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Journal of Translational Medicine

Ausgabe 1/2014

Inhalt (354 Artikel)

Open Access Research

XB130 promotes proliferation and invasion of gastric cancer cells

Min Shi, Dayong Zheng, Li Sun, Lin Wang, Li Lin, Yajun Wu, Minyu Zhou, Wenjun Liao, Yulin Liao, Qiang Zuo, Wangjun Liao

Open Access Research

Metabolic phenotypes in primary unknown metastatic carcinoma

Hye Min Kim, Do Hee Kim, Woo Hee Jung, Ja Seung Koo

Open Access Research

Methods and matrices: approaches to identifying miRNAs for Nasopharyngeal carcinoma

Jordan L Plieskatt, Gabriel Rinaldi, Yanjung Feng, Paul H Levine, Samantha Easley, Elizabeth Martinez, Salman Hashmi, Nader Sadeghi, Paul J Brindley, Jeffrey M Bethony, Jason P Mulvenna

Open Access Research

Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice

Yue Shen, Yongzhi Guo, Malgorzata Wilczynska, Jinan Li, Sten Hellström, Tor Ny

Open Access Review

Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer

Jiebai Zhou, Zhitu Zhu, Chunxue Bai, Hongzhi Sun, Xiangdong Wang

Open Access Research

The clinical significance of tumor-infiltrating neutrophils and neutrophil-to-CD8+ lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma

Jianbo Wang, Yibin Jia, Nana Wang, Xiaomei Zhang, Bingxu Tan, Guangyu Zhang, Yufeng Cheng

Open Access Research

Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation

Mahmood S Choudhery, Michael Badowski, Angela Muise, John Pierce, David T Harris

Open Access Research

Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma

Wenli Cui, Ying Cai, Weige Wang, Zebing Liu, Ping Wei, Rui Bi, Weixiang Chen, Menghong Sun, Xiaoyan Zhou

Open Access Research

Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200

Miharu Kobayashi, Carlos Salomon, Jorge Tapia, Sebastian E Illanes, Murray D Mitchell, Gregory E Rice

Open Access Research

Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs

Pengfei Jiang, Rajesh Mukthavavam, Ying Chao, Ila Sri Bharati, Valentina Fogal, Sandra Pastorino, Xiuli Cong, Natsuko Nomura, Matt Gallagher, Taher Abbasi, Shireen Vali, Sandeep C Pingle, Milan Makale, Santosh Kesari

Open Access Research

miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family

Feng Ye, Hailin Tang, Qing Liu, Xinhua Xie, Minqing Wu, Xiaoping Liu, Bo Chen, Xiaoming Xie

Open Access Review

The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors

Yu Gu, Tianxiang Chen, Elena López, Weizhu Wu, Xiangdong Wang, Jiang Cao, Lisong Teng

Open Access Research

An experimental model to investigate the targeting accuracy of MR-guided focused ultrasound ablation in liver

Lorena Petrusca, Magalie Viallon, Romain Breguet, Sylvain Terraz, Gibran Manasseh, Vincent Auboiroux, Thomas Goget, Loredana Baboi, Patrick Gross, K Michael Sekins, Christoph D Becker, Rares Salomir

Open Access Research

Clustered precursors in bone marrow sections predict early relapse in patients with acute myeloid leukemia within hematologic remission

Yehua Yu, Zhentian Wu, Jing Zhang, Yuanmei Zhai, Yinghua Yuan, Sihong Liu, Hui Wang, Jun Shi

Open Access Research

Prediction of individual immune responsiveness to a candidate vaccine by a systems vaccinology approach

Annacarmen Petrizzo, Maria Tagliamonte, Maria Lina Tornesello, Franco M Buonaguro, Luigi Buonaguro

Open Access Research

Gene expression pattern of Treg and TCR Vγ subfamily T cells before and after specific immunotherapy in allergic rhinitis

Rui Zheng, Xiuli Wu, Xuekun Huang, Yulian Chen, Qintai Yang, Yangqiu Li, Gehua Zhang

Open Access Research

Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B

Geoffrey L Rogers, Ashley T Martino, Irene Zolotukhin, Hildegund CJ Ertl, Roland W Herzog

Open Access Meeting report

Dry computational approaches for wet medical problems

Frank Emmert-Streib, Shu-Dong Zhang, Peter Hamilton

Open Access Research

Assessment of liver stiffness in patients with HCV and mixed cryoglobulinemia undergoing rituximab treatment

Cristina Stasi, Elisa Triboli, Umberto Arena, Teresa Urraro, Antonio Petrarca, Laura Gragnani, Giacomo Laffi, Anna Linda Zignego

Open Access Research

A four-marker signature of TNF-RII, TGF-α, TIMP-1 and CRP is prognostic of worse survival in high-risk surgically resected melanoma

Ahmad A Tarhini, Yan Lin, Oladapo Yeku, William A LaFramboise, Madeeha Ashraf, Cindy Sander, Sandra Lee, John M Kirkwood

Open Access Reviewer acknowledgement

Journal of Translational Medicine reviewer acknowledgement 2013

Francesco Marincola

Open Access Research

A group-mediated, home-based physical activity intervention for patients with peripheral artery disease: effects on social and psychological function

W Jack Rejeski, Bonnie Spring, Kathryn Domanchuk, Huimin Tao, Lu Tian, Lihui Zhao, Mary M McDermott

Open Access Protocol

Autologous mesenchymal stem cell therapy for progressive supranuclear palsy: translation into a phase I controlled, randomized clinical study

Rosaria Giordano, Margherita Canesi, Maurizio Isalberti, Ioannis Ugo Isaias, Tiziana Montemurro, Mariele Viganò, Elisa Montelatici, Valentina Boldrin, Riccardo Benti, Agostino Cortelezzi, Nicola Fracchiolla, Lorenza Lazzari, Gianni Pezzoli

Open Access Research

Tumor infiltrating B-cells are increased in prostate cancer tissue

Jason R Woo, Michael A Liss, Michelle T Muldong, Kerrin Palazzi, Amy Strasner, Massimo Ammirante, Nissi Varki, Ahmed Shabaik, Stephen Howell, Christopher J Kane, Michael Karin, Christina AM Jamieson

Open Access Research

Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot

Wei Sheng, Yanyan Qian, Ping Zhang, Yao Wu, Huijun Wang, Xiaojing Ma, Long Chen, Duan Ma, Guoying Huang

Open Access Research

MicroRNA-362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF-κB signaling

Jin-tang Xia, Lian-zhou Chen, Wei-hua Jian, Ke-Bing Wang, Yong-zhen Yang, Wei-ling He, Yu-long He, De Chen, Wen Li

Open Access Research

Pathogen-free, plasma-poor platelet lysate and expansion of human mesenchymal stem cells

Paola Iudicone, Daniela Fioravanti, Giuseppina Bonanno, Michelina Miceli, Claudio Lavorino, Pierangela Totta, Luigi Frati, Marianna Nuti, Luca Pierelli

Open Access Research

Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects

Laura Soldati, Simona Bertoli, Annalisa Terranegra, Caterina Brasacchio, Alessandra Mingione, Elena Dogliotti, Benedetta Raspini, Alessandro Leone, Francesca Frau, Laila Vignati, Angela Spadafranca, Giuseppe Vezzoli, Daniele Cusi, Alberto Battezzati

Open Access Research

Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension

Ananda T Dias, Bianca P Rodrigues, Marcella L Porto, Agata L Gava, Camille M Balarini, Flavia P S Freitas, Zaira Palomino, Dulce E Casarini, Bianca P Campagnaro, Thiago M C Pereira, Silvana S Meyrelles, Elisardo C Vasquez

Open Access Methodology

Establishing a rabbit model of malignant esophagostenosis using the endoscopic implantation technique for studies on stent innovation

Jin Huang, Jinquan Shuang, Guanyin Xiong, Xiang Wang, Yin Zhang, Xiaowei Tang, Zhining Fan, Yingzhou Shen, Hanming Song, Zhi Liu

Open Access Research

Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial

Sophie Le Lamer, Stéphanie Paradis, Hidayat Rahmouni, Corinne Chaimbault, Magali Michaud, Marcel Culcasi, Jean Afxantidis, Mathilde Latreille, Patrick Berna, Alain Berdeaux, Sylvia Pietri, Didier Morin, Yves Donazzolo, Jean-Louis Abitbol, Rebacca M Pruss, Sophie Schaller

Open Access Research

Body image and weight perceptions in relation to actual measurements by means of a new index and level of physical activity in Italian university students

Luciana Zaccagni, Sabrina Masotti, Roberta Donati, Gianni Mazzoni, Emanuela Gualdi-Russo

Open Access Research

Survivin-responsive conditionally replicating adenovirus kills rhabdomyosarcoma stem cells more efficiently than their progeny

Kiyonori Tanoue, Yuqing Wang, Minako Ikeda, Kaoru Mitsui, Rie Irie, Takao Setoguchi, Setsuro Komiya, Shoji Natsugoe, Ken-ichiro Kosai

Open Access Methodology

Rat model of veno-arterial extracorporeal membrane oxygenation

Ayyaz A Ali, Peter Downey, Gopal Singh, Wei Qi, Isaac George, Hiroo Takayama, Ajay Kirtane, Prakash Krishnan, Adrian Zalewski, Darren Freed, Stephen R Large, Euan A Ashley, Martin B Leon, Matthew Bacchetta, Ziad A Ali

Open Access Research

Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells

Martin Wilhelm, Manfred Smetak, Kerstin Schaefer-Eckart, Brigitte Kimmel, Josef Birkmann, Hermann Einsele, Volker Kunzmann

Open Access Research

Human papillomavirus 16 E2-, E6- and E7-specific T-cell responses in children and their mothers who developed incident cervical intraepithelial neoplasia during a 14-year follow-up of the Finnish Family HPV cohort

Hanna-Mari Koskimaa, Anna E Paaso, Marij JP Welters, Seija E Grénman, Kari J Syrjänen, Sjoerd H van der Burg, Stina M Syrjänen

Open Access Research

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor

Jason K Sicklick, Stephanie Y Leonard, Michele L Babicky, Chih-Min Tang, Evangeline S Mose, Randall P French, Dawn V Jaquish, Carl K Hoh, Michael Peterson, Richard Schwab, Andrew M Lowy

Open Access Research

The link between nutritional parameters and bone mineral density in women: results of a screening programme for osteoporosis

Theodora Lamprinoudi, Elisa Mazza, Yvelise Ferro, Simona Brogneri, Daniela Foti, Elio Gulletta, Maurizio Iocco, Carmine Gazzaruso, Stefano Romeo, Arturo Pujia, Tiziana Montalcini

Open Access Research

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

Alpha A Fowler III, Aamer A Syed, Shelley Knowlson, Robin Sculthorpe, Don Farthing, Christine DeWilde, Christine A Farthing, Terri L Larus, Erika Martin, Donald F Brophy, Seema Gupta, Bernard J Fisher, Ramesh Natarajan

Open Access Research

Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model

Zitong Zhao, Cheng Yang, Long Li, Tian Zhao, Lingyan Wang, Ruiming Rong, Bin Yang, Ming Xu, Tongyu Zhu

Open Access Research

Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients

Giuseppe Roscilli, Manuela Cappelletti, Claudia De Vitis, Gennaro Ciliberto, Arianna Di Napoli, Luigi Ruco, Rita Mancini, Luigi Aurisicchio

Open Access Research

Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling

Yu Ah Hong, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Eun Sil Koh, Seok Joon Shin, Bum Soon Choi, Cheol Whee Park, Yoon Sik Chang, Sungjin Chung

Open Access Research

Incomplete recovery of mechanical and endocrine left atrial functions one month after electrical cardioversion for persistent atrial fibrillation: a pilot study

Anne Bernard-Brunet, Christophe Saint Etienne, Eric Piver, Noura Zannad, Jean-Christophe Pagés, Laurent Fauchier, Dominique Babuty

Open Access Research

The immunological and clinical effects of mutated ras peptide vaccine in combination with IL-2, GM-CSF, or both in patients with solid tumors

Osama E Rahma, J Michael Hamilton, Malgorzata Wojtowicz, Omar Dakheel, Sarah Bernstein, David J Liewehr, Seth M Steinberg, Samir N Khleif

