Let’s functionalize the myocardial flow reserve

Heinrich R. Schelbert

A quick glance at selected topics in this issue

Pradeep Bhambhvani, Fadi G. Hage, Ami E. Iskandrian

Timing is everything

Ami E. Iskandrian

Cardiovascular disease in the literature: A selection of recent original research papers

Fadi G. Hage, Wael AlJaroudi

Nuclear cardiology in the literature: A selection of recent, original research papers

Vasvi Singh, Saurabh Malhotra

What is this image? 2021: image 4

What is this image? 2021 image 3 result

Yuhua Yang, Yiling Wang, Juyi Lin, Lisha Liu, Shengcai Huang

Daniel S. Berman, MD, born on July 15, 1944

Heinrich R. Schelbert

An optimized imaging protocol for [99mTc]Tc-DPD scintigraphy and SPECT/CT quantification in cardiac transthyretin (ATTR) amyloidosis

Imke Schatka, Anne Bingel, Franziska Schau, Stephanie Bluemel, Daniel R. Messroghli, David Frumkin, Fabian Knebel, Sonja M. Diekmann, Ahmed Elsanhoury, Carsten Tschöpe, Katrin Hahn, Holger Amthauer, Julian M. M. Rogasch, Christoph Wetz

Optimizing 99mTc-DPD scintigraphy: Adding value to the diagnosis and treatment of cardiac transthyretin amyloidosis

Jan Stassen, Pieter van der Bijl, Jeroen J. Bax

New insights for early assessment of cardiac involvement in Anderson-Fabry disease

Alberto Cuocolo, Carmela Nappi, Valeria Gaudieri, Antonio Pisani, Massimo Imbriaco

Avijit (Tultul) Lahiri (1948–2021): A friend, mentor and inspiration to all!

Jeffrey Leppo, Prem Soman, Barry L. Zaret

Imaging inflammation in atherosclerotic plaques, targeting SST2 with [111In]In-DOTA-JR11

Eric J. Meester, Boudewijn J. Krenning, Erik de Blois, Marion de Jong, Antonius F. W. van der Steen, Monique R. Bernsen, Kim van der Heiden

Imaging inflammation in atherosclerosis: Exploring all avenues

Ahmed Haider, Susan Bengs, Catherine Gebhard

Reduced acquisition times for measurement of myocardial blood flow with 99mTc-tetrofosmin and solid-state detector SPECT

Jeffrey Do, Terrence D. Ruddy, R. Glenn Wells

Dynamic ultrafast CZT imaging: Time for a paradigm change in myocardial perfusion imaging

Riccardo Liga, Alessia Gimelli

Hypermetabolism of the spleen or bone marrow is an additional albeit indirect sign of infective endocarditis at FDG-PET

Caroline Boursier, Xavier Duval, Besma Mahida, Bruno Hoen, François Goehringer, Christine Selton-Suty, Elodie Chevalier, Véronique Roch, Zohra Lamiral, Aurélie Bourdon, Nicolas Piriou, Amandine Pallardy, Olivier Morel, François Rouzet, Pierre-Yves Marie

FDG uptake in marrow and spleen: What does it mean?

Asbjørn M. Scholtens, Hein J. Verberne

Incremental value of myocardial wall motion and thickening to perfusion alone by gated SPECT myocardial perfusion imaging for viability assessment in patients with ischemic heart failure

Feifei Zhang, Jianfeng Wang, Xiaoliang Shao, Minfu Yang, Yongxiang Qian, Xiaoyu Yang, Zhifang Wu, Sijin Li, Wenchong Xin, Yunmei Shi, Bao Liu, Wenji Yu, Zhuo He, Weihua Zhou, Yuetao Wang

How viable is SPECT for viability assessment in the PET era?

