Ausgabe 1/2019
Inhalt (503 Artikel)
Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells
Rossella Loria, Claudia Giliberti, Angelico Bedini, Raffaele Palomba, Giulio Caracciolo, Pierpaolo Ceci, Elisabetta Falvo, Raffaella Marconi, Rita Falcioni, Gianluca Bossi, Lidia Strigari
N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling
Jie Deng, An-Dong Liu, Guo-Qing Hou, Xi Zhang, Kun Ren, Xuan-Zuo Chen, Shawn S. C. Li, Yao-Song Wu, Xuan Cao
14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling
Jia Song, Xiaochao Zhang, Zhibin Liao, Huifang Liang, Liang Chu, Wei Dong, Xuewu Zhang, Qianyun Ge, Qiumeng Liu, Pan Fan, Zhanguo Zhang, Bixiang Zhang
Star-related lipid transfer protein 10 (STARD10): a novel key player in alcohol-induced breast cancer progression
Andrea Floris, Jia Luo, Jacqueline Frank, Jennifer Zhou, Sandro Orrù, Michela Biancolella, Sabina Pucci, Augusto Orlandi, Paolo Campagna, Antonella Balzano, Komal Ramani, Maria Lauda Tomasi
Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis
Pei-Fang Hung, Tse-Ming Hong, Che-Chang Chang, Chung-Lieh Hung, Yuan-Ling Hsu, Yih-Leong Chang, Chen-Tu Wu, Gee-Chen Chang, Nei-Li Chan, Sung-Liang Yu, Pan-Chyr Yang, Szu-Hua Pan
Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells
Sen Li, Xiliang Cong, Hongyu Gao, Xiuwen Lan, Zhiguo Li, Wenpeng Wang, Shubin Song, Yimin Wang, Chunfeng Li, Hongfeng Zhang, Yingwei Xue, Yuzhou Zhao
MiR-6875-3p promotes the proliferation, invasion and metastasis of hepatocellular carcinoma via BTG2/FAK/Akt pathway
Yingjun Xie, Jian Du, Zefeng Liu, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang
RETRACTED ARTICLE: Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma
Zichao Li, Luying Zhang, Mingquan Gao, Mei Han, Kaili Liu, Zhuang Zhang, Zhi Gong, Lifei Xing, Xianzhou Shi, Kui Lu, Hui Gao
MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change
Qianru He, Lini Zhao, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Heng Cai, Zhen Li, Yixue Xue
Anti-tumour effects of all-trans retinoid acid on serous ovarian cancer
Noor A. Lokman, Rachel Ho, Kavyadharshini Gunasegaran, Wendy M. Bonner, Martin K. Oehler, Carmela Ricciardelli
ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma
Hao Peng, Jian Zhang, Pan-Pan Zhang, Lei Chen, Ling-Long Tang, Xiao-Jing Yang, Qing-Mei He, Xin Wen, Ying Sun, Na Liu, Ying-Qin Li, Jun Ma
RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives
Marco Infante, Alessandra Fabi, Francesco Cognetti, Stefania Gorini, Massimiliano Caprio, Andrea Fabbri
Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage
Zhangjian Zhou, Heng Lu, Shoumin Zhu, Ahmed Gomaa, Zheng Chen, Jin Yan, Kay Washington, Wael El-Rifai, Chengxue Dang, Dunfa Peng
Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer
Sheng Zhang, Yongzhi Yang, Wenhao Weng, Bomin Guo, Guoxiang Cai, Yanlei Ma, Sanjun Cai
RER1 enhances carcinogenesis and stemness of pancreatic cancer under hypoxic environment
Shi Chen, Jiaqiang Zhang, Jiangzhi Chen, Yaodong Wang, Songqiang Zhou, Long Huang, Yannan Bai, Chenghong Peng, Baiyong Shen, Huixing Chen, Yifeng Tian
Therapeutic impact of Nintedanib with paclitaxel and/or a PD-L1 antibody in preclinical models of orthotopic primary or metastatic triple negative breast cancer
Elaine Reguera-Nuñez, Ping Xu, Annabelle Chow, Shan Man, Frank Hilberg, Robert S. Kerbel
SOX9 is a dose-dependent metastatic fate determinant in melanoma
Xintao Yang, Rui Liang, Chunxi Liu, Jessica Aijia Liu, May Pui Lai Cheung, Xuelai Liu, On Ying Man, Xin-Yuan Guan, Hong Lok Lung, Martin Cheung
ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma
Zhenyu Zhou, Hai Jiang, Kangsheng Tu, Wei Yu, Jianlong Zhang, Zhigang Hu, Heyun Zhang, Dake Hao, Pinbo Huang, Jie Wang, Aijun Wang, Zhiyu Xiao, Chuanchao He
RETRACTED ARTICLE: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis
Yingxia Ning, Weifeng Feng, Xiaocheng Cao, Kaiqun Ren, Meifang Quan, A. Chen, Chang Xu, Yebei Qiu, Jianguo Cao, Xiang Li, Xin Luo
Downregulation of miRNA-214 in cancer-associated fibroblasts contributes to migration and invasion of gastric cancer cells through targeting FGF9 and inducing EMT
Ruifen Wang, Yeqi Sun, Wenwei Yu, Yu Yan, Meng Qiao, Ruiqi Jiang, Wenbin Guan, Lifeng Wang
Emerging roles of telomeric chromatin alterations in cancer
Stefano Cacchione, Annamaria Biroccio, Angela Rizzo
miR-190 enhances endocrine therapy sensitivity by regulating SOX9 expression in breast cancer
Yue Yu, Wen Yin, Zhi-Hao Yu, Yan-Jun Zhou, Jiang-Rui Chi, Jie Ge, Xu-Chen Cao
Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traits
Binbin Ma, Li Zhang, Yujie Zou, Ruiping He, Qiong Wu, Chuanchun Han, Bo Zhang
PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway
Chengcheng Lv, Shui Fu, Qingzhuo Dong, Zi Yu, Gejun Zhang, Chuize Kong, Cheng Fu, Yu Zeng
DHHC protein family targets different subsets of glioma stem cells in specific niches
Xueran Chen, Lei Hu, Haoran Yang, Huihui Ma, Kaiqin Ye, Chenggang Zhao, Zhiyang Zhao, Haiming Dai, Hongzhi Wang, Zhiyou Fang
miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2
Ying Zhang, Fan Xia, Fan Zhang, Yingying Cui, Qingling Wang, Hui Liu, Yongping Wu
Elevated expression of Gab1 promotes breast cancer metastasis by dissociating the PAR complex
Xiao Wang, Jing Peng, Ziqiang Yang, Pei-Jie Zhou, Na An, Lianzi Wei, Helen He Zhu, Jinsong Lu, Yu-Xiang Fang, Wei-Qiang Gao
JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer
Guido Giordano, Pietro Parcesepe, Mario Rosario D’Andrea, Luigi Coppola, Tania Di Raimo, Andrea Remo, Erminia Manfrin, Claudia Fiorini, Aldo Scarpa, Carla Azzurra Amoreo, Fabiana Conciatori, Michele Milella, Francesca Pia Caruso, Luigi Cerulo, Almudena Porras, Massimo Pancione
Therapeutic efficacy of a novel βIII/βIV-tubulin inhibitor (VERU-111) in pancreatic cancer
Vivek K. Kashyap, Qinghui Wang, Saini Setua, Prashanth K. B. Nagesh, Neeraj Chauhan, Sonam Kumari, Pallabita Chowdhury, Duane D. Miller, Murali M. Yallapu, Wei Li, Meena Jaggi, Bilal Bin Hafeez, Subhash C. Chauhan
Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer
Jui-Chih Chang, Huei-Shin Chang, Yao-Chung Wu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ju Chang, Shou-Jen Kuo, Shou-Tung Chen, Chin-San Liu
Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway
Lehe Yang, Shichong Lin, Yanting Kang, Youqun Xiang, Lingyuan Xu, Jifa Li, Xuanxuan Dai, Guang Liang, Xiaoying Huang, Chengguang Zhao
CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p
Xinfeng Yu, Dong Wang, Xiaohui Wang, Shiyue Sun, Yuhang Zhang, Shuqing Wang, Rongrong Miao, Xiaoxue Xu, Xianjun Qu
Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling
Han Li, Weijing Zhang, Ming Yan, Jiaqi Qiu, Jueming Chen, Xiaoying Sun, Xiangfu Chen, Libing Song, Yanna Zhang
Correction to: EBV-miR-BART8-3p induces epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma cells through activating NF-κB and Erk1/2 pathways
Cheng Lin, Jingfeng Zong, Wansong Lin, Minghui Wang, Yuanji Xu, Rui Zhou, Shaojun Lin, Qiaojuan Guo, Honglin Chen, Yunbin Ye, Bin Zhang, Jianji Pan
PRDM16 functions as a suppressor of lung adenocarcinoma metastasis
Liang-Ru Fei, Wen-Jing Huang, Yuan Wang, Lei Lei, Zhi-Han Li, Yi-Wen Zheng, Zhao Wang, Mai-Qing Yang, Chen-Chen Liu, Hong-Tao Xu
MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma
Yun Zhao, Wei Huang, Tae-Min Kim, Yuchae Jung, Lata G. Menon, Hongyan Xing, Hongwei Li, Rona S. Carroll, Peter J. Park, Hong Wei Yang, Mark D. Johnson
FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG
Shuo Cao, Jian Zheng, Xiaobai Liu, Yunhui Liu, Xuelei Ruan, Jun Ma, Libo Liu, Di Wang, Chunqing Yang, Heng Cai, Zhen Li, Ziyi Feng, Yixue Xue
RETRACTED ARTICLE: Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2
Jun Li, Rumeng Yang, Yuting Dong, Manyao Chen, Yu Wang, Guoping Wang
Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway
Chunfeng Xie, Jianyun Zhu, Xueqi Wang, Jiaqi Chen, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Xiaoting Li
ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway
Xinmiao Yu, Minghao Wang, Jingjing Wu, Qiang Han, Xiupeng Zhang
Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines
Pietro Paolo Vitiello, Claudia Cardone, Giulia Martini, Davide Ciardiello, Valentina Belli, Nunzia Matrone, Giusi Barra, Stefania Napolitano, Carmina Della Corte, Mimmo Turano, Maria Furia, Teresa Troiani, Floriana Morgillo, Ferdinando De Vita, Fortunato Ciardiello, Erika Martinelli
Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone
Jia-Hau Yen, Hung Sen Huang, Chia Ju Chuang, Sheng-Teng Huang
Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance
Yingqiu Xie, Ayan A. Nurkesh, Nazgul Ibragimova, Zhuldyz Zhanzak, Aizhan Meyerbekova, Zhanna Alexeyeva, Aiya Yesbolatova, Madina Satayeva, Aidana Mustafa, Limara Manarbek, Aisulu Maipas, Akerke Altaikyzy, Zhibek Keneskhanova, Burkitkan Akbay, Zhenbang Chen
CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma
Zongyi Wang, Fei Yin, Jing Xu, Tao Zhang, Gangyang Wang, Ming Mao, Zhuoying Wang, Wei Sun, Jing Han, Mengkai Yang, Yafei Jiang, Yingqi Hua, Zhengdong Cai
Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells
Valerio Ciccone, Erika Terzuoli, Sandra Donnini, Antonio Giachetti, Lucia Morbidelli, Marina Ziche
GSK-3β regulates the endothelial-to-mesenchymal transition via reciprocal crosstalk between NSCLC cells and HUVECs in multicellular tumor spheroid models
Se-Hyuk Kim, Yeonhwa Song, Haeng Ran Seo
Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer
Ping Fan, Jingyuan Zhao, Zibo Meng, Heyu Wu, Bo Wang, Heshui Wu, Xin Jin
Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
Jiaojiao Hao, Wenhua Fan, Yizhuo Li, Ranran Tang, Chunfang Tian, Qian Yang, Tianhua Zhu, Chaoliang Diao, Sheng Hu, Manyu Chen, Ping Guo, Qian Long, Changlin Zhang, Ge Qin, Wendan Yu, Miao Chen, Liren Li, Lijun Qin, Jingshu Wang, Xiuping Zhang, Yandong Ren, Penghui Zhou, Lijuan Zou, Kui Jiang, Wei Guo, Wuguo Deng
Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2V617F against myeloproliferative neoplasms
Min Hu, Chengbo Xu, Chao Yang, Hongli Zuo, Chengjuan Chen, Dan Zhang, Gaona Shi, Wenjie Wang, Jiangong Shi, Tiantai Zhang
PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis
Lin Tuo, Jin Xiang, Xuanming Pan, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang, Kai Wang, Ni Tang
miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition
Rihan El Bezawy, Stella Tinelli, Monica Tortoreto, Valentina Doldi, Valentina Zuco, Marco Folini, Claudio Stucchi, Tiziana Rancati, Riccardo Valdagni, Paolo Gandellini, Nadia Zaffaroni
CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway
Jiaomeng Pan, Zhiyuan Fan, Zhenqiang Wang, Qingqiang Dai, Zhen Xiang, Fei Yuan, Min Yan, Zhenggang Zhu, Bingya Liu, Chen Li
MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer
Lu Zhang, Yi Liao, Liling Tang
CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p/MAPK4 pathway
Yashu Feng, Ling Zhang, Jieying Wu, Bijay Khadka, Zhigang Fang, Jiaming Gu, Baoqiang Tang, Ruozhi Xiao, Guangjin Pan, Jiajun Liu
MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer
Tingbo Ye, Meihua Yang, Daochao Huang, Xin Wang, Bingqian Xue, Na Tian, Xiaohui Xu, Liming Bao, Huajian Hu, Tiewei Lv, Yi Huang
Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells
Christiane Margue, Demetra Philippidou, Ines Kozar, Giulia Cesi, Paul Felten, Dagmar Kulms, Elisabeth Letellier, Claude Haan, Stephanie Kreis
RETRACTED ARTICLE: Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells
Shuang Feng, Xiaomin Cai, Yangyang Li, Xiaoguang Jian, Linxin Zhang, Bin Li
Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
Damiano Cosimo Rigiracciolo, Maria Francesca Santolla, Rosamaria Lappano, Adele Vivacqua, Francesca Cirillo, Giulia Raffaella Galli, Marianna Talia, Lucia Muglia, Michele Pellegrino, Nijiro Nohata, Maria Teresa Di Martino, Marcello Maggiolini
SNHG1 promotes malignant biological behaviors of glioma cells via microRNA-154-5p/miR-376b-3p- FOXP2- KDM5B participating positive feedback loop
Han Li, Yixue Xue, Jun Ma, Lianqi Shao, Di Wang, Jian Zheng, Xiaobai Liu, Chunqing Yang, Qianru He, Xuelei Ruan, Zhen Li, Yunhui Liu
Long non-coding RNA LINC00346 promotes pancreatic cancer growth and gemcitabine resistance by sponging miR-188-3p to derepress BRD4 expression