Open Access Research

Good manufacturing practice-compliant isolation and culture of human umbilical cord blood-derived mesenchymal stem cells

Phuc Van Pham, Ngoc Bich Vu, Vuong Minh Pham, Nhung Hai Truong, Truc Le-Buu Pham, Loan Thi-Tung Dang, Tam Thanh Nguyen, Anh Nguyen-Tu Bui, Ngoc Kim Phan

Open Access Research

Peripheral medulloepithelioma: a rare tumor with a potential target therapy

Maria Debora De Pasquale, Maria Antonietta De Ioris, Angela Gallo, Angela Mastronuzzi, Alessandro Crocoli, Raffaele Cozza, Renata Boldrini

Open Access Research

Epigenetic inactivation of mir-34b/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemia

Lu Qian Wang, Yok Lam Kwong, Kit Fai Wong, Chi Shan Bonnie Kho, Dong Yan Jin, Eric Tse, Anders Rosèn, Chor Sang Chim

Open Access Research

Potential therapeutic targets for hypoxia-induced pulmonary artery hypertension

Li Dong, Yuping Li, HongLing Hu, Lin Shi, Junjie Chen, Beibei Wang, Chaolei Chen, Haiping Zhu, Yunlei Li, Qiu Li, Liping Zhang, Chengshui Chen

Open Access Review

Time-restricted feeding and the realignment of biological rhythms: translational opportunities and challenges

Jag Sunderram, Stavroula Sofou, Kubra Kamisoglu, Vassiliki Karantza, Ioannis P Androulakis

Open Access Research

Liver myofibroblasts up-regulate monocyte CD163 expression via PGE2 during hepatitis B induced liver failure

Min Zhang, Yinong Ye, Fenglan Wang, Jianyun Zhu, Qiyi Zhao, Yubao Zheng, Yurong Gu, Chan Xie, Zhanlian Huang, Qiang Tai, Yutian Chong, Zhiliang Gao

Open Access Research

Phase I clinical trial of multiple-peptide vaccination for patients with advanced biliary tract cancer

Atsushi Aruga, Nobuhiro Takeshita, Yoshihito Kotera, Ryuji Okuyama, Norimasa Matsushita, Takehiro Ohta, Kazuyoshi Takeda, Masakazu Yamamoto

Open Access Research

Significance of red cell distribution width measurement for the patients with isolated coronary artery ectasia

Xiao-Lin Li, Li-Feng Hong, Yan-Jun Jia, Shao-Ping Nie, Yuan-Lin Guo, Rui-Xia Xu, Cheng-Gang Zhu, Li-Xin Jiang, Jian-Jun Li

Open Access Research

A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

Shoichi Hazama, Yusuke Nakamura, Hiroko Takenouchi, Nobuaki Suzuki, Ryouichi Tsunedomi, Yuka Inoue, Yoshihiro Tokuhisa, Norio Iizuka, Shigefumi Yoshino, Kazuyoshi Takeda, Hirokazu Shinozaki, Akira Kamiya, Hiroyuki Furukawa, Masaaki Oka

Open Access Research

Developing regional genetic counseling for southern Chinese with nonsyndromic hearing impairment: a unique mutational spectrum

Kaitian Chen, Ling Zong, Min Liu, Xianren Wang, Wei Zhou, Yuan Zhan, Hui Cao, Chang Dong, Haocheng Tang, Hongyan Jiang

Open Access Research

A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients’ plasma

Prasong Khaenam, Darawan Rinchai, Matthew C Altman, Laurent Chiche, Surachat Buddhisa, Chidchamai Kewcharoenwong, Duangchan Suwannasaen, Michael Mason, Elizabeth Whalen, Scott Presnell, Wattanachai Susaengrat, Kimberly O’Brien, Quynh-Ahn Nguyen, Vivian Gersuk, Peter S Linsley, Ganjana Lertmemongkolchai, Damien Chaussabel

Open Access Research

Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer

Wenyu Zhang, Jin Zang, Xinhua Jing, Zhandong Sun, Wenying Yan, Dongrong Yang, Feng Guo, Bairong Shen

Open Access Research

Existence of a potential neurogenic system in the adult human brain

Adriano Barreto Nogueira, Mari Cleide Sogayar, Alison Colquhoun, Sheila Aparecida Siqueira, Ariel Barreto Nogueira, Paulo Eurípedes Marchiori, Manoel Jacobsen Teixeira

Open Access Research

Expression and prognostic significance of the polymeric immunoglobulin receptor in esophageal and gastric adenocarcinoma

Richard Fristedt, Alexander Gaber, Charlotta Hedner, Björn Nodin, Mathias Uhlén, Jakob Eberhard, Karin Jirström

Open Access Research

Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients

Hisae Iinuma, Ryoji Fukushima, Tsuyoshi Inaba, Junko Tamura, Taisuke Inoue, Etsushi Ogawa, Masahiro Horikawa, Yoshibumi Ikeda, Noriyuki Matsutani, Kazuyoshi Takeda, Koji Yoshida, Takuya Tsunoda, Tadashi Ikeda, Yusuke Nakamura, Kota Okinaga

Open Access Research

Treatment of lipoid proteinosis due to the p.C220G mutation in ECM1, a major allele in Chinese patients

Rong Zhang, Yang Liu, Yang Xue, Yinan Wang, Xinwen Wang, Songtao Shi, Tao Cai, Qintao Wang

Open Access Review

Extracellular matrix production in vitro in cartilage tissue engineering

Jie-Lin Chen, Li Duan, Weimin Zhu, Jianyi Xiong, Daping Wang

Open Access Review

Role of estrogen in hepatocellular carcinoma: is inflammation the key?

Liang Shi, Yili Feng, Hui Lin, Rui Ma, Xiujun Cai

Open Access Research

Activities of cardiac tissue matrix metalloproteinases 2 and 9 are reduced by remote ischemic preconditioning in cardiosurgical patients with cardiopulmonary bypass

Karina Zitta, Patrick Meybohm, Berthold Bein, Matthias Gruenewald, Fabian Lauer, Markus Steinfath, Jochen Cremer, Kai Zacharowski, Martin Albrecht

Open Access Research

In vitro biosafety profile evaluation of multipotent mesenchymal stem cells derived from the bone marrow of sarcoma patients

Enrico Lucarelli, Chiara Bellotti, Melissa Mantelli, Maria Antonietta Avanzini, Rita Maccario, Francesca Novara, Giulia Arrigo, Orsetta Zuffardi, Monia Zuntini, Martina Pandolfi, Luca Sangiorgi, Daniela Lisini, Davide Donati, Serena Duchi

Open Access Research

On the inflammatory response in metal-on-metal implants

Ulrike Dapunt, Thomas Giese, Felix Lasitschka, Jörn Reinders, Burkhard Lehner, Jan Philippe Kretzer, Volker Ewerbeck, Gertrud Maria Hänsch

Open Access Research

Diet-induced increase in plasma oxidized LDL promotes early fibrosis in a renal porcine auto-transplantation model

Nicolas Chatauret, Frédéric Favreau, Sebastien Giraud, Antoine Thierry, Ludivine Rossard, Sylvain Le Pape, Lilach O Lerman, Thierry Hauet

Open Access Research

Infection risk in Rheumatoid Arthritis and Spondyloarthropathy patients under treatment with DMARDs, Corticosteroids and TNF-α antagonists

Valentina Germano, Maria Sofia Cattaruzza, John Osborn, Aurora Tarantino, Roberta Di Rosa, Simonetta Salemi, Raffaele D’Amelio

Open Access Research

Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma

Wei Kang, Joanna HM Tong, Anthony WH Chan, Junhong Zhao, Yujuan Dong, Shiyan Wang, Weiqin Yang, Frankie MC Sin, Simon SM Ng, Jun Yu, Alfred SL Cheng, Ka Fai To

Open Access Research

CD8/CD45RO T-cell infiltration in endoscopic biopsies of colorectal cancer predicts nodal metastasis and survival

Viktor H Koelzer, Alessandro Lugli, Heather Dawson, Marion Hädrich, Martin D Berger, Markus Borner, Makhmudbek Mallaev, José A Galván, Jennifer Amsler, Beat Schnüriger, Inti Zlobec, Daniel Inderbitzin

Open Access Research

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas

Li Zhenye, Li Chuzhong, Wu Youtu, Lan Xiaolei, Cao Lei, Hong Lichuan, Wang Hongyun, Wu Yonggang, Wang Fei, Zhang Yazhuo

Open Access Research

Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats

Kun Lu, Shuanshuan Xie, Shilong Han, Jidong Zhang, Xinwen Chang, Jin Chao, Qingqing Huang, Qing Yuan, Haiyan Lin, Lei Xu, Changxing Shen, Min Tan, Shen Qu, Changhui Wang, Xiaolian Song

Open Access Research

Thymidylate synthase polymorphisms in genomic DNA as clinical outcome predictors in a European population of advanced non-small cell lung cancer patients receiving pemetrexed

Estefanía Arévalo, Eduardo Castañón, Inés López, Josefa Salgado, Víctor Collado, Marta Santisteban, María Rodríguez-Ruiz, Patricia Martín, Leire Zubiri, Ana Patiño-García, Christian Rolfo, Ignacio Gil-Bazo

Open Access Research

Unraveling human protein interaction networks underlying co-occurrences of diseases and pathological conditions

Hyojung Paik, Hyoung-Sam Heo, Hyo-jeong Ban, Seong Beom Cho

Open Access Review

The role of quantitative mass spectrometry in the discovery of pancreatic cancer biomarkers for translational science

Daniel Ansari, Linus Aronsson, Agata Sasor, Charlotte Welinder, Melinda Rezeli, György Marko-Varga, Roland Andersson

Open Access Research

Up-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept

Claudia Kusmic, Cristina Barsanti, Marco Matteucci, Nicoletta Vesentini, Gualtiero Pelosi, Nader G Abraham, Antonio L’Abbate

Open Access Research

Macrophage migration inhibitory factor is overexpressed in pancreatic cancer tissues and impairs insulin secretion function of β-cell

Langping Tan, Xiao Ye, Yu Zhou, Min Yu, Zhiqiang Fu, Ruiwan Chen, Baoxiong Zhuang, Bing Zeng, Huilin Ye, Wenchao Gao, Qing Lin, Zhihua Li, Quanbo Zhou, Rufu Chen

Open Access Research

MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial

Emanuela Romano, Olivier Michielin, Verena Voelter, Julien Laurent, Hélène Bichat, Athina Stravodimou, Pedro Romero, Daniel E Speiser, Frédéric Triebel, Serge Leyvraz, Alexandre Harari

Open Access Research

Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats

Yan-Jun Jia, Rui-Xa Xu, Jing Sun, Yue Tang, Jian-Jun Li

Open Access Research

Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory t cells

Wei Ye, Yun Xing, Christopher Paustian, Rieneke van de Ven, Tarsem Moudgil, Traci L Hilton, Bernard A Fox, Walter J Urba, Wei Zhao, Hong-Ming Hu

Open Access Research

Alpha fetoprotein DNA prime and adenovirus boost immunization of two hepatocellular cancer patients

Lisa H Butterfield, James S Economou, T Clark Gamblin, David A Geller

Open Access Research

ShaoYao decoction ameliorates colitis-associated colorectal cancer by downregulating proinflammatory cytokines and promoting epithelial-mesenchymal transition

Xiaochang Lin, Zhiyong Yi, Jianxin Diao, Meng Shao, Liang Zhao, Hongbing Cai, Qin Fan, Xueqing Yao, Xuegang Sun

Open Access Research

Effects of intra-aortic balloon pump on cerebral blood flow during peripheral venoarterial extracorporeal membrane oxygenation support

Feng Yang, Zai-shen Jia, Jia-lin Xing, Zheng Wang, Yuan Liu, Xing Hao, Chun-jing Jiang, Hong Wang, Ming Jia, Xiao-tong Hou

Open Access Review

Immunocompetent murine models for the study of glioblastoma immunotherapy

Taemin Oh, Shayan Fakurnejad, Eli T Sayegh, Aaron J Clark, Michael E Ivan, Matthew Z Sun, Michael Safaee, Orin Bloch, Charles D James, Andrew T Parsa

