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Journal of Translational Medicine

Ausgabe 1/2015

Inhalt (391 Artikel)

Open Access Research

Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study

Júlia Aliz Baán, Zoltán V Varga, Przemyslaw Leszek, Mariusz Kuśmierczyk, Tamás Baranyai, László Dux, Péter Ferdinandy, Thomas Braun, Luca Mendler

Open Access Research

The number of circulating monocytes as biomarkers of the clinical response to methotrexate in untreated patients with rheumatoid arthritis

Luis Chara, Ana Sánchez-Atrio, Ana Pérez, Eduardo Cuende, Fernando Albarrán, Ana Turrión, Julio Chevarria, Angel Asunsolo del Barco, Miguel A Sánchez, Jorge Monserrat, Alfredo Prieto, Antonio de la Hera, Ignacio Sanz, David Diaz, Melchor Alvarez-Mon

Open Access Review

Overcoming tumor immune evasion with an unique arbovirus

Bruce Lyday, Tony Chen, Santosh Kesari, Boris Minev

Open Access Research

Renal denervation decreases effective refractory period but not inducibility of ventricular fibrillation in a healthy porcine biomodel: a case control study

Jean-Claude Lubanda, Jaroslav Kudlicka, Mikulas Mlcek, Miroslav Chochola, Petr Neuzil, Ales Linhart, Otomar Kittnar

Open Access Review

PD-1/PD-L1 pathway in non-small-cell lung cancer and its relation with EGFR mutation

Mei Ji, Yan Liu, Qing Li, Xiao-Dong Li, Wei-Qing Zhao, Hanze Zhang, Xiaofei Zhang, Jing-Ting Jiang, Chang-Ping Wu

Open Access Research

Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response

Ritu Khanra, Saikat Dewanjee, Tarun K Dua, Ranabir Sahu, Moumita Gangopadhyay, Vincenzo De Feo, Muhammad Zia-Ul-Haq

Open Access Research

Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments

Cindy E McCrea, Sheila G West, Penny M Kris-Etherton, Joshua D Lambert, Trent L Gaugler, Danette L Teeter, Katherine A Sauder, Yeyi Gu, Shannon L Glisan, Ann C Skulas-Ray

Open Access Research

Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients

Manish Kumar, Gunjan Srivastava, Jatinder Kaur, Jasmeet Assi, Akram Alyass, Iona Leong, Christina MacMillan, Ian Witterick, Nootan Kumar Shukla, Alok Thakar, Ritu Duggal, Ajoy Roychoudhury, Mehar Chand Sharma, Paul G Walfish, Shyam Singh Chauhan, Ranju Ralhan

Open Access Research

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma

Ines Chevolet, Reinhart Speeckaert, Max Schreuer, Bart Neyns, Olga Krysko, Claus Bachert, Mireille Van Gele, Nanja van Geel, Lieve Brochez

Open Access Review

Ebola: translational science considerations

Francesco Chiappelli, Andre Bakhordarian, April D Thames, Angela M Du, Allison L Jan, Melissa Nahcivan, Mia T Nguyen, Nateli Sama, Ercolano Manfrini, Francesco Piva, Rafael Malagoli Rocha, Carl A Maida

Open Access Research

Reduced T-cell repertoire restrictions in abatacept-treated rheumatoid arthritis patients

Luisa Imberti, Mirko Scarsi, Cinzia Zanotti, Marco Chiarini, Diego Bertoli, Angela Tincani, Paolo Airò

Open Access Editorial

Stakeholder engagement analysis - a bioethics dilemma in patient-targeted intervention: patients with temporomandibular joint disorders

Andre Barkhordarian, Gary Demerjian, Allison Jan, Nateli Sama, Mia Nguyen, Angela Du, Francesco Chiappelli

Open Access Research

Human neural stem cell transplantation in ALS: initial results from a phase I trial

Letizia Mazzini, Maurizio Gelati, Daniela Celeste Profico, Giada Sgaravizzi, Massimo Projetti Pensi, Gianmarco Muzi, Claudia Ricciolini, Laura Rota Nodari, Sandro Carletti, Cesare Giorgi, Cristina Spera, Frondizi Domenico, Enrica Bersano, Francesco Petruzzelli, Carlo Cisari, Annamaria Maglione, Maria Francesca Sarnelli, Alessandro Stecco, Giorgia Querin, Stefano Masiero, Roberto Cantello, Daniela Ferrari, Cristina Zalfa, Elena Binda, Alberto Visioli, Domenico Trombetta, Antonio Novelli, Barbara Torres, Laura Bernardini, Alessandro Carriero, Paolo Prandi, Serena Servo, Annalisa Cerino, Valentina Cima, Alessandra Gaiani, Nicola Nasuelli, Maurilio Massara, Jonathan Glass, Gianni Sorarù, Nicholas M Boulis, Angelo L Vescovi

Open Access Research

Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?

Luigi Barrea, Nicola Balato, Carolina Di Somma, Paolo Emidio Macchia, Maddalena Napolitano, Maria Cristina Savanelli, Katherine Esposito, Annamaria Colao, Silvia Savastano

Open Access Research

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

Christine M Freeman, Sean Crudgington, Valerie R Stolberg, Jeanette P Brown, Joanne Sonstein, Neil E Alexis, Claire M Doerschuk, Patricia V Basta, Elizabeth E Carretta, David J Couper, Annette T Hastie, Robert J Kaner, Wanda K O’Neal, Robert Paine III, Stephen I Rennard, Daichi Shimbo, Prescott G Woodruff, Michelle Zeidler, Jeffrey L Curtis

Open Access Research

Deeper insight into chronic kidney disease-related atherosclerosis: comparative proteomic studies of blood plasma using 2DE and mass spectrometry

Magdalena Luczak, Dorota Formanowicz, Łukasz Marczak, Elżbieta Pawliczak, Maria Wanic-Kossowska, Marek Figlerowicz, Maciej Stobiecki

Open Access Research

Postconditioning in major vascular surgery: prevention of renal failure

Peter Aranyi, Zsolt Turoczi, David Garbaisz, Gabor Lotz, Janos Geleji, Viktor Hegedus, Zoltan Rakonczay, Zsolt Balla, Laszlo Harsanyi, Attila Szijarto

Open Access Research

ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1

Cai Guo Ye, Liping Liu, George G Chen, Xiao Lin Tang, Zhiwei He, Ming-Liang He, Paul BS Lai

Open Access Research

Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles

Xinlu Yuan, Jie Wang, Xiaoyan Tang, Yixue Li, Pu Xia, Xin Gao

Open Access Research

DNA methylation patterns in newborns exposed to tobacco in utero

Carmen Ivorra, Mario F Fraga, Gustavo F Bayón, Agustín F Fernández, Consuelo Garcia-Vicent, F Javier Chaves, Josep Redon, Empar Lurbe

Open Access Research

Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy

Letizia Porcelli, Gabriella Guida, Anna E Quatrale, Tiziana Cocco, Letizia Sidella, Immacolata Maida, Rosa M Iacobazzi, Anna Ferretta, Diana A Stolfa, Sabino Strippoli, Stefania Guida, Stefania Tommasi, Michele Guida, Amalia Azzariti

Open Access Research

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche

Pegah Ghiabi, Jie Jiang, Jennifer Pasquier, Mahtab Maleki, Nadine Abu-Kaoud, Najeeb Halabi, Bella S Guerrouahen, Shahin Rafii, Arash Rafii

Open Access Research

Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice

Xuefeng Qiu, Kai Fu, Xiaozhi Zhao, Yanting Zhang, Yimin Yuan, Shiwei Zhang, Xiaoping Gu, Hongqian Guo

Open Access Research

Inhibition of human diffuse large B-cell lymphoma growth by JC polyomavirus-like particles delivering a suicide gene

Chun-Nun Chao, Yih-Leh Huang, Mien-Chun Lin, Chiung-Yao Fang, Cheng-Huang Shen, Pei-Lain Chen, Meilin Wang, Deching Chang, Chih-En Tseng

Open Access Research

The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals

Reena Rajasuriar, Yong Yean Kong, Reshika Nadarajah, Noor Kamila Abdullah, Tim Spelman, Muhamad Yazli Yuhana, Sasheela Ponampalavanar, Adeeba Kamarulzaman, Sharon R Lewin

Open Access Research

Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues

Alina Kurylowicz, Marta Jonas, Wojciech Lisik, Maurycy Jonas, Zofia Agnieszka Wicik, Zbigniew Wierzbicki, Andrzej Chmura, Monika Puzianowska-Kuznicka

Open Access Research

NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy

Michel M van den Heuvel, Marcel Verheij, Rogier Boshuizen, José Belderbos, Anne-Marie C Dingemans, Dirk De Ruysscher, Julien Laurent, Robert Tighe, John Haanen, Sonia Quaratino