Weidong Shi, Chenyue Zhang, Zhouyu Ning, Yongqiang Hua, Ye Li, Lianyu Chen, Luming Liu, Zhen Chen, Zhiqiang Meng
Cathepsin L activated by mutant p53 and Egr-1 promotes ionizing radiation-induced EMT in human NSCLC
Wenjuan Wang, Yajie Xiong, Xinyuan Ding, Long Wang, Yifan Zhao, Yao Fei, Ying Zhu, Xiao Shen, Caihong Tan, Zhongqin Liang
Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery
Weihua Ren, Jianfeng Hou, Chenguang Yang, Hanjun Wang, Shuangting Wu, Yabin Wu, Xingpeng Zhao, Chao Lu
Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy
Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang, Huameng Li, Chenglong Li, Jiayuh Lin
The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
Mingyue Li, Wentao An, Linyan Xu, Yidan Lin, Ling Su, Xiangguo Liu
FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma
Zhenwei He, Xuelei Ruan, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Lianqi Shao, Di Wang, Shuyuan Shen, Chunqing Yang, Yixue Xue
Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E
Xuhui Ma, Boya Li, Jie Liu, Yan Fu, Yongzhang Luo
Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage
Yunong Li, Xiuxing Jiang, Yanhao Zhang, Ziyi Gao, Yanxia Liu, Jinjiao Hu, Xiaoye Hu, Lirong Li, Jingshan Shi, Ning Gao
ZRANB2/SNHG20/FOXK1 Axis regulates Vasculogenic mimicry formation in glioma
Xiaozhi Li, Yixue Xue, Xiaobai Liu, Jian Zheng, Shuyuan Shen, Chunqing Yang, Jiajia Chen, Zhen Li, Libo Liu, Jun Ma, Teng Ma, Yunhui Liu
PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level
Vid Mlakar, Simona Jurkovic Mlakar, Laurence Lesne, Denis Marino, Komal S. Rathi, John M. Maris, Marc Ansari, Fabienne Gumy-Pause
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production
Changwei Dou, Qiuran Xu, Jie Liu, Yufeng Wang, Zhenyu Zhou, Weifeng Yao, Kai Jiang, Jian Cheng, Chengwu Zhang, Kangsheng Tu
Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells
Lijun Liang, Kaiyuan Hui, Chenxi Hu, Yixuan Wen, Shikun Yang, Panrong Zhu, Lei Wang, Youyou Xia, Yun Qiao, Wen Sun, Jiayan Fei, Ting Chen, Fenghua Zhao, Baocheng Yang, Xiaodong Jiang
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53
Muli Wudu, Hongjiu Ren, Linping Hui, Jun Jiang, Siyang Zhang, Yitong Xu, Qiongzi Wang, Hongbo Su, Xizi Jiang, Runa Dao, Xueshan Qiu
Human bone marrow-derived mesenchymal stem cells promote the growth and drug-resistance of diffuse large B-cell lymphoma by secreting IL-6 and elevating IL-17A levels
Weijie Zhong, Zhigang Zhu, Xin Xu, Hui Zhang, Huabao Xiong, Qingshan Li, Yaming Wei
MiR-223-3p functions as a tumor suppressor in lung squamous cell carcinoma by miR-223-3p-mutant p53 regulatory feedback loop
Peng Luo, Qi Wang, Yuanyuan Ye, Ju Zhang, Dapeng Lu, Longqiang Cheng, Hangcheng Zhou, Mingran Xie, Baolong Wang
LRG-1 promotes pancreatic cancer growth and metastasis via modulation of the EGFR/p38 signaling
Zhi-Bo Xie, Yi-Fan Zhang, Chen Jin, Yi-Shen Mao, De-Liang Fu
SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination
Ce Li, Lutao Du, Yidan Ren, Xiaoyan Liu, Qinlian Jiao, Donghai Cui, Mingxin Wen, Chuanxin Wang, Guangwei Wei, Yunshan Wang, Aiguo Ji, Qin Wang
Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways
Liwei Ma, Jianwei Wei, Junhu Wan, Weiwei Wang, Li Wang, Yongjie Yuan, Zijun Yang, Xianzhi Liu, Liang Ming
Poly-specific neoantigen-targeted cancer vaccines delay patient derived tumor growth
Luigi Aurisicchio, Erika Salvatori, Lucia Lione, Silvio Bandini, Matteo Pallocca, Roberta Maggio, Maurizio Fanciulli, Francesca De Nicola, Frauke Goeman, Gennaro Ciliberto, Antonella Conforti, Laura Luberto, Fabio Palombo
Landscape of tumor suppressor long noncoding RNAs in breast cancer
Boran Pang, Qin Wang, Shipeng Ning, Junqiang Wu, Xingda Zhang, Yanbo Chen, Shouping Xu
SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia
Alejandro Pérez-Fernández, Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Carla Ijurko, María Díez-Campelo, Fermín Sánchez-Guijo, Ángel Hernández-Hernández
Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype
Xiaolan Zhu, Huiling Shen, Xinming Yin, Meiling Yang, Hong Wei, Qi Chen, Fan Feng, Yueqin Liu, Wenlin Xu, Yuefeng Li
EVI1 promotes epithelial-to-mesenchymal transition, cancer stem cell features and chemo−/radioresistance in nasopharyngeal carcinoma
Yaoyong Lu, Yingying Liang, Xin Zheng, Xubin Deng, Wendong Huang, Gong Zhang
EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC
Yalei Yin, Mingju Sun, Xi Zhan, Changqing Wu, Pengyu Geng, Xiaoyan Sun, Yunsong Wu, Shuijun Zhang, Jianhua Qin, Zhengping Zhuang, Yang Liu
Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis
Leilei He, Lixia Gao, Chloe Shay, Liwei Lang, Fenglin Lv, Yong Teng
Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer
Murugan Kalimutho, Debottam Sinha, Deepak Mittal, Sriganesh Srihari, Devathri Nanayakkara, Shagufta Shafique, Prahlad Raninga, Purba Nag, Kate Parsons, Kum Kum Khanna
Combination of Enzastaurin and Ibrutinib synergistically induces anti-tumor effects in diffuse large B cell lymphoma
Yizi He, Jiao Li, Ning Ding, Xiaogan Wang, Lijuan Deng, Yan Xie, Zhitao Ying, Weiping Liu, Lingyan Ping, Chen Zhang, Yuqin Song, Jun Zhu
Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma
Xin Wang, Gaochao Guo, Hui Guan, Yang Yu, Jie Lu, Jinming Yu
H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma
Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang, Qing Yang
A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway
Wei-Chieh Huang, Te-Hsuan Jang, Shiao-Lin Tung, Tzu-Chen Yen, Shih-Hsuan Chan, Lu-Hai Wang
CCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer
Francesco Morra, Francesco Merolla, Daniela Criscuolo, Luigi Insabato, Riccardo Giannella, Gennaro Ilardi, Aniello Cerrato, Roberta Visconti, Stefania Staibano, Angela Celetti
New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment
Daniela Criscuolo, Francesco Morra, Riccardo Giannella, Roberta Visconti, Aniello Cerrato, Angela Celetti
Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression
Yi Zhang, Bo Tang, Jun Song, Shuiping Yu, Yang Li, Huizhao Su, Songqing He
Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways
Li Wang, Yanyang Liu, Yueling Zhou, Jiantao Wang, Li Tu, Zhen Sun, Xiujie Wang, Feng Luo
RETRACTED ARTICLE: Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2
Dian-Hui Xiu, Gui-Feng Liu, Shao-Nan Yu, Long-Yun Li, Guo-Qing Zhao, Lin Liu, Xue-Feng Li
LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway
Chunhua Wei, Xiaomin Dong, Hui Lu, Fan Tong, Lingjuan Chen, Ruiguang Zhang, Jihua Dong, Yu Hu, Gang Wu, Xiaorong Dong
Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
Jian Zhou, Guimei Qu, Ge Zhang, Zuoren Wu, Jing Liu, Dawei Yang, Jing Li, Meijia Chang, Hengshan Zeng, Jie Hu, Tao Fang, Yuanlin Song, Chunxue Bai
RETRACTED ARTICLE: MicroRNA-506 inhibits tumor growth and metastasis in nasopharyngeal carcinoma through the inactivation of the Wnt/β-catenin signaling pathway by down-regulating LHX2
Tian-Song Liang, Ying-Juan Zheng, Juan Wang, Jing-Yi Zhao, Dao-Ke Yang, Zhang-Suo Liu
CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth
Liangliang Xu, Xinfu Feng, Xiangyong Hao, Peng Wang, Yanfang Zhang, Xiaobo Zheng, Lian Li, Shengsheng Ren, Ming Zhang, Mingqing Xu
MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma
Xu Chen, Fan Yang, Tianze Zhang, Wei Wang, Wenjin Xi, Yufang Li, Dan Zhang, Yi Huo, Jianning Zhang, Angang Yang, Tao Wang
Aberrant fatty acid profile and FFAR4 signaling confer endocrine resistance in breast cancer
Xiao Chu, Qi Zhou, Yingchun Xu, Jingting Jiang, Qing Li, Qianjun Zhou, Qiong Wu, Min Jin, Hui Wang, Yuting Gu, Xue Wang, Bei Wang, Songbing He, Xiaozhou He, Changping Wu, Fengchun Zhang, Yanyun Zhang
FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21
Long Zhang, Jin Chen, Deng Ning, Qiumeng Liu, Chao Wang, Zhaoqi Zhang, Liang Chu, Chengpeng Yu, Hui-fang Liang, Bixiang Zhang, Xiaoping Chen
WISP2 exhibits its potential antitumor activity via targeting ERK and E-cadherin pathways in esophageal cancer cells
Da-Min Chai, Yan-Zi Qin, Shi-Wu Wu, Li Ma, Yuan-Yuan Tan, Xiang Yong, Xiao-Li Wang, Z. Peter Wang, Yi-Sheng Tao
Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence
Durai Sundar, Yue Yu, Shashank P. Katiyar, Jayarani F. Putri, Jaspreet Kaur Dhanjal, Jia Wang, Anissa Nofita Sari, Evangelos Kolettas, Sunil C. Kaul, Renu Wadhwa
RETRACTED ARTICLE: TRIM29 facilitates the epithelial-to-mesenchymal transition and the progression of colorectal cancer via the activation of the Wnt/β-catenin signaling pathway
Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang, Jie Zhong
The RNA binding protein RBMS3 inhibits the metastasis of breast cancer by regulating Twist1 expression
Lei Zhu, Pei-Wen Xi, Xiao-Xia Li, Xi Sun, Wen-Bin Zhou, Tian-Song Xia, Liang Shi, Yue Hu, Qiang Ding, Ji-Fu Wei
TRPM7 promotes the epithelial–mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling
Lu Liu, Nayiyuan Wu, Ying Wang, Xiaoyun Zhang, Bing Xia, Jie Tang, Jingting Cai, Zitong Zhao, Qianjin Liao, Jing Wang
Cross-talk among AFAP1-AS1, ACVR1 and microRNA-384 regulates the stemness of pancreatic cancer cells and tumorigenicity in nude mice
Xu-Bo Wu, Xia Feng, Qi-Meng Chang, Cheng-Wu Zhang, Zhi-Fei Wang, Jie Liu, Zhi-Qiu Hu, Jia-Zhe Liu, Wei-Ding Wu, Zi-Ping Zhang, Xi-Qiang Liu
Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development
Patrizia Sarogni, Orazio Palumbo, Adele Servadio, Simonetta Astigiano, Barbara D’Alessio, Veronica Gatti, Dubravka Cukrov, Silvia Baldari, Maria Michela Pallotta, Paolo Aretini, Felice Dell’Orletta, Silvia Soddu, Massimo Carella, Gabriele Toietta, Ottavia Barbieri, Gabriella Fontanini, Antonio Musio
HOXD-AS1 promotes the epithelial to mesenchymal transition of ovarian cancer cells by regulating miR-186-5p and PIK3R3
Shanshan Dong, Ranran Wang, Hui Wang, Qi Ding, Xiao Zhou, Jing Wang, Keqiang Zhang, Ying Long, Shan Lu, Ting Hong, Huayi Ren, Kee Wong, Xiaowu Sheng, Yu Wang, Yong Zeng
Estrogen receptor-α-miR-1271-SNAI2 feedback loop regulates transforming growth factor-β-induced breast cancer progression
Bo-Wen Liu, Zhi-Hao Yu, Ao-Xiang Chen, Jiang-Rui Chi, Jie Ge, Yue Yu, Xu-Chen Cao
Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-β1 in bladder cancer cells
Ruxu Gao, Naiwen Zhang, Jianyu Yang, Yuyan Zhu, Zhe Zhang, Jianfeng Wang, Xiaolong Xu, Zeliang Li, Xiankui Liu, Zhenhua Li, Jun Li, Chuize Kong, Jianbin Bi
FAT4 regulates the EMT and autophagy in colorectal cancer cells in part via the PI3K-AKT signaling axis
Ran Wei, Yuhong Xiao, Yi Song, Huiping Yuan, Jun Luo, Wei Xu
Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
Rui Peng, Peng-Fei Zhang, Xuan Yang, Chuan-Yuan Wei, Xiao-Yong Huang, Jia-Bin Cai, Jia-Cheng Lu, Chao Gao, Hai-Xiang Sun, Qiang Gao, Dou-Sheng Bai, Guo-Ming Shi, Ai-Wu Ke, Jia Fan
Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment
Wanfu Xu, Jiabi Qian, Fangyin Zeng, Songyu Li, Wenjing Guo, Liping Chen, Guihuan Li, Zhishuai Zhang, Qiming Jane Wang, Fan Deng
Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology
Neel I. Nissen, Morten Karsdal, Nicholas Willumsen
Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress
Qingyu Zhang, Shan Yu, Melody Man Ting Lam, Terence Chuen Wai Poon, Litao Sun, Yufei Jiao, Alice Sze Tsai Wong, Leo Tsz On Lee
3D models in the new era of immune oncology: focus on T cells, CAF and ECM
Francesca Di Modugno, Cristina Colosi, Paola Trono, Giuseppe Antonacci, Giancarlo Ruocco, Paola Nisticò
The anti-tumor growth effect of a novel agent DMAMCL in rhabdomyosarcoma in vitro and in vivo
Ning Xu, Zhongyan Hua, Gen Ba, Simeng Zhang, Zhihui Liu, Carol J. Thiele, Zhijie Li
TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas
Xiaoqin Yin, Bo Wang, Weidong Gan, Wenyuan Zhuang, Zou Xiang, Xiaodong Han, Dongmei Li
Cysteine-rich intestinal protein 1 suppresses apoptosis and chemosensitivity to 5-fluorouracil in colorectal cancer through ubiquitin-mediated Fas degradation
Lanzhi Zhang, Rui Zhou, Weibin Zhang, Xueqing Yao, Weidong Li, Lijun Xu, Xuegang Sun, Liang Zhao
MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
Sourabh Soni, Prince Anand, Yogendra S. Padwad
Nck-associated protein 1 associates with HSP90 to drive metastasis in human non-small-cell lung cancer
Yuanping Xiong, Leilei He, Chloe Shay, Liwei Lang, Jenni Loveless, Jieqing Yu, Ron Chemmalakuzhy, Hongqun Jiang, Manran Liu, Yong Teng
Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade
Linan Fang, Dalam Ly, Si-si Wang, Jong Bok Lee, Hyeonjeong Kang, Hao Xu, Junlin Yao, Ming-sound Tsao, Wei Liu, Li Zhang
GAGE7B promotes tumor metastasis and growth via activating the p38δ/pMAPKAPK2/pHSP27 pathway in gastric cancer
Duan-Bo Shi, Ran-Ran Ma, Hui Zhang, Feng Hou, Xiang-Yu Guo, Peng Gao
Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases
Barbara Frigerio, Claudia Bizzoni, Gerrit Jansen, Christopher P. Leamon, Godefridus J. Peters, Philip S. Low, Larry H. Matherly, Mariangela Figini
MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12
Zhiwei He, Xingjun Guo, She Tian, Changhao Zhu, Shiyu Chen, Chao Yu, Jianxin Jiang, Chengyi Sun
A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors
Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi, Kiichiro Tsuchiya, Kazuyuki Kojima, Takashi Tokino, Yoshinobu Eishi, Yong Sung Kim, Woo Ho Kim, Yasuhito Yuasa, Shinji Tanaka
Cell communication and signaling: how to turn bad language into positive one
Claudia Chiodoni, Maria Teresa Di Martino, Francesca Zazzeroni, Michele Caraglia, Massimo Donadelli, Stefania Meschini, Carlo Leonetti, Katia Scotlandi
Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer
Quanfu Huang, Qiuguo Wang, Dong Li, Xiao Wei, Yijuan Jia, Zheng Zhang, Bo Ai, Xiaonian Cao, Tao Guo, Yongde Liao
A selective c-Met and Trks inhibitor Indo5 suppresses hepatocellular carcinoma growth
Teng Luo, Shou-Guo Zhang, Ling-Fei Zhu, Fei-Xiang Zhang, Wei Li, Ke Zhao, Xiao-Xue Wen, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Hui-Ying Gao, Lin Wang, Xiao-Ming Yang, Chang-Yan Li
CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression
Yichong Ning, Chunqing Wang, Xin Liu, Yan Du, Shunlian Liu, Kaili Liu, Jianlin Zhou, Chang Zhou
Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming
Zhe Wang, Hanxue Sun, Jan Provaznik, Thilo Hackert, Margot Zöller
The miR155HG/miR-185/ANXA2 loop contributes to glioblastoma growth and progression
Weining Wu, Tianfu Yu, Youzhi Wu, Wei Tian, Junxia Zhang, Yingyi Wang
Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ/BMP signaling in triple-negative breast cancer
Lei Di, Li-Juan Liu, Yong-Ming Yan, Rong Fu, Yi Li, Ying Xu, Yong-Xian Cheng, Zhao-Qiu Wu
Correction to: Targeted radiotherapy of pigmented melanoma with 131I-5-IPN
Xiaodong Xu, Lujie Yuan, Yongkang Gai, Qingyao Liu, Lianglan Yin, Yaqun Jiang, Yichun Wang, Yongxue Zhang, Xiaoli Lan
MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma
Mingpeng Jin, Jiaojiao Wang, Xiaoying Ji, Haiyan Cao, Jianjun Zhu, Yibing Chen, Jin Yang, Zheng Zhao, Tingting Ren, Jinliang Xing
TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4
Chuan-Yuan Wei, Lu Wang, Meng-Xuan Zhu, Xin-Yi Deng, Dao-He Wang, Si-Min Zhang, Jiang-Hui Ying, Xin Yuan, Qiang Wang, Tian-Fan Xuan, An-Qi He, Fa-Zhi Qi, Jian-Ying Gu
Sox11 promotes head and neck cancer progression via the regulation of SDCCAG8
Junwei Huang, Eoon Hye Ji, Xinyuan Zhao, Li Cui, Kaori Misuno, Mian Guo, Zhigang Huang, Xiaohong Chen, Shen Hu
RETRACTED ARTICLE: Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway
Zizhuo Li, Yaodong Chen, Tingting An, Pengfei Liu, Jiyuan Zhu, Haichao Yang, Wei Zhang, Tianxiu Dong, Jian Jiang, Yu Zhang, Maitao Jiang, Xiuhua Yang
Autophagy inhibition enhances PD-L1 expression in gastric cancer
Xiaojuan Wang, William K. K. Wu, Jing Gao, Zhongwu Li, Bin Dong, Xiaoting Lin, Yilin Li, Yanyan Li, Jifang Gong, Changsong Qi, Zhi Peng, Jun Yu, Lin Shen
miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells
Mahrou Vahabi, Claudio Pulito, Andrea Sacconi, Sara Donzelli, Marco D’Andrea, Valentina Manciocco, Raul Pellini, Paola Paci, Giuseppe Sanguineti, Lidia Strigari, Giuseppe Spriano, Paola Muti, Pier Paolo Pandolfi, Sabrina Strano, Shahrokh Safarian, Federica Ganci, Giovanni Blandino
Correction to: LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway
Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu, Li Jia
LINC00612 enhances the proliferation and invasion ability of bladder cancer cells as ceRNA by sponging miR-590 to elevate expression of PHF14
Liying Miao, Hong Yue Liu, Cuixing Zhou, Xiaozhou He
Retraction Note: MicroRNA-31-5p regulates chemosensitivity by preventing the nuclear location of PARP1 in hepatocellular carcinoma
Ke-ting Que, Yun Zhou, Yu You, Zhen Zhang, Xiao-ping Zhao, Jian-ping Gong, Zuo-jin Liu
Cx32 exerts anti-apoptotic and pro-tumor effects via the epidermal growth factor receptor pathway in hepatocellular carcinoma
Yuke Xiang, Qin Wang, Yunquan Guo, Hui Ge, Yile Fu, Xiyan Wang, Liang Tao
Cancer DNA vaccines: current preclinical and clinical developments and future perspectives
Alessandra Lopes, Gaëlle Vandermeulen, Véronique Préat
Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Yinfang Wang, Yanli Hou, Weiwei Zhang, Angel A. Alvarez, Yongrui Bai, Bo Hu, Shi-Yuan Cheng, Kun Yang, Yanxin Li, Haizhong Feng
Sequence-dependent synergistic cytotoxicity of icotinib and pemetrexed in human lung cancer cell lines in vitro and in vivo
Tianze Liu, Lizi Jin, Wenjing Lu, Hairun Gan, Zhidong Lin, Miao Chen, Jiani Liu, Fan Zhang, Siyang Wang, Hongyu Zhang, Wuguo Deng, Hongtao Chen
Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway
Mingjing Shen, Zhonghua Xu, Weihua Xu, Kanqiu Jiang, Fuquan Zhang, Qifeng Ding, Zhonghen Xu, Yongbing Chen
Valproic acid exhibits anti-tumor activity selectively against EGFR/ErbB2/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs
Tingting Lin, Qun Ren, Weimin Zuo, Ruxue Jia, Linhui Xie, Rong Lin, Hu Zhao, Jin Chen, Yan Lei, Ping Wang, Huiyue Dong, Lianghu Huang, Jinquan Cai, Yonghai Peng, Zongyang Yu, Jianming Tan, Shuiliang Wang
Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression
Xiaoning Wang, Xing Qin, Ming Yan, Jianbo Shi, Qin Xu, Zhihui Li, Wenjun Yang, Jianjun Zhang, Wantao Chen
GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner
Fen Lin, Yu-Jie Xie, Xin-Ke Zhang, Tie-Jun Huang, Hong-Fa Xu, Yan Mei, Hu Liang, Hao Hu, Si-Ting Lin, Fei-Fei Luo, Yan-Hong Lang, Li-Xia Peng, Chao-Nan Qian, Bi-Jun Huang
Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1
Yu-Gang Wang, Tao Wang, Min Shi, Bo Zhai
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner
Zhaoyu Qin, Chan Xiang, Fan Zhong, Yang Liu, Qiongzhu Dong, Kai Li, Wenhao Shi, Chen Ding, Lunxiu Qin, Fuchu He
Sodium new houttuyfonate suppresses metastasis in NSCLC cells through the Linc00668/miR-147a/slug axis
Rilei Jiang, Cheng Hu, Qian Li, Ziyu Cheng, Ling Gu, Hongxiao Li, Yuanyuan Guo, Qirui Li, Yueyang Lu, Ke Li, Meijuan Chen, Xu Zhang
Clinical development of targeted and immune based anti-cancer therapies
N. A. Seebacher, A. E. Stacy, G. M. Porter, A. M. Merlot
Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer
Yuning Liao, Zhiqiang Guo, Xiaohong Xia, Yuan Liu, Chuyi Huang, Lili Jiang, Xuejun Wang, Jinbao Liu, Hongbiao Huang
NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells
Maureen Keller, Fatéméh Dubois, Sylvain Teulier, Alexandre P. J. Martin, Jérôme Levallet, Elodie Maille, Solenn Brosseau, Nicolas Elie, Alexander Hergovich, Emmanuel Bergot, Jacques Camonis, Gérard Zalcman, Guénaëlle Levallet
TRIM47 is up-regulated in colorectal cancer, promoting ubiquitination and degradation of SMAD4
Qian Liang, Chaotao Tang, Mingyu Tang, Qingwei Zhang, Yunjie Gao, Zhizheng Ge
Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation
Luigi Mele, Marcella la Noce, Francesca Paino, Tarik Regad, Sarah Wagner, Davide Liccardo, Gianpaolo Papaccio, Angela Lombardi, Michele Caraglia, Virginia Tirino, Vincenzo Desiderio, Federica Papaccio
LINC01354 interacting with hnRNP-D contributes to the proliferation and metastasis in colorectal cancer through activating Wnt/β-catenin signaling pathway
Jing Li, Meirong He, Wen Xu, Silin Huang
Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment
Chin-King Looi, Felicia Fei-Lei Chung, Chee-Onn Leong, Shew-Fung Wong, Rozita Rosli, Chun-Wai Mai
ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2
Hongtao Zhu, Xiaoling Gan, Xingwei Jiang, Shuai Diao, Huan Wu, Jianguo Hu
RETRACTED ARTICLE: A positive feedback loop consisting of C12orf59/NF-κB/CDH11 promotes gastric cancer invasion and metastasis
Zhang Jia-Xing, He Wei-Ling, Feng Zi-Hao, Chen Dong-Liang, Gao Ying, He Ying, Qin Kai, Zheng Zhou-San, Chen Cui, Weng Hui-Wen, Yun Miao, Ye Sheng, Xu Rui-Hua, Xie Dan
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression
Hua Jin, Yoonjeong Jang, Nian Cheng, Qing Li, Peng-Fei Cui, Zhi-Wei Zhou, Hu-Lin Jiang, Myung-Haing Cho, Kenneth D. Westover, Qun-You Tan, Cheng-Xiong Xu
Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma
Zhuoran Zhang, Jianxing Yin, Chenfei Lu, Yutian Wei, Ailiang Zeng, Yongping You
Xenotropic and polytropic retrovirus receptor 1 (XPR1) promotes progression of tongue squamous cell carcinoma (TSCC) via activation of NF-κB signaling
Wei-chao Chen, Qiu-li Li, Qimei Pan, Hua-yong Zhang, Xiao-yan Fu, Fan Yao, Jian-ning Wang, An-kui Yang
Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma
Yitian Wang, Wei Yu, Jian Zhu, Junjie Wang, Kaishun Xia, Chengzhen Liang, Huimin Tao
Circular RNA hsa_circ_0068871 regulates FGFR3 expression and activates STAT3 by targeting miR-181a-5p to promote bladder cancer progression
Weipu Mao, Xin Huang, Longsheng Wang, Ziwei Zhang, Mengnan Liu, Yan Li, Ming Luo, Xudong Yao, Jie Fan, Jiang Geng
Resolvin D1 prevents epithelial-mesenchymal transition and reduces the stemness features of hepatocellular carcinoma by inhibiting paracrine of cancer-associated fibroblast-derived COMP
Liankang Sun, Yufeng Wang, Liang Wang, Bowen Yao, Tianxiang Chen, Qing Li, Zhikui Liu, Runkun Liu, Yongshen Niu, Tao Song, Qingguang Liu, Kangsheng Tu
The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
Yuanliang Yan, Xi Chen, Xiang Wang, Zijin Zhao, Wenfeng Hu, Shuangshuang Zeng, Jie Wei, Xue Yang, Long Qian, Shuyi Zhou, Lunquan Sun, Zhicheng Gong, Zhijie Xu
SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF
Morvarid Saeinasab, Ahmad Reza Bahrami, Jovanna González, Francesco P. Marchese, Dannys Martinez, Seyed Javad Mowla, Maryam M. Matin, Maite Huarte
ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway
Qi Zhang, Sihong Lu, Tianfu Li, Liang Yu, Yunjian Zhang, Huijuan Zeng, Xueke Qian, Jiong Bi, Ying Lin
Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling
Ting Wang, Ying Xing, Qingwei Meng, Hailing Lu, Wei Liu, Shi Yan, Yang Song, Xinyuan Xu, Jian Huang, Yue Cui, Dexin Jia, Li Cai
MAPKAPK2 plays a crucial role in the progression of head and neck squamous cell carcinoma by regulating transcript stability
Sourabh Soni, Munish Kumar Saroch, Bal Chander, Narendra Vijay Tirpude, Yogendra S. Padwad
Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation
An-Yue Wu, Li-Ying Gu, Wei Cang, Meng-Xing Cheng, Wen-Jing Wang, Wen Di, Lei Huang, Li-Hua Qiu
Correction to: Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells
Sen Li, Xiliang Cong, Hongyu Gao, Xiuwen Lan, Zhiguo Li, Wenpeng Wang, Shubin Song, Yimin Wang, Chunfeng Li, Hongfeng Zhang, Yuzhou Zhao, Yingwei Xue
Activity and molecular targets of pioglitazone via blockade of proliferation, invasiveness and bioenergetics in human NSCLC
Vincenza Ciaramella, Ferdinando Carlo Sasso, Raimondo Di Liello, Carminia Maria Della Corte, Giusi Barra, Giuseppe Viscardi, Giovanna Esposito, Francesca Sparano, Teresa Troiani, Erika Martinelli, Michele Orditura, Ferdinando De Vita, Fortunato Ciardiello, Floriana Morgillo
FOXO1-regulated lncRNA LINC01197 inhibits pancreatic adenocarcinoma cell proliferation by restraining Wnt/β-catenin signaling
Jing Ling, Fan Wang, Chuan Liu, Xiao Dong, Ying Xue, Xuebing Jia, Weifeng Song, Qi Li
Cisplatin resistant lung cancer cells promoted M2 polarization of tumor-associated macrophages via the Src/CD155/MIF functional pathway
Wen-Chien Huang, Kuang-Tai Kuo, Chun-Hua Wang, Chi-Tai Yeh, Yongjie Wang
Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells
Wentao An, Shun Yao, Xiaoyang Sun, Zhaoyuan Hou, Yidan Lin, Ling Su, Xiangguo Liu
MicroRNA-139 inhibits hepatocellular carcinoma cell growth through down-regulating karyopherin alpha 2
Ying Zan, Baofeng Wang, Liang Liang, Yujiao Deng, Tian Tian, Zhijun Dai, Lei Dong
LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells
