Tang, Jianjie Zhu, Wenwen Du, Shunlin Liu, Yuanyuan Zeng, Zongli Ding, Yang Zhang, Xueting Wang, Zeyi Liu, Jianan Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase

Wan Li, Jinyi Liu, Weiqi Fu, Xiangjin Zheng, Liwen Ren, Shiwei Liu, Jinhua Wang, Tengfei Ji, Guanhua Du

01.12.2018 | Research | Ausgabe 1/2018 Open Access

17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression

Quanfu Huang, Zheng Zhang, Yongde Liao, Changyu Liu, Sheng Fan, Xiao Wei, Bo Ai, Jing Xiong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long non-coding RNA UFC1 promotes gastric cancer progression by regulating miR-498/Lin28b

Xu Zhang, Wei Liang, Jibin Liu, Xueyan Zang, Jianmei Gu, Lei Pan, Hui Shi, Min Fu, Zhenhua Huang, Yu Zhang, Hui Qian, Pengcheng Jiang, Wenrong Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy

Fan Zhang, Taiqiang Yan, Wei Guo, Kunkun Sun, Shidong Wang, Xing Bao, Kuisheng Liu, Bingxin Zheng, Hongliang Zhang, Tingting Ren

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver

Guozhen Cui, Robert C. Martin, Hang Jin, Xingkai Liu, Harshul Pandit, Hengjun Zhao, Lu Cai, Ping Zhang, Wei Li, Yan Li

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Activities of stromal and immune cells in HPV-related cancers

Marconi Rego Barros Jr, Cristiane Moutinho Lagos de Melo, Maria Luiza Carneiro Moura Gonçalves Rego Barros, Rita de Cássia Pereira de Lima, Antonio Carlos de Freitas, Aldo Venuti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

(Arg)9-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling

An-dong Liu, Hui Xu, Ya-nan Gao, Dan-ni Luo, Zhao-feng Li, Courtney Voss, Shawn S. C. Li, Xuan Cao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Endometrial cancer prognosis correlates with the expression of L1CAM and miR34a biomarkers

Giacomo Corrado, Valentina Laquintana, Rossella Loria, Mariantonia Carosi, Laura de Salvo, Isabella Sperduti, Ashanti Zampa, Lucia Cicchillitti, Giulia Piaggio, Giuseppe Cutillo, Rita Falcioni, Enrico Vizza

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

Anais Del Curatolo, Fabiana Conciatori, Ursula Cesta Incani, Chiara Bazzichetto, Italia Falcone, Vincenzo Corbo, Sabrina D’Agosto, Adriana Eramo, Giovanni Sette, Isabella Sperduti, Teresa De Luca, Mirko Marabese, Senji Shirasawa, Ruggero De Maria, Aldo Scarpa, Massimo Broggini, Donatella Del Bufalo, Francesco Cognetti, Michele Milella, Ludovica Ciuffreda

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene

Yongwen Li, Hongbing Zhang, Hao Gong, Yin Yuan, Ying Li, Cong Wang, Weiting Li, Zihe Zhang, Minghui Liu, Hongyu Liu, Jun Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells

Ling Liu, Zile Huang, Jingjing Chen, Jiangang Wang, Shuying Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma

Meng Xiao, Jianjun Zhang, Wanjun Chen, Wantao Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer

Fan Wu, Pin Gao, Wei Wu, Zaozao Wang, Jie Yang, Jiabo Di, Beihai Jiang, Xiangqian Su

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression

Jian Ma, Kun Chang, Jingtao Peng, Qing Shi, Hualei Gan, Kun Gao, Kai Feng, Fujiang Xu, Hailiang Zhang, Bo Dai, Yao Zhu, Guohai Shi, Yijun Shen, Yiping Zhu, Xiaojian Qin, Yao Li, Pingzhao Zhang, Dingwei Ye, Chenji Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth

Katia Rea, Francesca Roggiani, Loris De Cecco, Francesco Raspagliesi, Maria Luisa Carcangiu, Joyce Nair-Menon, Marina Bagnoli, Ileana Bortolomai, Delia Mezzanzanica, Silvana Canevari, Antonis Kourtidis, Panos Z. Anastasiadis, Antonella Tomassetti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma

Juan Lu, Qi-Hui Liu, Fan Wang, Jia-Jie Tan, Yue-Qin Deng, Xiao-Hong Peng, Xiong Liu, Bao Zhang, Xia Xu, Xiang-Ping Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation

Wenlu Li, Dandan Zhu, Shuaihua Qin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LINC01287/miR-298/STAT3 feedback loop regulates growth and the epithelial-to-mesenchymal transition phenotype in hepatocellular carcinoma cells

Yichao Mo, Longguang He, Zeru Lai, Zhiheng Wan, Qinshou Chen, Sibo Pan, Liangfu Li, Dasheng Li, Junwei Huang, Fan Xue, Siyao Che

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Paramount therapy for young and fit patients with mantle cell lymphoma: strategies for front-line therapy

Haige Ye, Aakash Desai, Shengjian Huang, Dayoung Jung, Richard Champlin, Dongfeng Zeng, Fangfang Yan, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed, Michael L. Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regorafenib suppresses colon tumorigenesis and the generation of drug resistant cancer stem-like cells via modulation of miR-34a associated signaling

Mao-Hua Cai, Xiao-Gang Xu, Shi-Li Yan, Ze Sun, Yin Ying, Bai-Kui Wang, Yue-Xing Tu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop

Feifei Zhang, Kaitao Li, Mingxin Pan, Weidong Li, Juan Wu, Mingyi Li, Liang Zhao, Hui Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells

Linglong Yin, Youhong Liu, Yuchong Peng, Yongbo Peng, Xiaohui Yu, Yingxue Gao, Bowen Yuan, Qianling Zhu, Tuoyu Cao, Leye He, Zhicheng Gong, Lunquan Sun, Xuegong Fan, Xiong Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Motor neuron and pancreas homeobox 1/HLXB9 promotes sustained proliferation in bladder cancer by upregulating CCNE1/2