Open Access Review

The XIX century smallpox prevention in Naples and the risk of transmission of human blood-related pathogens

Franco Maria Buonaguro, Maria Lina Tornesello, Luigi Buonaguro

Open Access Research

Profiling of cell stress protein expression in cardiac tissue of cardiosurgical patients undergoing remote ischemic preconditioning: implications for thioredoxin in cardioprotection

Karina Zitta, Patrick Meybohm, Matthias Gruenewald, Jochen Cremer, Kai D Zacharowski, Jens Scholz, Markus Steinfath, Martin Albrecht

Open Access Research

Perioperative dynamics and significance of amino acid profiles in patients with cancer

Yu Gu, Tianxiang Chen, Suzhen Fu, Xin Sun, Lingyan Wang, Jian Wang, Yingfeng Lu, Songming Ding, Guodong Ruan, Lisong Teng, Min Wang

Open Access Research

Interleukin-37 is increased in ankylosing spondylitis patients and associated with disease activity

Bingni Chen, Kunzhao Huang, Liang Ye, Yanqun Li, Jiawei Zhang, Jinshun Zhang, Xinmin Fan, Xiaokai Liu, Li Li, Jinxia Sun, Jing Du, Zhong Huang

Open Access Research

Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas

Antonella Manca, Amelia Lissia, Mariaelena Capone, Paolo A Ascierto, Gerardo Botti, Corrado Caracò, Ignazio Stanganelli, Maria Colombino, MariaCristina Sini, Antonio Cossu, Giuseppe Palmieri

Open Access Research

NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse

Fang Xu, Ying Liu, Lei Shi, Wei Liu, Li Zhang, Hongjing Cai, Jie Qi, Yong Cui, Weichen Wang, Yejia Hu

Open Access Review

Fighting against kidney diseases with small interfering RNA: opportunities and challenges

Cheng Yang, Chao Zhang, Zitong Zhao, Tongyu Zhu, Bin Yang

Open Access Editorial

State of art and science advances on nutrition and nutrigenetics in nutrition-related non-communicable diseases in Middle East

Laura Soldati, Abdelhamid Kerkadi, Paul Amuna, Annalisa Terranegra

Open Access Research

Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma

Jia-hong Wang, Wei Wei, Zhi-xing Guo, Ming Shi, Rong-ping Guo

Open Access Research

Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer

Jun Lu, Guangliang Li, Kuifeng He, Weiqin Jiang, Cong Xu, Zhongqi Li, Haohao Wang, Weibin Wang, Haiyong Wang, Xiaodong Teng, Lisong Teng

Open Access Research

Personalization of cancer treatment using predictive simulation

Nicole A Doudican, Ansu Kumar, Neeraj Kumar Singh, Prashant R Nair, Deepak A Lala, Kabya Basu, Anay A Talawdekar, Zeba Sultana, Krishna Kumar Tiwari, Anuj Tyagi, Taher Abbasi, Shireen Vali, Ravi Vij, Mark Fiala, Justin King, MaryAnn Perle, Amitabha Mazumder

Open Access Research

Effects of GRK5 and ADRB1 polymorphisms influence on systolic heart failure

Sheng Kang, Xuan Hong, Chang-wu Ruan, Ping Yu, Shan-shan Yu, Ming Chen, Dai-fu Zhang, Hui-min Fan, Zhong-min Liu

Open Access Research

Pharmacokinetic model of unfractionated heparin during and after cardiopulmonary bypass in cardiac surgery

Zaishen Jia, Ganzhong Tian, Yupeng Ren, Zhiquan Sun, Wei Lu, Xiaotong Hou

Open Access Research

Comparison between xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute cerebral infarct: proof of concept in rats

María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, Laura Otero-Ortega, Blanca Fuentes, María Teresa Vallejo-Cremades, Borja Enrique Sanz-Cuesta, Exuperio Díez-Tejedor

Open Access Research

Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer

Li-Ying OuYang, Xiao-Jun Wu, Shu-Biao Ye, Rong-xin Zhang, Ze-Lei Li, Wei Liao, Zhi-Zhong Pan, Li-Min Zheng, Xiao-Shi Zhang, Zhong Wang, Qing Li, Gang Ma, Jiang Li

Open Access Research

Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities

Javier Angulo, Pedro Cuevas, Begoña Cuevas, Mohammad El Youssef, Argentina Fernández, Eduardo Martínez-Salamanca, Rocío González-Corrochano, Guillermo Giménez-Gallego

Open Access Research

Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis

Jieyuan Zhang, Junjie Guan, Xin Niu, Guowen Hu, Shangchun Guo, Qing Li, Zongping Xie, Changqing Zhang, Yang Wang

Open Access Research

A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice

Javier Gordon Ogembo, Matthew R Muraswki, Lori W McGinnes, Agapi Parcharidou, Rujapak Sutiwisesak, Timelia Tison, Juan Avendano, Deep Agnani, Robert W Finberg, Trudy G Morrison, Joyce D Fingeroth

Open Access Research

Calcineurin inhibitors differentially alter the circadian rhythm of T-cell functionality in transplant recipients

Sarah Leyking, Karin Budich, Kai van Bentum, Stephan Thijssen, Hashim Abdul-Khaliq, Danilo Fliser, Martina Sester, Urban Sester

Open Access Methodology

An RNA editing fingerprint of cancer stem cell reprogramming

Leslie A Crews, Qingfei Jiang, Maria A Zipeto, Elisa Lazzari, Angela C Court, Shawn Ali, Christian L Barrett, Kelly A Frazer, Catriona HM Jamieson

Open Access Methodology

Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods

Jintang He, Athena A Schepmoes, Tujin Shi, Chaochao Wu, Thomas L Fillmore, Yuqian Gao, Richard D Smith, Wei-Jun Qian, Karin D Rodland, Tao Liu, David G Camp II, Anshu Rastogi, Shyh-Han Tan, Wusheng Yan, Ahmed A Mohamed, Wei Huang, Sreedatta Banerjee, Jacob Kagan, Sudhir Srivastava, David G McLeod, Shiv Srivastava, Gyorgy Petrovics, Albert Dobi, Alagarsamy Srinivasan

Open Access Research

Performance of a multiplexed dual analyte immunoassay for the early detection of non-small cell lung cancer

Victoria Doseeva, Tracey Colpitts, Grace Gao, Juliana Woodcock, Vladimir Knezevic

Open Access Research

Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma

Xin Ma, Liangyou Gu, Hongzhao Li, Yu Gao, Xintao Li, Donglai Shen, Huijie Gong, Shichao Li, Shaoxi Niu, Yu Zhang, Yang Fan, Qingbo Huang, Xiangjun Lyu, Xu Zhang

Open Access Research

Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib

Andrea Li Ann Wong, Joline Si Jing Lim, Arvind Sinha, Anil Gopinathan, Robert Lim, Chee-Seng Tan, Thomas Soh, Sudhakar Venkatesh, Christina Titin, Nur Sabrina Sapari, Soo-Chin Lee, Wei-Peng Yong, David Shao Ping Tan, Brendan Pang, Ting-Ting Wang, Ying-Kiat Zee, Richie Soong, Zuzana Trnkova, Chetan Lathia, Jean-Paul Thiery, Scott Wilhelm, Michael Jeffers, Boon-Cher Goh

Open Access Research

Validation of a continuous infusion of low dose Iohexol to measure glomerular filtration rate: randomised clinical trial

John J Dixon, Katie Lane, R Neil Dalton, Charles Turner, R Michael Grounds, Iain AM MacPhee, Barbara J Philips

Open Access Research

Administered circulating microparticles derived from lung cancer patients markedly improved angiogenesis, blood flow and ischemic recovery in rat critical limb ischemia

Jiunn-Jye Sheu, Fan-Yen Lee, Christopher Glenn Wallace, Tzu-Hsien Tsai, Steve Leu, Yung-Lung Chen, Han-Tan Chai, Hung-I Lu, Cheuk-Kwan Sun, Hon-Kan Yip

Open Access Research

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Beatriz Mothe, Xintao Hu, Anuska Llano, Margherita Rosati, Alex Olvera, Viraj Kulkarni, Antonio Valentin, Candido Alicea, Guy R Pilkington, Niranjan Y Sardesai, Muntsa Rocafort, Manel Crespo, Jorge Carrillo, Andrés Marco, James I Mullins, Lucy Dorrell, Tomáš Hanke, Bonaventura Clotet, George N Pavlakis, Barbara K Felber, Christian Brander

Open Access Research

Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population

Rohit Upadhyay, Amal Robay, Khalid Fakhro, Charbel Abi Khadil, Mahmoud Zirie, Amin Jayyousi, Maha El-Shafei, Szilard Kiss, Donald J D′Amico, Jacqueline Salit, Michelle R Staudt, Sarah L O′Beirne, Xiaoliang Chen, Balwant Tuana, Ronald G Crystal, Hong Ding