Weidong Li, Xuesong Dong, Changjun He, Gang Tan, Ziyi Li, Bo Zhai, Jing Feng, Xian Jiang, Chang Liu, Hongchi Jiang, Xueying Sun
Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
Xihong Liu, Peiyuan Zhao, Xiujuan Wang, Lei Wang, Yingjun Zhu, Yadi Song, Wei Gao
Knockdown of HMGA2 regulates the level of autophagy via interactions between MSI2 and Beclin1 to inhibit NF1-associated malignant peripheral nerve sheath tumour growth
Kang Yang, Wei Guo, Tingting Ren, Yi Huang, Yu Han, Hongliang Zhang, Jie Zhang
Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis
Hsin-Ling Yang, Varadharajan Thiyagarajan, Pei-Chun Shen, Dony Chacko Mathew, Kai-Yuan Lin, Jiunn-Wang Liao, You-Cheng Hseu
Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer
Maria Karmella Apaya, Jeng-Yuan Shiau, Guo-Shiou Liao, Yu-Jen Liang, Chia-Wei Chen, Hsin-Chou Yang, Chi-Hong Chu, Jyh-Cherng Yu, Lie-Fen Shyur
FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression
Guohui Hu, Zhengwei Yan, Cheng Zhang, Minzhang Cheng, Yehong Yan, Yiting Wang, Libin Deng, Quqin Lu, Shiwen Luo
RETRACTED ARTICLE: Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation
Hongda Ding, Junpeng Liu, Ruoyao Zou, Pengrui Cheng, Yang Su
Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells
Chiara Marchiori, Melania Scarpa, Andromachi Kotsafti, Susan Morgan, Matteo Fassan, Vincenza Guzzardo, Andrea Porzionato, Imerio Angriman, Cesare Ruffolo, Stefania Sut, Stefano Dall’Acqua, Romeo Bardini, Raffaele De Caro, Carlo Castoro, Marco Scarpa, Ignazio Castagliuolo
Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer
Aikaterini Emmanouilidi, Chanse A. Fyffe, Riccardo Ferro, Charlotte E. Edling, Emily Capone, Simona Sestito, Simona Rapposelli, Rossano Lattanzio, Stefano Iacobelli, Gianluca Sala, Tania Maffucci, Marco Falasca
High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway
Qingke Duan, Hehe Li, Chenggang Gao, Hengqiang Zhao, Shihong Wu, Heshui Wu, Chunyou Wang, Qiang Shen, Tao Yin
PD-L1 expression and tumor mutational burden status for prediction of response to chemotherapy and targeted therapy in non-small cell lung cancer
Yanhui Chen, Quanxing Liu, Zhiming Chen, Yating Wang, Wanning Yang, Ying Hu, Wenbo Han, Hui Zeng, Haitao Ma, Jigang Dai, Henghui Zhang
RETRACTED ARTICLE: Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma
Zhikui Liu, Yufeng Wang, Liang Wang, Bowen Yao, Liankang Sun, Runkun Liu, Tianxiang Chen, Yongshen Niu, Kangsheng Tu, Qingguang Liu
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
Jiang-Jiang Qin, Li Yan, Jia Zhang, Wei-Dong Zhang
Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer
Zhan-Hong Chen, Jing-Jing Qi, Qi-Nian Wu, Jia-Huan Lu, Ze-Xian Liu, Yun Wang, Pei-Shan Hu, Ting Li, Jin-Fei Lin, Xiang-Yuan Wu, Lei Miao, Zhao-Lei Zeng, Dan Xie, Huai-Qiang Ju, Rui-Hua Xu, Feng Wang
Nalbuphine suppresses breast cancer stem-like properties and epithelial-mesenchymal transition via the AKT-NFκB signaling pathway
Jiachuan Yu, Yuanyuan Luo, Qingping Wen
Molecular pattern of lncRNAs in hepatocellular carcinoma
Haoming Mai, Bin Zhou, Li Liu, Fu Yang, Carly Conran, Yuan Ji, Jinlin Hou, Deke Jiang
The regulatory ZFAS1/miR-150/ST6GAL1 crosstalk modulates sialylation of EGFR via PI3K/Akt pathway in T-cell acute lymphoblastic leukemia
Qianqian Liu, Hongye Ma, Xiuhua Sun, Bing Liu, Yang Xiao, Shimeng Pan, Huimin Zhou, Weijie Dong, Li Jia
MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia
Bing Liu, Hongye Ma, Qianqian Liu, Yang Xiao, Shimeng Pan, Huimin Zhou, Li Jia
Glioma stem cells-derived exosomal miR-26a promotes angiogenesis of microvessel endothelial cells in glioma
Zhi-Fei Wang, Fan Liao, Hao Wu, Jin Dai
The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells
Silvia Matteoni, Claudia Abbruzzese, Paola Matarrese, Gabriele De Luca, Anna M. Mileo, Stefania Miccadei, Silvia Schenone, Francesca Musumeci, Tobias L. Haas, Giovanni Sette, Carmine M. Carapella, Rosario Amato, Nicola Perrotti, Michele Signore, Marco G. Paggi
Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
Ignacio Campillo-Marcos, Pedro A. Lazo
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
Jiao Feng, Liwei Wu, Jie Ji, Kan Chen, Qiang Yu, Jie Zhang, Jiaojiao Chen, Yuqing Mao, Fan Wang, Weiqi Dai, Ling Xu, Jianye Wu, Chuanyong Guo
The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation
Bosen Zhang, Liwei Song, Jiali Cai, Lei Li, Hong Xu, Mengying Li, Jiamin Wang, Minmin Shi, Hao Chen, Hao Jia, Zhaoyuan Hou
MTMR2 promotes invasion and metastasis of gastric cancer via inactivating IFNγ/STAT1 signaling
Lei Jiang, Jun-yan Liu, Yan Shi, Bo Tang, Tao He, Jia-jia Liu, Jun-yan Fan, Bin Wu, Xian-hui Xu, Yong-liang Zhao, Feng Qian, You-hong Cui, Pei-wu Yu
Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells
Wei He, Yiqun Xia, Peihai Cao, Lin Hong, Tingting Zhang, Xin Shen, Peisen Zheng, Huanpei Shen, Guang Liang, Peng Zou
Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism
Mara Mazzoni, Giuseppe Mauro, Marco Erreni, Paola Romeo, Emanuela Minna, Maria Grazia Vizioli, Cristina Belgiovine, Maria Grazia Rizzetti, Sonia Pagliardini, Roberta Avigni, Maria Chiara Anania, Paola Allavena, Maria Grazia Borrello, Angela Greco
Effects of short-term fasting on cancer treatment
Stefanie de Groot, Hanno Pijl, Jacobus J. M. van der Hoeven, Judith R. Kroep
PYK2 promotes HER2-positive breast cancer invasion
Shaymaa IK. Al-Juboori, Jayakumar Vadakekolathu, Sarra Idri, Sarah Wagner, Dimitrios Zafeiris, Joshua RD. Pearson, Rukaia Almshayakhchi, Michele Caraglia, Vincenzo Desiderio, Amanda K. Miles, David J. Boocock, Graham R. Ball, Tarik Regad
A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation
Meifang Li, Jilong Yang, Lenghe Zhang, Sanfang Tu, Xuan Zhou, Ze Tan, Weijun Zhou, Yanjie He, Yuhua Li
miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy
Huan Tang, Meng Ma, Jie Dai, Chuanliang Cui, Lu Si, Xinan Sheng, Zhihong Chi, Longwen Xu, Sifan Yu, Tianxiao Xu, Junya Yan, Huan Yu, Lu Yang, Yan Kong, Jun Guo
Aberrant activation of CYR61 enhancers in colorectal cancer development
Lingzhu Xie, Xuhong Song, Hao Lin, Zikai Chen, Qidong Li, Tangfei Guo, Tian Xu, Ting Su, Man Xu, Xiaolan Chang, Long-Kun Wang, Bin Liang, Dongyang Huang
GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway
Xiao-Xin Zhang, Bo Ni, Qing Li, Li-Peng Hu, Shu-Heng Jiang, Rong-Kun Li, Guang-Ang Tian, Li-Li Zhu, Jun Li, Xue-Li Zhang, Yan-Li Zhang, Xiao-Mei Yang, Qin Yang, Ya-Hui Wang, Chun-Chao Zhu, Zhi-Gang Zhang
Retraction Note: Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression
Yitao Wang, Xian Qin, Tao Guo, Pengpeng Liu, Ping Wu, Zhisu Liu
Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors
M. Mancini, S. De Santis, C. Monaldi, L. Bavaro, M. Martelli, F. Castagnetti, G. Gugliotta, G. Rosti, M. A. Santucci, G. Martinelli, M. Cavo, S. Soverini
Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis
Xia Liang, Renxiang Xie, Jinfeng Su, Bingqi Ye, Saisai Wei, Zhibing Liang, Rongpan Bai, Zhanghui Chen, Zhongxiang Li, Xiangwei Gao
The roles of glucose metabolic reprogramming in chemo- and radio-resistance
Jinguan Lin, Longzheng Xia, Jiaxin Liang, Yaqian Han, Heran Wang, Linda Oyang, Shiming Tan, Yutong Tian, Shan Rao, Xiaoyan Chen, Yanyan Tang, Min Su, Xia Luo, Ying Wang, Hui Wang, Yujuan Zhou, Qianjin Liao
The third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma
Xuejiao Liu, Xiangyu Chen, Lin Shi, Qianqian Shan, Qiyu Cao, Chenglong Yue, Huan Li, Shengsheng Li, Jie Wang, Shangfeng Gao, Mingshan Niu, Rutong Yu
Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide
Xiaohong Xia, Chuyi Huang, Yuning Liao, Yuan Liu, Jinchan He, Zhiqiang Guo, Lili Jiang, Xuejun Wang, Jinbao Liu, Hongbiao Huang
Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis
Zilong Yan, Kenoki Ohuchida, Shuang Fei, Biao Zheng, Weiyu Guan, Haimin Feng, Shin Kibe, Yohei Ando, Kazuhiro Koikawa, Toshiya Abe, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Makoto Hashizume, Masafumi Nakamura
Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC
Silvia La Monica, Roberta Minari, Daniele Cretella, Lisa Flammini, Claudia Fumarola, Mara Bonelli, Andrea Cavazzoni, Graziana Digiacomo, Maricla Galetti, Denise Madeddu, Angela Falco, Costanza Annamaria Lagrasta, Anna Squadrilli, Elisabetta Barocelli, Alessandro Romanel, Federico Quaini, Pier Giorgio Petronini, Marcello Tiseo, Roberta Alfieri
RETRACTED ARTICLE: Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression
Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun, Changhua Wang
Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells
Zhenhong Luo, Miao Gao, Ningshu Huang, Xin Wang, Zesong Yang, Hao Yang, Zhenglan Huang, Wenli Feng
ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine
Jinjiao Hu, Yanhao Zhang, Xiuxing Jiang, Hongwei Zhang, Ziyi Gao, Yunong Li, Ruoqiu Fu, Lirong Li, Jie Li, Hongjuan Cui, Ning Gao
The TGFβ-miR-499a-SHKBP1 pathway induces resistance to EGFR inhibitors in osteosarcoma cancer stem cell-like cells
Tian Wang, Dexing Wang, Lian Zhang, Ping Yang, Jing Wang, Qi Liu, Fei Yan, Feng Lin
BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1
Jing Hu, Feifei Sun, Weiwen Chen, Jing Zhang, Tao Zhang, Mei Qi, Tingting Feng, Hui Liu, Xinjun Li, Yuanxin Xing, Xueting Xiong, Benkang Shi, Gengyin Zhou, Bo Han
The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming
Yang Liu, Haozhen Ren, Yuan Zhou, Longcheng Shang, Yuheng Zhang, Faji Yang, Xiaolei Shi
Hypoxia-inducible gene 2 promotes the immune escape of hepatocellular carcinoma from nature killer cells through the interleukin-10-STAT3 signaling pathway
Chuanbao Cui, Kaiwen Fu, Lu Yang, Shuzhi Wu, Zuojie Cen, Xingxing Meng, Qiongguang Huang, Zhichun Xie
FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer
Dominika Piasecka, Marcin Braun, Kamila Kitowska, Kamil Mieczkowski, Radzislaw Kordek, Rafal Sadej, Hanna Romanska
MicroRNA based theranostics for brain cancer: basic principles
George E. D. Petrescu, Alexandru A. Sabo, Ligia I. Torsin, George A. Calin, Mihnea P. Dragomir
Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib
Ning Zheng, Weiqun Liu, Bifei Li, Huifang Nie, Jian Liu, Yunlong Cheng, Jichuang Wang, Haiyan Dong, Lee Jia
The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway
Dongkui Gong, Jin Zhang, Yonghui Chen, Yunfei Xu, Junjie Ma, Guanghui Hu, Yiran Huang, Junhua Zheng, Wei Zhai, Wei Xue
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools
Sandra Muñoz-Galván, Blanca Felipe-Abrio, Miguel García-Carrasco, Julia Domínguez-Piñol, Elisa Suarez-Martinez, Eva M. Verdugo-Sivianes, Asunción Espinosa-Sánchez, Lola E. Navas, Daniel Otero-Albiol, Juan J. Marin, Manuel P. Jiménez-García, Jose M. García-Heredia, Adoración G. Quiroga, Purificacion Estevez-Garcia, Amancio Carnero
Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation
Ji-Chang Wang, Guang-Yue Li, Bo Wang, Su-Xia Han, Xin Sun, Yi-Na Jiang, Yan-Wei Shen, Can Zhou, Jun Feng, Shao-Ying Lu, Jian-Lin Liu, Mao-De Wang, Pei-Jun Liu
Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models
Valentina Belli, Nunzia Matrone, Stefania Napolitano, Giorgia Migliardi, Francesca Cottino, Andrea Bertotti, Livio Trusolino, Erika Martinelli, Floriana Morgillo, Davide Ciardiello, Vincenzo De Falco, Emilio Francesco Giunta, Umberto Bracale, Fortunato Ciardiello, Teresa Troiani
RETRACTED ARTICLE: Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells
Dong-Mei Wu, Zi-Hui Zheng, Ying-Bo Zhang, Shao-Hua Fan, Zi-Feng Zhang, Yong-Jian Wang, Yuan-Lin Zheng, Jun Lu
β-Catenin nuclear localization positively feeds back on EGF/EGFR-attenuated AJAP1 expression in breast cancer
Cong Xu, Fang Liu, Guomin Xiang, Lu Cao, Shuling Wang, Jing Liu, Qingxiang Meng, Danni Xu, Shuhua Lv, Jiao Jiao, Yun Niu
NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer
Xingguo Song, Lisheng Liu, Minghui Chang, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie, Xianrang Song
Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells
Qun Wang, Weijun Lu, Tao Yin, Li Lu
Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration
Svenja Offer, Julien A. Menard, Julio Enríquez Pérez, Kelin G. de Oliveira, Vineesh Indira Chandran, Maria C. Johansson, Anna Bång-Rudenstam, Peter Siesjö, Anna Ebbesson, Ingrid Hedenfalk, Pia C. Sundgren, Anna Darabi, Mattias Belting
Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1/NQO-1 signaling pathway