Mingkun Chen, Rongpei Wu, Gang Li, Cundong Liu, Lei Tan, Kanghua Xiao, Yunlin Ye, Zike Qin

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Emerging role of lipid metabolism alterations in Cancer stem cells

Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li, Bo Xiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation

Ganlu Deng, Shan Zeng, Yanling Qu, Qingqing Luo, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Changjing Cai, Yaojie Fu, Hong Shen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lycorine inhibits glioblastoma multiforme growth through EGFR suppression

Jia Shen, Tao Zhang, Zheng Cheng, Ni Zhu, Hua Wang, Li Lin, Zexia Wang, Haotian Yi, Meichun Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion

Xiupeng Xu, Zhongyuan Bao, Yinlong Liu, Kuan Jiang, Tongle Zhi, Dong Wang, Liang Fan, Ning Liu, Jing Ji

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Paired box 8 suppresses tumor angiogenesis and metastasis in gastric cancer through repression of FOXM1 via induction of microRNA-612

Liyan Wang, Xiaotong Bo, Qinghua Zheng, Wenhong Ge, Yanhua Liu, Bin Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K/AKT signaling

Yubo Tang, Jincheng Pan, Shuai Huang, Xinsheng Peng, Xuenong Zou, Yongxiang Luo, Dong Ren, Xin Zhang, Ronggang Li, Peiheng He, Qingde Wa

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells

Huei-Yu Chen, Atikul Islam, Tien-Ming Yuan, Shi-Wen Chen, Pei-Fen Liu, Pin Ju Chueh

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Exosomal TRIM3 is a novel marker and therapy target for gastric cancer

Hailong Fu, Huan Yang, Xu Zhang, Bo Wang, Jiahui Mao, Xia Li, Mei Wang, Bin Zhang, Zixuan Sun, Hui Qian, Wenrong Xu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The expansion of targetable biomarkers for CAR T cell therapy

Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison, Kim L. O’Neill

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-22/KAT6B axis is a chemotherapeutic determiner via regulation of PI3k-Akt-NF-kB pathway in tongue squamous cell carcinoma

Yixue Gu, Hao Liu, Fangren Kong, Jiahui Ye, Xiaoting Jia, Zhijie Zhang, Nan Li, Jiang Yin, Guopei Zheng, Zhimin He

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation

Min Liu, Ke Jiang, Guibin Lin, Peng Liu, Yumei Yan, Tian Ye, Gang Yao, Martin P. Barr, Dapeng Liang, Yang Wang, Peng Gong, Songshu Meng, Haozhe Piao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer

Yan Sun, Wenfang Peng, Weiwei He, Man Luo, Guilin Chang, Jiping Shen, Xiaoping Zhao, Yu Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC

Yu Pan, Fengchun Lu, Ping Xiong, Maoen Pan, Zheyang Zhang, Xianchao Lin, Minggui Pan, Heguang Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells

Sumit Mukherjee, Angela Fried, Rahman Hussaini, Richard White, Juliet Baidoo, Sri Yalamanchi, Probal Banerjee

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long non-coding RNA TPT1-AS1 promotes cell growth and metastasis in cervical cancer via acting AS a sponge for miR-324-5p

Hui Jiang, Guanqun Huang, Nianzhang Zhao, Ting Zhang, Mengni Jiang, Yueming He, Xinke Zhou, Xianhan Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis

Francesca Monteleone, Simona Taverna, Riccardo Alessandro, Simona Fontana

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA

Min Kang, Meiping Ren, Yan Li, Yuqiong Fu, Minmin Deng, Changping Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346

Ning Bai, Eming Peng, Xingsheng Qiu, Ning Lyu, Zhejia Zhang, Yiming Tao, Xinying Li, Zhiming Wang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Emerging roles of Myc in stem cell biology and novel tumor therapies

Go J. Yoshida

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells

Yanyan Zhang, Zhi Xu, Jiaji Ding, Chunli Tan, Weizi Hu, Yunman Li, Wenlong Huang, Yong Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer

Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong, Daxing Xie

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression

Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao, Chuanchun Han

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis

Jie Li, Zhonghu Li, Peng Jiang, Minjie Peng, Xi Zhang, Kai Chen, Hui Liu, Huaqiang Bi, Xiangde Liu, Xiaowu Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway

Liguo Liu, Xuebing Yan, Dapeng Wu, Yi Yang, Mengcheng Li, Yang Su, Wenchao Yang, Zezhi Shan, Yuping Gao, Zhiming Jin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma

Xiaomei Gao, Yuanyuan Sheng, Jing Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun, Jinwang Wei, Xuan Wang, Xinxin Yu, Yu Zhang, Qin Luo, Yan Zheng, Peng Qiao, Yue Zhao, Qiongzhu Dong, Lunxiu Qin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells

Jinfang Xu, Jun Fang, Zhonghao Cheng, Longlong Fan, Weiwei Hu, Feng Zhou, Hong Shen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors

Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RIF1 promotes human epithelial ovarian cancer growth and progression via activating human telomerase reverse transcriptase expression

Yong-Bin Liu, Ying Mei, Jing Long, Yu Zhang, Dong-Li Hu, Hong-Hao Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis

Sai Ma, Chen-Chen Lu, Li-Yan Yang, Juan-Juan Wang, Bo-Shi Wang, Hong-Qing Cai, Jia-Jie Hao, Xin Xu, Yan Cai, Yu Zhang, Ming-Rong Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling

Shijian Xiang, Huoji Chen, Xiaojun Luo, Baichao An, Wenfeng Wu, Siwei Cao, Shifa Ruan, Zhuxian Wang, Lidong Weng, Hongxia Zhu, Qiang Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma

Ting Xiao, Qiang Zhang, Shumin Zong, Wei-long Zhong, Yuan Qin, Zhun Bi, Shuang Chen, Hui-juan Liu, Jun-jie Wei, Bi-jiao Zhou, Lu-meng Wang, Hong-gang Zhou, Yan-rong Liu, Tao Sun, Cheng Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long noncoding RNA HEGBC promotes tumorigenesis and metastasis of gallbladder cancer via forming a positive feedback loop with IL-11/STAT3 signaling pathway

Liang Yang, Qingxiang Gao, Xiaoxiong Wu, Feiling Feng, Kaiyun Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation

Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

Guo-sheng Zhao, Zi-ran Gao, Qiao Zhang, Xue-feng Tang, Yang-fan Lv, Zhao-si Zhang, Yuan Zhang, Qiu-lin Tan, Dong-bin Peng, Dian-ming Jiang, Qiao-Nan Guo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway

Jun Jiang, Yitong Xu, Hongjiu Ren, Muli Wudu, Qiongzi Wang, Xin Song, Hongbo Su, Xizi Jiang, Lihong Jiang, Xueshan Qiu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo

Zhenzhen Chen, Liangshun You, Lei Wang, Xianbo Huang, Hui Liu, Ju ying Wei, Li Zhu, Wenbin Qian

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer

Jonas Steenbrugge, Koen Breyne, Kristel Demeyere, Olivier De Wever, Niek N. Sanders, Wim Van Den Broeck, Cecile Colpaert, Peter Vermeulen, Steven Van Laere, Evelyne Meyer

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells

Heng Zhou, Yu Liu, Chao Wang, Limei Liu, Huan Wang, Yaqian Zhang, Cong Long, Xiaoping Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways

Tianchi Chen, Hechen Huang, Yuan Zhou, Lei Geng, Tian Shen, Shengyong Yin, Lin Zhou, Shusen Zheng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc

Jie Li, Qian Liu, Zihao Liu, Qian Xia, Zihao Zhang, Rui Zhang, Taihong Gao, Guangyan Gu, Yanan Wang, Dan Wang, Xiuyang Chen, Yihang Yang, Dong He, Tao Xin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma

Irene Ferrer, Álvaro Quintanal-Villalonga, Sonia Molina-Pinelo, Jose Manuel Garcia-Heredia, Marco Perez, Rocío Suárez, Santiago Ponce-Aix, Luis Paz-Ares, Amancio Carnero

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IL-33 facilitates proliferation of colorectal cancer dependent on COX2/PGE2

Yongkui Li, Jie Shi, Shanshan Qi, Jian Zhang, Dong Peng, Zhenzhen Chen, Guobin Wang, Zheng Wang, Lin Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibitory effects of low intensity pulsed ultrasound on osteoclastogenesis induced in vitro by breast cancer cells

Valeria Carina, Viviana Costa, Stefania Pagani, Angela De Luca, Lavinia Raimondi, Daniele Bellavia, Stefania Setti, Milena Fini, Gianluca Giavaresi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis

Wenting Xu, Zhen Yang, Chuan Xie, Yin Zhu, Xu Shu, Zhe Zhang, Nianshuang Li, Na Chai, Song Zhang, Kaichun Wu, Yongzhan Nie, Nonghua Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

Jer-Hwa Chang, Chao-Wen Cheng, Yi-Chieh Yang, Wan-Shen Chen, Wen-Yueh Hung, Jyh-Ming Chow, Pai-Sheng Chen, Michael Hsiao, Wei-Jiunn Lee, Ming-Hsien Chien

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression

Hoe Suk Kim, Minji Jung, Sul Ki Choi, Jisu Woo, Yin Ji Piao, Eun Hye Hwang, Hyelim Kim, Seung Ja Kim, Woo Kyung Moon

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Xin Xiao, Wei Wang, Yuqian Li, Di Yang, Xiaokang Li, Chao Shen, Yan Liu, Xianzhu Ke, Shuo Guo, Zheng Guo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SP1-induced lncRNA AGAP2-AS1 expression promotes chemoresistance of breast cancer by epigenetic regulation of MyD88

Huaying Dong, Wei Wang, Shaowei Mo, Ru Chen, Kejian Zou, Jing Han, Fan Zhang, Jianguo Hu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma

Long Yan, Feng Xu, Chao-liu Dai

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia

Chao Tang, Ming-Hao Li, Ya-Li Chen, Hui-Ying Sun, Sheng-Li Liu, Wei-Wei Zheng, Meng-Yi Zhang, Hui Li, Wei Fu, Wen-Jun Zhang, Ai-Bin Liang, Zhong-Hua Tang, Deng-Li Hong, Bin-Bing S. Zhou, Cai-Wen Duan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair

Xing Guo, Donghua He, Enfan Zhang, Jing Chen, Qingxiao Chen, Yi Li, Li Yang, Yang Yang, Yi Zhao, Gang Wang, Jingsong He, Zhen Cai

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Advances in circular RNAs and their roles in breast Cancer

Xuehui Wang, Lin Fang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling

Fei Xu, Wen-Qiang Cui, Ying Wei, Jie Cui, Jian Qiu, Ling-Li Hu, Wei-Yi Gong, Jing-Cheng Dong, Bao-Jun Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer

Biao Geng, Jinshun Pan, Ting Zhao, Jie Ji, Chen Zhang, Ying Che, Jing Yang, Hui Shi, Juan Li, Hong Zhou, Xianmin Mu, Che Xu, Chao Wang, Yue Xu, Zheng Liu, Hao Wen, Qiang You

01.12.2018 | Research | Ausgabe 1/2018 Open Access

BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer

Marie Ouarné, Claire Bouvard, Gabriela Boneva, Christine Mallet, Johnny Ribeiro, Agnès Desroches-Castan, Emmanuelle Soleilhac, Emmanuelle Tillet, Olivier Peyruchaud, Sabine Bailly

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

Bo Ma, Hang Zhang, Yu Wang, Ang Zhao, Zhiming Zhu, Xiaowen Bao, Yang Sun, Lin Li, Qi Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