Pavithra S. Jayadeva, Nathan Better

Impact of attenuation correction for CZT-SPECT measurement of myocardial blood flow

Matthieu Bailly, Frédérique Thibault, Maxime Courtehoux, Gilles Metrard, Maria Joao Ribeiro

The utility of heart-to-mediastinum ratio using a planar image created from IQ-SPECT with Iodine-123 meta-iodobenzylguanidine

Takayuki Shibutani, Kenichi Nakajima, Hiroto Yoneyama, Takahiro Konishi, Koichi Okuda, Masahisa Onoguchi, Seigo Kinuya

The 123I-mIBG heart/mediastinum ratio: Moving from 2D to 3D imaging

Giuseppe De Vincentis, Viviana Frantellizzi

Anxiety and hemodynamic reactivity during cardiac stress testing: The role of gender and age in myocardial ischemia

Maria T. Bekendam, Paula M. C. Mommersteeg, Willem J. Kop, Jos W. Widdershoven, Ilse A. C. Vermeltfoort

Anxiety as a risk factor in coronary artery disease among young women

Sang-Geon Cho, Hyung Yoon Kim, Hee-Seung Bom

The indications and utility of adjunctive imaging modalities for chronic total occlusion (CTO) intervention

Usaid K. Allahwala, Emmanouil S. Brilakis, Hosen Kiat, Sally Ayesa, Daniel Nour, Michael Ward, Sidney Lo, James C. Weaver, Ravinay Bhindi

Imaging in CTO: Should you look before you open?

C. Wiefels, R. S. B. Beanlands, A. Y. Chong

CME INSTRUCTIONS: Evaluation of cardiac allograft vasculopathy by positron emission tomography

Evaluation of cardiac allograft vasculopathy by positron emission tomography

Attila Feher, Albert J. Sinusas

Is faster always better? What is the implication of a shorter time to imaging with tetrofosmin compared to sestamibi?

Kelly Laipply, Myron Gerson

3D iterative reconstruction can do so much more than reduce dose

James A. Case

Preparation is everything: The impact of a structured preparation protocol on cardiac 18F-FDG PET imaging for cardiac sarcoidosis

Sanjay Divakaran, Michael T. Osborne

Beware! Some crucial information is left unattended on our myocardial perfusion scans!

Sylvain Prevost

Utility of diastolic dyssynchrony in the setting of cardiac resynchronization therapy

Marat Fudim, Salvador Borges-Neto

Development and feasibility of quantitative dynamic cardiac imaging for mice using μSPECT

M. A. Guerraty, L. C. Johnson, E. Blankemeyer, D. J. Rader, S. C. Moore, S. D. Metzler

Microvascular function measurement in mice: From large to small

Ichiro Matsunari

Coronary artery calcium burden, carotid atherosclerotic plaque burden, and myocardial blood flow in patients with end-stage renal disease: A non-invasive imaging study combining PET/CT and 3D ultrasound

Christian Wenning, Alexis Vrachimis, Hermann-Joseph Pavenstädt, Stefan Reuter, Michael Schäfers

Choosing between anatomy and function is not always evident for the heart of end-stage renal disease patients. How low can we go?

Amalia Peix

Relationship between heart rate response and cardiac innervation in patients with suspected or known coronary artery disease

Carmela Nappi, Roberta Assante, Emilia Zampella, Valeria Gaudieri, Giovanni De Simini, Alessia Giordano, Adriana D’Antonio, Wanda Acampa, Mario Petretta, Alberto Cuocolo

Heart rate response to vasodilator stress: A potential new application for a proven prognostic parameter

Christopher L. Schumann, Jamieson M. Bourque

99mTc-3SPboroxime: A neutral 99mTc(III) radiotracer with high heart uptake and long myocardial retention

Xiao-Ying Xi, Lei Wang, Bailing Hsu, Zuo-Quan Zhao, Shuang Liu, Wei Fang

99mTc-labeled boronic acid derivatives for SPECT myocardial perfusion imaging: Improved version 2.0

Raymond Taillefer

Determinants of 18F-NaF uptake in femoral arteries in patients with type 2 diabetes mellitus

Richard A. P. Takx, Ruth van Asperen, Jonas W. Bartstra, Sabine R. Zwakenberg, Jelmer M. Wolterink, Csilla Celeng, Pim A. de Jong, Joline W. Beulens

18F-sodium fluoride: An emerging tracer to assess active vascular microcalcification

William Y. Raynor, Austin J. Borja, Chaitanya Rojulpote, Poul Flemming Høilund-Carlsen, Abass Alavi

Site qualification and clinical interpretation standards for 99mTc-SPECT perfusion imaging in a multi-center study of MITNEC (Medical Imaging Trials Network of Canada)