Open Access Research

A phase ΙI study of five peptides combination with oxaliplatin-based chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study)

Shoichi Hazama, Yusuke Nakamura, Hiroaki Tanaka, Kosei Hirakawa, Ko Tahara, Ryoichi Shimizu, Hiroaki Ozasa, Ryuichi Etoh, Fumiaki Sugiura, Kiyotaka Okuno, Takumi Furuya, Taku Nishimura, Koichiro Sakata, Kazuhiko Yoshimatsu, Hiroko Takenouchi, Ryouichi Tsunedomi, Yuka Inoue, Shinsuke Kanekiyo, Yoshitaro Shindo, Nobuaki Suzuki, Shigefumi Yoshino, Hirokazu Shinozaki, Akira Kamiya, Hiroyuki Furukawa, Takeharu Yamanaka, Tomonobu Fujita, Yutaka Kawakami, Masaaki Oka

Open Access Research

Genetic variability of the core protein in hepatitis C virus genotype 4 in Saudi Arabian patients and its implication on pegylated interferon and ribavirin therapy

Fatimah S Alhamlan, Mohammed N Al-Ahdal, Nisreen Z Khalaf, Ayman A Abdo, Faisal M Sanai, Hamad I Al-Ashgar, Mahmoud ElHefnawi, Amina Zaid, Ahmed A Al-Qahtani

Open Access Research

Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma

Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura

Open Access Research

Phage idiotype vaccination: first phase I/II clinical trial in patients with multiple myeloma

Tim Roehnisch, Cornelia Then, Wolfgang Nagel, Christina Blumenthal, Todd Braciak, Mariel Donzeau, Thomas Böhm, Michael Flaig, Carole Bourquin, Fuat S Oduncu

Open Access Research

Prednisolone has a positive effect on the kidney but not on the liver of brain dead rats: a potencial role in complement activation

Rolando Rebolledo, Bo Liu, Mohammed Z Akhtar, Petra J Ottens, Jian-ning Zhang, Rutger J Ploeg, Henri GD Leuvenink

Open Access Research

microRNA-182 targets special AT-rich sequence-binding protein 2 to promote colorectal cancer proliferation and metastasis

Min-Hui Yang, Jiang Yu, Dong-Mei Jiang, Wen-Lu Li, Shuang Wang, Yan-Qing Ding

Open Access Research

Efficacy of a mesenchymal stem cell loaded surgical mesh for tendon repair in rats

Lew C Schon, Nicholas Gill, Margaret Thorpe, Joel Davis, Joshua Nadaud, Jooyoung Kim, Jeremy Molligan, Zijun Zhang

Open Access Research

Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer

Jianning Mao, Jon Ladd, Ekram Gad, Lauren Rastetter, Melissa M Johnson, Edmond Marzbani, Jennifer S Childs, Hailing Lu, Yushe Dang, Elizabeth Broussard, Sasha E Stanton, Sam M Hanash, Mary L Disis

Open Access Research

Discrepant alterations in main candidate genes among multiple primary melanomas

Maria Colombino, MariaCristina Sini, Amelia Lissia, Vincenzo De Giorgi, Ignazio Stanganelli, Fabrizio Ayala, Daniela Massi, Corrado Rubino, Antonella Manca, Panagiotis Paliogiannis, Susanna Rossari, Serena Magi, Laura Mazzoni, Gerardo Botti, Mariaelena Capone, Marco Palla, Paolo A Ascierto, Antonio Cossu, Giuseppe Palmieri

Open Access Review

Subsets of regulatory T cells and their roles in allergy

Huiyun Zhang, Hui Kong, Xiaoning Zeng, Lianyi Guo, Xiaoyun Sun, Shaoheng He

Open Access Research

Body composition and physical activity in Italian university students

Luciana Zaccagni, Davide Barbieri, Emanuela Gualdi-Russo

Open Access Review

Intravenous ascorbic acid as an adjuvant to interleukin-2 immunotherapy

Samuel C Wagner, Boris Markosian, Naseem Ajili, Brandon R Dolan, Andy J Kim, Doru T Alexandrescu, Constantin A Dasanu, Boris Minev, James Koropatnick, Francesco M Marincola, Neil H Riordan

Open Access Research

Intratumoral delivery of recombinant vaccinia virus encoding for ErbB2/Neu inhibits the growth of salivary gland carcinoma cells

Laura Masuelli, Massimo Fantini, Monica Benvenuto, Pamela Sacchetti, Maria Gabriella Giganti, Ilaria Tresoldi, Paolo Lido, Florigio Lista, Federica Cavallo, Patrizia Nanni, Jeffrey Schlom, Andrea Modesti, Roberto Bei

Open Access Research

In silico modeling predicts drug sensitivity of patient-derived cancer cells

Sandeep C Pingle, Zeba Sultana, Sandra Pastorino, Pengfei Jiang, Rajesh Mukthavaram, Ying Chao, Ila Sri Bharati, Natsuko Nomura, Milan Makale, Taher Abbasi, Shweta Kapoor, Ansu Kumar, Shahabuddin Usmani, Ashish Agrawal, Shireen Vali, Santosh Kesari

Open Access Research

Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort

Paolo A Ascierto, Ester Simeone, Vanna Chiarion Sileni, Jacopo Pigozzo, Michele Maio, Maresa Altomonte, Michele Del Vecchio, Lorenza Di Guardo, Paolo Marchetti, Ruggero Ridolfi, Francesco Cognetti, Alessandro Testori, Maria Grazia Bernengo, Michele Guida, Riccardo Marconcini, Mario Mandalà, Carolina Cimminiello, Gaetana Rinaldi, Massimo Aglietta, Paola Queirolo

Open Access Research

Characterization of monocarboxylate transporters (MCTs) expression in soft tissue sarcomas: distinct prognostic impact of MCT1 sub-cellular localization

Céline Pinheiro, Valter Penna, Filipa Morais-Santos, Lucas F Abrahão-Machado, Guilherme Ribeiro, Emílio C Curcelli, Marcus V Olivieri, Sandra Morini, Isabel Valença, Daniela Ribeiro, Fernando C Schmitt, Rui M Reis, Fátima Baltazar

Open Access Research

Repair of orbital bone defects in canines using grafts of enriched autologous bone marrow stromal cells

Yefei Wang, Xiaoping Bi, Huifang Zhou, Yuan Deng, Jing Sun, Caiwen Xiao, Ping Gu, Xianqun Fan

Open Access Research

A decrease in aquaporin 2 excretion is associated with bed rest induced high calciuria

Grazia Tamma, Annarita Di Mise, Marianna Ranieri, Maria Svelto, Rado Pisot, Giancarlo Bilancio, Pierpaolo Cavallo, Natale G De Santo, Massimo Cirillo, Giovanna Valenti

Open Access Commentary

What have we learned from cancer immunotherapy in the last 3 years?

Paolo A Ascierto, Francesco M Marincola

Open Access Review

Tickling the TLR7 to cure viral hepatitis

Emily Funk, Shyam Kottilil, Bruce Gilliam, Rohit Talwani

Open Access Research

Nerve growth factor improves functional recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis in rats with spinal cord injury

Hongyu Zhang, Fenzan Wu, Xiaoxia Kong, Jie Yang, Huijun Chen, Liancheng Deng, Yi Cheng, Libing Ye, Sipin Zhu, Xie Zhang, Zhouguang Wang, Hongxue Shi, Xiaobing Fu, Xiaokun Li, Huazi Xu, Li Lin, Jian Xiao

Open Access Research

Azithromycin is able to control Toxoplasma gondii infection in human villous explants

Letícia S Castro-Filice, Bellisa F Barbosa, Mariana B Angeloni, Neide M Silva, Angelica O Gomes, Celene M O S Alves, Deise A O Silva, Olindo A Martins-Filho, Maria C Santos, José R Mineo, Eloisa A V Ferro

Open Access Research

Biomarkers of early sepsis may be correlated with outcome

Tsai-Hsia Hong, Chin-Hao Chang, Wen-Je Ko, Ching-Feng Lin, Heng-Hsiu Liu, Lu-Ping Chow, Chun-Ta Huang, Sun-Liang Yu, Yih-Sharng Chen

Open Access Research

Synergic silencing of costimulatory molecules prevents cardiac allograft rejection

Xusheng Zhang, Yanling Liu, Guangfeng Zhang, Jun Shi, Xiao Zhang, Xiufen Zheng, Alex T Jiang, Zhu-Xu Zhang, Nathan Johnston, King Sun Siu, Ruiqi Chen, Dameng Lian, David Koos, Douglas Quan, Wei-Ping Min

Open Access Research

Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?

Audrey Mansuet-Lupo, Fouzia Zouiti, Marco Alifano, Anne Tallet, Marie-Christine Charpentier, Véronique Ducruit, Fabrice Devez, Fanny Lemaitre, Pierre Laurent-Puig, Diane Damotte, Hélène Blons

Open Access Research

An aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer

Ling Yao, Kai Li, Wenting Peng, Qiang Lin, Shan Li, Xin Hu, Xinmin Zheng, Zhiming Shao

Open Access Protocol

Cohort profile: Greifswald approach to individualized medicine (GANI_MED)

Hans J Grabe, Heinrich Assel, Thomas Bahls, Marcus Dörr, Karlhans Endlich, Nicole Endlich, Pia Erdmann, Ralf Ewert, Stephan B Felix, Beate Fiene, Tobias Fischer, Steffen Flessa, Nele Friedrich, Mariacarla Gadebusch-Bondio, Manuela Gesell Salazar, Elke Hammer, Robin Haring, Christoph Havemann, Michael Hecker, Wolfgang Hoffmann, Birte Holtfreter, Tim Kacprowski, Kathleen Klein, Thomas Kocher, Holger Kock, Janina Krafczyk, Jana Kuhn, Martin Langanke, Uwe Lendeckel, Markus M Lerch, Wolfgang Lieb, Roberto Lorbeer, Julia Mayerle, Konrad Meissner, Henriette Meyer zu Schwabedissen, Matthias Nauck, Konrad Ott, Wolfgang Rathmann, Rainer Rettig, Claudia Richardt, Karen Saljé, Ulf Schminke, Andrea Schulz, Matthias Schwab, Werner Siegmund, Sylvia Stracke, Karsten Suhre, Marius Ueffing, Saskia Ungerer, Uwe Völker, Henry Völzke, Henri Wallaschofski, Vivian Werner, Marek T Zygmunt, Heyo K Kroemer

Open Access Research

Sulfur compounds block MCP-1 production by Mycoplasma fermentans-infected macrophages through NF-κB inhibition

Francesca Benedetti, Sergio Davinelli, Selvi Krishnan, Robert C Gallo, Giovanni Scapagnini, Davide Zella, Sabrina Curreli

Open Access Research

Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

Igor Khaliulin, Andrew P Halestrap, Simon M Bryant, Declan J Dudley, Andrew F James, M-Saadeh Suleiman

Open Access Research

Comparison of two preclinical myocardial infarct models: coronary coil deployment versus surgical ligation

Carolina Gálvez-Montón, Cristina Prat-Vidal, Idoia Díaz-Güemes, Verónica Crisóstomo, Carolina Soler-Botija, Santiago Roura, Aida Llucià-Valldeperas, Isaac Perea-Gil, Francisco M Sánchez-Margallo, Antoni Bayes-Genis

Open Access Research

Characteristics of TCM constitutions of adult Chinese women in Hong Kong and identification of related influencing factors: a cross-sectional survey

Youzhi Sun, Pei Liu, Yi Zhao, Lei Jia, Yanhua He, Steve An Xue, Xiao Zheng, Zhiyu Wang, Neng Wang, Jianping Chen

Open Access Research

Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes

Ling Jin, Jian Tu, Jianwei Jia, Wenbin An, Huanran Tan, Qinghua Cui, Zhixin Li

Open Access Research

Modeling the transmission of community-associated methicillin-resistant Staphylococcus aureus: a dynamic agent-based simulation

Charles M Macal, Michael J North, Nicholson Collier, Vanja M Dukic, Duane T Wegener, Michael Z David, Robert S Daum, Philip Schumm, James A Evans, Jocelyn R Wilder, Loren G Miller, Samantha J Eells, Diane S Lauderdale

Open Access Research

Induction of proline-rich tyrosine kinase 2 activation-mediated C6 glioma cell invasion after anti-vascular endothelial growth factor therapy

Cheng-Shi Xu, Ze-Fen Wang, Li-Ming Dai, Sheng-Hua Chu, Ling-Ling Gong, Ming-Huan Yang, Zhi-Qiang Li

Open Access Research

Increased expression of stathmin and elongation factor 1α in precancerous nodules with telomere dysfunction in hepatitis B viral cirrhotic patients

Ei Yong Ahn, Jeong Eun Yoo, Hyungjin Rhee, Myung Soo Kim, Junjeong Choi, Jung Eun Ko, Jee San Lee, Young Nyun Park

Open Access Editorial

Resveratrol: a supplementation for men or for mice?