Yanmei Lou, Zhenzhen Guo, Yuanfeng Zhu, Muyan Kong, Rongrong Zhang, Linlin Lu, Feichi Wu, Zhongqiu Liu, Jinjun Wu
Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-catenin
Honghong Shen, Wenpeng Yan, Jinyang Yuan, Ziyue Wang, Chen Wang
Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells
Nan Lin, Zhicheng Yao, Mingxing Xu, Jingyao Chen, Yi Lu, Lin Yuan, Shuqin Zhou, Xiaoguang Zou, Ruiyun Xu
AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway
Wei-Min Chang, Yu-Chan Chang, Yi-Chieh Yang, Sze-Kwan Lin, Peter Mu-Hsin Chang, Michael Hsiao
Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis
Ming-Hsien Chien, Yung-Wei Lin, Yu-Ching Wen, Yi-Chieh Yang, Michael Hsiao, Junn-Liang Chang, Hsiang-Ching Huang, Wei-Jiunn Lee
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway
Hui Shen, Min He, Ruirong Lin, Ming Zhan, Sunwang Xu, Xince Huang, Chu Xu, Wei Chen, Yanhua Yao, Man Mohan, Jian Wang
Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells
Yichen Song, Lianqi Shao, Yixue Xue, Xuelei Ruan, Xiaobai Liu, Chunqing Yang, Jian Zheng, Shuyuan Shen, Jiajia Chen, Zhen Li, Yunhui Liu
LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer
Kaili Luo, Jingwen Geng, Qinkai Zhang, Yesha Xu, Xunzhu Zhou, Zheng Huang, Ke-Qing Shi, Chenwei Pan, Jianmin Wu
The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review
Jin Zhou, Qian Yi, Liling Tang
Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation
Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Flores-Díaz, André Haman, Trang Hoang, Daniel Sinnett, Christian Beauséjour, Serge McGraw, Noël J.-M. Raynal
SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway
Jie Zhao, Ann Wozniak, Abby Adams, Josiah Cox, Anusha Vittal, Jordan Voss, Brian Bridges, Steven A. Weinman, Zhuan Li
Antitumor activity of dual blockade of PD-L1 and MEK in NSCLC patients derived three-dimensional spheroid cultures
Carminia Maria Della Corte, Giusi Barra, Vincenza Ciaramella, Raimondo Di Liello, Giovanni Vicidomini, Silvia Zappavigna, Amalia Luce, Marianna Abate, Alfonso Fiorelli, Michele Caraglia, Mario Santini, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello, Floriana Morgillo
Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death
Ping Chen, Han-Peng Huang, Yi Wang, Jun Jin, Wei-Guo Long, Kan Chen, Xiao-Hui Zhao, Chen-Guo Chen, Jian Li
PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway
Xue Gao, Tao Qin, Jun Mao, Jun Zhang, Shujun Fan, Ying Lu, Zhigang Sun, Qingqing Zhang, Bo Song, Lianhong Li
Colorectal cancer-derived extracellular vesicles induce transformation of fibroblasts into colon carcinoma cells
Mohamed Abdouh, Matteo Floris, Zu-Hua Gao, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena
Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells
Hyun Ju Hwang, Min-Suk Oh, Dong Woo Lee, Hyo-Jeong Kuh
USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer
Xiaojun Man, Chiyuan Piao, Xuyong Lin, Chuize Kong, Xiaolu Cui, Yuanjun Jiang
p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma
Federica Giordano, Valentina Vaira, Diego Cortinovis, Sara Bonomo, Joyce Goedmakers, Federica Brena, Annamaria Cialdella, Leonarda Ianzano, Irene Forno, Maria Grazia Cerrito, Roberto Giovannoni, Gian Luca Ferri, Ennio Tasciotti, Silve Vicent, Francesco Damarco, Silvano Bosari, Marialuisa Lavitrano, Emanuela Grassilli
Viral integration drives multifocal HCC during the occult HBV infection
Xiao-Ping Chen, Xin Long, Wen-long Jia, Han-Jie Wu, Jing Zhao, Hui-Fang Liang, Arian Laurence, Jun Zhu, Dong Dong, Yan Chen, Long Lin, Yu-Dong Xia, Wei-Yang Li, Gui-Bo Li, Zhi-Kun Zhao, Kui Wu, Yong Hou, Jing-Jing Yu, Wei Xiao, Guo-Ping Wang, Peng-Cheng Zhu, Wei Chen, Ming-Zhou Bai, Yi-Xing Jian, Karsten Kristiansen, Qian Chen
Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni, Gabriella D’Orazi
Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway
Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li, Binsheng Fu
RETRACTED ARTICLE: Isovitexin reduces carcinogenicity and stemness in hepatic carcinoma stem-like cells by modulating MnSOD and FoxM1
Xiaocheng Cao, Lihua Liu, Qing Yuan, Xiang Li, Yinghong Cui, Kaiqun Ren, Chang Zou, A. Chen, Chang Xu, Yebei Qiu, Meifang Quan, Jiansong Zhang, Jianguo Cao, Xiangding Chen
Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway
Lu Jiang, Pan Wang, Ying-Jian Sun, Yi-Jun Wu
Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
Raghupathy Vengoji, Muzafar A. Macha, Rama Krishna Nimmakayala, Satyanarayana Rachagani, Jawed A. Siddiqui, Kavita Mallya, Santhi Gorantla, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra, Nicole Shonka
FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas
Kyoung Min Kim, Usama Khamis Hussein, See-Hyoung Park, Mi Ae Kang, Young Jae Moon, Zhongkai Zhang, Yiping Song, Ho Sung Park, Jun Sang Bae, Byung-Hyun Park, Sang Hoon Ha, Woo Sung Moon, Jung Ryul Kim, Kyu Yun Jang
Advances in cancer immunotherapy 2019 – latest trends
Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner, Michael von Bergwelt-Baildon
A novel method to establish glucocorticoid resistant acute lymphoblastic leukemia cell lines
Ling Gu, Ge Zhang, Yanle Zhang
MET in glioma: signaling pathways and targeted therapies
Fangling Cheng, Dongsheng Guo
CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway
Mansi Babbar, Ying Huang, Christopher M. Curtiss, M. Saeed Sheikh
miR-126-3p down-regulation contributes to dabrafenib acquired resistance in melanoma by up-regulating ADAM9 and VEGF-A
Simona Caporali, Adriana Amaro, Lauretta Levati, Ester Alvino, Pedro Miguel Lacal, Simona Mastroeni, Federica Ruffini, Laura Bonmassar, Gian Carlo Antonini Cappellini, Nadia Felli, Alessandra Carè, Ulrich Pfeffer, Stefania D’Atri
DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFβ1 signaling and is associated with poor prognosis in hepatocellular carcinoma
Jin Chen, Haidan Zhu, Qiumeng Liu, Deng Ning, Zhaoqi Zhang, Long Zhang, Jie Mo, Pengcheng Du, Xu Liu, Shasha Song, Yawei Fan, Huifang Liang, Jikui Liu, Bixiang Zhang, Xiaoping Chen
Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway
Yujia Wang, Yue Jing, Liang Ding, Xiaoxin Zhang, Yuxian Song, Sheng Chen, Xingxing Zhao, Xiaofeng Huang, Yumei Pu, Zhiyong Wang, Yanhong Ni, Qingang Hu
ASC-J9® increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-κB survival signals
Chi-Ping Huang, Jinbo Chen, Chi-Cheng Chen, Guodong Liu, Yong Zhang, Edward Messing, Shuyuan Yeh, Chawnshang Chang
E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway
Hongchao Zhao, Chunlin Zhao, Haohao Li, Danhua Zhang, Guanghui Liu
Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
Xiaosheng Wu, Mengwei Liu, Huiqiong Zhu, Jing Wang, Weiyu Dai, Jiaying Li, Danping Zhu, Weimei Tang, Yizhi Xiao, Jianjiao Lin, Wenjing Zhang, Yong Sun, Yi Zhang, Yaying Chen, Guoxin Li, Aimin Li, Li Xiang, Side Liu, Jide Wang
Long noncoding RNA MYOSLID promotes invasion and metastasis by modulating the partial epithelial-mesenchymal transition program in head and neck squamous cell carcinoma
Hong-Gang Xiong, Hao Li, Yao Xiao, Qi-Chao Yang, Lei-Lei Yang, Lei Chen, Lin-Lin Bu, Wen-Feng Zhang, Jia-Li Zhang, Zhi-Jun Sun
A combined ANXA2-NDRG1-STAT1 gene signature predicts response to chemoradiotherapy in cervical cancer
Marianna Buttarelli, Gabriele Babini, Giuseppina Raspaglio, Flavia Filippetti, Alessandra Battaglia, Alessandra Ciucci, Gabriella Ferrandina, Marco Petrillo, Carmela Marino, Mariateresa Mancuso, Anna Saran, Maria Elena Villani, Angiola Desiderio, Chiara D’Ambrosio, Andrea Scaloni, Giovanni Scambia, Daniela Gallo
LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer
Rui Yang, Na Liu, Ling Chen, Yiqun Jiang, Ying Shi, Chao Mao, Yating Liu, Min Wang, Weiwei Lai, Haosheng Tang, Menghui Gao, Desheng Xiao, Xiang Wang, Fenglei Yu, Ya Cao, Qin Yan, Shuang Liu, Yongguang Tao
MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1
Sung-Tau Chou, Hsuan-Yu Peng, Kuan-Chi Mo, Yuan-Ming Hsu, Guan-Hsun Wu, Jenn-Ren Hsiao, Su-Fang Lin, Horng-Dar Wang, Shine-Gwo Shiah
The dual PI3K/mTOR inhibitor BEZ235 restricts the growth of lung cancer tumors regardless of EGFR status, as a potent accompanist in combined therapeutic regimens
Yi-Ying Wu, Hung-Chang Wu, Jia-En Wu, Kuo-Yen Huang, Shuenn-Chen Yang, Si-Xuan Chen, Chao-Jung Tsao, Keng-Fu Hsu, Yuh-Ling Chen, Tse-Ming Hong
Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop
Bing Yang, Aiwen Wu, Yingqi Hu, Cuijian Tao, Ji Ming Wang, Youyong Lu, Rui Xing
Correction to: Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
Xihong Liu, Peiyuan Zhao, Xiujuan Wang, Lei Wang, Yingjun Zhu, Yadi Song, Wei Gao
6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression
Weilong Zhong, Wendong Yang, Yuan Qin, Wenguang Gu, Yinyin Xue, Yuanhao Tang, Hengwei Xu, Hongzhi Wang, Chao Zhang, Changhua Wang, Bo Sun, Yanrong Liu, Huijuan Liu, Honggang Zhou, Shuang Chen, Tao Sun, Cheng Yang
CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis
Fuqiang Wang, Wenxing Zhao, Yuehong Gao, Jiechao Zhou, Huifang Li, Guanyun Zhang, Dong Guo, Chengrong Xie, Jie Li, Zhenyu Yin, Jie Zhang
Role of protein kinase CK2 in antitumor drug resistance
Christian Borgo, Maria Ruzzene
Correction to: Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells
Qun Wang, Weijun Lu, Tao Yin, Li Lu
Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells
Dongfeng Han, Tianfu Yu, Nan Dong, Bo Wang, Fei Sun, Dehua Jiang
Targeting mutant p53 in cancer: the latest insights
Silvia Di Agostino, Giulia Fontemaggi, Sabrina Strano, Giovanni Blandino, Gabriella D’Orazi
NKAP alters tumor immune microenvironment and promotes glioma growth via Notch1 signaling
Guangyan Gu, Taihong Gao, Lu Zhang, Xiuyang Chen, Qi Pang, Yanan Wang, Dan Wang, Jie Li, Qian Liu
Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness
Christin Richter, Stephan Marquardt, Fanghua Li, Alf Spitschak, Nico Murr, Berdien A. H. Edelhäuser, George Iliakis, Brigitte M. Pützer, Stella Logotheti
Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy
Shichong Lin, Lehe Yang, Yulei Yao, Lingyuan Xu, Youqun Xiang, Haiyang Zhao, Liangxing Wang, Zhigui Zuo, Xiaoying Huang, Chengguang Zhao
Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells
Biswajit Das, Shantibhusan Senapati
Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes
Peixin Dong, Ying Xiong, Junming Yue, Daozhi Xu, Kei Ihira, Yosuke Konno, Noriko Kobayashi, Yukiharu Todo, Hidemichi Watari
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation
Wenjuan Zhang, Yanxia Lu, Xiaomin Li, Jianming Zhang, Weihao Lin, Wei Zhang, Lin Zheng, Xuenong Li
UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1
Hongze Chen, Le Li, Jisheng Hu, Zhongjie Zhao, Liang Ji, Chundong Cheng, Guangquan Zhang, Tao zhang, Yilong Li, Hua Chen, Shangha Pan, Bei Sun
Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux
Zhi-peng Wen, Wen-jing Zeng, Yan-hong Chen, He Li, Jie-ya Wang, Quan Cheng, Jing Yu, Hong-hao Zhou, Zheng-zheng Liu, Jian Xiao, Xiao-ping Chen
Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis
Liling Wen, Huanzi Lu, Qiusheng Li, Qunxing Li, Shuqiong Wen, Dikan Wang, Xi Wang, Juan Fang, Jun Cui, Bin Cheng, Zhi Wang
DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma
Xiangjian Luo, Namei Li, Xu Zhao, Chaoliang Liao, Runxin Ye, Can Cheng, Zhijie Xu, Jing Quan, Jikai Liu, Ya Cao
PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α
Pingfu Hou, Fang Chen, Hongmei Yong, Tian Lin, Jingjing Li, Yu Pan, Tao Jiang, Minle Li, Yansu Chen, Jun Song, Junnian Zheng, Jin Bai
High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer
Cancan Zhou, Weikun Qian, Jie Li, Jiguang Ma, Xin Chen, Zhengdong Jiang, Liang Cheng, Wanxing Duan, Zheng Wang, Zheng Wu, Qingyong Ma, Xuqi Li
Intestinal dysbacteriosis-induced IL-25 promotes development of HCC via alternative activation of macrophages in tumor microenvironment
Qiao Li, Lei Ma, Shunli Shen, Yu Guo, Qinghua Cao, Xiuqin Cai, Juan Feng, Yuan Yan, Tianyu Hu, Shiya Luo, Lin Zhou, Baogang Peng, Zhonghan Yang, Yunpeng Hua
The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma
Yue Zhao, Ji Zhu, Bowen Shi, Xinyu Wang, Qijue Lu, Chunguang Li, Hezhong Chen
Long non-coding RNA LUCAT1/miR-5582-3p/TCF7L2 axis regulates breast cancer stemness via Wnt/β-catenin pathway
Ang Zheng, Xinyue Song, Lin Zhang, Lin Zhao, Xiaoyun Mao, Minjie Wei, Feng Jin