Open Access Review

Mechanisms involved in breast cancer liver metastasis

Rui Ma, Yili Feng, Shuang Lin, Jiang Chen, Hui Lin, Xiao Liang, Heming Zheng, Xiujun Cai

Open Access Research

Quantitative analysis of proteins of metabolism by reverse phase protein microarrays identifies potential biomarkers of rare neuromuscular diseases

Fulvio Santacatterina, Margarita Chamorro, Cristina Núñez de Arenas, Carmen Navarro, Miguel A Martín, José M Cuezva, María Sánchez-Aragó

Open Access Research

Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model

Qiwen Deng, Bangshun He, Xian Liu, Jin Yue, Houqun Ying, Yuqin Pan, Huiling Sun, Jie Chen, Feng Wang, Tianyi Gao, Lei Zhang, Shukui Wang

Open Access Research

Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis

Hongyan Lu, Christophe Poirier, Todd Cook, Dmitry O Traktuev, Stephanie Merfeld-Clauss, Benjamin Lease, Irina Petrache, Keith L March, Natalia V Bogatcheva

Open Access Research

PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL

Hao Zhang, Teng Sun, Xia Jiang, Hongli Yu, Meng Wang, Tengteng Wei, Huazhu Cui, Wei Zhuang, Zhiwei Liu, Zhongming Zhang, Hongyan Dong

Open Access Erratum

Erratum to: a randomised translational trial of lifestyle intervention using a 3-tier shared care approach on pregnancy outcomes in Chinese women with gestational diabetes mellitus but without diabetes

Xilin Yang, Huiguang Tian, Fuxia Zhang, Cuiping Zhang, Yi Li, Junhong Leng, Leishen Wang, Gongshu Liu, Ling Dong, Zhijie Yu, Gang Hu, Juliana CN Chan

Open Access Research

Identification of stroke-associated-antigens via screening of recombinant proteins from the human expression cDNA library (SEREX)

Toshio Machida, Motoo Kubota, Eiichi Kobayashi, Yasuo Iwadate, Naokatsu Saeki, Akira Yamaura, Fumio Nomura, Masaki Takiguchi, Takaki Hiwasa

Open Access Research

Inducibility of ventricular fibrillation during mild therapeutic hypothermia: electrophysiological study in a swine model

Jaroslav Kudlicka, Mikulas Mlcek, Jan Belohlavek, Pavel Hala, Stanislav Lacko, David Janak, Stepan Havranek, Jan Malik, Tomas Janota, Petr Ostadal, Petr Neuzil, Otomar Kittnar

Open Access Research

Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition

Elisabeth Streckel, Christina Braun-Reichhart, Nadja Herbach, Maik Dahlhoff, Barbara Kessler, Andreas Blutke, Andrea Bähr, Nicole Übel, Matthias Eddicks, Mathias Ritzmann, Stefan Krebs, Burkhard Göke, Helmut Blum, Rüdiger Wanke, Eckhard Wolf, Simone Renner

Open Access Research

ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells

Rutger K Balvers, Martine LM Lamfers, Jenneke J Kloezeman, Anne Kleijn, Lotte ME Berghauser Pont, Clemens MF Dirven, Sieger Leenstra

Open Access Research

Body shape index versus body mass index as correlates of health risk in young healthy sedentary men

Marzena Malara, Anna Kęska, Joanna Tkaczyk, Grażyna Lutosławska

Open Access Research

A small molecule activator of AKT does not reduce ischemic injury of the rat heart

Jose BN Moreira, Martin Wohlwend, Marcia NM Alves, Ulrik Wisløff, Anja Bye

Open Access Research

Inherent transcriptional signatures of NK cells are associated with response to IFNα + rivabirin therapy in patients with Hepatitis C Virus

Maria Libera Ascierto, Federica Bozzano, Davide Bedognetti, Francesco Marras, Cathy Schechterly, Kentaro Matsuura, Antonino Picciotto, Simona Marenco, Yingdong Zhao, Valeria DeGiorgi, Michele Sommariva, Lorenzo Moretta, Ena Wang, Harvey J Alter, Francesco M Marincola, Andrea De Maria

Open Access Research

Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer

Irina V Alekseenko, Eugene V Snezhkov, Igor P Chernov, Victor V Pleshkan, Victor K Potapov, Alexander V Sass, Galina S Monastyrskaya, Eugene P Kopantzev, Tatyana V Vinogradova, Yuri V Khramtsov, Alexey V Ulasov, Andrey A Rosenkranz, Alexander S Sobolev, Olga A Bezborodova, Anna D Plyutinskaya, Elena R Nemtsova, Raisa I Yakubovskaya, Eugene D Sverdlov

Open Access Research

Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia

Rabia Shabir Ahmad, Masood Sadiq Butt, M Tauseef Sultan, Zarina Mushtaq, Shakeel Ahmad, Saikat Dewanjee, Vincenzo De Feo, Muhammad Zia-Ul-Haq

Open Access Research

A prime/boost strategy using DNA/fowlpox recombinants expressing the genetically attenuated E6 protein as a putative vaccine against HPV-16-associated cancers

Massimiliano Bissa, Elena Illiano, Sole Pacchioni, Francesca Paolini, Carlo Zanotto, Carlo De Giuli Morghen, Silvia Massa, Rosella Franconi, Antonia Radaelli, Aldo Venuti

Open Access Research

Ameliorative effect of water spinach, Ipomea aquatica (Convolvulaceae), against experimentally induced arsenic toxicity

Tarun K Dua, Saikat Dewanjee, Moumita Gangopadhyay, Ritu Khanra, Muhammad Zia-Ul-Haq, Vincenzo De Feo

Open Access Research

The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer

Zhihua Li, Xiaohui Zhao, Yu Zhou, Yimin Liu, Quanbo Zhou, Huilin Ye, YinXue Wang, Jinlong Zeng, Yadong Song, Wenchao Gao, ShangYou Zheng, Baoxiong Zhuang, Huimou Chen, Wenzhu Li, Haigang Li, Haifeng Li, Zhiqiang Fu, Rufu Chen

Open Access Research

The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes

Emanuela Lapice, Antonella Monticelli, Sergio Cocozza, Michele Pinelli, Sara Cocozza, Dario Bruzzese, Gabriele Riccardi, Olga Vaccaro

Open Access Research

Mir-135a enhances cellular proliferation through post-transcriptionally regulating PHLPP2 and FOXO1 in human bladder cancer

Xiao Peng Mao, Luo Sheng Zhang, Bin Huang, Shi Ying Zhou, Jun Liao, Ling Wu Chen, Shao Peng Qiu, Jun Xing Chen

Open Access Research

Impacts of ezetimibe on PCSK9 in rats: study on the expression in different organs and the potential mechanisms

Rui-Xia Xu, Jun Liu, Xiao-Lin Li, Sha Li, Yan Zhang, Yan-Jun Jia, Jing Sun, Jian-Jun Li

Open Access Research

HIF2α induces cardiomyogenesis via Wnt/β-catenin signaling in mouse embryonic stem cells

Xiaotian Sun, Liewen Pang, Meng Shi, Jiechun Huang, Yiqing Wang

Open Access Research

The prognostic role of systemic inflammatory markers on HIV-infected patients with non-Hodgkin lymphoma, a multicenter cohort study

Elena Raffetti, Francesco Donato, Filippo Castelnuovo, Nicoletta Ladisa, Giuseppe Paraninfo, Elisa Di Filippo, Daniela Segala, Giuliana Cologni, Alessandra Bandera, Fabio Zacchi, Simona Digiambenedetto, Massimo Di Pietro, Francesco Castelli, Eugenia Quiros-Roldan

Open Access Research

Induction of tumor inhibitory anti-angiogenic response through immunization with interferon Gamma primed placental endothelial cells: ValloVax™

Thomas E Ichim, Shuang Li, Hong Ma, Yuliya V Yurova, Julia S Szymanski, Amit N Patel, Santosh Kesari, Wei-Ping Min, Samuel C Wagner

Open Access Research

Total saponin from Anemone flaccida Fr. Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL-induced NF-κB, JNK and p38 MAPKs activation

Xiangying Kong, Wenbin Wu, Yue Yang, Hongye Wan, Xiaomin Li, Michun Zhong, Hongyan Zhao, Xiaohui Su, Shiwei Jia, Dahong Ju, Na Lin

Open Access Research

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway

Xiaodi Fan, Jun Wang, Jincai Hou, Chengren Lin, Alan Bensoussan, Dennis Chang, Jianxun Liu, Bing Wang

Open Access Research

Focused ultrasound-induced blood–brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study

Pin-Yuan Chen, Han-Yi Hsieh, Chiung-Yin Huang, Chun-Yen Lin, Kuo-Chen Wei, Hao-Li Liu

Open Access Research

Detecting primitive hematopoietic stem cells in total nucleated and mononuclear cell fractions from umbilical cord blood segments and units

John Patterson, Cally H Moore, Emily Palser, Jason C Hearn, Daniela Dumitru, Holli A Harper, Ivan N Rich

Open Access Research

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia

Cheng-Shi Xu, Ze-Fen Wang, Xiao-Dong Huang, Li-Ming Dai, Chang-Jun Cao, Zhi-Qiang Li

Open Access Review

Aquaporins as diagnostic and therapeutic targets in cancer: How far we are?