Valentina Ponzo, Laura Soldati, Simona Bo

Open Access Research

Comparing the cultivated cochlear cells derived from neonatal and adult mouse

Xiangxin Lou, Youyi Dong, Jing Xie, Xianliu Wang, Liangliang Yang, Masaaki Tokuda, Yanzhong Zhang

Open Access Research

Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis

Oksana Kehoe, Alison Cartwright, Ayman Askari, Alicia J El Haj, Jim Middleton

Open Access Methodology

A novel flow cytometry-based cell capture platform for the detection, capture and molecular characterization of rare tumor cells in blood

Masaru Watanabe, Masakuni Serizawa, Takeshi Sawada, Kazuo Takeda, Toshiaki Takahashi, Nobuyuki Yamamoto, Fumiaki Koizumi, Yasuhiro Koh

Open Access Research

Detection of activated KRAS from cancer patient peripheral blood using a weighted enzymatic chip array

Ming-Yii Huang, Hsueh-Chiao Liu, Li-Chen Yen, Jia-Yuan Chang, Jian-Jhang Huang, Jaw-Yuan Wang, Chao-Peng Hsiao, Shiu-Ru Lin

Open Access Review

Exosomal miRNAs as potential biomarkers of cardiovascular risk in children

Abdelnaby Khalyfa, David Gozal

Open Access Research

Overexpression of IL-17RC associated with ocular sarcoidosis

Wenting Wu, Ming Jin, Yujuan Wang, Baoying Liu, Defen Shen, Ping Chen, Susan Hannes, Zhiyu Li, Sima Hirani, Shayma Jawad, H Nida Sen, Chi-Chao Chan, Robert B Nussenblatt, Lai Wei

Open Access Research

The validation of a novel method combining both HER2 immunohistochemistry and HER2 dual-colour silver in situ hybridization on one slide for gastric carcinoma testing

Dominique Werner, Achim Battmann, Kristina Steinmetz, Tobin Jones, Tiffany Lamb, Michele Martinez, Hans-Michael Altmannsberger, Salah-Eddin Al-Batran

Open Access Research

An eight-miRNA signature as a potential biomarker for predicting survival in lung adenocarcinoma

Xuelian Li, Yunrui Shi, Zhihua Yin, Xiaoxia Xue, Baosen Zhou

Open Access Research

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell proliferation, migration and invasion in epithelial ovarian cancer

Ning Wen, Yu Wang, Li Wen, Shu-Hua Zhao, Zhen-Hua Ai, Yi Wang, Bo Wu, Huai-Xiu Lu, Hong Yang, Wen-Chao Liu, Yu Li

Open Access Research

Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake

Sweety Mathew, Susanne Krug, Thomas Skurk, Anna Halama, Antonia Stank, Anna Artati, Cornelia Prehn, Joel A Malek, Gabi Kastenmüller, Werner Römisch-Margl, Jerzy Adamski, Hans Hauner, Karsten Suhre

Open Access Review

Impact of carbon nanotubes and graphene on immune cells

Marco Orecchioni, Davide Bedognetti, Francesco Sgarrella, Francesco M Marincola, Alberto Bianco, Lucia Gemma Delogu

Open Access Research

An innovative system for 3D clinical photography in the resource-limited settings

Saharnaz Baghdadchi, Kimberly Liu, Jacquelyn Knapp, Gabriel Prager, Susannah Graves, Kevan Akrami, Rolanda Manuel, Rui Bastos, Erin Reid, Dennis Carson, Sadik Esener, Joseph Carson, Yu-Tsueng Liu

Open Access Editorial

It’s time for a practical method quantifying vascular calcification

Giuseppe Vezzoli, Alessandro Rubinacci, Monica Lazzaroni, Laura Soldati

Open Access Research

Hepatitis B virus infection in a cohort of HIV infected blood donors and AIDS patients in Sichuan, China

Yu Liu, Peibin Zeng, Jingxing Wang, Gui Liu, Min Xu, Ling Ke, Miao He, Zhong Liu

Open Access Research

Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients

Pan-Pan Niu, Yu Cao, Ting Gong, Jin-Hui Guo, Bi-Kui Zhang, Su-Jie Jia

Open Access Methodology

Anti-inflammatory loaded poly-lactic glycolic acid nanoparticle formulations to enhance myocardial gene transfer: an in-vitro assessment of a drug/gene combination therapeutic approach for direct injection

Anthony S Fargnoli, Anbin Mu, Michael G Katz, Richard D Williams, Kenneth B Margulies, David B Weiner, Shu Yang, Charles R Bridges

Open Access Commentary

Ecto-protein kinases and phosphatases: an emerging field for translational medicine

Garif Yalak, Yigal H Ehrlich, Bjorn R Olsen

Open Access Methodology

Rapid molecular genetic diagnosis of hypertrophic cardiomyopathy by semiconductor sequencing

Zongzhe Li, Jin Huang, Jinzhao Zhao, Chen Chen, Hong Wang, Hu Ding, Dao Wu Wang, Dao Wen Wang

Open Access Methodology

Combined intermittent hypobaric hypoxia and muscle electro-stimulation: a method to increase circulating progenitor cell concentration?

Luisa Corral, Casimiro Javierre, Juan Blasi, Ginés Viscor, Antoni Ricart, Josep Lluis Ventura

Open Access Research

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

Jie Zha, Feili Chen, Huijuan Dong, Pengcheng Shi, Yao Yao, Yanyan Zhang, Rongwei Li, Shiyun Wang, Peng Li, Weiguang Wang, Bing Xu

Open Access Research

Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer

Yoshitaro Shindo, Shoichi Hazama, Yoshinari Maeda, Hiroto Matsui, Michihisa Iida, Nobuaki Suzuki, Kiyoshi Yoshimura, Tomio Ueno, Shigefumi Yoshino, Kohei Sakai, Yutaka Suehiro, Takahiro Yamasaki, Yuji Hinoda, Masaaki Oka

Open Access Research

Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation

Dagmar Quandt, Simon Jasinski-Bergner, Ulrike Müller, Bianca Schulze, Barbara Seliger

Open Access Research

Clinical hypothermia temperatures increase complement activation and cell destruction via the classical pathway

Tushar A Shah, Clifford T Mauriello, Pamela S Hair, Amandeep Sandhu, Michael P Stolz, William Thomas Bass, Neel K Krishna, Kenji M Cunnion

Open Access Methodology

Capillary nano-immunoassay for Akt 1/2/3 and 4EBP1 phosphorylation in acute myeloid leukemia

Himalee Sabnis, Heath L Bradley, Silvia T Bunting, Todd M Cooper, Kevin D Bunting

Open Access Research

Gene expression identifies heterogeneity of metastatic behavior among high-grade non-translocation associated soft tissue sarcomas

Keith M Skubitz, Amy PN Skubitz, Wayne W Xu, Xianghua Luo, Pauline Lagarde, Jean-Michel Coindre, Frédéric Chibon

Open Access Research

Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation

Yan-Fang Tao, Li-Xiao Xu, Jun Lu, Lan Cao, Zhi-Heng Li, Shao-Yan Hu, Na-Na Wang, Xiao-Juan Du, Li-Chao Sun, Wen-Li Zhao, Pei-Fang Xiao, Fang Fang, Yan-Hong Li, Gang Li, He Zhao, Yi-Ping Li, Yun-Yun Xu, Jian Ni, Jian Wang, Xing Feng, Jian Pan

Open Access Research

Variability in CRP, regulatory T cells and effector T cells over time in gynaecological cancer patients: a study of potential oscillatory behaviour and correlations

Mutsa T Madondo, Sandra Tuyaerts, Brit B Turnbull, Anke Vanderstraeten, Holbrook Kohrt, Balasubramanian Narasimhan, Frederic Amant, Michael Quinn, Magdalena Plebanski

Open Access Research

NF-κB-modulated miR-130a targets TNF-α in cervical cancer cells

Jian Zhang, Haidong Wu, Pu Li, Yanzheng Zhao, Min Liu, Hua Tang

Open Access Research

The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients

Ashham Mansur, Luisa von Gruben, Aron F Popov, Maximilian Steinau, Ingo Bergmann, Daniel Ross, Michael Ghadimi, Tim Beissbarth, Martin Bauer, José Hinz

Open Access Research

Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of kruppel-like-factor 10 in mice

Ja Kyung Kim, Kwan Sik Lee, Hye Young Chang, Woon Kyu Lee, Jung Il Lee

Open Access Research

Circulating N-terminal brain natriuretic peptide and cardiac function in response to acute systemic hypoxia in healthy humans

Ilkka Heinonen, Matti Luotolahti, Olli Vuolteenaho, Mikko Nikinmaa, Antti Saraste, Jaakko Hartiala, Juha Koskenvuo, Juhani Knuuti, Olli Arjamaa

Open Access Research

Non-traditional CD4+CD25−CD69+ regulatory T cells are correlated to leukemia relapse after allogeneic hematopoietic stem cell transplantation

Xiao-su Zhao, Xu-hua Wang, Xiang-yu Zhao, Ying-jun Chang, Lan-ping Xu, Xiao-hui Zhang, Xiao-jun Huang

Open Access Research

AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment

Emilia Caputo, Roberta Miceli, Maria Letizia Motti, Rosarita Taté, Federica Fratangelo, Gerardo Botti, Nicola Mozzillo, Maria Vincenza Carriero, Ernesta Cavalcanti, Giuseppe Palmieri, Gennaro Ciliberto, Giuseppe Pirozzi, Paolo Antonio Ascierto

Open Access Research

Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models

Patricia Martínez-Sánchez, María Gutiérrez-Fernández, Blanca Fuentes, Jaime Masjuán, María Alonso de Leciñana Cases, Maria Elena Novillo-López, Exuperio Díez-Tejedor

Open Access Review

Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

Stefania Bulotta, Marilena Celano, Saverio Massimo Lepore, Tiziana Montalcini, Arturo Pujia, Diego Russo

Open Access Research

A microRNA profile of human CD8+ regulatory T cells and characterization of the effects of microRNAs on Treg cell-associated genes

Fadi Jebbawi, Hussein Fayyad-Kazan, Makram Merimi, Philippe Lewalle, Jean-Christophe Verougstraete, Oberdan Leo, Pedro Romero, Arsene Burny, Bassam Badran, Philippe Martiat, Redouane Rouas

Open Access Research

Is serum Interleukin-17 associated with early atherosclerosis in obese patients?

Giovanni Tarantino, Susan Costantini, Carmine Finelli, Francesca Capone, Eliana Guerriero, Nicolina La Sala, Saverio Gioia, Giuseppe Castello

Open Access Research

University courses, eating problems and muscle dysmorphia: are there any associations?