Zeribe C. Nwosu, Nadia Battello, Melanie Rothley, Weronika Piorońska, Barbara Sitek, Matthias P. Ebert, Ute Hofmann, Jonathan Sleeman, Stefan Wölfl, Christoph Meyer, Dominik A. Megger, Steven Dooley

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma

Jiazhou Ye, Rong Liang, Tao Bai, Yan Lin, Rongyun Mai, Meng Wei, Xinqin Ye, Lequn Li, Feixiang Wu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Clinical applications of liquid biopsy as prognostic and predictive biomarkers in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA

Jie Li, Xu Han, Xiaona Yu, Zongzhen Xu, Guangsheng Yang, Bingqi Liu, Peng Xiu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression

Shaoying Yan, Zhenrong Tang, Ke Chen, Yuyang Liu, Gangfeng Yu, Qiuxu Chen, Hao Dang, Fengjiao Chen, Jiaji Ling, Liying Zhu, Ailong Huang, Hua Tang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

Wuhua Zhou, Li Gong, Qinchuan Wu, Chunyang Xing, Bajin Wei, Tianchi Chen, Yuan Zhou, Shengyong Yin, Bin Jiang, Haiyang Xie, Lin Zhou, Shusen Zheng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress

Xiaodong Zhang, Yan Li, Yingbo Ma, Liang Yang, Tao Wang, Xin Meng, Zhihong Zong, Xun Sun, Xiangdong Hua, Hangyu Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Renal cancer: new models and approach for personalizing therapy

Simona di Martino, Gabriele De Luca, Ludovica Grassi, Giulia Federici, Romina Alfonsi, Michele Signore, Antonio Addario, Laura De Salvo, Federica Francescangeli, Massimo Sanchez, Valentina Tirelli, Giovanni Muto, Isabella Sperduti, Steno Sentinelli, Manuela Costantini, Luca Pasquini, Michele Milella, Mustapha Haoui, Giuseppe Simone, Michele Gallucci, Ruggero De Maria, Désirée Bonci

01.12.2018 | Research | Ausgabe 1/2018 Open Access

ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells

Sheng Zhou, Hongwei Xia, Huanji Xu, Qiulin Tang, Yongzhan Nie, Qi yong Gong, Feng Bi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The putative tumour suppressor miR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1

Sen-Mao Li, Huan-Lei Wu, Xiao Yu, Kun Tang, Shao-Gang Wang, Zhang-Qun Ye, Jia Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC

Sisi Cao, Zhuo Wang, Xiujuan Gao, Wenjuan He, Yue Cai, Hui Chen, Rong Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Endothelial cells promote metastasis of prostate cancer by enhancing autophagy

Ruizhe Zhao, Xiaoyu Bei, Boyu Yang, Xiaohai Wang, Chenyi Jiang, Fei Shi, Xingjie Wang, Yiping Zhu, Yifeng Jing, Bangmin Han, Shujie Xia, Qi Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LncRNA SLCO4A1-AS1 facilitates growth and metastasis of colorectal cancer through β-catenin-dependent Wnt pathway

Jiangtao Yu, Zhiyang Han, Ziquan Sun, Yue Wang, Ming Zheng, Chunfang Song

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Regulation of PTEN expression by noncoding RNAs

Wang Li, Ting Zhang, Lianying Guo, Lin Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma

Bo Wang, Ping Fan, Jingyuan Zhao, Heyu Wu, Xin Jin, Heshui Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients

Jin Zhang, Hongqing Cai, Lixin Sun, Panpan Zhan, Meng Chen, Feng Zhang, Yuliang Ran, Jinghai Wan

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

Hongmei Zheng, Yuting Zhan, Sile Liu, Junmi Lu, Jiadi Luo, Juan Feng, Songqing Fan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TIPE3 hypermethylation correlates with worse prognosis and promotes tumor progression in nasopharyngeal carcinoma

Xian-Yue Ren, Xin Wen, Ying-Qing Li, Jian Zhang, Qing-Mei He, Xiao-Jing Yang, Xin-Ran Tang, Ya-Qin Wang, Pan-Pan Zhang, Xiao-Zhong Chen, Bin Cheng, Jun Ma, Na Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling

Yang Cheng, Tianlu Hou, Jian Ping, Tianyang Chen, Baobing Yin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SPAG5 promotes hepatocellular carcinoma progression by downregulating SCARA5 through modifying β-catenin degradation

Hongliang Liu, Junwen Hu, Ran Wei, Longfei Zhou, Hua Pan, Hongchao Zhu, Mingwen Huang, Jun Luo, Wei Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2)

Xi He, Si-yuan Chen, Zhao Yang, Jie Zhang, Wei Wang, Mei-yue Liu, Yi Niu, Xiao-mei Wei, Hong-min Li, Wan-ning Hu, Guo-gui Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways

Qing Li, Cong Wang, Yufeng Wang, Liankang Sun, Zhikui Liu, Liang Wang, Tao Song, Yingmin Yao, Qingguang Liu, Kangsheng Tu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo

Chixiong Huang, Senlin Huang, Hairui Li, Xinzhong Li, Bing Li, Lintao Zhong, Junfeng Wang, Meishen Zou, Xiang He, Hao Zheng, Xiaoyun Si, Wangjun Liao, Yulin Liao, Li Yang, Jianping Bin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma

Cheng-Lung Hsu, Kar-Wai Lui, Lang-Ming Chi, Yung-Chia Kuo, Yin-Kai Chao, Chun-Nan Yeh, Li-Yu Lee, Yenlin Huang, Tung-Liang Lin, Mei-Yuan Huang, Yi-Ru Lai, Yuan-Ming Yeh, Hsien-Chi Fan, An-Chi Lin, Yen-Jung Lu, Chia-Hsun Hsieh, Kai-Ping Chang, Ngan-Ming Tsang, Hung-Ming Wang, Alex Y. Chang, Yu-Sun Chang, Hsin-Pai Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