Jennifer M. Renaud, Manuja Premaratne, Marie-Claude Villeneuve, Vincent Finnerty, Francois Harel, Therèse Heinonen, Jean-Claude Tardif, Terrence D. Ruddy, Robert A. deKemp

ISCHEMIA questions and MITNEC answers: Defining and standardizing clinical ischemic jeopardy with SPECT myocardial perfusion imaging

Erin M. Armenia, Ronald G. Schwartz

Cardiac SPECT radiomic features repeatability and reproducibility: A multi-scanner phantom study

Mohammad Edalat-Javid, Isaac Shiri, Ghasem Hajianfar, Hamid Abdollahi, Hossein Arabi, Niki Oveisi, Mohammad Javadian, Mojtaba Shamsaei Zafarghandi, Hadi Malek, Ahmad Bitarafan-Rajabi, Mehrdad Oveisi, Habib Zaidi

Reproducible Quantification of Regional Sympathetic Denervation with [11C]meta-Hydroxyephedrine PET Imaging

Jean Z. Wang, Jonathan B. Moody, Nicole Kaps, Deron Britt, Aaryn Lavallee, Jennifer M. Renaud, Jason G. E. Zelt, Kai Yi Wu, Rob S. Beanlands, James A. Fallavollita, John M. Canty, Robert A. deKemp

Cardiac software repeatability beyond correlations: Clinical outcomes matter

H. J. Harms, M. Lubberink

Standard SPECT myocardial perfusion estimation from half-time acquisitions using deep convolutional residual neural networks

Isaac Shiri, Kiarash AmirMozafari Sabet, Hossein Arabi, Mozhgan Pourkeshavarz, Behnoosh Teimourian, Mohammad Reza Ay, Habib Zaidi

Deep learning, another important tool for improving acquisition efficiency in SPECT MPI Imaging

Ernest V. Garcia

Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodeling and decreased event-free survival in heart failure patients

Ali Ahmadi, Jennifer M. Renaud, Steven Promislow, Ian G. Burwash, Girish Dwivedi, Ran Klein, Jason G. E. Zelt, Robert A. deKemp, Rob S. Beanlands, Lisa M. Mielniczuk

Hello from the other side: Molecular imaging of the right ventricle

Jens Sörensen

The prognostic value of regadenoson SPECT myocardial perfusion imaging: The largest cohort to date

Ajoe John Kattoor, Ahmed A. Kolkailah, Fady Iskander, Mina Iskander, Lisa Diep, Rozi Khan, Rami Doukky

The evolution of the prognostic value of regadenoson SPECT myocardial perfusion imaging

Gursukhmandeep S. Sidhu, Robert C. Hendel

Preserved myocardial viability in patients with chronic total occlusion of a single coronary artery

Xiao-Xin Sun, Shuheng Li, Wei Fang, Yue-Qin Tian, Rui Shen, Hongxing Wei, Zuo-Xiang He

Is what you see what you get?

M. H. Stewart

Quantification of myocardial perfusion reserve by CZT-SPECT: A head to head comparison with 82Rubidium PET imaging

Wanda Acampa, Emilia Zampella, Roberta Assante, Andrea Genova, Giovanni De Simini, Teresa Mannarino, Adriana D’Antonio, Valeria Gaudieri, Carmela Nappi, Pietro Buongiorno, Ciro Gabriele Mainolfi, Mario Petretta, Alberto Cuocolo

SPECT quantification of myocardial blood flow: Another step toward widespread availability

Marie A. Guerraty, Scott D. Metzler, Paco E. Bravo

Estimation of prevalence of transthyretin (ATTR) cardiac amyloidosis in an Australian subpopulation using bone scans with echocardiography and clinical correlation

Claire Cuscaden, Stuart C. Ramsay, Sandhir Prasad, Bruce Goodwin, Jye Smith

Wild-type transthyretin cardiac amyloidosis: When is a rare disease no longer a rare disease?