Simona Bo, Rossana Zoccali, Valentina Ponzo, Laura Soldati, Luca De Carli, Andrea Benso, Elisabetta Fea, Alberto Rainoldi, Marilena Durazzo, Secondo Fassino, Giovanni Abbate-Daga

Open Access Research

Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma

Jing-Ping Zhang, Hua Zhang, Hong-Bo Wang, Yan-Xian Li, Gui-Hong Liu, Shan Xing, Man-Zhi Li, Mu-Sheng Zeng

Open Access Editorial

Single-cell transcriptome in the identification of disease biomarkers: opportunities and challenges

Zhitu Zhu, Diane C Wang, Laurenţiu M Popescu, Xiangdong Wang

Open Access Review

Evaluation of tumor response to cytokine-induced killer cells therapy in malignant solid tumors

Xiao-Dong Li, Mei Ji, Xiao Zheng, Zhong-Hua Ning, Jun Wu, Binfeng Lu, Chang-Ping Wu, Jing-Ting Jiang

Open Access Research

A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones

H-H Sherry Chow, Linda L Garland, Brandy M Heckman-Stoddard, Chiu-Hsieh Hsu, Valerie D Butler, Catherine A Cordova, Wade M Chew, Terri L Cornelison

Open Access Research

Rapamycin protects kidney against ischemia reperfusion injury through recruitment of NKT cells

Chao Zhang, Long Zheng, Long Li, Lingyan Wang, Liping Li, Shang Huang, Chenli Gu, Lexi Zhang, Cheng Yang, Tongyu Zhu, Ruiming Rong

Open Access Review

The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer

Peixin Dong, Yosuke Konno, Hidemichi Watari, Masayoshi Hosaka, Masayuki Noguchi, Noriaki Sakuragi

Open Access Research

Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells

Jiandong Wang, Xiaoli Ma, Hannah M Jones, Leo Li-Ying Chan, Fang Song, Weiyuan Zhang, Victoria L Bae-Jump, Chunxiao Zhou

Open Access Research

Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus - associated hepatocellular carcinoma

Marta Melis, Giacomo Diaz, David E Kleiner, Fausto Zamboni, Juraj Kabat, Jinping Lai, Giulia Mogavero, Ashley Tice, Ronald E Engle, Steven Becker, Charles R Brown, Jeffrey C Hanson, Jaime Rodriguez-Canales, Michael Emmert-Buck, Sugantha Govindarajan, Michael Kew, Patrizia Farci

Open Access Research

High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

Enrico P Spugnini, Sabrina Buglioni, Francesca Carocci, Menicagli Francesco, Bruno Vincenzi, Maurizio Fanciulli, Stefano Fais

Open Access Research

Fluid resuscitation therapy in endotoxemic hamsters improves survival and attenuates capillary perfusion deficits and inflammatory responses by a mechanism related to nitric oxide

Nivaldo Ribeiro Villela, Ana Olimpia Maia Teixeira dos Santos, Marcos Lopes de Miranda, Eliete Bouskela

Open Access Research

Remote ischemic preconditioning preserves Connexin 43 phosphorylation in the rat heart in vivo

Timo Brandenburger, Ragnar Huhn, Andreas Galas, Benedikt H Pannen, Verena Keitel, Franziska Barthel, Inge Bauer, André Heinen

Open Access Research

PPARγ2 Pro12Ala polymorphism was associated with favorable cardiometabolic risk profile in HIV/HCV coinfected patients: a cross-sectional study

Pilar García-Broncano, Juan Berenguer, Amanda Fernández-Rodríguez, Daniel Pineda-Tenor, María Ángeles Jiménez-Sousa, Mónica García–Alvarez, Pilar Miralles, Teresa Aldámiz-Echevarria, Juan Carlos López, Dariela Micheloud, Salvador Resino

Open Access Research

Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity

Li Zhang, Jiaoya Xu, Haiyan Song, Zemin Yao, Guang Ji

Open Access Commentary

Genetics and primary care: where are we headed?

Vasiliki Rahimzadeh, Gillian Bartlett

Open Access Research

Association of decreased expression of long non-coding RNA LOC285194 with chemoradiotherapy resistance and poor prognosis in esophageal squamous cell carcinoma

Yu-suo Tong, Xi-lei Zhou, Xiao-wei Wang, Qing-quan Wu, Tong-xin Yang, Jin Lv, Jin-song Yang, Bin Zhu, Xiu-feng Cao

Open Access Research

Mobilization of healthy donors with plerixafor affects the cellular composition of T-cell receptor (TCR)-αβ/CD19-depleted haploidentical stem cell grafts

Sergio Rutella, Perla Filippini, Valentina Bertaina, Giuseppina Li Pira, Lidia Altomare, Stefano Ceccarelli, Letizia P Brescia, Barbarella Lucarelli, Elia Girolami, Gianpiero Conflitti, Maria Giuseppina Cefalo, Alice Bertaina, Tiziana Corsetti, Lorenzo Moretta, Franco Locatelli

Open Access Research

CD160 isoforms and regulation of CD4 and CD8 T-cell responses

Mohamed El-Far, Charles Pellerin, Louise Pilote, Jean-Francois Fortin, Ivan A D Lessard, Yoav Peretz, Elizabeth Wardrop, Patrick Salois, Richard C Bethell, Michael G Cordingley, George Kukolj

Open Access Research

Promoter hypermethylation and silencing of tissue factor pathway inhibitor-2 in oral squamous cell carcinoma

Yi-Hui Lai, Ru-Yin He, Jian-Liang Chou, Michael W-Y Chan, Yu-Fen Li, Chien-Kuo Tai

Open Access Research

Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition

Cecilie Abildgaard, Christina Dahl, Astrid L Basse, Tao Ma, Per Guldberg

Open Access Research

Mapping knowledge translation and innovation processes in Cancer Drug Development: the case of liposomal doxorubicin

David Fajardo-Ortiz, Luis Duran, Laura Moreno, Hector Ochoa, Victor M Castaño

Open Access Review

Advancing stem cell therapy from bench to bedside: lessons from drug therapies

Thekkeparambil Chandrabose Srijaya, Thamil Selvee Ramasamy, Noor Hayaty Abu Kasim

Open Access Research

Neoadjuvant anti-tumor vaccination prior to surgery enhances survival

Scott A Fisher, Amanda Cleaver, Devina D Lakhiani, Andrea Khong, Theresa Connor, Ben Wylie, W Joost Lesterhuis, Bruce WS Robinson, Richard A Lake

Open Access Research

Multiple injections of human umbilical cord-derived mesenchymal stromal cells through the tail vein improve microcirculation and the microenvironment in a rat model of radiation myelopathy

Li Wei, Jing Zhang, Xiu-Bin Xiao, Hai-Xing Mai, Ke Zheng, Wan-Liang Sun, Lei Wang, Feng Liang, Zai-Liang Yang, Yuan Liu, Yan-Qing Wang, Zhi-Fang Li, Jia-Ning Wang, Wei-Jing Zhang, Hua You

Open Access Research

Tumor suppressor miR-1 restrains epithelial-mesenchymal transition and metastasis of colorectal carcinoma via the MAPK and PI3K/AKT pathway

Lijun Xu, Yue Zhang, Hui Wang, Guanhua Zhang, Yanqing Ding, Liang Zhao

Open Access Research

The prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohort

Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, Søren Morgenthaler, Thorarinn Blondal, Jan Lindebjerg, Anders Jakobsen, Flemming Brandt Sørensen

Open Access Research

Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients

Francesca Tavano, Andrea Fontana, Fabio Pellegrini, Francesca Paola Burbaci, Francesca Rappa, Francesco Cappello, Massimiliano Copetti, Evaristo Maiello, Lucia Lombardi, Paolo Graziano, Manlio Vinciguerra, Fabio Francesco di Mola, Pierluigi di Sebastiano, Angelo Andriulli, Valerio Pazienza

Open Access Research

BurnCalc assessment study of computer-aided individual three-dimensional burn area calculation

Wen-bo Sheng, Ding Zeng, Yan Wan, Li Yao, Hong-tai Tang, Zhao-fan Xia

Open Access Research

Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury

Hongbin Cheng, Xuebin Liu, Rongrong Hua, Guanghui Dai, Xiaodong Wang, Jianhua Gao, Yihua An

Open Access Research

TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high-grade intraepithelial neoplasia of the cervix

Maria Lina Tornesello, Clorinda Annunziata, Luigi Buonaguro, Simona Losito, Stefano Greggi, Franco M Buonaguro

Open Access Research

Inhibition of phosphodiesterase 5 restores endothelial function in renovascular hypertension

Ananda T Dias, Amanda S Cintra, Jéssica C Frossard, Zaira Palomino, Dulce E Casarini, Isabele BS Gomes, Camille M Balarini, Agata L Gava, Bianca P Campagnaro, Thiago MC Pereira, Silvana S Meyrelles, Elisardo C Vasquez

Open Access Research

Characterization of immune cells in psoriatic adipose tissue

Shawn Rose, Elena Stansky, Pradeep K Dagur, Leigh Samsel, Elizabeth Weiner, Amir Jahanshad, Julia Doveikis, Haley B Naik, Martin P Playford, J Philip McCoy, Nehal N Mehta

Open Access Research

Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus-K (HERV-K) in psoriasis

Rashmi Gupta, Henri-Alexandre Michaud, Xue Zeng, Maya Debbaneh, Sarah T Arron, R Brad Jones, Christopher E Ormsby, Douglas F Nixon, Wilson Liao

Open Access Research

Counter-flow elutriation of clinical peripheral blood mononuclear cell concentrates for the production of dendritic and T cell therapies

David F Stroncek, Vicki Fellowes, Chauha Pham, Hanh Khuu, Daniel H Fowler, Lauren V Wood, Marianna Sabatino

Open Access Research

miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs

Cheng-gong Liao, Ling-min Kong, Ping Zhou, Xiu-li Yang, Jian-guo Huang, He-long Zhang, Ning Lu

Open Access Research

AAV2/8-hSMAD3 gene delivery attenuates aortic atherogenesis, enhances Th2 response without fibrosis, in LDLR-KO mice on high cholesterol diet

Hongqing Zhu, Maohua Cao, Jose A Figueroa, Everado Cobos, Barry F Uretsky, Maurizio Chiriva-Internati, Paul L Hermonat

Open Access Research

Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor

Takumi Kumai, Kensuke Oikawa, Naoko Aoki, Shoji Kimura, Yasuaki Harabuchi, Esteban Celis, Hiroya Kobayashi

Open Access Research

Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages

Jiatian Cao, Zhihua Han, Lei Tian, Kan Chen, Yuqi Fan, Bozhi Ye, Weijian Huang, Changqian Wang, Zhouqing Huang

Open Access Research

MiR-126-3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2

Chengli Du, Zhen Lv, Linping Cao, Chaofeng Ding, Owusu-ansah K Gyabaah, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng

Open Access Protocol

Radiotherapy as an immunological booster in patients with metastatic melanoma or renal cell carcinoma treated with high-dose Interleukin-2: evaluation of biomarkers of immunologic and therapeutic response

Laura Ridolfi, Francesco de Rosa, Ruggero Ridolfi, Giorgia Gentili, Linda Valmorri, Emanuela Scarpi, Elisabetta Parisi, Antonino Romeo, Massimo Guidoboni

Open Access Research

The role of the CCL22-CCR4 axis in the metastasis of gastric cancer cells into omental milky spots

Liang Cao, Xiang Hu, Jian Zhang, Gang Huang, Yi Zhang

Open Access Research

ERCC1 polymorphisms as prognostic markers in T4 breast cancer patients treated with platinum-based chemotherapy

Grazia Palomba, Francesco Atzori, Mario Budroni, MariaNeve Ombra, Antonio Cossu, MariaCristina Sini, Valeria Pusceddu, Bruno Massidda, Barbara Frau, Francesca Notari, MariaTeresa Ionta, Giuseppe Palmieri

Open Access Methodology

Bone marrow-derived cells for cardiovascular cell therapy: an optimized GMP method based on low-density gradient improves cell purity and function

Marina Radrizzani, Viviana Lo Cicero, Sabrina Soncin, Sara Bolis, Daniel Sürder, Tiziano Torre, Francesco Siclari, Tiziano Moccetti, Giuseppe Vassalli, Lucia Turchetto

Open Access Research

Galectin-3 is associated with a poor prognosis in primary hepatocellular carcinoma

Shan-Shan Jiang, De-Sheng Weng, Qi-Jing Wang, Ke Pan, Yao-Jun Zhang, Yong-Qiang Li, Jian-Jun Li, Jing-Jing Zhao, Jia He, Lin Lv, Qiu-Zhong Pan, Jian-Chuan Xia