Pascal Häfliger, Julien Graff, Matthias Rubin, Amandine Stooss, Matthias S. Dettmer, Karl-Heinz Altmann, Jürg Gertsch, Roch-Philippe Charles

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway

Baojin Wang, Xia Li, Guannan Zhao, Huan Yan, Peixin Dong, Hidemichi Watari, Michelle Sims, Wei Li, Lawrence M Pfeffer, Yuqi Guo, Junming Yue

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects of repurposed drug candidates nitroxoline and nelfinavir as single agents or in combination with erlotinib in pancreatic cancer cells

Serena Veschi, Laura De Lellis, Rosalba Florio, Paola Lanuti, Alberto Massucci, Nicola Tinari, Michele De Tursi, Pierluigi di Sebastiano, Marco Marchisio, Clara Natoli, Alessandro Cama

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375/YAP1 axis

Huan Yan, Hong Li, Pengyun Li, Xia Li, Jianjian Lin, Linlin Zhu, Maria A. Silva, Xiaofang Wang, Ping Wang, Zhan Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop

Tingting Li, Xiangyu Jian, Han He, Qiuhua Lai, Xianzheng Li, Danling Deng, Tengfei Liu, Jiehong Zhu, Hongli Jiao, Yaping Ye, Shuyang Wang, Minhui Yang, Lin Zheng, Weijie Zhou, Yanqing Ding

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli, Valentina Folgiero

01.12.2018 | Research | Ausgabe 1/2018 Open Access

An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer

Xiang Ling, Wenjie Wu, Chuandong Fan, Chao Xu, Jianqun Liao, Laurie J. Rich, Ruea-Yea Huang, Elizabeth A. Repasky, Xinjiang Wang, Fengzhi Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma

Wei Meng, Baocheng Wang, Weiwei Mao, Jiajia Wang, Yang Zhao, Qifeng Li, Chenran Zhang, Yujie Tang, Jie Ma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway

Xiaocheng Zhou, Tinglin Yan, Chunming Huang, Zhi Xu, Lin Wang, Erhui Jiang, Hui Wang, Yang Chen, Ke Liu, Zhe Shao, Zhengjun Shang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2’, 4’-Tetrahydroxychalcone

Changliang Chen, Anitha K. Shenoy, Ravi Padia, Dongdong Fang, Qing Jing, Ping Yang, Shi-Bing Su, Shuang Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells

Dongqing Zuo, Kristen L Shogren, Jie Zang, Donna E Jewison, Brian E Waletzki, Alan L Miller II, Scott H Okuno, Zhengdong Cai, Michael J Yaszemski, Avudaiappan Maran

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia, Jessica Lamberti, Fabrizio Mattei, Elisabetta Pizzi, Rossella Puglisi, Cristiana Zanetti, Luca Pasquini, Federica Fratini, Luca Fantozzi, Federica Felicetti, Katia Fecchi, Carla Raggi, Massimo Sanchez, Stefania D’Atri, Alessandra Carè, Massimo Sargiacomo, Isabella Parolini

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mechanism of piR-DQ590027/MIR17HG regulating the permeability of glioma conditioned normal BBB

Xue Leng, Jun Ma, Yunhui Liu, Shuyuan Shen, Hai Yu, Jian Zheng, Xiaobai Liu, Libo Liu, Jiajia Chen, Lini Zhao, Xuelei Ruan, Yixue Xue

01.12.2018 | Research | Ausgabe 1/2018 Open Access

GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells

Dengliang Huang, Yiting Wang, Linlin Xu, Limin Chen, Minzhang Cheng, Wei Shi, Huanting Xiong, Detina Zalli, Shiwen Luo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

Yulin Peng, Yan Wang, Ning Tang, Dongdong Sun, Yulong Lan, Zhenlong Yu, Xinyu Zhao, Lei Feng, Baojing Zhang, Lingling Jin, Fabiao Yu, Xiaochi Ma, Chuanzhu Lv

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Anti-tumor effects of Atractylenolide I on bladder cancer cells

Rui Yu, Bi-xia Yu, Jun-feng Chen, Xiu-yi Lv, Ze-jun Yan, Yue Cheng, Qi Ma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation

Minghui Chang, Xingguo Song, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie, Xianrang Song

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts

Yang Wang, Xu Deng, Chang Yu, Guosheng Zhao, Jing Zhou, Ge Zhang, Ming Li, Dianming Jiang, Zhengxue Quan, Yuan Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axis

Yu-Shui Ma, Zhong-Wei Lv, Fei Yu, Zheng-Yan Chang, Xian-Ling Cong, Xiao-Ming Zhong, Gai-Xia Lu, Jian Zhu, Da Fu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway

Yu Lian, Fang Xiong, Liting Yang, Hao Bo, Zhaojian Gong, Yumin Wang, Fang Wei, Yanyan Tang, Xiayu Li, Qianjin Liao, Hui Wang, Ming Zhou, Bo Xiang, Xu Wu, Yong Li, Xiaoling Li, Xiang Chen, Guiyuan Li, Can Guo, Zhaoyang Zeng, Wei Xiong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

AFF3 upregulation mediates tamoxifen resistance in breast cancers

Yawei Shi, Yang Zhao, Yunjian Zhang, NiJiati AiErken, Nan Shao, Runyi Ye, Ying Lin, Shenming Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas

Xiudong Guan, Lanxin Luo, Gulnaz Begum, Gary Kohanbash, Qingkun Song, Aparna Rao, Nduka Amankulor, Baoshan Sun, Dandan Sun, Wang Jia

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways

Yuanyuan Yan, Fangxiao Liu, Li Han, Lin Zhao, Jianjun Chen, Olufunmilayo I Olopade, Miao He, Minjie Wei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Aberrant miRNAs expressed in HER-2 negative breast cancers patient