Jian Wang, Li Feng, Zhitu Zhu, Minghuan Zheng, Diane Wang, Zhihong Chen, Hongzhi Sun

Open Access Editorial

Imaging technologies from bench to bedside

Ravinder Reddy, Mohammad Haris

Open Access Research

GLI2 inhibition abrogates human leukemia stem cell dormancy

Anil Sadarangani, Gabriel Pineda, Kathleen M Lennon, Hye-Jung Chun, Alice Shih, Annelie E Schairer, Angela C Court, Daniel J Goff, Sacha L Prashad, Ifat Geron, Russell Wall, John D McPherson, Richard A Moore, Minya Pu, Lei Bao, Amy Jackson-Fisher, Michael Munchhof, Todd VanArsdale, Tannishtha Reya, Sheldon R Morris, Mark D Minden, Karen Messer, Hanna KA Mikkola, Marco A Marra, Thomas J Hudson, Catriona HM Jamieson

Open Access Research

Characterization of a novel endothelial biosensor assay reveals increased cumulative serum inflammatory potential in stabilized coronary artery disease patients

Heidi Cung, Mario J Aragon, Katherine Zychowski, Joe R Anderson, James Nawarskas, Carlos Roldan, Akshay Sood, Clifford Qualls, Matthew J Campen

Open Access Research

Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients

Monica Benvenuto, Pierpaolo Sileri, Piero Rossi, Laura Masuelli, Massimo Fantini, Monica Nanni, Luana Franceschilli, Giuseppe Sconocchia, Giulia Lanzilli, Roberto Arriga, Giovanni Faggioni, Florigio Lista, Augusto Orlandi, Vittorio Manzari, Achille Lucio Gaspari, Andrea Modesti, Roberto Bei

Open Access Protocol

A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer

Mythili Koneru, Roisin O’Cearbhaill, Swati Pendharkar, David R Spriggs, Renier J Brentjens

Open Access Research

Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

Nathalie Piazzon, Florian Bernet, Linda Guihard, Wouter N Leonhard, Séverine Urfer, Dmitri Firsov, Hassib Chehade, Bruno Vogt, Sophia Piergiovanni, Dorien JM Peters, Olivier Bonny, Daniel B Constam

Open Access Research

FH535 increases the radiosensitivity and reverses epithelial-to-mesenchymal transition of radioresistant esophageal cancer cell line KYSE-150R

Huafang Su, Xiance Jin, Xuebang Zhang, Lihao Zhao, Baochai Lin, Lili Li, Zhenghua Fei, Lanxiao Shen, Ya Fang, Huanle Pan, Congying Xie

Open Access Research

Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma

Aibing Wu, Kunpeng Wu, Jinmei Li, Yanli Mo, Yanming Lin, Yuzhou Wang, Xiang Shen, Shujun Li, Lixia Li, Zhixiong Yang

Open Access Research

Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains

Francesca Sironi, Mauro Malnati, Nicola Mongelli, Paolo Cozzi, Christina Guzzo, Silvia Ghezzi, Carles Martínez-Romero, Adolfo García-Sastre, Paolo Lusso, Daniela Jabes, Priscilla Biswas

Open Access Research

Fourier transform infrared spectroscopy for the distinction of MCF-7 cells treated with different concentrations of 5-fluorouracil

Bi-Bo Wu, Yi-Ping Gong, Xin-Hong Wu, Yuan-Yuan Chen, Fang-Fang Chen, Li-Ting Jin, Bo-Ran Cheng, Fen Hu, Bin Xiong

Open Access Editorial

Docosahexaenoic acid and non-alcoholic fatty liver disease in obese children: a novel approach?

Elvira Verduci, Carlotta Lassandro, Giovanni Radaelli, Laura Soldati

Open Access Research

Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling

Jessica M Foley, Donald J Scholten II, Noel R Monks, David Cherba, David J Monsma, Paula Davidson, Dawna Dylewski, Karl Dykema, Mary E Winn, Matthew R Steensma

Open Access Research

Diagnosing inflammation and infection in the urinary system via proteomics

Yanbao Yu, Patricia Sikorski, Cynthia Bowman-Gholston, Nicolas Cacciabeve, Karen E Nelson, Rembert Pieper

Open Access Research

CXCL13, CCL4, and sTNFR as circulating inflammatory cytokine markers in primary and SLE-related autoimmune hemolytic anemia

Boting Wu, Weiguang Wang, Yanxia Zhan, Feng Li, Shanhua Zou, Lihua Sun, Yunfeng Cheng

Open Access Review

The non-coding RNAs of the H19-IGF2 imprinted loci: A focus on biological roles and therapeutic potential in Lung Cancer

Imad J Matouk, David Halle, Michal Gilon, Abraham Hochberg

Open Access Research

Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy

Jack JA van Asten, Riyas Vettukattil, Tessa Buckle, Sven Rottenberg, Fijs van Leeuwen, Tone F Bathen, Arend Heerschap

Open Access Research

Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract

Helene Damhofer, Eva A Ebbing, Anne Steins, Lieke Welling, Johanna A Tol, Kausilia K Krishnadath, Tom van Leusden, Marc J van de Vijver, Marc G Besselink, Olivier R Busch, Mark I van Berge Henegouwen, Otto van Delden, Sybren L Meijer, Frederike Dijk, Jan Paul Medema, Hanneke W van Laarhoven, Maarten F Bijlsma

Open Access Research

Oncogenic HER2 fusions in gastric cancer

De-Hua Yu, Lili Tang, Hua Dong, Zhengwei Dong, Lianhai Zhang, Jiangang Fu, Xinying Su, Tianwei Zhang, Haihua Fu, Lu Han, Liang Xie, Hao Chen, Ziliang Qian, Guanshan Zhu, Jia Wang, Qingqing Ye, Jingchuan Zhang, Xiaolu Yin, Xiaolin Zhang, Jiafu Ji, Qunsheng Ji

Open Access Research

Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients

Elaheh Rahbar, Jessica C Cardenas, Gyulnar Baimukanova, Benjamin Usadi, Roberta Bruhn, Shibani Pati, Sisse R Ostrowski, Pär I Johansson, John B Holcomb, Charles E Wade

Open Access Review

Perspective of synaptic protection after post-infarction treatment with statins

Johanna Andrea Gutiérrez-Vargas, Angel Cespedes-Rubio, Gloria Patricia Cardona-Gómez

Open Access Research

Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population

Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A Rouh, Idil I Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M Marincola, Javaid Sheikh, Lotfi Chouchane

Open Access Research

Favorable in vitro effects of combined IL-12 and IL-18 treatment on NK cell cytotoxicity and CD25 receptor expression in metastatic melanoma patients

Katarina Mirjačić Martinović, Nada Babović, Radan Džodić, Vladimir Jurišić, Suzana Matković, Gordana Konjević

Open Access Research

Evaluation of the anaphylactoid potential of Andrographis paniculata extracts using the popliteal lymph node assay and P815 cell degranulation in vitro

Xuguang Hu, Ya Wen, Shasha Liu, Jiabo Luo, Xiaomei Tan, Zhiheng Li, Xinhua Lu, Xiaoying Long

Open Access Research

BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma

Hakan Alakus, Shawn E Yost, Brian Woo, Randall French, Grace Y Lin, Kristen Jepsen, Kelly A Frazer, Andrew M Lowy, Olivier Harismendy

Open Access Research

Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in culture

Valérie Janelle, Cédric Carli, Julie Taillefer, Julie Orio, Jean-Sébastien Delisle

Open Access Research

Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative

David Fajardo-Ortiz, José Ortega-Sánchez-de-Tagle, Victor M Castaño

Open Access Research

A novel method for downstream characterization of breast cancer circulating tumor cells following CellSearch isolation

Henrik Frithiof, Charlotte Welinder, Anna-Maria Larsson, Lisa Rydén, Kristina Aaltonen

Open Access Methodology

Food safety and nutritional quality for the prevention of non communicable diseases: the Nutrient, hazard Analysis and Critical Control Point process (NACCP)

Laura Di Renzo, Carmen Colica, Alberto Carraro, Beniamino Cenci Goga, Luigi Tonino Marsella, Roberto Botta, Maria Laura Colombo, Santo Gratteri, Ting Fa Margherita Chang, Maurizio Droli, Francesca Sarlo, Antonino De Lorenzo