Open Access Research

The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer

Chih-Hao Chang, Tan-Chi Fan, Jyh-Cherng Yu, Guo-Shiou Liao, You-Chin Lin, Arthur Chun-Chieh Shih, Wen-Hsiung Li, Alice Lin-Tsing Yu

Open Access Research

Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy

Xin-chen Xu, Hui Chen, Xi Zhang, Zan-jing Zhai, Xu-qiang Liu, An Qin, Er-yi Lu

Open Access Methodology

Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. multiple E1-L1/E6E7 ratio-based detection techniques

Rong Zhang, Yi-feng He, Mo Chen, Chun-mei Chen, Qiu-jing Zhu, Huan Lu, Zhen-hong Wei, Fang Li, Xiao-xin Zhang, Cong-jian Xu, Long Yu

Open Access Research

Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis

Yinxin Fu, Junjie Guan, Shangchun Guo, Fei Guo, Xin Niu, Qiang Liu, Changqing Zhang, Huarong Nie, Yang Wang

Open Access Research

PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-niche

Elana Godebu, Michelle Muldong, Amy Strasner, Christina N Wu, Seung Chol Park, Jason R Woo, Wenxue Ma, Michael A Liss, Takeshi Hirata, Omer Raheem, Nicholas A Cacalano, Anna A Kulidjian, Christina AM Jamieson

Open Access Research

A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma

Ning Yang, Tao Yan, Huaiyang Zhu, Xiao Liang, Lina Leiss, Per Øystein Sakariassen, Kai Ove Skaftnesmo, Bin Huang, Daniela Elena Costea, Per Øyvind Enger, Xingang Li, Jian Wang

Open Access Research

Growth factor-eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis

Yayoi S Kikkawa, Takayuki Nakagawa, Lin Ying, Yasuhiko Tabata, Hirohito Tsubouchi, Akio Ido, Juichi Ito

Open Access Research

let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis

Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Weiqin Yang, Yi Pan, Kin Mang Lau, Jun Yu, Alfred SL Cheng, Ka Fai To

Open Access Editorial

Pain, Critical Care and Anesthesia section

Yasin Said AlMakadma

Open Access Research

Propofol exerts anti-hepatocellular carcinoma by microvesicle-mediated transfer of miR-142-3p from macrophage to cancer cells

Jian Zhang, Wei-feng Shan, Te-te Jin, Guo-qing Wu, Xiao-xing Xiong, Hai-yan Jin, Sheng-mei Zhu

Open Access Research

Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets

Rohit Vashisht, Ashwini G Bhat, Shreeram Kushwaha, Anshu Bhardwaj, OSDD Consortium, Samir K Brahmachari

Open Access Review

Role of mesenchymal cells in the natural history of ovarian cancer: a review

Cyril Touboul, Fabien Vidal, Jennifer Pasquier, Raphael Lis, Arash Rafii

Open Access Research

Expression and prognostic significance of TCTN1 in human glioblastoma

Delong Meng, Yuanyuan Chen, Yingjie Zhao, Jingkun Wang, Dapeng Yun, Song Yang, Juxiang Chen, Hongyan Chen, Daru Lu

Open Access Research

Therapeutic effect of daphnetin on the autoimmune arthritis through demethylation of proapoptotic genes in synovial cells

Kuanyong Shu, Nanzhen Kuang, Zhiqin Zhang, Ziling Hu, Yujuan Zhang, Yingyuan Fu, Weiping Min

Open Access Research

Prognostic and treatment predictive significance of SATB1 and SATB2 expression in pancreatic and periampullary adenocarcinoma

Jacob Elebro, Margareta Heby, Alexander Gaber, Björn Nodin, Liv Jonsson, Richard Fristedt, Mathias Uhlén, Karin Jirström, Jakob Eberhard

Open Access Meeting report

The role of immunotherapy in solid tumors: report from the Campania Society of Oncology Immunotherapy (SCITO) meeting, Naples 2014

Paolo A Ascierto, Raffaele Addeo, Giacomo Cartenì, Bruno Daniele, Michele De Laurentis, Giovanni Pietro Ianniello, Alessandro Morabito, Giovannella Palmieri, Stefano Pepe, Francesco Perrone, Sandro Pignata, Vincenzo Montesarchio

Open Access Research

MicroRNA regulation in human CD8+ T cell subsets – cytokine exposure alone drives miR-146a expression

Hilary M Sheppard, Daniel Verdon, Anna ES Brooks, Vaughan Feisst, Yu-Yu Joyce Ho, Natalie Lorenz, Vicky Fan, Nigel P Birch, Alicia Didsbury, P Rod Dunbar

Open Access Research

Diffusion weighted imaging and blood oxygen level-dependent MR imaging of kidneys in patients with lupus nephritis

Xiao Li, Xueqin Xu, Qianying Zhang, Hong Ren, Wen Zhang, Yan Liu, Fuhua Yan, Nan Chen

Open Access Review

Graphene based scaffolds effects on stem cells commitment

Eriberto Bressan, Letizia Ferroni, Chiara Gardin, Luca Sbricoli, Luca Gobbato, Francesco Saverio Ludovichetti, Ilaria Tocco, Amedeo Carraro, Adriano Piattelli, Barbara Zavan

Open Access Research

High-throughput profiling identifies clinically actionable mutations in salivary duct carcinoma

Bo Mi Ku, Hyun Ae Jung, Jong-Mu Sun, Young Hyeh Ko, Han-Sin Jeong, Young-Ik Son, Chung-Hwan Baek, Keunchil Park, Myung-Ju Ahn

Open Access Research

Collagen II antibody-induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess treatments targeting human TNFα in rheumatoid arthritis

Adrian Richard Moore, Sarah Allden, Tim Bourne, Maria C Denis, Ksanthi Kranidioti, Remi Okoye, Yannis Sotsios, Zofia Stencel, Alexander Vugler, Gillian Watt, Stevan Shaw

Open Access Review

The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis

Marco Genua, Sergio Rutella, Carmen Correale, Silvio Danese

Open Access Meeting report

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013

Paolo A Ascierto, Antonio M Grimaldi, Ana Carrizosa Anderson, Carlo Bifulco, Alistair Cochran, Claus Garbe, Alexander M Eggermont, Mark Faries, Soldano Ferrone, Jeffrey E Gershenwald, Thomas F Gajewski, Ruth Halaban, F Stephen Hodi, Richard Kefford, John M Kirkwood, James Larkin, Sancy Leachman, Michele Maio, Richard Marais, Giuseppe Masucci, Ignacio Melero, Giuseppe Palmieri, Igor Puzanov, Antoni Ribas, Yvonne Saenger, Bastian Schilling, Barbara Seliger, David Stroncek, Ryan Sullivan, Alessandro Testori, Ena Wang, Gennaro Ciliberto, Nicola Mozzillo, Francesco M Marincola, Magdalena Thurin

Open Access Research

A randomised translational trial of lifestyle intervention using a 3-tier shared care approach on pregnancy outcomes in Chinese women with gestational diabetes mellitus but without diabetes

Xilin Yang, Huiguang Tian, Fuxia Zhang, Cuiping Zhang, Yi Li, Junhong Leng, Leishen Wang, Gongsu Liu, Ling Dong, Zhijie Yu, Gang Hu, Juliana CN Chan

Open Access Research

GnRH agonists induce endometrial epithelial cell apoptosis via GRP78 down-regulation

Huinan Weng, Fenghua Liu, Shuiwang Hu, Li Li, Yifeng Wang

Open Access Research

Chronic vagus nerve stimulation improves left ventricular function in a canine model of chronic mitral regurgitation

Haiwen Yu, Min Tang, Jun Yu, Xiaohong Zhou, Lepeng Zeng, Shu Zhang

Open Access Research

miR-200c Inhibits invasion, migration and proliferation of bladder cancer cells through down-regulation of BMI-1 and E2F3

Lei Liu, Mingning Qiu, Guobin Tan, Ziji Liang, Yue Qin, Lieqian Chen, Hege Chen, Jianjun Liu

Open Access Research

AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues

Gloria Juan, Tammy L Bush, Connie Ma, Raffi Manoukian, Grace Chung, Jennifer M Hawkins, Stephen Zoog, Richard Kendall, Robert Radinsky, Robert Loberg, Greg Friberg, Marc Payton

Open Access Research

Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

Yi Zhu, Jing-Jing Zhang, Kun-Ling Xie, Jie Tang, Wen-Biao Liang, Rong Zhu, Yan Zhu, Bin Wang, Jin-Qiu Tao, Xiao-Fei Zhi, Zheng Li, Wen-Tao Gao, Kui-Rong Jiang, Yi Miao, Ze-Kuan Xu

Open Access Research

Liver myofibroblasts from hepatitis B related liver failure patients may regulate natural killer cell function via PGE2

Min Zhang, Fenglan Wang, Yutian Chong, Qiang Tai, Qiyi Zhao, Yubao Zheng, Liang Peng, Shumei Lin, Zhiliang Gao

Open Access Research

Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus

Yu-Jih Su, Tien-Tsai Cheng, Chung-Jen Chen, Wen-Neng Chang, Nai-Wen Tsai, Chia-Te Kung, Hung-Chen Wang, Wei-Che Lin, Chih-Cheng Huang, Ya-Ting Chang, Chih-Min Su, Yi-Fang Chiang, Ben-Chung Cheng, Yu-Jun Lin, Cheng-Hsien Lu

Open Access Research

Enhanced frequency and potential mechanism of B regulatory cells in patients with lung cancer

Jiebai Zhou, Zhihui Min, Ding Zhang, William Wang, Francesco Marincola, Xiangdong Wang

Open Access Research

Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss

Qinjun Wei, Hongmei Zhu, Xuli Qian, Zhibin Chen, Jun Yao, Yajie Lu, Xin Cao, Guangqian Xing

Open Access Methodology

CMV-specific T cell isolation from G-CSF mobilized peripheral blood: depletion of myeloid progenitors eliminates non-specific binding of MHC-multimers

Lorea Beloki, Miriam Ciaurriz, Cristina Mansilla, Amaya Zabalza, Estela Perez-Valderrama, Edward R Samuel, Mark W Lowdell, Natalia Ramirez, Eduardo Olavarria

Open Access Research

Combined microRNA and ER expression: a new classifier for familial and sporadic breast cancer patients

Katia Danza, Simona De Summa, Brunella Pilato, Massimo Carella, Orazio Palumbo, Ondina Popescu, Angelo Paradiso, Rosamaria Pinto, Stefania Tommasi

Open Access Research

Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer

Jun Xiang, Lekun Fang, Yanxin Luo, Zuli Yang, Yi Liao, Ji Cui, Meijin Huang, Zihuan Yang, Yan Huang, Xinjuan Fan, Huashe Wang, Lei Wang, Junsheng Peng, Jianping Wang

Open Access Methodology

Saliva as a sampling source for the detection of leukemic fusion transcripts

Dongmei Chen, Najie Song, Runfang Ni, Jiangning Zhao, Jiasheng Hu, Quanyi Lu, Qingge Li

Open Access Protocol

Effects of zoledronic acid and the association between its efficacy and γδT cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol

Eriko Sumi, Tomoharu Sugie, Kenichi Yoshimura, Harue Tada, Takafumi Ikeda, Eiji Suzuki, Yoshimasa Tanaka, Satoshi Teramukai, Akira Shimizu, Masakazu Toi, Nagahiro Minato

Open Access Research

Quantitative characterization of androgen receptor protein expression and cellular localization in circulating tumor cells from patients with metastatic castration-resistant prostate cancer

Edwin E Reyes, David J VanderWeele, Masis Isikbay, Ryan Duggan, Alexa Campanile, Walter M Stadler, Donald J Vander Griend, Russell Z Szmulewitz

Open Access Research

Reversal of severe angioproliferative pulmonary arterial hypertension and right ventricular hypertrophy by combined phosphodiesterase-5 and endothelin receptor inhibition

Maria A Cavasin, Kimberly M Demos-Davies, Katherine B Schuetze, Weston W Blakeslee, Matthew S Stratton, Rubin M Tuder, Timothy A McKinsey

Open Access Research

Multiple pathways are responsible for Anti-inflammatory and Cardiovascular activities of Hordeum vulgare L.