Cornelia Braicu, Lajos Raduly, Gabriela Morar-Bolba, Roxana Cojocneanu, Ancuta Jurj, Laura-Ancuta Pop, Valentina Pileczki, Cristina Ciocan, Alin Moldovan, Alexandru Irimie, Alexandru Eniu, Patriciu Achimas-Cadariu, Angelo Paradiso, Ioana Berindan-Neagoe

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation

Yuting Gu, Fan Lv, Mingxing Xue, Kai Chen, Cheng Cheng, Xinyuan Ding, Min Jin, Guofeng Xu, Yanyun Zhang, Zhixiang Wu, Leizhen Zheng, Yeming Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages

Yong Li, Fengjun Cao, Mingxing Li, Pindong Li, Yuandong Yu, Longchao Xiang, Tao Xu, Jinhua Lei, Yun Yan Tai, Jianyong Zhu, Bingbing Yang, Yingpin Jiang, Xiufang Zhang, Long Duo, Ping Chen, Xiongjie Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner

Shengming Deng, Guoxi Zhang, Jiajie Kuai, Peng Fan, Xuexiang Wang, Pei Zhou, Dan Yang, Xichen Zheng, Xiaomei Liu, Qunli Wu, Yuhui Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

Lu Xu, Yang Zhang, Kang Tian, Xi Chen, Rongxin Zhang, Xindi Mu, Yueguang Wu, Duchuang Wang, Shanshan Wang, Fang Liu, Taishu Wang, Jinrui Zhang, Shuyan Liu, Yingqiu Zhang, Caixia Tu, Han Liu

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Nobel committee honors tumor immunologists

Anand Rotte, Gabriella D’Orazi, Madhuri Bhandaru

01.12.2018 | Research | Ausgabe 1/2018 Open Access

ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression

Cong Chen, Chao Ge, Zheng Liu, Liangyu Li, Fangyu Zhao, Hua Tian, Taoyang Chen, Hong Li, Ming Yao, Jinjun Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma

Miyong Yun, Ae Jin Choi, Young Chan Lee, Munkyoo Kong, Ji-Youn Sung, Sung Soo Kim, Young-Gyu Eun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme

Qi Li, Chengya Dong, Jiayue Cui, Yubo Wang, Xinyu Hong

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The role of cellular reactive oxygen species in cancer chemotherapy

Haotian Yang, Rehan M Villani, Haolu Wang, Matthew J Simpson, Michael S Roberts, Min Tang, Xiaowen Liang

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

Zeribe C. Nwosu, Nadia Battello, Melanie Rothley, Weronika Piorońska, Barbara Sitek, Matthias P. Ebert, Ute Hofmann, Jonathan Sleeman, Stefan Wölfl, Christoph Meyer, Dominik A. Megger, Steven Dooley

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RETRACTED ARTICLE: MicroRNA-31-5p regulates chemosensitivity by preventing the nuclear location of PARP1 in hepatocellular carcinoma

Ke-ting Que, Yun Zhou, Yu You, Zhen Zhang, Xiao-ping Zhao, Jian-ping Gong, Zuo-jin Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Vitexin compound 1, a novel extraction from a Chinese herb, suppresses melanoma cell growth through DNA damage by increasing ROS levels

Nian Liu, Kuan Song Wang, Min Qi, Ying Jun Zhou, Guang Yao Zeng, Juan Tao, Jian Da Zhou, Jiang Lin Zhang, Xiang Chen, Cong Peng

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

Wuhua Zhou, Li Gong, Qinchuan Wu, Chunyang Xing, Bajin Wei, Tianchi Chen, Yuan Zhou, Shengyong Yin, Bin Jiang, Haiyang Xie, Lin Zhou, Shusen Zheng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas

Zoltán Hujber, Gergő Horváth, Gábor Petővári, Ildikó Krencz, Titanilla Dankó, Katalin Mészáros, Hajnalka Rajnai, Norbert Szoboszlai, William P. J. Leenders, András Jeney, László Tretter, Anna Sebestyén

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation

Jian Wu, Sheng Chen, Hao Liu, Zhe Zhang, Zhen Ni, Jie Chen, Zhiping Yang, Yongzhan Nie, Daiming Fan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long non-coding RNA DANCR promotes malignant phenotypes of bladder cancer cells by modulating the miR-149/MSI2 axis as a ceRNA

Yonghao Zhan, Zhicong Chen, Yifan Li, Anbang He, Shiming He, Yanqing Gong, Xuesong Li, Liqun Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

Mengyu Feng, Guangbing Xiong, Zhe Cao, Gang Yang, Suli Zheng, Jiangdong Qiu, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway

Wen Bi, Jiayu Huang, Chunlei Nie, Bo Liu, Guoqing He, Jihua Han, Rui Pang, Zhaoming Ding, Jin Xu, Jiewu Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis

Yifan Li, Yanqing Gong, Xianghui Ning, Ding Peng, Libo Liu, Shiming He, Kan Gong, Cuijian Zhang, Xuesong Li, Liqun Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway

Yanxia Jin, Qian Yang, Li Liang, Lu Ding, Yuxing Liang, Dongdong Zhang, Balu Wu, Tian Yang, Hailing Liu, Tingting Huang, Hui Shen, Honglei Tu, Yunbao Pan, Yongchang Wei, Yi Yang, Fuling Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb

Simona D’Aguanno, Elisabetta Valentini, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Manuela Spagnuolo, Simonetta Buglioni, Cristiana Ercolani, Italia Falcone, Marco De Dominici, Michele Milella, Maria Giulia Rizzo, Bruno Calabretta, Carlo Cota, Andrea Anichini, Daniela Trisciuoglio, Donatella Del Bufalo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling

Hua Liu, Haoyu Deng, Yajie Zhao, Can Li, Yu Liang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway

Nianshuang Li, Yan Feng, Yi Hu, Cong He, Chuan Xie, Yaobin Ouyang, Stephen C. Artim, Deqiang Huang, Yin Zhu, Zhijun Luo, Zhongming Ge, Nonghua Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Distinct expression profiles and functions of Kindlins in breast cancer