Open Access Research

Diurnal rhythms of serum and plasma cytokine profiles in healthy elderly individuals assessed using membrane based multiplexed immunoassay

Raffaele Altara, Marco Manca, Kevin CM Hermans, Evangelos P Daskalopoulos, Hans-Peter Brunner-La Rocca, Rob JJ Hermans, Harry AJ Struijker-Boudier, Matthijs W Blankesteijn

Open Access Protocol

Pei regimen: a therapeutic option in small cell lung cancer? A retrospective monoinstitutional analysis of 46 consecutive cases

Corrado Boni, Maria Pagano, Licia Baldi, Roberta Gnoni, Luca Braglia, Luisa Savoldi, Francesca Zanelli

Open Access Research

Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial

Maria Feldt, Olöf Bjarnadottir, Siker Kimbung, Karin Jirström, Pär-Ola Bendahl, Srinivas Veerla, Dorthe Grabau, Ingrid Hedenfalk, Signe Borgquist

Open Access Research

Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders

Khalid Hussain Janbaz, Tashfeen Akhtar, Fatima Saqib, Imran Imran, Muhammad Zia-Ul-Haq, Chaweeewan Jansakul, Vincenzo De Feo, Marius Moga

Open Access Research

Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype

Andrea Guennoun, Melissa Kazantzis, Remy Thomas, Martin Wabitsch, Daniel Tews, Konduru Seetharama Sastry, Mouaadh Abdelkarim, Vladimir Zilberfarb, Arthur Donny Strosberg, Lotfi Chouchane

Open Access Research

Establishment of a patient-derived orthotopic osteosarcoma mouse model

Claudia Blattmann, Markus Thiemann, Albrecht Stenzinger, Eva K Roth, Anne Dittmar, Hendrik Witt, Burkhard Lehner, Eva Renker, Manfred Jugold, Viktoria Eichwald, Wilko Weichert, Peter E Huber, Andreas E Kulozik

Open Access Research

High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma

Yibiao Ye, Jie Chen, Yu Zhou, Zhiqiang Fu, Quanbo Zhou, YingXue Wang, Wenchao Gao, ShangYou Zheng, Xiaohui Zhao, Tao Chen, Rufu Chen

Open Access Research

Systems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer

Andrea Remo, Ines Simeone, Massimo Pancione, Pietro Parcesepe, Pascal Finetti, Luigi Cerulo, Halima Bensmail, Daniel Birnbaum, Steven J Van Laere, Vittorio Colantuoni, Franco Bonetti, François Bertucci, Erminia Manfrin, Michele Ceccarelli

Open Access Research

Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma

Carmela Rozera, Giancarlo Antonini Cappellini, Giuseppina D’Agostino, Laura Santodonato, Luciano Castiello, Francesca Urbani, Iole Macchia, Eleonora Aricò, Ida Casorelli, Paola Sestili, Enrica Montefiore, Domenica Monque, Davide Carlei, Mariarosaria Napolitano, Paola Rizza, Federica Moschella, Carla Buccione, Roberto Belli, Enrico Proietti, Antonio Pavan, Paolo Marchetti, Filippo Belardelli, Imerio Capone

Open Access Research

Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab

Riccardo Giampieri, Alessandra Mandolesi, Khaled M Abouelkhair, Cristian Loretelli, Michela Del Prete, Luca Faloppi, Bianconi Maristella, Ezzeldin M Ibrahim, Marina Scarpelli, Stefano Cascinu, Mario Scartozzi

Open Access Research

Development of genetically engineered iNKT cells expressing TCRs specific for the M. tuberculosis 38-kDa antigen

Zhen-Min Jiang, Wei Luo, Qian Wen, Su-Dong Liu, Pei-Pei Hao, Chao-Ying Zhou, Ming-Qian Zhou, Li Ma

Open Access Research

Endothelial progenitor cells inhibit platelet function in a P-selectin-dependent manner

Haissam Abou-Saleh, Ahmed Hachem, Daniel Yacoub, Marc-Antoine Gillis, Yahye Merhi

Open Access Research

Cysteamine treatment restores the in vitro ability to differentiate along the osteoblastic lineage of mesenchymal stromal cells isolated from bone marrow of a cystinotic patient

Antonella Conforti, Anna Taranta, Simone Biagini, Nadia Starc, Angela Pitisci, Francesco Bellomo, Valentina Cirillo, Franco Locatelli, Maria Ester Bernardo, Francesco Emma

Open Access Research

Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients

Gaojie Liu, Jie Zhu, Menglei Yu, Canfeng Cai, Yu Zhou, Min Yu, Zhiqiang Fu, Yuanfeng Gong, Bin Yang, Yingru Li, Quanbo Zhou, Qin Lin, Huilin Ye, Liangtao Ye, Xiaohui Zhao, Zhihua Li, Rufu Chen, Fanghai Han, Chaoming Tang, Bing Zeng

Open Access Research

Higher frequency of regulatory T cells in granulocyte colony-stimulating factor (G-CSF)-primed bone marrow grafts compared with G-CSF-primed peripheral blood grafts

Xiang-Yu Zhao, Yu-Tong Wang, Xiao-Dong Mo, Xiao-Su Zhao, Ya-Zhe Wang, Ying-Jun Chang, Xiao-Jun Huang

Open Access Research

Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer

Dirk O Bauerschlag, Nicolai Maass, Peter Leonhardt, Frederik A Verburg, Ulrich Pecks, Felix Zeppernick, Agnieszka Morgenroth, Felix M Mottaghy, Rene Tolba, Ivo Meinhold-Heerlein, Karen Bräutigam

Open Access Research

Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling

Daniyil A Svystonyuk, Janet MC Ngu, Holly EM Mewhort, Brodie D Lipon, Guoqi Teng, David G Guzzardi, Getanshu Malik, Darrell D Belke, Paul WM Fedak

Open Access Research

MicroRNA-572 expression in multiple sclerosis patients with different patterns of clinical progression

Roberta Mancuso, Ambra Hernis, Simone Agostini, Marco Rovaris, Domenico Caputo, Mario Clerici

Open Access Research

Detection and quantification of microRNA in cerebral microdialysate

Søren Bache, Rune Rasmussen, Maria Rossing, Niels Risør Hammer, Marianne Juhler, Lennart Friis-Hansen, Finn Cilius Nielsen, Kirsten Møller

Open Access Research

Evaluation of in vivo responses of sorafenib therapy in a preclinical mouse model of PTEN-deficient of prostate cancer

Yutaka Yamamoto, Marco A De Velasco, Yurie Kura, Masahiro Nozawa, Yuji Hatanaka, Takashi Oki, Takayuki Ozeki, Nobutaka Shimizu, Takafumi Minami, Kazuhiro Yoshimura, Kazuhiro Yoshikawa, Kazuto Nishio, Hirotsugu Uemura

Open Access Research

DNA methylation analysis of phenotype specific stratified Indian population

Harish Rotti, Sandeep Mallya, Shama Prasada Kabekkodu, Sanjiban Chakrabarty, Sameer Bhale, Ramachandra Bharadwaj, Balakrishna K Bhat, Amrish P Dedge, Vikram Ram Dhumal, GG Gangadharan, Puthiya M Gopinath, Periyasamy Govindaraj, Kalpana S Joshi, Paturu Kondaiah, Sreekumaran Nair, SN Venugopalan Nair, Jayakrishna Nayak, BV Prasanna, Pooja Shintre, Mayura Sule, Kumarasamy Thangaraj, Bhushan Patwardhan, Marthanda Varma Sankaran Valiathan, Kapaettu Satyamoorthy

Open Access Research

Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer

Weizhen Xu, Yinyin Ying, Lihong Shan, Jianguo Feng, Shengjie Zhang, Yun Gao, Xiaoling Xu, Yinli Yao, Chihong Zhu, Weimin Mao

Open Access Research

A novel EYA4 mutation causing hearing loss in a Chinese DFNA family and genotype-phenotype review of EYA4 in deafness

Aiping Huang, Yongyi Yuan, Yanping Liu, Qingwen Zhu, Pu Dai

Open Access Research

Delayed administration of allogeneic cardiac stem cell therapy for acute myocardial infarction could ameliorate adverse remodeling: experimental study in swine

Veronica Crisostomo, Claudia Baez-Diaz, Juan Maestre, Monica Garcia-Lindo, Fei Sun, Javier G. Casado, Rebeca Blazquez, Jose L. Abad, Itziar Palacios, Luis Rodriguez-Borlado, Francisco M. Sanchez-Margallo

Open Access Research

Development of a novel IGRA assay to test T cell responsiveness to HBV antigens in whole blood of chronic Hepatitis B patients

Werner Dammermann, Frank Bentzien, Eva-Maria Stiel, Claudia Kühne, Sebastian Ullrich, Julian Schulze zur Wiesch, Stefan Lüth