Pulsed-laser irradiation of multifunctional gold nanoshells to overcome trastuzumab resistance in HER2-overexpressing breast cancer
Toni Nunes, Thomas Pons, Xue Hou, Khanh Van Do, Benoît Caron, Marthe Rigal, Mélanie Di Benedetto, Bruno Palpant, Christophe Leboeuf, Anne Janin, Guilhem Bousquet
p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition
Monika Aggarwal, Rahul Saxena, Nasir Asif, Elizabeth Sinclair, Judy Tan, Idalia Cruz, Deborah Berry, Bhaskar Kallakury, Quynhchi Pham, Thomas T. Y. Wang, Fung-Lung Chung
Synergistic killing effects of homoharringtonine and arsenic trioxide on acute myeloid leukemia stem cells and the underlying mechanisms
Ming Tan, Qian Zhang, Xiaohong Yuan, Yuanzhong Chen, Yong Wu
APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC
Matilde Clarissa Malfatti, Lorenzo Gerratana, Emiliano Dalla, Miriam Isola, Giuseppe Damante, Carla Di Loreto, Fabio Puglisi, Gianluca Tell
Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway
Zi Yin, Tingting Ma, Bowen Huang, Lehang Lin, Yu Zhou, Jinhai Yan, Yiping Zou, Sheng Chen
G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells
F. Berardinelli, M. Tanori, D. Muoio, M. Buccarelli, A. di Masi, S. Leone, L. Ricci-Vitiani, R. Pallini, M. Mancuso, A. Antoccia
Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer
Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J. Linton, Pierluigi Di Sebastiano, Xi Chen, Adam B. Keeton, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Gary A. Piazza, Vincenzo De Laurenzi, Gianluca Sala, Marco Falasca
HMGA1 promotes breast cancer angiogenesis supporting the stability, nuclear localization and transcriptional activity of FOXM1
Rossella Zanin, Silvia Pegoraro, Gloria Ros, Yari Ciani, Silvano Piazza, Fleur Bossi, Roberta Bulla, Cristina Zennaro, Federica Tonon, Dejan Lazarevic, Elia Stupka, Riccardo Sgarra, Guidalberto Manfioletti
A positive feedback between IDO1 metabolite and COL12A1 via MAPK pathway to promote gastric cancer metastasis
Zhen Xiang, Jun Li, Shuzheng Song, Jiexuan Wang, Wei Cai, Wenjun Hu, Jun Ji, Zhenggang Zhu, Lu Zang, Ranlin Yan, Yingyan Yu
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation
Xue Liu, Yu Fu, Jiadong Huang, Meng Wu, Zhenxing Zhang, Rongyao Xu, Ping Zhang, Shouwei Zhao, Laikui Liu, Hongbing Jiang
Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma
Ling Deng, Jingyuan Sun, Xiaohui Chen, Li Liu, Dehua Wu
Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation
Chiara Ciardiello, Alessandra Leone, Paola Lanuti, Maria S. Roca, Tania Moccia, Valentina R. Minciacchi, Michele Minopoli, Vincenzo Gigantino, Rossella De Cecio, Massimo Rippa, Lucia Petti, Francesca Capone, Carlo Vitagliano, Maria R. Milone, Biagio Pucci, Rita Lombardi, Federica Iannelli, Elena Di Gennaro, Francesca Bruzzese, Marco Marchisio, Maria V. Carriero, Dolores Di Vizio, Alfredo Budillon
Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis
Yao Yao, Xinyuan Chen, Hong Yang, Wei Chen, Yichun Qian, Zhongyi Yan, Tian Liao, Weiping Yao, Wenlan Wu, Tonghua Yu, Yun Chen, Yuan Zhang
Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation of NF-κB signaling in lung cancer
Xianglin Hao, Li-yun Gao, Ning Zhang, Hongqiang Chen, Xiao Jiang, Wenbin Liu, Lin Ao, Jia Cao, Fei Han, Jinyi Liu
Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells
Qian Zhang, Rui-Xian Liu, Ka-Wo Chan, Jiancong Hu, Jingdan Zhang, Lili Wei, Huiliu Tan, Xiangling Yang, Huanliang Liu
IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma
Jian Wu, Feng-xia Gao, Chao Wang, Mei Qin, Fei Han, Tao Xu, Zhi Hu, Yang Long, Xue-mei He, Xin Deng, De-lian Ren, Tian-yang Dai
Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer
Zhichao Tong, Anuja Sathe, Benedikt Ebner, Pan Qi, Christian Veltkamp, Juergen E. Gschwend, Per Sonne Holm, Roman Nawroth
Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway
Alexandre Vallée, Yves Lecarpentier, Jean-Noël Vallée
HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K/AKT pathway
Hongqiang Wang, Xuchun Yang, Yan Guo, Lin Shui, Shi Li, Yifeng Bai, Yu Liu, Ming Zeng, Jianling Xia
HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells
Wenwen Chai, Fanghua Ye, Li Zeng, Yanling Li, Liangchun Yang
Anti-PSMA 124I-scFvD2B as a new immuno-PET tool for prostate cancer: preclinical proof of principle
B. Frigerio, S. Morlino, E. Luison, E. Seregni, A. Lorenzoni, A. Satta, R. Valdagni, A. Bogni, C. Chiesa, M. Mira, S. Canevari, A. Alessi, M. Figini
Effects of hyperglycemia on the progression of tumor diseases
Wenjie Li, Xuehui Zhang, Hui Sang, Ying Zhou, Chunyu Shang, Yongqing Wang, Hong Zhu
RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target
Pavana Thomas, Annapurna Pranatharthi, Cecil Ross, Sweta Srivastava
KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity
Kai Teng, Shi Wei, Chi Zhang, Jiewei Chen, Jinbin Chen, Kanghua Xiao, Jun Liu, Miaomiao Dai, Xinyuan Guan, Jingping Yun, Dan Xie
RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer
Veenita Khare, Shaheda Tabassum, Uttara Chatterjee, Sandip Chatterjee, Mrinal K. Ghosh
Correction to: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Yinfang Wang, Yanli Hou, Weiwei Zhang, Angel A. Alvarez, Yongrui Bai, Bo Hu, Shi-Yuan Cheng, Kun Yang, Yanxin Li, Haizhong Feng
Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B
Lawrence H. Cheung, Yunli Zhao, Ana Alvarez-Cienfuegos, Khalid A. Mohamedali, Yu J. Cao, Walter N. Hittelman, Michael G. Rosenblum
Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms
Yifan Zhao, Xiao Shen, Ying Zhu, Anqi Wang, Yajie Xiong, Long Wang, Yao Fei, Yan Wang, Wenjuan Wang, Fang Lin, Zhongqin Liang
RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer
Qingyuan Li, Qiuhua Lai, Chengcheng He, Yuxin Fang, Qun Yan, Yue Zhang, Xinke Wang, Chuncai Gu, Yiqing Wang, Liangying Ye, Lu Han, Xin Lin, Junsheng Chen, Jianqun Cai, Aimin Li, Side Liu
AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)
Francesca Cirillo, Rosamaria Lappano, Leonardo Bruno, Bruno Rizzuti, Fedora Grande, Rita Guzzi, Sara Briguori, Anna Maria Miglietta, Miki Nakajima, Maria Teresa Di Martino, Marcello Maggiolini
Correction to: Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway
Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li, Binsheng Fu
PLCε regulates prostate cancer mitochondrial oxidative metabolism and migration via upregulation of Twist1
Jiaxin Fan, Yanru Fan, Xiao Wang, Lingfang Niu, Limei Duan, Jinxiao Yang, Luo Li, Yingying Gao, Xiaohou Wu, Chunli Luo
GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway
Ziqiang Zhang, Hongyuan Xue, Yuanqiang Dong, Jun Zhang, Yida Pan, Liubin Shi, Panpan Xiong, Jie Zhu, Wenshuai Li, Wanwei Zheng, Jie Liu, Jianjun Du
Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4
Li Yi, Xingchen Zhou, Tao Li, Peidong Liu, Long Hai, Luqing Tong, Haiwen Ma, Zhennan Tao, Yang Xie, Chen Zhang, Shengping Yu, Xuejun Yang
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells
Ruizhi He, Min Wang, Chunle Zhao, Ming Shen, Yahong Yu, Li He, Yan Zhao, Hua Chen, Xiuhui Shi, Min Zhou, Shutao Pan, Yuhui Liu, Xingjun Guo, Xu Li, Renyi Qin
Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits
Zhiqiang Wu, Zhuang Liu, Xiangli Jiang, Zeyun Mi, Maobin Meng, Hui Wang, Jinlin Zhao, Boyu Zheng, Zhiyong Yuan
The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway
Sahyun Pak, Sejun Park, Yunlim Kim, Jung-Hyuck Park, Chan-Hee Park, Kyoung-June Lee, Choung-soo Kim, Hanjong Ahn
NR1B2 suppress kidney renal clear cell carcinoma (KIRC) progression by regulation of LATS 1/2-YAP signaling
Lei Yin, Wenjia Li, Guangchun Wang, Heng Shi, Keyi Wang, Huan Yang, Bo Peng
RETRACTED ARTICLE: Long non-coding RNA MACC1-AS1 promoted pancreatic carcinoma progression through activation of PAX8/NOTCH1 signaling pathway
Chen Qi, Chen Xiaofeng, Li Dongen, Yang Liang, Xu Liping, Hu Yue, Jiang Jianshuai
Long non-coding RNA GAS5 inhibits DDP-resistance and tumor progression of epithelial ovarian cancer via GAS5-E2F4-PARP1-MAPK axis
Xiaoran Long, Keqi Song, Hao Hu, Qi Tian, Wenjing Wang, Qian Dong, Xia Yin, Wen Di
HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms
Gloria Manzotti, Federica Torricelli, Benedetta Donati, Valentina Sancisi, Mila Gugnoni, Alessia Ciarrocchi
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis
Anbin Wang, Haisu Dai, Yi Gong, Chengcheng Zhang, Junjie Shu, Yuandeng Luo, Yan Jiang, Wei Liu, Ping Bie
TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells
Jian Wu, Hongzhe Li, Minmin Shi, Youwei Zhu, Yang Ma, Yiming Zhong, Cheng Xiong, Hao Chen, Chenghong Peng
Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma
Claudio Pulito, Etleva Korita, Andrea Sacconi, Mariacristina Valerio, Luca Casadei, Federica Lo Sardo, Federica Mori, Maria Ferraiuolo, Giuseppe Grasso, Anna Maidecchi, Jacopo Lucci, Marius Sudol, Paola Muti, Giovanni Blandino, Sabrina Strano
DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation
Haoran Cui, Qin Wang, Zhenchuan Lei, Maoxiao Feng, Zhongxi Zhao, Yunshan Wang, Guangwei Wei
Correction to: Molecular pattern of lncRNAs in hepatocellular carcinoma
Haoming Mai, Bin Zhou, Li Liu, Fu Yang, Carly Conran, Yuan Ji, Jinlin Hou, Deke Jiang
Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation
Jianghong Yan, Xiaoyun Dou, Jing Zhou, Yuanfeng Xiong, Ling Mo, Longhao Li, Yunlong Lei
Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy
Peiye Song, Yanru Li, Yuan Dong, Yingying Liang, Huinan Qu, Da Qi, Yan Lu, Xiangshu Jin, Yantong Guo, Yiyang Jia, Xinqi Wang, Wenhong Xu, Chengshi Quan
A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells
Shengnan Yu, Jing Zhang, Yongxiang Yan, Xudong Yao, Lijuan Fang, Hui Xiong, Yang Liu, Qian Chu, Pengfei Zhou, Kongming Wu
LncRNA FLVCR1-AS1 mediates miR-513/YAP1 signaling to promote cell progression, migration, invasion and EMT process in ovarian cancer
Huan Yan, Hong Li, Maria A. Silva, Yichun Guan, Li Yang, Linlin Zhu, Zhan Zhang, Genxia Li, Chenchen Ren
Correction to: The regulatory ZFAS1/miR-150/ST6GAL1 crosstalk modulates sialylation of EGFR via PI3K/Akt pathway in T-cell acute lymphoblastic leukemia
Qianqian Liu, Hongye Ma, Xiuhua Sun, Bing Liu, Yang Xiao, Shimeng Pan, Huimin Zhou, Weijie Dong, Li Jia
miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt–β-catenin pathway
Qiang Liu, Yanlei Guan, Zhenhang Li, Yao Wang, Yu Liu, Run Cui, Yunjie Wang
Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis
Ming-Yue Li, Li-Zhong Liu, Wende Li, Calvin S. H. Ng, Yi Liu, Angel W. Y. Kong, Zhili Zhao, Shanshan Wang, Haolong Qi, Hao Jia, Shucai Yang, Jing Du, Xiang Long, Rocky L. K. Ho, Ernest C. W. Chak, Innes Y. P. Wan, Tony S. K. Mok, Malcolm J. Underwood, Nirmal Kumar Gali, Zhi Ning, George G. Chen
Curcumin C3 complex®/Bioperine® has antineoplastic activity in mesothelioma: an in vitro and in vivo analysis
Francesco Di Meo, Stefania Filosa, Michele Madonna, Gerarda Giello, Alba Di Pardo, Vittorio Maglione, Alfonso Baldi, Stefania Crispi
CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status
Xuefei Feng, Miao Zhang, Bo Wang, Can Zhou, Yudong Mu, Juan Li, Xiaoxu Liu, Yaochun Wang, Zhangjun Song, Peijun Liu
Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma
Xiaoge Gao, Pin Jiang, Qian Zhang, Qian Liu, Shuangshuang Jiang, Ling Liu, Maomao Guo, Qian Cheng, Junnian Zheng, Hong Yao
Targeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies
Ki Yeon Kim, Minsang Yoon, Youngkyung Cho, Kwang-Hoon Lee, Sora Park, Se-ra Lee, So-Young Choi, Deokjae Lee, Chansik Yang, Eun Hye Cho, Sangjun Davie Jeon, Seok-Hyung Kim, Chungho Kim, Moon Gyo Kim
Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
Apostolos Zaravinos, Constantinos Roufas, Majdi Nagara, Beatriz de Lucas Moreno, Maria Oblovatskaya, Christodoulos Efstathiades, Christos Dimopoulos, Georgios D. Ayiomamitis
LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus
Yingying Jiang, Wei Cao, Kun Wu, Xing Qin, Xiaoning Wang, Yan Li, Binbin Yu, Zhen Zhang, Xu Wang, Ming Yan, Qin Xu, Jianjun Zhang, Wantao Chen
A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma
Erbao Bian, Xueran Chen, Yadi Xu, Xinghu Ji, Meng Cheng, Hongliang Wang, Zhiyou Fang, Bing Zhao
Correction to: LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway
Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu, Li Jia
Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?