Paula Azorin, Florian Bonin, Ahmad Moukachar, Aurélie Ponceau, Sophie Vacher, Ivan Bièche, Elisabetta Marangoni, Laetitia Fuhrmann, Anne Vincent-Salomon, Rosette Lidereau, Keltouma Driouch

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer

Yuyuan Yao, Qinglong Guo, Yue Cao, Yangmin Qiu, Renxiang Tan, Zhou Yu, Yuxin Zhou, Na Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

EBV-miR-BART8-3p induces epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma cells through activating NF-κB and Erk1/2 pathways

Cheng Lin, Jingfeng Zong, Wansong Lin, Minghui Wang, Yuanji Xu, Rui Zhou, Shaojun Lin, Qiaojuan Guo, Honglin Chen, Yunbin Ye, Bin Zhang, Jianji Pan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance

Shan Zhou, Jinping Lu, Yuejin Li, Chan Chen, Yongqiang Cai, Gongjun Tan, Zhengke Peng, Zhenlin Zhang, Zigang Dong, Tiebang Kang, Faqing Tang

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Emerging roles of Myc in stem cell biology and novel tumor therapies

Go J. Yoshida

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

Iris C. Salaroglio, Elena Gazzano, Ahmad Abdullrahman, Eleonora Mungo, Barbara Castella, Gamal Eldein Fathy Abd-ellatef Abd-elrahman, Massimo Massaia, Massimo Donadelli, Menachem Rubinstein, Chiara Riganti, Joanna Kopecka

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity

Tao Qin, Bai Li, Xiaoyue Feng, Shujun Fan, Lei Liu, Dandan Liu, Jun Mao, Ying Lu, Jinfeng Yang, Xiaotang Yu, Qingqing Zhang, Jun Zhang, Bo Song, Man Li, Lianhong Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D

Zhe Qiang, Zong-yuan Zhou, Ting Peng, Pu-zi Jiang, Nan Shi, Emmanuel Mfotie Njoya, Bahtigul Azimova, Wan-li Liu, Wei-hua Chen, Guo-lin Zhang, Fei Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis

Guanming Lu, Yueyong Li, Yanfei Ma, Jinlan Lu, Yongcheng Chen, Qiulan Jiang, Qiang Qin, Lifeng Zhao, Qianfang Huang, Zhizhai Luo, Shiqing Huang, Zhongheng Wei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6

Chuanchuan Zhou, Fengrui Bi, Jihang Yuan, Fu Yang, Shuhan Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling

Zhengle Zhang, Han Han, Yuping Rong, Kongfan Zhu, Zhongchao Zhu, Zhigang Tang, Chenglong Xiong, Jing Tao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dysregulation of miR-6868-5p/FOXM1 circuit contributes to colorectal cancer angiogenesis

Ye Wang, Meijuan Wu, Zengjie Lei, Mengxi Huang, Zhiping Li, Liya Wang, Qijun Cao, Dong Han, Yue Chang, Yanyan Chen, Xiaobei Liu, Lijun Xue, Xiaobei Mao, Jian Geng, Yanan Chen, Tingting Dai, Lili Ren, Qian Wang, Hongju Yu, Cheng Chen, Xiaoyuan Chu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of skin carcinogenesis by suppression of NF-κB dependent ITGAV and TIMP-1 expression in IL-32γ overexpressed condition

Yong Sun Lee, Chung Hee Lee, Jun Tae Bae, Kyung Tak Nam, Dae Bong Moon, Ok Kyung Hwang, Jeong Soon Choi, Tae Hoon Kim, Hyoung Ok Jun, Young Suk Jung, Dae Yeon Hwang, Sang-Bae Han, Do Young Yoon, Jin Tae Hong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling

Dong-Min Shi, Li-Xin Li, Xin-Yu Bian, Xue-Jiang Shi, Li-Li Lu, Hong-Xin Zhou, Ting-Jia Pan, Jian Zhou, Jia Fan, Wei-Zhong Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy

Ji Hye Im, Keon Wook Kang, Sun Young Kim, Yoon Gyoon Kim, Yong Jin An, Sunghyouk Park, Byung Hwa Jeong, Song-Yi Choi, Jin-Sun Lee, Keon Wook Kang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

Marcella La Noce, Francesca Paino, Luigi Mele, Gianpaolo Papaccio, Tarik Regad, Angela Lombardi, Federica Papaccio, Vincenzo Desiderio, Virginia Tirino

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity

Anna Maria Trotta, Sara Santagata, Serena Zanotta, Crescenzo D’Alterio, Maria Napolitano, Giuseppina Rea, Rosa Camerlingo, Fabio Esposito, Elvira Lamantia, Annamaria Anniciello, Giovanni Botti, Nicola Longo, Gerardo Botti, Sandro Pignata, Sisto Perdonà, Stefania Scala

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer

Xi Sun, Yue Hu, Jing Wu, Liang Shi, Lei Zhu, Pei-Wen Xi, Ji-Fu Wei, Qiang Ding

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation

Ya-Ping Ye, Hong-Li Jiao, Shu-Yang Wang, Zhi-Yuan Xiao, Dan Zhang, Jun-Feng Qiu, Ling-Jie Zhang, Ya-Li Zhao, Ting-Ting Li, Li-Liang, Wen-Ting Liao, Yan-Qing Ding

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling

Yan Wang, Yingjian Liang, Guangchao Yang, Yaliang Lan, Jihua Han, Jiabei Wang, Dalong Yin, Ruipeng Song, Tongsen Zheng, Shugeng Zhang, Shangha Pan, Xirui Liu, Mingxi Zhu, Yao Liu, Yifeng Cui, Fanzheng Meng, Bo Zhang, Shuhang Liang, Hongrui Guo, Yufeng Liu, Md Khaled Hassan, Lianxin Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