Open Access Research

Cellular immunotherapy as maintenance therapy prolongs the survival of the patients with small cell lung cancer

Xiao Ding, He Cao, Xiao Chen, Haofan Jin, Ziling Liu, Guanjun Wang, Lu Cai, Dan Li, Chao Niu, Huimin Tian, Lei Yang, Yuguang Zhao, Wei Li, Jiuwei Cui

Open Access Research

Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case–control study

Ruth R Miller, W Darlene Reid, Andre Mattman, Cristiane Yamabayashi, Theodore Steiner, Shoshana Parker, Jennifer Gardy, Patrick Tang, David M Patrick

Open Access Research

Preclinical good laboratory practice-compliant safety study to evaluate biodistribution and tumorigenicity of a cartilage advanced therapy medicinal product (ATMP)

Matthias Zscharnack, Christoph Krause, Gabriela Aust, Christian Thümmler, Frank Peinemann, Thomas Keller, Jeske J. Smink, Heidrun Holland, Jeremy S. Somerson, Jens Knauer, Ronny M. Schulz, Jörg Lehmann

Open Access Review

Diverse functions of miR-373 in cancer

Furong Wei, Chuanhua Cao, Xiaoqun Xu, Junfu Wang

Open Access Research

Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years

Anna Paaso, Hanna-Mari Koskimaa, Marij JP Welters, Seija Grénman, Kari Syrjänen, Sjoerd H van der Burg, Stina Syrjänen

Open Access Research

VEGF111b, a C-terminal splice variant of VEGF-A and induced by mitomycin C, inhibits ovarian cancer growth

Xiuli Li, Fang Gu, Chenguang Niu, Yuanfen Wang, Zhongyu Liu, Na Li, Bing Pan, Dan He, Jian Kong, Shaobo Zhang, Xu Wang, Yuanqing Yao, Lemin Zheng

Open Access Research

Assessment of the effector function of CMV-specific CTLs isolated using MHC-multimers from granulocyte-colony stimulating factor mobilized peripheral blood

Lorea Beloki, Miriam Ciaurriz, Cristina Mansilla, Amaya Zabalza, Estela Perez-Valderrama, Edward R. Samuel, Mark W. Lowdell, Natalia Ramirez, Eduardo Olavarria

Open Access Research

A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma

Guimiao Lin, Xiaomei Wang, Wanxian Yi, Chuanxia Zhang, Gaixia Xu, Xiaomei Zhu, Zhiming Cai, Yu Liu, Yuwen Diao, Marie Chia-Mi Lin, Guangyi Jin

Open Access Research

Notch-1 knockdown suppresses proliferation, migration and metastasis of salivary adenoid cystic carcinoma cells

Wei Chen, Gang Cao, Xinran Yuan, Xiang Zhang, Qingqing Zhang, Yinglan Zhu, Zhen Dong, Senlin Zhang

Open Access Research

The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer

Lujia Chen, Zhongxi Huang, Guangyu Yao, Xiaoming Lyu, Jinbang Li, Xiaolei Hu, Yahong Cai, Wenji Li, Xin Li, Changsheng Ye

Open Access Research

Bisphenol-A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: a cross-sectional study on adult male population

Silvia Savastano, Giovanni Tarantino, Vittoria D’Esposito, Federica Passaretti, Serena Cabaro, Antonietta Liotti, Domenico Liguoro, Giuseppe Perruolo, Fabiana Ariemma, Carmine Finelli, Francesco Beguinot, Pietro Formisano, Rossella Valentino

Open Access Research

Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers

Krystyna M Wozniak, James J Vornov, Bipin M Mistry, Ying Wu, Rana Rais, Barbara S Slusher

Open Access Research

Evaluation of the prognostic significance of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) validation study

Angelos Koutras, Konstantine T Kalogeras, Ralph M Wirtz, Zoi Alexopoulou, Mattheos Bobos, Flora Zagouri, Elke Veltrup, Eleni Timotheadou, Helen Gogas, George Pentheroudakis, Nikolaos Pisanidis, Christina Magkou, Christos Christodoulou, Dimitrios Bafaloukos, Pavlos Papakostas, Gerasimos Aravantinos, Dimitrios Pectasides, Haralambos P Kalofonos, George Fountzilas

Open Access Research

Diagnostic and prognostic utility of tissue factor for severe sepsis and sepsis-induced acute lung injury

Mingming Xue, Zhan Sun, Mian Shao, Jun Yin, Zhi Deng, Jin Zhang, Lingyu Xing, Xiaoliang Yang, Bin Chen, Zhimin Dong, Yi Han, Si Sun, Yuxin Wang, Chenling Yao, Xun Chu, Chaoyang Tong, Zhenju Song

Open Access Research

Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome

Angad S Johar, Claudio Mastronardi, Adriana Rojas-Villarraga, Hardip R Patel, Aaron Chuah, Kaiman Peng, Angela Higgins, Peter Milburn, Stephanie Palmer, Maria Fernanda Silva-Lara, Jorge I Velez, Dan Andrews, Matthew Field, Gavin Huttley, Chris Goodnow, Juan-Manuel Anaya, Mauricio Arcos-Burgos

Open Access Research

Treatment of rats with Jiangzhi Capsule improves liquid fructose-induced fatty liver: modulation of hepatic expression of SREBP-1c and DGAT-2

Yuanyang Zhao, Yongquan Pan, Yifan Yang, Robert Batey, Jianwei Wang, Yuhao Li

Open Access Research

Different maturation cocktails provide dendritic cells with different chemoattractive properties

Chiara Massa, Carolin Thomas, Ena Wang, Francesco Marincola, Barbara Seliger

Open Access Methodology

A workflow-driven approach to integrate generic software modules in a Trusted Third Party

Martin Bialke, Peter Penndorf, Tim Wegner, Thomas Bahls, Christoph Havemann, Jens Piegsa, Wolfgang Hoffmann

Open Access Research

Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells

Hui Zhang, Chunmei Zhao, Shuang Wang, Yuefang Huang, Hongyue Wang, Jijun Zhao, Niansheng Yang

Open Access Research

Whole exome sequencing confirms the clinical diagnosis of Marfan syndrome combined with X-linked hypophosphatemia

Xunlun Sheng, Xue Chen, Bo Lei, Rui Chen, Hui Wang, Fangxia Zhang, Weining Rong, Ruoshui Ha, Yani Liu, Feng Zhao, Peizeng Yang, Chen Zhao

Open Access Review

Impact of heparanase on renal fibrosis

Valentina Masola, Gianluigi Zaza, Maurizio Onisto, Antonio Lupo, Giovanni Gambaro

Open Access Research

Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation

Song-Xue Guo, Quan Fang, Chuan-Gang You, Yun-Yun Jin, Xin-Gang Wang, Xin-Lei Hu, Chun-Mao Han

Open Access Research

Combined genetic effects of EGLN1 and VWF modulate thrombotic outcome in hypoxia revealed by Ayurgenomics approach

Shilpi Aggarwal, Atish Gheware, Anurag Agrawal, Saurabh Ghosh, Bhavana Prasher, Mitali Mukerji

Open Access Research

Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models

Inge M Worni-Schudel, Amy G Clark, Tiffany Chien, Kwan-Ki Hwang, Benny J Chen, Mary H Foster

Open Access Research

Long-term kidney survival analyses in IgA nephropathy patients under steroids therapy: a case control study

Yanhong Yuan, Qin Wang, Zhaohui Ni, Xiajing Che, Liou Cao, Xinghua Shao, Minfang Zhang, Yuanyuan Xie, Chaojun Qi, Wenyan Zhou, Lei Tian, Shan Mou

Open Access Research

Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction

Derek W Hanes, Maelene L Wong, C W Jenny Chang, Sterling Humphrey, J Kevin Grayson, Walter D Boyd, Leigh G Griffiths

Open Access Research

Increased CD160 expression on circulating natural killer cells in atherogenesis

Jin Zuo, Zhaoliang Shan, Lin Zhou, Jian Yu, Xiaopeng Liu, Yuan Gao

Open Access Methodology

Unravelling personalized dysfunctional gene network of complex diseases based on differential network model

Xiangtian Yu, Tao Zeng, Xiangdong Wang, Guojun Li, Luonan Chen

Open Access Research

Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts

Woan-Ruoh Lee, Shing-Chuan Shen, Yi-Hsien Shih, Chia-Lun Chou, Jonathan Te-Peng Tseng, Szu-Ying Chin, Kao-Hui Liu, Yen-Chou Chen, Ming-Chung Jiang

Open Access Research

Analysis of multivariate longitudinal kidney function outcomes using generalized linear mixed models