Fengzhi Li, Ieman Aljahdali, Xiang Ling
S1PR1 promotes proliferation and inhibits apoptosis of esophageal squamous cell carcinoma through activating STAT3 pathway
Yan Liu, Yingru Zhi, Haizhu Song, Mingzhu Zong, Jun Yi, Guoxin Mao, Longbang Chen, Guichun Huang
Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway
Jiafei Liu, Like Qu, Lin Meng, Chengchao Shou
Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
Chenlong Wang, Yaxin Chen, Yang Wang, Xiaoxiao Liu, Yanzhuo Liu, Ying Li, Honglei Chen, Chengpeng Fan, Dongfang Wu, Jing Yang
Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models
Xia Peng, Pengcong Hou, Yi Chen, Yang Dai, Yinchun Ji, Yanyan Shen, Yi Su, Bo Liu, Yueliang Wang, Deqiao Sun, Yuchen Jiang, Chuantao Zha, Zuoquan Xie, Jian Ding, Meiyu Geng, Jing Ai
A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells
Isabella Orienti, Valentina Salvati, Giovanni Sette, Massimo Zucchetti, Lucilla Bongiorno-Borbone, Angelo Peschiaroli, Lello Zolla, Federica Francescangeli, Mariella Ferrari, Cristina Matteo, Ezia Bello, Antonio Di Virgilio, Mario Falchi, Maria Laura De Angelis, Marta Baiocchi, Gerry Melino, Ruggero De Maria, Ann Zeuner, Adriana Eramo
Correction to: Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy
Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang, Huameng Li, Chenglong Li, Jiayuh Lin
LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway
Deyao Shi, Fashuai Wu, Shidai Mu, Binwu Hu, Binlong Zhong, Feng Gao, Xiangcheng Qing, Jianxiang Liu, Zhicai Zhang, Zengwu Shao
Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells
Yanju Wu, Qianqian Zheng, Yan Li, Guang Wang, Shuting Gao, Xiaodong Zhang, Xu Yan, Xinwen Zhang, Jisheng Xie, Yuanyuan Wang, Xun Sun, Xin Meng, Bo Yin, Biao Wang
Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming
Jinmei Jin, Shuiping Qiu, Ping Wang, Xiaohui Liang, Fei Huang, Hui Wu, Beibei Zhang, Weidong Zhang, Xinhui Tian, Ren Xu, Hailian Shi, Xiaojun Wu
Cripto-1 expression in patients with clear cell renal cell carcinoma is associated with poor disease outcome
Yi-Jun Xue, Song-Ning Chen, Wei-Guang Chen, Geng-Qing Wu, Yun-Feng Liao, Jian-Bin Xu, Hao Tang, Shui-Hua Yang, Shui-Yong He, Yun-Fei Luo, Zhi-Hui Wu, Hai-Wen Huang
P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs
Yuechao Zhao, Yiran Li, Jie Sheng, Fan Wu, Kai Li, Rong Huang, Xiaojuan Wang, Tao Jiao, Xin Guan, Yan Lu, Xiao Chen, Zhiwen Luo, Yanchi Zhou, Hanjie Hu, Wenjie Liu, Boyu Du, Shiying Miao, Jianqiang Cai, Linfang Wang, Hong Zhao, Jianming Ying, Xinyu Bi, Wei Song
Modulating lncRNA SNHG15/CDK6/miR-627 circuit by palbociclib, overcomes temozolomide resistance and reduces M2-polarization of glioma associated microglia in glioblastoma multiforme
Zhenzhe Li, Jixing Zhang, Hongshan Zheng, Chenlong Li, Jinsheng Xiong, Weiliang Wang, Hongbo Bao, Hua Jin, Peng Liang
RETRACTED ARTICLE: Receptor tyrosine kinase inhibitor Sunitinib and integrin antagonist peptide HM-3 show similar lipid raft dependent biphasic regulation of tumor angiogenesis and metastasis
Jialiang Hu, Wenjing Wang, Chen Liu, Mengwei Li, Edouard Nice, Hanmei Xu
Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway
Syed S. Islam, Abdelilah Aboussekhra
Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer
María del Mar Noblejas-López, Cristina Nieto-Jimenez, Miguel Burgos, Mónica Gómez-Juárez, Juan Carlos Montero, Azucena Esparís-Ogando, Atanasio Pandiella, Eva M. Galán-Moya, Alberto Ocaña
An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma
Lei Zhang, Jiewei Chen, Juanjuan Yong, Liang Qiao, Leibo Xu, Chao Liu
Correction to: Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer
Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong, Yingbin Liu
The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-κB signaling axis
Yong Wang, Jing Su, Yiting Wang, Donghe Fu, Justin E. Ideozu, Hua Geng, Qiqi Cui, Chao Wang, Ruibing Chen, Yixi Yu, Yuanjie Niu, Dan Yue
Correction to: Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway
Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li, Binsheng Fu
Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia
Shasha Ren, Jiuzhou Liu, Yun Feng, Zhenyu Li, Liang He, Leilei Li, Xiaozhong Cao, Zhenghua Wang, Yanwu Zhang
Hypoxic exosomes facilitate angiogenesis and metastasis in esophageal squamous cell carcinoma through altering the phenotype and transcriptome of endothelial cells
Yu Mao, Yimin Wang, Lixin Dong, Yunjie Zhang, Yanqiu Zhang, Chao Wang, Qiang Zhang, Sen Yang, Liyan Cao, Xinyuan Zhang, Xin Li, Zhanzhao Fu
Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression
Jiayan Yan, Yunxi Jia, Han Chen, Wei Chen, Xiaoying Zhou
MAZ promotes prostate cancer bone metastasis through transcriptionally activating the KRas-dependent RalGEFs pathway
Qing Yang, Chuandong Lang, Zhengquan Wu, Yuhu Dai, Shaofu He, Wei Guo, Shuai Huang, Hong Du, Dong Ren, Xinsheng Peng
RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer
Annapurna Pranatharthi, Pavana Thomas, Avinash H. Udayashankar, Chandra Bhavani, Srinag Bangalore Suresh, Sudhir Krishna, Jayashree Thatte, Nirmala Srikantia, Cecil R. Ross, Sweta Srivastava
Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway
Wen Peng, Jie Li, Ranran Chen, Qiou Gu, Peng Yang, Wenwei Qian, Dongjian Ji, Qingyuan Wang, Zhiyuan Zhang, Junwei Tang, Yueming Sun
Nuclear FAM289-Galectin-1 interaction controls FAM289-mediated tumor promotion in malignant glioma
Xing Rong Guo, Mu Yu Wu, Long Jun Dai, Yu Huang, Meng Ye Shan, Shi Nan Ma, Jue Wang, Hao Peng, Yan Ding, Qiu Fang Zhang, Jun Ming Tang, Xu Zhi Ruan, Dong Sheng Li
Long non-coding RNA LINC00174 promotes glycolysis and tumor progression by regulating miR-152-3p/SLC2A1 axis in glioma
Jian Shi, Yang Zhang, Bing Qin, Yongjie Wang, Xiangdong Zhu
From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma
Yaojie Fu, Shanshan Liu, Shan Zeng, Hong Shen
IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression
Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben, David Schrama
circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma
Jiansheng Chen, Taoliang Chen, Yubo Zhu, Yan Li, Yuxuan Zhang, Yun Wang, Xiao Li, Xiaomi Xie, Jihui Wang, Min Huang, Xinlin Sun, Yiquan Ke
The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
So-Yeon Park, Choong-Jae Lee, Jang-Hyun Choi, Jee-Heun Kim, Ji-Won Kim, Ji-Young Kim, Jeong-Seok Nam
FUBP1 promotes neuroblastoma proliferation via enhancing glycolysis-a new possible marker of malignancy for neuroblastoma
Ping Jiang, Mao Huang, Weiwei Qi, Fenghua Wang, Tianyou Yang, Tianxiao Gao, Chuanghua Luo, Jing Deng, Zhonghan Yang, Ti Zhou, Yan Zou, Guoquan Gao, Xia Yang
ACLY facilitates colon cancer cell metastasis by CTNNB1
Jun Wen, Xuejie Min, Mengqin Shen, Qian Hua, Yuan Han, Li Zhao, Liu Liu, Gang Huang, Jianjun Liu, Xiaoping Zhao
Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
Yibing Chen, Yanjun Mi, Xiaofei Zhang, Qian Ma, Yucen Song, Liwei Zhang, Dandan Wang, Jinliang Xing, Benxin Hou, Haolong Li, Huan Jin, Wei Du, Zhengzhi Zou
Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy
Zhongping Yin, Ling Bai, Wei Li, Tanlun Zeng, Huimin Tian, Jiuwei Cui
SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation
Xiao Ding, Kexia Fan, Jintao Hu, Zhenle Zang, Shunli Zhang, Yin Zhang, Zhichao Lin, Xiangdong Pei, Xin Zheng, Feng Zhu, Hui Yang, Song Li
Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment
Elena Gómez-Abenza, Sofía Ibáñez-Molero, Diana García-Moreno, Inmaculada Fuentes, Leonard I. Zon, Maria C. Mione, María L. Cayuela, Chiara Gabellini, Victoriano Mulero
Iron and leukemia: new insights for future treatments
Fang Wang, Huanhuan Lv, Bin Zhao, Liangfu Zhou, Shenghang Wang, Jie Luo, Junyu Liu, Peng Shang
Correction to: Synergistic killing effects of homoharringtonine and arsenic trioxide on acute myeloid leukemia stem cells and the underlying mechanisms
Ming Tan, Qian Zhang, Xiaohong Yuan, Yuanzhong Chen, Yong Wu
Graphene oxide arms oncolytic measles virus for improved effectiveness of cancer therapy
Mao Xia, Dongjun Luo, Jie Dong, Meihong Zheng, Gang Meng, Junhua Wu, Jiwu Wei
Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4
Meng-Xuan Zhu, Chuan-Yuan Wei, Peng-Fei Zhang, Dong-Mei Gao, Jie Chen, Yan Zhao, Shuang-Shuang Dong, Bin-Bin Liu
UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling
Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Sheng-Liang Qiu, Changhwan Yoon, Ning-Zi Lian, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li
Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils
Anquan Shang, Weiwei Wang, Chenzheng Gu, Chen Chen, Bingjie Zeng, Yibao Yang, Ping Ji, Junjun Sun, Junlu Wu, Wenying Lu, Zujun Sun, Dong Li
HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3
Huiqiong Zhu, Weiyu Dai, Jiaying Li, Li Xiang, Xiaosheng Wu, Weimei Tang, Yaying Chen, Qiong Yang, Mengwei Liu, Yizhi Xiao, Wenjing Zhang, Jianjiao Lin, Jing Wang, Guangnan Liu, Yong Sun, Ping Jiang, Guoxin Li, Aimin Li, Side Liu, Ye Chen, Jide Wang
CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma
Yongqiang Qi, Da Wang, Wenhua Huang, Bing Wang, Di Huang, Fei Xiong, Xiaoping Chen, Yongjun Chen
Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells
Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, Xuesen Zhang
Correction to: FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer
Huiling Lai, Xuejiao Zhao, Yu Qin, Yi Ding, Ruqi Chen, Guannan Li, Marilyne Labrie, Zhiyong Ding, Jianfeng Zhou, Junbo Hu, Ding Ma, Yong Fang, Qinglei Gao
NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis
Kotaro Saga, Jinhee Park, Keisuke Nimura, Norihiko Kawamura, Airi Ishibashi, Norio Nonomura, Yasufumi Kaneda
MEIS2C and MEIS2D promote tumor progression via Wnt/β-catenin and hippo/YAP signaling in hepatocellular carcinoma
Lei Guan, Ting Li, Nanping Ai, Wei Wang, Bing He, Yanxia Bai, Zhaocai Yu, Mingyue Li, Shanshan Dong, Qingge Zhu, Xiao Xiao Ding, Shiming Zhang, Ming li, Guangbo Tang, Xiaochun Xia, Jing Zhao, Song lin, Shi yao, Lei zhang, Geng chen, Fang-E Liu, Xinyuan Li, Huqin Zhang
LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway
Kun Qiao, Shipeng Ning, Lin Wan, Hao Wu, Qin Wang, Xingda Zhang, Shouping Xu, Da Pang
Immunotherapy of brain metastases: breaking a “dogma”
Anna Maria Di Giacomo, Monica Valente, Alfonso Cerase, Maria Fortunata Lofiego, Francesca Piazzini, Luana Calabrò, Elisabetta Gambale, Alessia Covre, Michele Maio
The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment
Ina Patties, Sonja Kallendrusch, Lisa Böhme, Eva Kendzia, Henry Oppermann, Frank Gaunitz, Rolf-Dieter Kortmann, Annegret Glasow
Activity of MCPIP1 RNase in tumor associated processes
Katarzyna Miekus, Jerzy Kotlinowski, Agata Lichawska-Cieslar, Janusz Rys, Jolanta Jura
A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer
Jinhua Wang, Yajing Xing, Yingying Wang, Yundong He, Liting Wang, Shihong Peng, Lianfang Yang, Jiuqing Xie, Xiaotao Li, Wenwei Qiu, Zhengfang Yi, Mingyao Liu
Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells
Zoe Leung, Frankie Chi Fat Ko, Sze Keong Tey, Ernest Man Lok Kwong, Xiaowen Mao, Bonnie Hei Man Liu, Angel Po Yee Ma, Yi Man Eva Fung, Chi-Ming Che, Danny Ka Ho Wong, Ching Lung Lai, Irene Oi-Lin Ng, Judy Wai Ping Yam
A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target
Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina, Andrew Reay Mackay
Correction to: Cell communication and signaling: how to turn bad language into positive one
Claudia Chiodoni, Maria Teresa Di Martino, Francesca Zazzeroni, Michele Caraglia, Massimo Donadelli, Stefania Meschini, Carlo Leonetti, Katia Scotlandi
Polo-like kinase 3 inhibits glucose metabolism in colorectal cancer by targeting HSP90/STAT3/HK2 signaling
Baochi Ou, Hongze Sun, Jingkun Zhao, Zhuoqing Xu, Yuan Liu, Hao Feng, Zhihai Peng
Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin
Yanwei Shen, Shuting Li, Xin Wang, Mengying Wang, Qi Tian, Jiao Yang, Jichang Wang, Biyuan Wang, Peijun Liu, Jin Yang
BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways
Jialing Wen, Xianglin Liu, Yan Qi, Feng Niu, Zhitong Niu, Wenjing Geng, Zhaowei Zou, Renli Huang, Jianping Wang, Hongzhi Zou
Methylation-mediated silencing of miR-133a-3p promotes breast cancer cell migration and stemness via miR-133a-3p/MAML1/DNMT3A positive feedback loop
Wanyue Shi, Tingting Tang, Xinping Li, Siwei Deng, Ruiyi Li, Yingshan Wang, Yifei Wang, Tiansong Xia, Yanfeng Zhang, Ke Zen, Liang Jin, Yi Pan
Recent advances in nanotheranostics for triple negative breast cancer treatment
Vikram Thakur, Rajaletchumy Veloo Kutty
Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer
Claudia M. Kowolik, Min Lin, Jun Xie, Larry E. Overman, David A. Horne
Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1
Crescenzo D’Alterio, Maria Buoncervello, Caterina Ieranò, Maria Napolitano, Luigi Portella, Giuseppina Rea, Antonio Barbieri, Antonio Luciano, Giosuè Scognamiglio, Fabiana Tatangelo, Anna Maria Anniciello, Mario Monaco, Ernesta Cavalcanti, Piera Maiolino, Giulia Romagnoli, Claudio Arra, Gerardo Botti, Lucia Gabriele, Stefania Scala
Connecting the dots between different networks: miRNAs associated with bladder cancer risk and progression
Cornelia Braicu, Rares Buiga, Roxana Cojocneanu, Mihail Buse, Lajos Raduly, Laura Ancuta Pop, Sergiu Chira, Liviuta Budisan, Ancuta Jurj, Cristina Ciocan, Lorand Magdo, Alexandru Irimie, Florentin Dobrota, Bogdan Petrut, Ioana Berindan-Neagoe
Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
Simon Bernatz, Elena I. Ilina, Kavi Devraj, Patrick N. Harter, Klaus Mueller, Sascha Kleber, Yannick Braun, Cornelia Penski, Christoph Renner, Rashi Halder, Lukas Jennewein, Christine Solbach, Frits Thorsen, Bernhard C. Pestalozzi, Axel Mischo, Michel Mittelbronn
JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway
Xinnan Wu, Ruixiao Li, Qing Song, Chengcheng Zhang, Ru Jia, Zhifen Han, Lihong Zhou, Hua Sui, Xuan Liu, Huirong Zhu, Liu Yang, Yan Wang, Qing Ji, Qi Li
Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid
Mineko Terao, Laura Goracci, Valentina Celestini, Mami Kurosaki, Marco Bolis, Alessandra Di Veroli, Arianna Vallerga, Maddalena Fratelli, Monica Lupi, Alessandro Corbelli, Fabio Fiordaliso, Maurizio Gianni, Gabriela Paroni, Adriana Zanetti, Gabriele Cruciani, Enrico Garattini
CircWHSC1 promotes ovarian cancer progression by regulating MUC1 and hTERT through sponging miR-145 and miR-1182
Zhi-Hong Zong, Yu-Ping Du, Xue Guan, Shuo Chen, Yang Zhao
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
Jingjing Li, Qiujie Wang, Yi Yang, Chong Lei, Fan Yang, Li Liang, Chang Chen, Jie Xia, Kai Wang, Ni Tang
Upregulation of ERp57 promotes clear cell renal cell carcinoma progression by initiating a STAT3/ILF3 feedback loop
Yan Liu, Jian-Xing Wang, Zi-Yuan Nie, Yue Wen, Xin-Ju Jia, Li-Na Zhang, Hui-Jun Duan, Yong-Hong Shi
Correction to: The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway
Sahyun Pak, Sejun Park, Yunlim Kim, Jung-Hyuck Park, Chan-Hee Park, Kyoung-June Lee, Choung-soo Kim, Hanjong Ahn
Correction to: SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF
Morvarid Saeinasab, Ahmad Reza Bahrami, Jovanna González, Francesco P. Marchese, Dannys Martinez, Seyed Javad Mowla, Maryam M. Matin, Maite Huarte
Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity
Kai Teng, Shi Wei, Chi Zhang, Jiewei Chen, Jinbin Chen, Kanghua Xiao, Jun Liu, Miaomiao Dai, Xinyuan Guan, Jingping Yun, Dan Xie
Correction to: Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4
Meng-Xuan Zhu, Chuan-Yuan Wei, Peng-Fei Zhang, Dong-Mei Gao, Jie Chen, Yan Zhao, Shuang-Shuang Dong, Bin-Bin Liu
Correction to: Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer
Yuyuan Yao, Kai Zhao, Zhou Yu, Haochuan Ren, Li Zhao, Zhiyu Li, Qinglong Guo, Na Lu
Correction to: PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
Wuhua Zhou, Li Gong, Qinchuan Wu, Chunyang Xing, Bajin Wei, Tianchi Chen, Yuan Zhou, Shengyong Yin, Bin Jiang, Haiyang Xie, Lin Zhou, Shusen Zheng
Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy
Elisabeth Silkenstedt, Fabian Arenas, Berta Colom-Sanmartí, Sílvia Xargay-Torrent, Morihiro Higashi, Ariadna Giró, Vanina Rodriguez, Patricia Fuentes, Walter E. Aulitzky, Heiko van der Kuip, Sílvia Beà, Maria L. Toribio, Elias Campo, Mònica López-Guerra, Dolors Colomer
Molecular targeted and immune checkpoint therapy for advanced hepatocellular carcinoma
Ziyu Liu, Yan Lin, Jinyan Zhang, Yumei Zhang, Yongqiang Li, Zhihui Liu, Qian Li, Ming Luo, Rong Liang, Jiazhou Ye
SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells
Haiyang Yu, Chun-Li Wu, Xiangyu Wang, Qianhong Ban, Chunhua Quan, Mengbo Liu, Hangqi Dong, Jinfeng Li, Gi-Young Kim, Yung Hyun Choi, Zhenya Wang, Cheng-Yun Jin
Interleukin-8 promotes integrin β3 upregulation and cell invasion through PI3K/Akt pathway in hepatocellular carcinoma
Fengkai Sun, Jianping Wang, Qi Sun, Fanni Li, Hengjun Gao, Lin Xu, Jiao Zhang, Xiaoyan Sun, Yanan Tian, Qiujie Zhao, Huimin Shen, Kai Zhang, Jun Liu
Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects
Hafidha Bentayeb, Marine Aitamer, Barbara Petit, Lydie Dubanet, Sabria Elderwish, Laurent Désaubry, Armand de Gramont, Eric Raymond, Agnès Olivrie, Julie Abraham, Marie-Odile Jauberteau, Danielle Troutaud
Correction to: Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer
Yuyuan Yao, Qinglong Guo, Yue Cao, Yangmin Qiu, Renxiang Tan, Zhou Yu, Yuxin Zhou, Na Lu
STRA6 exerts oncogenic role in gastric tumorigenesis by acting as a crucial target of miR-873
Linling Lin, Jian Xiao, Liang Shi, Wangwang Chen, Yugang Ge, Mingkun Jiang, Zengliang Li, Hao Fan, Li Yang, Zekuan Xu
Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma
Liling Jiang, Yuening Sun, Jinxiang Wang, Qingyan He, Xinmei Chen, Xiaoying Lan, Jinghong Chen, Q. Ping Dou, Xianping Shi, Jinbao Liu
Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma
Junbin Liao, Huilin Jin, Shaoqiang Li, Lixia Xu, Zhenwei Peng, Guangyan Wei, Jianting Long, Yu Guo, Ming Kuang, Qi Zhou, Sui Peng
The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal cancer procession through mediating sialylated c-Met via JAK2/STAT3 cascade
Bing Liu, Qianqian Liu, Shimeng Pan, Yiran Huang, Yu Qi, Shuangda Li, Yang Xiao, Li Jia
NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma
You Zou, Rui Yang, Mao-Ling Huang, Yong-Gang Kong, Jian-Fei Sheng, Ze-Zhang Tao, Ling Gao, Shi-Ming Chen
Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network
Yanhao Zhang, Xiuxing Jiang, Qin Deng, Ziyi Gao, Xiangyu Tang, Ruoqiu Fu, Jinjiao Hu, Yunong Li, Lirong Li, Ning Gao
Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms
Yusha Xiao, Rahmathullah Mohamed Najeeb, Dong Ma, Kang Yang, Qiu Zhong, Quanyan Liu
Targeting the Formyl Peptide Receptor type 1 to prevent the adhesion of ovarian cancer cells onto mesothelium and subsequent invasion
Michele Minopoli, Giovanni Botti, Vincenzo Gigantino, Concetta Ragone, Sabrina Sarno, Maria Letizia Motti, Giosuè Scognamiglio, Stefano Greggi, Cono Scaffa, Maria Serena Roca, Maria Patrizia Stoppelli, Gennaro Ciliberto, Nunzia Simona Losito, Maria Vincenza Carriero
Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer
Lihua Wang, Canwei Wang, Zheying Tao, Liqian Zhao, Zheng Zhu, Wencan Wu, Ye He, Hong Chen, Bin Zheng, Xiangjie Huang, Yun Yu, Linjun Yang, Guang Liang, Ri Cui, Tongke Chen
Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway
Yiwei Wang, Minghui Zhao, Sijia He, Yuntao Luo, Yucui Zhao, Jin Cheng, Yanping Gong, Jianzhu Xie, Yulan Wang, Binjie Hu, Ling Tian, Xinjian Liu, Chuanyuan Li, Qian Huang
Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer
Sehui Kim, Ji-Young Jang, Jaemoon Koh, Dohee Kwon, Young A. Kim, Jin Chul Paeng, Chan-Young Ock, Bhumsuk Keam, Miso Kim, Tae Min Kim, Dae Seog Heo, Doo Hyun Chung, Yoon Kyung Jeon
PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer
Xin Jin, Rui Fang, Ping Fan, Lipeng Zeng, Bin Zhang, Xiaoming Lu, Tao Liu
Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies
Denisa Baci, Antonino Bruno, Caterina Cascini, Matteo Gallazzi, Lorenzo Mortara, Fausto Sessa, Giuseppe Pelosi, Adriana Albini, Douglas M. Noonan
Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK/STAT signaling pathway by targeting STAT5 and STAT6
Li Jiang, Xu-Hai Zhao, Yin-Ling Mao, Jun-Feng Wang, Hui-Jun Zheng, Qing-Shan You
Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma
Yan Chen, Zhonghu Li, Mengyun Zhang, Bo Wang, Jiaxin Ye, Yang Zhang, Di Tang, Dandan Ma, Weidong Jin, Xiaowu Li, Shuguang Wang
CRISPR/Cas9-mediated knockout of NSD1 suppresses the hepatocellular carcinoma development via the NSD1/H3/Wnt10b signaling pathway
Shuhua Zhang, Fan Zhang, Qing Chen, Chidan Wan, Jun Xiong, Jianqun Xu
USP7 is a novel Deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis
Yuchong Peng, Youhong Liu, Yingxue Gao, Bowen Yuan, Xuli Qi, Yuxin Fu, Qianling Zhu, Tuoyu Cao, Songwei Zhang, Linglong Yin, Xiong Li
SIRT4 silencing in tumor-associated macrophages promotes HCC development via PPARδ signalling-mediated alternative activation of macrophages
Zhi Li, He Li, Zhi-Bo Zhao, Wei Zhu, Pan-Pan Feng, Xi-Wen Zhu, Jian-Ping Gong
Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway
Shan Lei, Zhiwei He, Tengxiang Chen, Xingjun Guo, Zhirui Zeng, Yiyi Shen, Jianxin Jiang
Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes
Shanshan Qi, Linjia Su, Jing Li, Chuanshan Zhang, Zhe Ma, Guiqiu Liu, Qing Zhang, Guhe Jia, Yongjun Piao, Sihe Zhang
Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth
Ouma Cisse, Muzthahid Quraishi, Federico Gulluni, Federica Guffanti, Ioanna Mavrommati, Methushaa Suthanthirakumaran, Lara C. R. Oh, Jessica N. Schlatter, Ambisha Sarvananthan, Massimo Broggini, Emilio Hirsch, Marco Falasca, Tania Maffucci
Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1
Yujun Tang, Yishi Lu, Yuan Chen, Lei Luo, Lei Cai, Bangjian Peng, Wenbin Huang, Hangyu Liao, Liang Zhao, Mingxin Pan
DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation
Ssu-Chuan Lai, Yu-Ting Su, Ching-Chi Chi, Yung-Che Kuo, Kam-Fai Lee, Yu-Chih Wu, Pei-Chi Lan, Muh-Hwa Yang, Te-Sheng Chang, Yen-Hua Huang
RETRACTED ARTICLE: Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Beta-catenin/FOXG1 complex
Xingrong Zheng, Jiaxin Lin, Hewei Wu, Zhishuo Mo, Yunwen Lian, Peipei Wang, Zhaoxia Hu, Zhiliang Gao, Liang Peng, Chan Xie
MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway
Jian-Hui Li, Xiao-Xu Zhu, Fu-Xi Li, Chen-Song Huang, Xi-Tai Huang, Jie-Qin Wang, Zhuo-Xing Gao, Shi-Jin Li, Qiong-Cong Xu, Wei Zhao, Xiao-Yu Yin
Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis
Zhirong Li, Xuebo Qin, Wei Bian, Yishuai Li, Baoen Shan, Zhimeng Yao, Shujun Li
RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer
Mingxia Yan, Lei Sun, Jing Li, Huajian Yu, Hechun Lin, Tao Yu, Fangyu Zhao, Miaoxin Zhu, Lei Liu, Qin Geng, Hanwei Kong, Hongyu Pan, Ming Yao
Inhibition of lung cancer growth and metastasis by DHA and its metabolite, RvD1, through miR-138-5p/FOXC1 pathway
Xiaoming Bai, Jiaofang Shao, Sujin Zhou, Zhenggang Zhao, Fanghong Li, Rong Xiang, Allan Z. Zhao, Jinshun Pan
Correction to: Viral integration drives multifocal HCC during the occult HBV infection
Xiao-Ping Chen, Xin Long, Wen-long Jia, Han-Jie Wu, Jing Zhao, Hui-Fang Liang, Arian Laurence, Jun Zhu, Dong Dong, Yan Chen, Long Lin, Yu-Dong Xia, Wei-Yang Li, Gui-Bo Li, Zhi-Kun Zhao, Kui Wu, Yong Hou, Jing-Jing Yu, Wei Xiao, Guo-Ping Wang, Peng-Cheng Zhu, Wei Chen, Ming-Zhou Bai, Yi-Xing Jian, Karsten Kristiansen, Qian Chen
Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties
Jiahui Si, Yuanyuan Ma, Ji Wang Bi, Ying Xiong, Chao Lv, Shaolei Li, Nan Wu, Yue Yang
Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma
Lucia Cappabianca, Antonietta Rosella Farina, Lucia Di Marcotullio, Paola Infante, Daniele De Simone, Michela Sebastiano, Andrew Reay Mackay
NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2
Pengfei Xu, Shuangyan Ye, Keyi Li, Mengqiu Huang, Qianli Wang, Sisi Zeng, Xi Chen, Wenwen Gao, Jianping Chen, Qianbing Zhang, Zhuo Zhong, Ying Lin, Zhili Rong, Yang Xu, Bingtao Hao, Anghui Peng, Manzhao Ouyang, Qiuzhen Liu
PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited by metformin
Won Jung Bae, Ji Mi Ahn, Hye Eun Byeon, Seokwhi Kim, Dakeun Lee
Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway
Dianyun Ren, Jingyuan Zhao, Yan Sun, Dan Li, Zibo Meng, Bo Wang, Ping Fan, Zhiqiang Liu, Xin Jin, Heshui Wu
Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression
Haiyang Xu, Guifang Zhao, Yu Zhang, Hong Jiang, Weiyao Wang, Donghai Zhao, Hongquan Yu, Ling Qi
Arsenic sulfide induces RAG1-dependent DNA damage for cell killing by inhibiting NFATc3 in gastric cancer cells
Ting Kang, Maolin Ge, Ruiheng Wang, Zhen Tan, Xiuli Zhang, Chuanying Zhu, Han Liu, Siyu Chen
miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells
Yongjun Luo, Wei Liu, Pengyu Tang, Dongdong Jiang, Changjiang Gu, Yumin Huang, Fangyi Gong, Yuluo Rong, Dingfei Qian, Jian Chen, Zheng Zhou, Shujie Zhao, Jiaxing Wang, Tao Xu, Yongzhong Wei, Guoyong Yin, Jin Fan, Weihua Cai
N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21
Sen Zhang, Chaoran Yu, Xiao Yang, Hiju Hong, Jiaoyang Lu, Wenjun Hu, Xiaohui Hao, Shuchun Li, Batuer Aikemu, Guang Yang, Zirui He, Luyang Zhang, Pei Xue, Zhenghao Cai, Junjun Ma, Lu Zang, Bo Feng, Fei Yuan, Jing Sun, Minhua Zheng
Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects
Muhamad Noor Alfarizal Kamarudin, Md. Moklesur Rahman Sarker, Jin-Rong Zhou, Ishwar Parhar
Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression
S. Napolitano, N. Matrone, A. L. Muddassir, G. Martini, A. Sorokin, V. De Falco, E. F. Giunta, D. Ciardiello, E. Martinelli, V. Belli, M. Furia, S. Kopetz, F. Morgillo, F. Ciardiello, T. Troiani
Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle
Ruixue Huang, Jing Xiang, Pingkun Zhou
RETRACTED ARTICLE: MicroRNA-338-3p suppresses ovarian cancer cells growth and metastasis: implication of Wnt/catenin beta and MEK/ERK signaling pathways
Ruitao Zhang, Huirong Shi, Fang Ren, Wei Feng, Yuan Cao, Gailing Li, Zheying Liu, Pengcheng Ji, Minghui Zhang
Human bone marrow mesenchymal stem cells-derived microRNA-205-containing exosomes impede the progression of prostate cancer through suppression of RHPN2
Shuangjian Jiang, Chengqiang Mo, Shengjie Guo, Jintao Zhuang, Bin Huang, Xiaopeng Mao
Correction to: Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid
Mineko Terao, Laura Goracci, Valentina Celestini, Mami Kurosaki, Marco Bolis, Alessandra Di Veroli, Arianna Vallerga, Maddalena Fratelli, Monica Lupi, Alessandro Corbelli, Fabio Fiordaliso, Maurizio Gianni, Gabriela Paroni, Adriana Zanetti, Gabriele Cruciani, Enrico Garattini
Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway
Xiaodong Xu, Yan Yu, Ke Zong, Pengwei Lv, Yuantin Gu
MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2
Yi Ding, Jie Yang, Yawen Ma, Tengteng Yao, Xingyu Chen, Shengfang Ge, Lihua Wang, Xianqun Fan
Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
Jayarani F. Putri, Priyanshu Bhargava, Jaspreet Kaur Dhanjal, Tomoko Yaguchi, Durai Sundar, Sunil C. Kaul, Renu Wadhwa
Correction to: LncMAPK6 drives MAPK6 expression and liver TIC self-renewal
Guanqun Huang, Hui Jiang, Yueming He, Ye Lin, Wuzheng Xia, Yuanwei Luo, Min Liang, Boyun Shi, Xinke Zhou, Zhixiang Jian
Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy
Lujuan Han, Suli Dai, Zhirong Li, Cong Zhang, Sisi Wei, Ruinian Zhao, Hongtao Zhang, Lianmei Zhao, Baoen Shan
HOXC-AS1-MYC regulatory loop contributes to the growth and metastasis in gastric cancer
Yangyang Dong, Xinyu Li, Zhibin Lin, Wenbing Zou, Yan Liu, Huiyang Qian, Jing Jia
ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity
Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi
Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway
Xiju Wang, Ronghua Wang, Shuya Bai, Si Xiong, Yawen Li, Man Liu, Zhenxiong Zhao, Yun Wang, Yuchong Zhao, Wei Chen, Timothy R. Billiar, Bin Cheng
CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis
Chenyu Ding, Zanyi Wu, Honghai You, Hongliang Ge, Shufa Zheng, Yuanxiang Lin, Xiyue Wu, Zhangya Lin, Dezhi Kang