Yi-fang Lu, Jia-rui Yu, Zhao Yang, Guan-xia Zhu, Peng Gao, Huan Wang, Si-yuan Chen, Jie Zhang, Mei-yue Liu, Yi Niu, Xiao-mei Wei, Wei Wang, Feng-jin Ye, Li-xin Zhang, Yue Zhao, Guo-gui Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach

Elisa Caiola, Francesca Falcetta, Silvia Giordano, Mirko Marabese, Marina C. Garassino, Massimo Broggini, Roberta Pastorelli, Laura Brunelli

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma

Ying Liu, Xinhua Wang, Shuang Zeng, Xiane Zhang, Jimin Zhao, Xiaoyan Zhang, Xinhuan Chen, Wanjing Yang, Yili Yang, Ziming Dong, Jingyu Zhu, Xin Xu, Fang Tian

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

Shiyu Duan, Wenqing Huang, Xiaoting Liu, Xuming Liu, Nana Chen, Qiong Xu, Yukun Hu, Wen Song, Jun Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

STON2 negatively modulates stem-like properties in ovarian cancer cells via DNMT1/MUC1 pathway

Shanshan Xu, Yongfang Yue, Songfa Zhang, Caiyun Zhou, Xiaodong Cheng, Xing Xie, Xinyu Wang, Weiguo Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Targeted radiotherapy of pigmented melanoma with 131I-5-IPN

Xiaodong Xu, Lujie Yuan, Yongkang Gai, Qingyao Liu, Lianglan Yin, Yaqun Jiang, Yichun Wang, Yongxue Zhang, Xiaoli Lan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer

Kazuya Kuwada, Shunsuke Kagawa, Ryuichi Yoshida, Shuichi Sakamoto, Atene Ito, Megumi Watanabe, Takeshi Ieda, Shinji Kuroda, Satoru Kikuchi, Hiroshi Tazawa, Toshiyoshi Fujiwara

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer

Dan-Hua Xu, Qing Li, Hao Hu, Bo Ni, Xu Liu, Chen Huang, Zi-Zhen Zhang, Gang Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells

Wei Chen, Ping Li, Yi Liu, Yu Yang, Xueting Ye, Fangyi Zhang, Hang Huang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia

Xianbo Huang, Feng Xiao, Yuan Li, Wenbin Qian, Wei Ding, Xiujin Ye

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells

Valerio Ciccone, Erika Terzuoli, Sandra Donnini, Antonio Giachetti, Lucia Morbidelli, Marina Ziche

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression

Kun Zhao, Zhe Wang, Thilo Hackert, Claudia Pitzer, Margot Zöller

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism

Yixiao Feng, Mingjun Wu, Shuman Li, Xiaoqian He, Jun Tang, Weiyan Peng, Beilei Zeng, Chuxia Deng, Guosheng Ren, Tingxiu Xiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors

Yanrong Su, Nathan R. Hopfinger, Theresa D. Nguyen, Thomas J. Pogash, Julia Santucci-Pereira, Jose Russo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells

Shuang Ma, Wan-Lin Zhang, Bruce D. Leckey Jr, Hong-Tao Xu, Lian-He Yang, Endi Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway

Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu, Li Jia

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cyclin G2 suppresses Wnt/β-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1

Jinlan Gao, Chenyang Zhao, Qi Liu, Xiaoyu Hou, Sen Li, Xuesha Xing, Chunhua Yang, Yang Luo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

Maria Elena Pisanu, Marcello Maugeri-Saccà, Luigi Fattore, Sara Bruschini, Claudia De Vitis, Eugenio Tabbì, Barbara Bellei, Emilia Migliano, Daniela Kovacs, Emanuela Camera, Mauro Picardo, Ziga Jakopin, Claudia Cippitelli, Armando Bartolazzi, Salvatore Raffa, Maria Rosaria Torrisi, Franco Fulciniti, Paolo A. Ascierto, Gennaro Ciliberto, Rita Mancini

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting

Ramesh Pothuraju, Satyanarayana Rachagani, Wade M. Junker, Sanjib Chaudhary, Viswanathan Saraswathi, Sukhwinder Kaur, Surinder K. Batra

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis

Xing Zhang, Zheng Li, Zhe Xuan, Penghui Xu, Weizhi Wang, Zheng Chen, Sen Wang, Guangli Sun, Jianghao Xu, Zekuan Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14–3-3η/NF-κB feedback loop

Yongxin Qiu, Yi Dai, Chi Zhang, Ye Yang, Ming Jin, Wenqi Shan, Jian Shen, Ming Lu, Zhaoyang Tang, Liang Ju, Yuting Wang, Ruonan Jiao, Yunwei Xia, Guangming Huang, Lihua Yang, Yuan Li, Jianping Zhang, Vincent Kam Wai Wong, Zhihong Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Osthole inhibits triple negative breast cancer cells by suppressing STAT3

Xuanxuan Dai, Changtian Yin, Yi Zhang, Guilong Guo, Chengguang Zhao, Ouchen Wang, Youqun Xiang, Xiaohua Zhang, Guang Liang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4

Ziming Li, Jia Huang, Shengping Shen, Zhenping Ding, Qingquan Luo, Zhiwei Chen, Shun Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Yuan Zhou, Haozhen Ren, Bo Dai, Jun Li, Longcheng Shang, Jianfei Huang, Xiaolei Shi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RNA sequencing reveals the expression profiles of circRNA and indicates that circDDX17 acts as a tumor suppressor in colorectal cancer

Xiang-Nan Li, Zhen-Jun Wang, Chun-Xiang Ye, Bao-Cheng Zhao, Zhu-Lin Li, Yong Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness

Stefania Rossi, Martina Cordella, Claudio Tabolacci, Giovanni Nassa, Daniela D’Arcangelo, Cinzia Senatore, Paolo Pagnotto, Roberta Magliozzi, Annamaria Salvati, Alessandro Weisz, Antonio Facchiano, Francesco Facchiano

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Classification of triple-negative breast cancers based on Immunogenomic profiling

Yin He, Zehang Jiang, Cai Chen, Xiaosheng Wang

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