Miran A Jaffa, Mulugeta Gebregziabher, Ayad A Jaffa

Open Access Research

Novel xeno-free human heart matrix-derived three-dimensional scaffolds

Dolly Holt-Casper, Jeff M Theisen, Alonso P Moreno, Mark Warren, Francisco Silva, David W Grainger, David A Bull, Amit N Patel

Open Access Research

Downregulation of microRNA-409-3p promotes aggressiveness and metastasis in colorectal cancer: an indication for personalized medicine

Mulin Liu, Aman Xu, Xiao Yuan, Qiao Zhang, Taotao Fang, Wenbin Wang, Chenglong Li

Open Access Research

An interactive web application for the dissemination of human systems immunology data

Cate Speake, Scott Presnell, Kelly Domico, Brad Zeitner, Anna Bjork, David Anderson, Michael J. Mason, Elizabeth Whalen, Olivia Vargas, Dimitry Popov, Darawan Rinchai, Noemie Jourde-Chiche, Laurent Chiche, Charlie Quinn, Damien Chaussabel

Open Access Research

Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma

Sara Yousef, Johanna Heise, Nesrine Lajmi, Katrin Bartels, Nicolaus Kröger, Tim Luetkens, Djordje Atanackovic

Open Access Research

Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer

Huan Li, Ji Zhang, Shu-Wei Chen, Lu-lu Liu, Lei Li, Fan Gao, Shi-Min Zhuang, Li-ping Wang, Yan Li, Ming Song

Open Access Research

The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts

Anne-France le Rolle, Thang K Chiu, Michael Fara, Jinru Shia, Zhaoshi Zeng, Martin R Weiser, Philip B Paty, Vi K Chiu

Open Access Research

Different tenogenic differentiation capacities of different mesenchymal stem cells in the presence of BMP-12

Linghui Dai, Xiaoqing Hu, Xin Zhang, Jingxian Zhu, Jiying Zhang, Xin Fu, Xiaoning Duan, Yingfang Ao, Chunyan Zhou

Open Access Research

Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice

Eun Sil Koh, Ji Hee Lim, Min Young Kim, Sungjin Chung, Seok Joon Shin, Bum Soon Choi, Hye Won Kim, Seong Yeon Hwang, Sae Woong Kim, Cheol Whee Park, Yoon Sik Chang

Open Access Research

Improved Natural Killer cell activity and retained anti-tumor CD8+ T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy

E Muraro, E Comaro, R Talamini, E Turchet, G Miolo, S Scalone, L Militello, D Lombardi, S Spazzapan, T Perin, S Massarut, D Crivellari, Riccardo Dolcetti, D Martorelli

Open Access Research

The clearance effect of bovine anti-Helicobacter pylori antibody-containing milk in O blood group Helicobacter pylori-infected patients: a randomized double-blind clinical trial

Dailun Hu, Feng Zhang, Jikun Zhou, Baohong Xu, Hongying Zhang, Huiqin Qiang, Shuguang Ren, Baoen Shan, Changfu Yin, Zhitao Zhang, Xian Wang, Chuan Zhao, Zhongli Shi

Open Access Research

Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study

María Guzmán-Fulgencio, Juan Berenguer, María A Jiménez-Sousa, Daniel Pineda-Tenor, Teresa Aldámiz-Echevarria, Pilar García-Broncano, Ana Carrero, Mónica García-Álvarez, Francisco Tejerina, Cristina Diez, Sonia Vazquez-Morón, Salvador Resino

Open Access Research

Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice

Anne Gomez-Brouchet, Nelly Blaes, Lionel Mouledous, Olivier Fourcade, Ivan Tack, Bernard Francès, Jean-Pierre Girolami, Vincent Minville

Open Access Research

Febuxostat pretreatment attenuates myocardial ischemia/reperfusion injury via mitochondrial apoptosis

Shulin Wang, Yunpeng Li, Xudong Song, Xianbao Wang, Cong Zhao, Aihua Chen, Pingzhen Yang

Open Access Research

Vemurafenib resistance reprograms melanoma cells towards glutamine dependence

Jenny E Hernandez-Davies, Thai Q Tran, Michael A Reid, Kimberly R Rosales, Xazmin H Lowman, Min Pan, Gatien Moriceau, Ying Yang, Jun Wu, Roger S Lo, Mei Kong

Open Access Research

Alternative transcripts of the SERPINA1 gene in alpha-1 antitrypsin deficiency

Nerea Matamala, Maria Teresa Martínez, Beatriz Lara, Laura Pérez, Irene Vázquez, Azucena Jimenez, Miguel Barquín, Ilaria Ferrarotti, Ignacio Blanco, Sabina Janciauskiene, Beatriz Martinez-Delgado

Open Access Research

Systemic immunity shapes the oral microbiome and susceptibility to bisphosphonate-associated osteonecrosis of the jaw

Shirin Kalyan, Jun Wang, Elgar Susanne Quabius, Jörn Huck, Jörg Wiltfang, John F Baines, Dieter Kabelitz

Open Access Editorial

What’s new in melanoma? Combination!

Paolo A Ascierto, Francesco M Marincola, Michael B Atkins

Open Access Research

Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting

Evan J Lipson, William H Sharfman, Shuming Chen, Tracee L McMiller, Theresa S Pritchard, January T Salas, Susan Sartorius-Mergenthaler, Irwin Freed, Sowmya Ravi, Hao Wang, Brandon Luber, Janice Davis Sproul, Janis M Taube, Drew M Pardoll, Suzanne L Topalian

Open Access Research

Characteristics of A20 gene polymorphisms and clinical significance in patients with rheumatoid arthritis

Lihua Zhu, Liang Wang, Xu Wang, Lingling Zhou, Ziwei Liao, Ling Xu, Huixia Wu, Jie Ren, Zhaoxia Li, Lijian Yang, Shaohua Chen, Bo Li, Xiuli Wu, Yi Zhou, Yangqiu Li

Open Access Research

Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1.1.1 in murine GL261 gliomas by acting as vaccinia virus traps

Christina Kober, Susanne Rohn, Stephanie Weibel, Ulrike Geissinger, Nanhai G Chen, Aladar A Szalay

Open Access Review

Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer

Ryan A Hutchinson, Richard A Adams, Darragh G McArt, Manuel Salto-Tellez, Bharat Jasani, Peter W Hamilton

Open Access Research

Dietary flavonoid intake and cardiovascular risk: a population-based cohort study

Valentina Ponzo, Ilaria Goitre, Maurizio Fadda, Roberto Gambino, Antonella De Francesco, Laura Soldati, Luigi Gentile, Paola Magistroni, Maurizio Cassader, Simona Bo

Open Access Research

Mesenchymal stromal cells for cutaneous wound healing in a rabbit model: pre-clinical study applicable in the pediatric surgical setting

Gloria Pelizzo, Maria Antonietta Avanzini, Antonia Icaro Cornaglia, Monica Osti, Piero Romano, Luigi Avolio, Rita Maccario, Massimo Dominici, Annalisa De Silvestri, Erika Andreatta, Federico Costanzo, Melissa Mantelli, Daniela Ingo, Serena Piccinno, Valeria Calcaterra

Open Access Research

Circulating hematopoietic stem cells and putative intestinal stem cells in coeliac disease

Anna Chiara Piscaglia, Sergio Rutella, Lucrezia Laterza, Valentina Cesario, Mariachiara Campanale, Immacolata Alessia Cazzato, Gianluca Ianiro, Federico Barbaro, Luca Di Maurizio, Giuseppina Bonanno, Tonia Cenci, Giovanni Cammarota, Luigi Maria Larocca, Antonio Gasbarrini

Open Access Research

KIR diversity in three ethnic minority populations in China

Qiongxiu Zhou, Jue Wang, Zhi He, Xiaojuan Li, Song Mao, Shu Huang, Guohui Bian, Feng Ma

Open Access Research

Metabolic signatures differentiate ovarian from colon cancer cell lines

Anna Halama, Bella S Guerrouahen, Jennifer Pasquier, Ilhem Diboun, Edward D Karoly, Karsten Suhre, Arash Rafii

Open Access Research

miFRame: analysis and visualization of miRNA sequencing data in neurological disorders

Christina Backes, Jan Haas, Petra Leidinger, Karen Frese, Thomas Großmann, Klemens Ruprecht, Benjamin Meder, Eckart Meese, Andreas Keller

Open Access Research

PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4+ T cell function

Mohamed A Ghonim, Kusma Pyakurel, Salome V Ibba, Amir A Al-Khami, Jeffrey Wang, Paulo Rodriguez, Hamada F Rady, Ali H El-Bahrawy, Matthew R Lammi, Moselhy S Mansy, Kamel Al-Ghareeb, Alistair Ramsay, Augusto Ochoa, Amarjit S Naura, A Hamid Boulares