Kshama Wechalekar, Ashutosh D. Wechalekar

Test–retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers

Christina Byrne, Andreas Kjaer, Naja Enevold Olsen, Julie Lyng Forman, Philip Hasbak

More evidence for adequate test–retest repeatability of myocardial blood flow quantification with 82Rb PET/CT

Robert A. deKemp, Emel Celiker Guler, Terrence D. Ruddy

Prognostic value of coronary risk factors, exercise capacity and single photon emission computed tomography in liver transplantation candidates: A 5-year follow-up study

William E. Moody, Benjamin Holloway, Parthiban Arumugam, Sharon Gill, Yasmin S. Wahid, Chris M. Boivin, Louise E. Thomson, Daniel S. Berman, Matthew J. Armstrong, James Ferguson, Richard P. Steeds

SPECT-MPI in evaluation of liver transplant candidates: Is the evidence mounting?

Javier Gomez

Stress myocardial perfusion imaging in patients presenting with syncope: Comparison of PET vs. SPECT

Merrill Thomas, Krishna K. Patel, Poghni Peri-Okonny, Brett W. Sperry, A. Iain McGhie, Firas Al Badarin, Ibrahim M. Saeed, Kevin F. Kennedy, Paul Chan, John A. Spertus, Randall C. Thompson, Timothy M. Bateman

Is cardiac nuclear imaging helpful for the faint of heart?

Todd D. Miller, J. Wells Askew, Win-Kuang Shen

To what extent are perfusion defects seen by myocardial perfusion SPECT in patients with left bundle branch block related to myocardial infarction, ECG characteristics, and myocardial wall motion?

Fredrik Hedeer, Ellen Ostenfeld, Bo Hedén, Frits W. Prinzen, Håkan Arheden, Marcus Carlsson, Henrik Engblom

Elucidating the pathophysiology of left bundle branch block related perfusion defects

Yuka Otaki, Robert J. H. Miller, Piotr J. Slomka

CZT camera systems may provide better risk stratification for low-risk patients

Robert J. H. Miller, Donghee Han, Alan Rozanski, Heidi Gransar, John D. Friedman, Sean Hayes, Louise Thomson, Balaji Tamarappoo, Piotr J. Slomka, Daniel S. Berman

Advanced technology in the risk stratification-based strategy: The way forward to keep going

Roberta Assante, Emilia Zampella, Wanda Acampa

Initial experience regarding the safety and yield of rest-stress myocardial perfusion imaging in emergency department patients with mildly abnormal high-sensitivity cardiac troponins

Arooj Khan, Rakesh Engineer, Sihe Wang, Wael A. Jaber, Venu Menon, Paul C. Cremer

Observations from stress testing in the troponin twilight zone

Michael C. Kontos, Todd C. Villines

Variation in additional testing and patient outcomes after stress echocardiography or myocardial perfusion imaging, according to accreditation status of testing site

Jay N. Shah, Kimberly M. Murray, F. L. Lucas, Kathleen M. Fairfield, Mylan C. Cohen

Evaluation of the impact of laboratory accreditation on downstream outcomes

Daniel Shpilsky, Matthew E. Harinstein

Molecular imaging of cardiac CXCR4 expression in a mouse model of acute myocardial infarction using a novel 68Ga-mCXCL12 PET tracer

Mathias Johannes Zacherl, Andrei Todica, Carmen Wängler, Ralf Schirrmacher, Mohammad Ali Hajebrahimi, Joachim Pircher, Xiang Li, Simon Lindner, Matthias Brendel, Peter Bartenstein, Steffen Massberg, Stefan Brunner, Sebastian Lehner, Marcus Hacker, Bruno C. Huber

Coronary vasomotor dysfunction in cancer survivors treated with thoracic irradiation

John D. Groarke, Sanjay Divakaran, Anju Nohria, Joseph H. Killoran, Sharmila Dorbala, Ruth M. Dunne, Jon Hainer, Viviany R. Taqueti, Ron Blankstein, Harvey J. Mamon, Marcelo F. Di Carli

Cardiac dysfunction in cancer survivors after thoracic irradiation: A necessary evil?