Saima Gul, Sagheer Ahmed, Nurolaini Kifli, Qazi Tahir Uddin, Nafisa Batool Tahir, Abrar Hussain, Hawa ZE Jaafar, Marius Moga, Muhammad Zia-Ul-Haq

Open Access Research

Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca2+ cycling proteins

Qi Dong, Zhiye Wu, Xiaoyun Li, Jianyun Yan, Luning Zhao, Chuntao Yang, Junjiang Lu, Ju Deng, Minsheng Chen

Open Access Research

Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE−/− mice

Junwen Chen, Jiatian Cao, Lu Fang, Bo Liu, Qing Zhou, Yinggang Sun, Yue Wang, Yigang Li, Shu Meng

Open Access Research

Molecular epidemiology and genotype distribution of Human Papillomavirus (HPV) among Arab women in the state of Qatar

Devendra Bansal, Asha A Elmi, Sini Skariah, Pascale Haddad, Laith J Abu-Raddad, Aysha H Al Hamadi, Nady Mohamed-Nady, Nahla M Affifi, Randa Ghedira, Elham Hassen, Asma AJ Al-Thani, Afaf AHM Al-Ansari, Ali A Sultan

Open Access Methodology

Empirical study using network of semantically related associations in bridging the knowledge gap

Vida Abedi, Mohammed Yeasin, Ramin Zand

Open Access Research

Targeting TLR-4 with a novel pharmaceutical grade plant derived agonist, Immunomax®, as a therapeutic strategy for metastatic breast cancer

Anahit Ghochikyan, Alexey Pichugin, Alexander Bagaev, Arpine Davtyan, Armine Hovakimyan, Amir Tukhvatulin, Hayk Davtyan, Dmitry Shcheblyakov, Denis Logunov, Marina Chulkina, Anastasia Savilova, Dmitry Trofimov, Edward L Nelson, Michael G Agadjanyan, Ravshan I Ataullakhanov

Open Access Research

Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: a case study with folic acid

Coert J Zuurbier, Andre Heinen, Anneke Koeman, Roy Stuifbergen, Theodorus BM Hakvoort, Nina C Weber, Markus W Hollmann

Open Access Research

C677T gene polymorphism of MTHFR and metabolic syndrome: response to dietary intervention

Laura Di Renzo, Luigi Tonino Marsella, Francesca Sarlo, Laura Soldati, Santo Gratteri, Ludovico Abenavoli, Antonino De Lorenzo

Open Access Research

Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu, Xiaomin Li, Danni Sun, Zhenli Liu, Ying Xu, Xia Mao, Qiuyan Guo, Na Lin

Open Access Research

Evaluation of clonal origin of malignant mesothelioma

Sabahattin Comertpay, Sandra Pastorino, Mika Tanji, Rosanna Mezzapelle, Oriana Strianese, Andrea Napolitano, Francine Baumann, Tracey Weigel, Joseph Friedberg, Paul Sugarbaker, Thomas Krausz, Ena Wang, Amy Powers, Giovanni Gaudino, Shreya Kanodia, Harvey I Pass, Barbara L Parsons, Haining Yang, Michele Carbone

Open Access Research

Stable luciferase expression does not alter immunologic or in vivo growth properties of GL261 murine glioma cells

Aaron J Clark, Michael Safaee, Taemin Oh, Michael E Ivan, Vamsi Parimi, Rintaro Hashizume, Tomoko Ozawa, Charles D James, Orin Bloch, Andrew T Parsa

Open Access Research

Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms

Marco Moroni, Silvia Ghezzi, Paolo Baroli, Silvia Heltai, Davide De Battista, Simone Pensieroso, Mariangela Cavarelli, Stefania Dispinseri, Irene Vanni, Claudia Pastori, Pietro Zerbi, Antonella Tosoni, Elisa Vicenzi, Manuela Nebuloni, Kim Wong, Hong Zhao, Sarah McHugh, Guido Poli, Lucia Lopalco, Gabriella Scarlatti, Roberto Biassoni, James I Mullins, Mauro S Malnati, Massimo Alfano

Open Access Research

Dendritic cell vaccines containing lymphocytes produce improved immunogenicity in patients with cancer

Mayu O Frank, Julia Kaufman, Salina Parveen, Nathalie E Blachère, Dana E Orange, Robert B Darnell

Open Access Review

Adrenomedullin and tumour microenvironment

Ignacio M Larráyoz, Sonia Martínez-Herrero, Josune García-Sanmartín, Laura Ochoa-Callejero, Alfredo Martínez

Open Access Research

Endometrial regenerative cells as a novel cell therapy attenuate experimental colitis in mice

Yongcheng Lv, Xiaoxi Xu, Bai Zhang, Guangying Zhou, Hongyue Li, Caigan Du, Hongqiu Han, Hao Wang

Open Access Research

Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret

Zengbing Lu, Nathalie Percie Du Sert, Sze Wa Chan, Chi-Kong Yeung, Ge Lin, David TW Yew, Paul LR Andrews, John A Rudd

Open Access Research

Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2

Nina A Dzhoyashvili, Anastasia Yu Efimenko, Tatiana N Kochegura, Natalia I Kalinina, Natalia V Koptelova, Olga Yu Sukhareva, Marina V Shestakova, Renat S Akchurin, Vsevolod A Tkachuk, Yelena V Parfyonova

Open Access Research

Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

Joël Ménard, Dean F Rigel, Catherine Watson, Arco Y Jeng, Fumin Fu, Michael Beil, Jing Liu, Wei Chen, Chii-Whei Hu, Jennifer Leung-Chu, Daniel LaSala, Guiqing Liang, Sam Rebello, Yiming Zhang, William P Dole

Open Access Research

Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy

Duane Moogk, Ines Pires da Silva, Michelle W Ma, Erica B Friedman, Eleazar Vega-Saenz de Miera, Farbod Darvishian, Patrick Scanlon, Arianne Perez-Garcia, Anna C Pavlick, Nina Bhardwaj, Paul J Christos, Iman Osman, Michelle Krogsgaard

Open Access Review

Immuno-pathomechanism of liver fibrosis: targeting chemokine CCL2-mediated HIV:HCV nexus

AW Wahid Ansari, Reinhold E Schmidt, Esaki M Shankar, Adeeba Kamarulzaman

Open Access Research

Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model

Rong Zhao, Ni-Nan Chen, Xiao-Wei Zhou, Ping Miao, Chao-Ying Hu, Liu Qian, Qi-Wen Yu, Ji-Ying Zhang, Hong Nie, Xue-hua Chen, Pu Li, Rong Xu, Lian-Bo Xiao, Xin Zhang, Jian-Ren Liu, Dong-Qing Zhang

Open Access Protocol

Autologous bone marrow derived mesenchymal stromal cell therapy in combination with everolimus to preserve renal structure and function in renal transplant recipients

Marlies EJ Reinders, Jonna R Bank, Geertje J Dreyer, Helene Roelofs, Sebastian Heidt, Dave L Roelen, Volkert AL Huurman, Jan Lindeman, Cees van Kooten, Frans HJ Claas, Wim E Fibbe, Ton J Rabelink, Johan W de Fijter

Open Access Research

Validation of a hemoglobin A1c model in patients with type 1 and type 2 diabetes and its use to go beyond the averaged relationship of hemoglobin A1c and mean glucose level

Piotr Ladyzynski, Piotr Foltynski, Marianna I Bak, Stanislawa Sabalinska, Janusz Krzymien, Jerzy Kawiak

Open Access Research

Associations between breakfast eating habits and health-promoting lifestyle, suboptimal health status in Southern China: a population based, cross sectional study

Jieyu Chen, Jingru Cheng, Yanyan Liu, Yang Tang, Xiaomin Sun, Tian Wang, Ya Xiao, Fei Li, Lei Xiang, Pingping Jiang, Shengwei Wu, Liuguo Wu, Ren Luo, Xiaoshan Zhao

Open Access Research

Therapeutic potential of human embryonic stem cell transplantation in patients with cerebral palsy

Geeta Shroff, Anupama Gupta, Jitender Kumar Barthakur

Open Access Research

Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation

Andrea D’Amico, Rosetta Ragusa, Raffaele Caruso, Tommaso Prescimone, Sandra Nonini, Manuela Cabiati, Silvia Del Ry, Maria Giovanna Trivella, Daniela Giannessi, Chiara Caselli

Open Access Research

Electroacupuncture stimulation at sub-specific acupoint and non-acupoint induced distinct brain glucose metabolism change in migraineurs: a PET-CT study

Mingxiao Yang, Jie Yang, Fang Zeng, Peng Liu, Zhenhong Lai, Shufang Deng, Li Fang, Wenzhong Song, Hongjun Xie, Fanrong Liang

Open Access Research

Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones

Riccardo Miglietta, Claudia Pastori, Assunta Venuti, Christina Ochsenbauer, Lucia Lopalco

Open Access Research

Targeted cancer immunotherapy via combination of designer bispecific antibody and novel gene-engineered T cells

Katarzyna Urbanska, Rachel C Lynn, Caitlin Stashwick, Archana Thakur, Lawrence G Lum, Daniel J Powell

Open Access Research

Inhibition of dipeptidyl peptidase-IV enzyme activity protects against myocardial ischemia-reperfusion injury in rats

Sarah Chua, Fan-Yen Lee, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Steve Leu, Cheuk-Kwan Sun, Yung-Lung Chen, Hsueh-Wen Chang, Han-Tan Chai, Chu-Feng Liu, Hung-I Lu, Hon-Kan Yip

Open Access Research

Site-specific metabolic phenotypes in metastatic breast cancer

Hye Min Kim, Woo Hee Jung, Ja Seung Koo

Open Access Research

Plasma mRNA expression levels of BRCA1 and TS as potential predictive biomarkers for chemotherapy in gastric cancer

Jie Shen, Jia Wei, Wenxian Guan, Hao Wang, Yitao Ding, Xiaoping Qian, Lixia Yu, Zhengyun Zou, Li Xie, Carlota Costa, Trever Bivona, Rafael Rosell, Baorui Liu

Open Access Research

Rapid generation of clinical-grade antiviral T cells: selection of suitable T-cell donors and GMP-compliant manufacturing of antiviral T cells

Sabine Tischer, Christoph Priesner, Hans-Gert Heuft, Lilia Goudeva, Wolfgang Mende, Marc Barthold, Stephan Kloeß, Lubomir Arseniev, Krasimira Aleksandrova, Britta Maecker-Kolhoff, Rainer Blasczyk, Ulrike Koehl, Britta Eiz-Vesper

Open Access Research

Pre-immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer

Osama E Rahma, Vincent E Herrin, Rami A Ibrahim, Anton Toubaji, Sarah Bernstein, Omar Dakheel, Seth M Steinberg, Rasha Abu Eid, Mikayel Mkrtichyan, Jay A Berzofsky, Samir N Khleif

Open Access Research

Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent

Francesca del Bufalo, Andrea Carai, Lorenzo Figà-Talamanca, Benedetta Pettorini, Conor Mallucci, Felice Giangaspero, Manila Antonelli, Manuela Badiali, Loredana Moi, Giuseppe Bianco, Antonella Cacchione, Franco Locatelli, Elisabetta Ferretti, Angela Mastronuzzi

Open Access Research

An autophagosome-based therapeutic vaccine for HBV infection: a preclinical evaluation

Meng Xue, Fei Fan, Lei Ding, Jingyu Liu, Shu Su, Pengfei Yin, Meng Cao, Wei Zhao, Hong-ming Hu, Lixin Wang

Open Access Research

Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

Suchismita Sarker, Katherin Scholz-Romero, Alejandra Perez, Sebastian E Illanes, Murray D Mitchell, Gregory E Rice, Carlos Salomon

Open Access Research

TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant

Rebecca Saenz, Diahnn Futalan, Lien Leutenez, Fien Eekhout, Jessie F Fecteau, Simeon Sundelius, Stig Sundqvist, Marie Larsson, Tomoko Hayashi, Boris Minev, Dennis Carson, Sadik Esener, Bradley Messmer, Davorka Messmer

Open Access Commentary

The shell game: how institutional review boards shuffle words

Simon N Whitney

Open Access Commentary

Liquid biopsy in gastrointestinal stromal tumors: a novel approach

Margherita Nannini, Annalisa Astolfi, Milena Urbini, Guido Biasco, Maria A Pantaleo