K. Carlos El-Tallawi, Talal Alnabelsi, Mouaz H. Al-Mallah

18F-FDG positron emission tomography/computed tomography of cardiac implantable electronic device infections

Soile Pauliina Salomäki, Antti Saraste, Jukka Kemppainen, Saija Hurme, Juhani Knuuti, Pirjo Nuutila, Marko Seppänen, Anne Roivainen, Juhani Airaksinen, Tiina Salo, Jarmo Oksi, Laura Pirilä, Ulla Hohenthal

Emergence of 18F-FDG positron emission tomography in the detection and characterization of cardiac implantable device infections

Thomas H. Schindler, Gabriel Felder

Myocardial blood flow reserve and absolute myocardial blood flow for the assessment of patients with coronary artery disease with or without microvascular dysfunction

Raffaele Giubbini, Elisabetta Cerudelli, Luca Camoni

Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease

Hanna Hämäläinen, Alisa Corovai, Jussi Laitinen, Tiina M. Laitinen, Marja Hedman, Antti Hedman, Antti Kivelä, Tomi P. Laitinen

Left ventricular mechanical dyssynchrony in patient with CAD: The Saga continues

Wael AlJaroudi

Prognostic value of myocardial perfusion imaging with D-SPECT camera in patients with ischemia and no obstructive coronary artery disease (INOCA)

Lu Liu, Fuad A. Abdu, Guoqing Yin, Bin Xu, Abdul-Quddus Mohammed, Siling Xu, Xian Lv, Yanru Luo, Lu Zu, Changrui Yang, Ziyi Zhang, Yuxiao Zhou, Haidong Cai, Zhongwei Lv, Yawei Xu, Wenliang Che

Can myocardial perfusion imaging predict outcome in patients with angina and ischemia but no obstructive coronary artery disease (INOCA)?

Tali Sharir, Boris Brodkin

Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18F- sodium fluoride PET/CT

Leila S. Arani, Mahdi Zirakchian Zadeh, Babak Saboury, Mona-Elisabeth Revheim, Brian Øestergaard, Austin J. Borja, Davoud Samadi Samarin, Siavash Mehdizadeh Seraj, Eman Kalbush, Cyrus Ayubcha, Michael A. Morris, Tom J. Werner, Niels Abildgaard, Poul F. Høilund-Carlsen, Abass Alavi

(18)F-sodium fluoride PET in multiple myeloma: Linking cancer to atherosclerosis?

Dominik C. Benz, Ronny R. Buechel, Sharmila Dorbala

18F-Sodium fluoride uptake is associated with severity of atherosclerotic stenosis in stable ischemic heart disease

Artineh Hayrapetian, Gholam R. Berenji, Kim-Lien Nguyen, Yuxin Li

Narrowing in on a PET tracer that characterizes coronary atheroma: 18F-NaF uptake is increased in stenotic coronary artery disease

Michael T. Osborne, Taimur A. Abbasi, Mazen S. Albaghdadi

Evaluation of the diagnostic value of joint PET myocardial perfusion and metabolic imaging for vascular stenosis in patients with obstructive coronary artery disease

Fanghu Wang, Weiping Xu, Wenbing Lv, Dongyang Du, Hui Feng, Xiaochun Zhang, Shuxia Wang, Wufan Chen, Lijun Lu

Value of combined perfusion and metabolic tracers versus stress–rest perfusion imaging for coronary heart disease

Kenichi Nakajima, Hiroshi Wakabayashi

18F-FDG PET/CT detected recurrent renal cell carcinoma presenting with cardiac metastasis

Jiahua Cao, Yuhua Yang

Mycotic coronary aneurysm detected by 18F-FDG PET/CT: A case report

Sara Pacella

Integration of ischemia localization and cardiac catheterization findings into the management algorithm

P. S. Jayadeva, D. Sivaratnam, N. Better

18F-FDG PET/CT in the diagnosis of cardiac device-related infective endocarditis

André Azul Freitas, Luis Elvas, Rodolfo Silva, Lino Gonçalves, Maria João Ferreira

Prominent aortic radiotracer activity on equilibrium radionuclide ventriculography (ERNV) due to anterior transposition of aorta: A clue to diagnosing levo-transposition of great arteries (L-TGA) ?

Anwin Joseph Kavanal, Harpreet Singh, Prashant Panda, Jyothi Vijay, Madan Parmar, Bhagwant Rai Mittal

Multi-modality imaging of inflammation and ischemia for assessment of myocardial injury in Covid-19

Abbas Yousefi-Koma, Farah Naghashzadeh, Gemma A. Figtree, Sanjay Patel, Keyvan Karimi Galougahi

The often-overlooked elements of #PatientFirst imaging: Focus on optimal quality, including up-to-date protocols and equipment

Randall C. Thompson