Open Access Research

Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics

Claire H Li, Robert E Stratford Jr, Nieves Velez de Mendizabal, Thomas IFH Cremers, Bruce G Pollock, Benoit H Mulsant, Gary Remington, Robert R Bies

Open Access Research

Detection of Cystatin C biomarker for clinical measurement of renal disease by developed ELISA diagnostic kits

Renren Jiang, Chao Xu, Xiaoli Zhou, Tianhao Wang, Gang Yao

Open Access Research

Preliminary evaluation of urinary soluble Met as a Biomarker for urothelial carcinoma of the bladder

Brian K McNeil, Maximiliano Sorbellini, Robert L Grubb III, Andrea B Apolo, Fabiola Cecchi, Gagani Athauda, Benjamin Cohen, Alessio Giubellino, Haley Simpson, Piyush K Agarwal, Jonathan Coleman, Robert H Getzenberg, George J Netto, Joanna Shih, W Marston Linehan, Peter A Pinto, Donald P Bottaro

Open Access Research

Roles of CXCL5 on migration and invasion of liver cancer cells

Xiaojing Xu, Peixin Huang, Biwei Yang, Xiangdong Wang, Jinglin Xia

Open Access Research

Ipilimumab augments antitumor activity of bispecific antibody-armed T cells

Hiroshi Yano, Archana Thakur, Elyse N Tomaszewski, Minsig Choi, Abhinav Deol, Lawrence G Lum

Open Access Research

Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Peter D Caie, Arran K Turnbull, Susan M Farrington, Anca Oniscu, David J Harrison

Open Access Research

Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP)

David B Rosen, Ling Y Leung, Brent Louie, James A Cordeiro, Andrew Conroy, Iuliana Shapira, Scott Z Fields, Alessandra Cesano, Rachael E Hawtin

Open Access Research

Time-averaged albumin predicts the long-term prognosis of IgA nephropathy patients who achieved remission

Zhaohui Ni, Yanhong Yuan, Qin Wang, Liou Cao, Xiajing Che, Minfang Zhang, Yuanyuan Xie, Chaojun Qi, Shan Mou

Open Access Research

The BAG3 gene variants in Polish patients with dilated cardiomyopathy: four novel mutations and a genotype-phenotype correlation

Maria Franaszczyk, Zofia T Bilinska, Małgorzata Sobieszczańska-Małek, Ewa Michalak, Justyna Sleszycka, Agnieszka Sioma, Łukasz A Małek, Dorota Kaczmarska, Ewa Walczak, Paweł Włodarski, Łukasz Hutnik, Blanka Milanowska, Zofia Dzielinska, Grzegorz Religa, Jacek Grzybowski, Tomasz Zieliński, Rafal Ploski

Open Access Editorial

Melanoma: the role of surgery in the era of new therapies

Nicola Mozzillo, Paolo A Ascierto

Open Access Research

Mir-208 promotes cell proliferation by repressing SOX6 expression in human esophageal squamous cell carcinoma

Heping Li, Dayong Zheng, Bing Zhang, Liangshuai Liu, Junwei Ou, Wei Chen, Shiqiu Xiong, Yong Gu, Jianyong Yang

Open Access Research

Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

Martin Grimm, Marcel Cetindis, Max Lehmann, Thorsten Biegner, Adelheid Munz, Peter Teriete, Wiebke Kraut, Siegmar Reinert

Open Access Research

In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients

Nollaig M Bourke, Mary-Teresa O’Neill, Shahzad Sarwar, Suzanne Norris, Stephen Stewart, John E Hegarty, Nigel J Stevenson, Cliona O’Farrelly

Open Access Research

Targeted DNA vaccines eliciting crossreactive anti-idiotypic antibody responses against human B cell malignancies in mice

Pier Adelchi Ruffini, Audun Os, Riccardo Dolcetti, Geir E Tjønnfjord, Ludvig A Munthe, Bjarne Bogen

Open Access Protocol

Vaccination with autologous dendritic cells loaded with autologous tumor lysate or homogenate combined with immunomodulating radiotherapy and/or preleukapheresis IFN-α in patients with metastatic melanoma: a randomised “proof-of-principle” phase II study

Francesco de Rosa, Laura Ridolfi, Ruggero Ridolfi, Giorgia Gentili, Linda Valmorri, Oriana Nanni, Massimiliano Petrini, Laura Fiammenghi, Anna Maria Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati, Serena Cassan, Angela Riccobon, Elisabetta Parisi, Antonino Romeo, Livia Turci, Massimo Guidoboni

Open Access Research

Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis

Jie Xu, Cai-feng Yue, Wei-hua Zhou, Yuan-min Qian, Yan Zhang, Shao-wu Wang, An-wen Liu, Quentin Liu

Open Access Research

Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study

Wanda K O’Neal, Wayne Anderson, Patricia V Basta, Elizabeth E Carretta, Claire M Doerschuk, R Graham Barr, Eugene R Bleecker, Stephanie A Christenson, Jeffrey L Curtis, Meilan K Han, Nadia N Hansel, Richard E Kanner, Eric C Kleerup, Fernando J Martinez, Bruce E Miller, Stephen P Peters, Stephen I Rennard, Mary Beth Scholand, Ruth Tal-Singer, Prescott G Woodruff, David J Couper, Sonia M Davis

Open Access Research

GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy

Zaozao Wang, Beihai Jiang, Lei Chen, Jiabo Di, Ming Cui, Maoxing Liu, Yiyuan Ma, Hong Yang, Jiadi Xing, Chenghai Zhang, Zhendan Yao, Nan Zhang, Bin Dong, Jiafu Ji, Xiangqian Su

Open Access Research

Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells

Claudia Rubie, Bianca Kruse, Vilma Oliveira Frick, Kathrin Kölsch, Pirus Ghadjar, Mathias Wagner, Friedrich Grässer, Stefan Wagenpfeil, Mathias Glanemann

Open Access Research

Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice

Zhou-Ji Zhang, Yun-Ke Yang, Wei-Zhong Wu

Open Access Research

Results of a phase I/II clinical trial: standardized, non-xenogenic, cultivated limbal stem cell transplantation

Nadia Zakaria, Tine Possemiers, Sorcha Ní Dhubhghaill, Inge Leysen, Jos Rozema, Carina Koppen, Jean-Pierre Timmermans, Zwi Berneman, Marie-Jose Tassignon

Open Access Research

Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile

Raphael Lis, Cyril Touboul, Najeeb M Halabi, Abishek Sainath Madduri, Denis Querleu, Jason Mezey, Joel A Malek, Karsten Suhre, Arash Rafii

Open Access Research

IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity

Liang Ye, Ling Ji, Zhongyang Wen, Yanfei Zhou, Dongsheng Hu, Yanqun Li, Ting Yu, Bingni Chen, Jinshun Zhang, Liping Ding, Jing Du, Zhong Huang

Open Access Research

A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women

Ramlah Mohamad Ibrahim, Nurul Syima Hamdan, Rozi Mahmud, Mustapha Umar Imam, Suraini Mohd Saini, Saiful Nizam Abd Rashid, Siti Aisyah Abd Ghafar, Latiffah Ab Latiff, Maznah Ismail

Open Access Research

Comprehensive proteomic analysis of white blood cells from chikungunya fever patients of different severities

Nitwara Wikan, Sarawut Khongwichit, Weerawat Phuklia, Sukathida Ubol, Tipparat Thonsakulprasert, Montri Thannagith, Duangrudee Tanramluk, Atchara Paemanee, Suthathip Kittisenachai, Sittiruk Roytrakul, Duncan R Smith

Open Access Research

Levels and values of lipoprotein-associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy

Jiunn-Jye Sheu, Pao-Yuan Lin, Pei-Hsun Sung, Yi-Ching Chen, Steve Leu, Yung-Lung Chen, Tzu-Hsien Tsai, Han-Tan Chai, Sarah Chua, Hsueh-Wen Chang, Sheng-Ying Chung, Chih-Hung Chen, Sheung-Fat Ko, Hon-Kan Yip

Open Access Research

Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells

Dae Won Kim, Andrew Zloza, Joseph Broucek, Jason M Schenkel, Carl Ruby, Georges Samaha, Howard L Kaufman

Open Access Research

Regulation gene expression of miR200c and ZEB1 positively enhances effect of tumor vaccine B16F10/GPI-IL-21 on inhibition of melanoma growth and metastasis

Xiaoying Wang, Xiangfeng He, Fengshu Zhao, Jing Wang, Hongyi Zhang, Fangfang Shi, Yunxia Zhang, Kai Cai, Jun Dou

Open Access Research

Regulatory mechanisms of betacellulin in CXCL8 production from lung cancer cells

Lin Shi, Lingyan Wang, Beibei Wang, Sanda Maria Cretoiu, Qun Wang, Xiangdong Wang, Chengshui Chen

Open Access Research

Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin-producing cells

Huiting Qu, Xiaoli Liu, Yihong Ni, Yang Jiang, Xiaoli Feng, Juan Xiao, Yanan Guo, Dexiao Kong, Ai Li, Xiaomei Li, Xianghua Zhuang, Zhilun Wang, Yongjing Wang, Yali Chang, Shihong Chen, Feng Kong, Xuhua Zhang, Shengtian Zhao, Yi Sun, Dawei Xu, Daoqing Wang, Chengyun Zheng

Open Access Research

High-dimensional analysis of the aging immune system: Verification of age-associated differences in immune signaling responses in healthy donors

Diane M Longo, Brent Louie, Jason Ptacek, Greg Friedland, Erik Evensen, Santosh Putta, Michelle Atallah, David Spellmeyer, Ena Wang, Zoltan Pos, Francesco M Marincola, Andrea Schaeffer, Suzanne Lukac, Radha Railkar, Chan R Beals, Alessandra Cesano, Leonidas N Carayannopoulos, Rachael E Hawtin

Open Access Research

HBsAg as an important predictor of HBeAg seroconversion following antiviral treatment for HBeAg-positive chronic hepatitis B patients

Jiezuan Yang, Jiajia Chen, Ping Ye, Linfeng Jin, Wei Wu, Guoping Sheng, Lan-Juan Li

Open Access Methodology

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

Héctor De León, Stéphanie Boué, Walter K Schlage, Natalia Boukharov, Jurjen W Westra, Stephan Gebel, Aaron VanHooser, Marja Talikka, R Brett Fields, Emilija Veljkovic, Michael J Peck, Carole Mathis, Vy Hoang, Carine Poussin, Renee Deehan, Katrin Stolle, Julia Hoeng, Manuel C Peitsch

Open Access Research

Full-length soluble CD147 promotes MMP-2 expression and is a potential serological marker in detection of hepatocellular carcinoma

Jiao Wu, Zhi-Wei Hao, You-Xu Zhao, Xiang-Min Yang, Hao Tang, Xin Zhang, Fei Song, Xiu-Xuan Sun, Bin Wang, Gang Nan, Zhi-Nan Chen, Huijie Bian

Open Access Erratum

Erratum to: Tumor grafts derived from patients with head and neck squamous carcinoma authentically maintain the molecular and Histologic characteristics of human cancers

Shaohua Peng, Chad J Creighton, Yiqun Zhang, Banibrata Sen, Tuhina Mazumdar, Jeffery N Myers, Stephen Y Lai, Adrian Woolfson, Matthew V Lorenzi, Diana Bell, Michelle D Williams, Faye M Johnson

Open Access Erratum

Erratum to: Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma

Xiaofang Xing, Shenyi Lian, Ying Hu, Ziyu Li, Lianhai Zhang, Xianzi Wen, Hong Du, Yongning Jia, Zhixue Zheng, Lin Meng, Chengchao Shou, Jiafu Ji

Open Access Erratum

Erratum to: novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs

Pengfei Jiang, Rajesh Mukthavaram, Ying Chao, Ila Sri Bharati, Valentina Fogal, Sandra Pastorino, Xiuli Cong, Natsuko Nomura, Matt Gallagher, Taher Abbasi, Shireen Vali, Sandeep C Pingle, Milan Makale, Santosh Kesari

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