Open Access Research

Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study

Mei-Ling Liu, Xiao-Tong Zhang, Xiang-Yu Du, Zheng Fang, Zhao Liu, Yi Xu, Peng Zheng, Xue-Jiao Xu, Peng-Fei Cheng, Ting Huang, Shun-Jie Bai, Li-Bo Zhao, Zhi-Guo Qi, Wei-Hua Shao, Peng Xie

Open Access Research

Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1

Sharon K Michelhaugh, Anthony R Guastella, Kaushik Varadarajan, Neil V Klinger, Prahlad Parajuli, Aamir Ahmad, Seema Sethi, Amro Aboukameel, Sam Kiousis, Ian M Zitron, Salah A Ebrahim, Lisa A Polin, Fazlul H Sarkar, Aliccia Bollig-Fischer, Sandeep Mittal

Open Access Research

A thermostable, chromatographically purified Ebola nano-VLP vaccine

John H Carra, Karen A O Martins, Rowena D Schokman, Camenzind G Robinson, Jesse T Steffens, Sina Bavari

Open Access Research

IL-17/IL-10 double-producing T cells: new link between infections, immunosuppression and acute myeloid leukemia

Gerardo Musuraca, Serena De Matteis, Roberta Napolitano, Cristina Papayannidis, Viviana Guadagnuolo, Francesco Fabbri, Delia Cangini, Michela Ceccolini, Maria Benedetta Giannini, Alessandro Lucchesi, Sonia Ronconi, Paolo Mariotti, Paolo Savini, Monica Tani, Pier Paolo Fattori, Massimo Guidoboni, Giovanni Martinelli, Wainer Zoli, Dino Amadori, Silvia Carloni

Open Access Research

Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

Marta Massanella, Elisabet Gómez-Mora, Jorge Carrillo, Marta Curriu, Dan Ouchi, Jordi Puig, Eugènia Negredo, Cecilia Cabrera, Bonaventura Clotet, Julià Blanco

Open Access Research

A potential signature of eight long non-coding RNAs predicts survival in patients with non-small cell lung cancer

Meng Zhou, Maoni Guo, Dongfeng He, Xiaojun Wang, Yinqiu Cui, Haixiu Yang, Dapeng Hao, Jie Sun

Open Access Research

Scalable efficient expansion of mesenchymal stem cells in xeno free media using commercially available reagents

Neil H Riordan, Marialaura Madrigal, Jason Reneau, Kathya de Cupeiro, Natalia Jiménez, Sergio Ruiz, Nelsy Sanchez, Thomas E Ichim, Francisco Silva, Amit N Patel

Open Access Research

Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model

Chuanhe Jiang, Xiaoxia Hu, Libing Wang, Hui Cheng, Yan Lin, Yakun Pang, Weiping Yuan, Tao Cheng, Jianmin Wang

Open Access Research

AAV2/8-humanFOXP3 gene therapy shows robust anti-atherosclerosis efficacy in LDLR-KO mice on high cholesterol diet

M Cao, S A Theus, K D Straub, J A Figueroa, L Mirandola, M Chiriva-Internati, P L Hermonat

Open Access Research

Effect of deworming on Th2 immune response during HIV-helminths co-infection

Andargachew Mulu, Belay Anagaw, Aschalew Gelaw, Fuso Ota, Afework Kassu, Sisay Yifru

Open Access Research

MRC-5 fibroblast-conditioned medium influences multiple pathways regulating invasion, migration, proliferation, and apoptosis in hepatocellular carcinoma

Songming Ding, Guoliang Chen, Wu Zhang, Chunyang Xing, Xiao Xu, Haiyang Xie, Aili Lu, Kangjie Chen, Haijun Guo, Zhigang Ren, Shusen Zheng, Lin Zhou

Open Access Research

Altered microRNAs expression profiling in cumulus cells from patients with polycystic ovary syndrome

Suying Liu, Xuan Zhang, Changgen Shi, Jimin Lin, Guowu Chen, Bin Wu, Ligang Wu, Huijuan Shi, Yao Yuan, Weijin Zhou, Zhaogui Sun, Xi Dong, Jian Wang

Open Access Research

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation

Bala Sai Sundarasetty, Stephan Kloess, Olaf Oberschmidt, Sonja Naundorf, Klaus Kuehlcke, Anusara Daenthanasanmak, Laura Gerasch, Constanca Figueiredo, Rainer Blasczyk, Eliana Ruggiero, Raffaele Fronza, Manfred Schmidt, Christof von Kalle, Michael Rothe, Arnold Ganser, Ulrike Koehl, Renata Stripecke

Open Access Research

The effect of socioeconomic status on health-care delay and treatment of esophageal cancer

Nana Wang, Fangli Cao, Fang Liu, Yibin Jia, Jianbo Wang, Cihang Bao, Xintong Wang, Qingxu Song, Bingxu Tan, Yufeng Cheng

Open Access Research

Case report of non-healing surgical wound treated with dehydrated human amniotic membrane

Neil H Riordan, Ben A George, Troy B Chandler, Randall W McKenna

Open Access Review

Taurine: the appeal of a safe amino acid for skeletal muscle disorders

Annamaria De Luca, Sabata Pierno, Diana Conte Camerino

Open Access Research

Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications

Sureewan Bumrungthai, Kavita Munjal, Shirish Nandekar, Kumarasen Cooper, Tipaya Ekalaksananan, Chamsai Pientong, Mark Francis Evans

Open Access Research

The effects of two common edible herbs, Ipomoea aquatica and Enhydra fluctuans, on cadmium-induced pathophysiology: a focus on oxidative defence and anti-apoptotic mechanism

Tarun K Dua, Saikat Dewanjee, Ritu Khanra, Niloy Bhattacharya, Bhuvan Bhaskar, Muhammad Zia-Ul-Haq, Vincenzo De Feo

Open Access Research

Combined Trabectedin and anti-PD1 antibody produces a synergistic antitumor effect in a murine model of ovarian cancer

Zhiqiang Guo, Haolin Wang, Fandong Meng, Jie Li, Shulan Zhang

Open Access Research

Prognostic relevance of LGALS3BP in human colorectal carcinoma

Enza Piccolo, Nicola Tinari, Domenica D’Addario, Cosmo Rossi, Valentina Iacobelli, Rossana La Sorda, Rossano Lattanzio, Maurizia D’Egidio, Annalisa Di Risio, Mauro Piantelli, Pier Giorgio Natali, Stefano Iacobelli

Open Access Research

Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis

Yohannes T Ghebremariam, John P Cooke, William Gerhart, Carol Griego, Jeremy B Brower, Melanie Doyle-Eisele, Benjamin C Moeller, Qingtao Zhou, Lawrence Ho, Joao de Andrade, Ganesh Raghu, Leif Peterson, Andreana Rivera, Glenn D Rosen

Open Access Research

Decreased long noncoding RNA SPRY4-IT1 contributing to gastric cancer cell metastasis partly via affecting epithelial–mesenchymal transition

Min Xie, Feng-qi Nie, Ming Sun, Rui Xia, Yan-wen Liu, Peng Zhou, Wei De, Xiang-hua Liu

Open Access Research

In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa and its modulation by azithromycin

Fabio Stellari, Gabriella Bergamini, Angela Sandri, Gaetano Donofrio, Claudio Sorio, Francesca Ruscitti, Gino Villetti, Barouk M Assael, Paola Melotti, Maria M Lleo

Open Access Research

MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer

Lin Zheng, Yuqin Zhang, Yan Liu, Min Zhou, Yanxia Lu, Li Yuan, Chao Zhang, Min Hong, Shuang Wang, Xuenong Li

Open Access Research

Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary 13C-glucose labeling metabolomics

Angelo D’Alessandro, Annie L Slaughter, Erik D Peltz, Ernest E Moore, Christopher C Silliman, Matthew Wither, Travis Nemkov, Anthony W Bacon, Miguel Fragoso, Anirban Banerjee, Kirk C Hansen

Open Access Research

A novel placental like alkaline phosphate promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting

Imran Khan, Mohammad Khalid Zakaria, Mukesh Kumar, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar, Subrata Sinha

Open Access Research

Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling

Hai-Yan Jin, Lai-Jiang Chen, Zhen-Zhou Zhang, Ying-Le Xu, Bei Song, Ran Xu, Gavin Y Oudit, Ping-Jin Gao, Ding-Liang Zhu, Jiu-Chang Zhong

Open Access Research

In vitro response pattern of monocytes after tmTNF reverse signaling predicts response to anti-TNF therapy in rheumatoid arthritis

Undine Meusch, Marco Krasselt, Manuela Rossol, Christoph Baerwald, Maria Klingner, Ulf Wagner

Open Access Research

Impact of epidermal growth factor receptor (EGFR) activating mutations and their targeted treatment in the prognosis of stage IV non-small cell lung cancer (NSCLC) patients harboring liver metastasis

Eduardo Castañón, Christian Rolfo, David Viñal, Inés López, Juan P Fusco, Marta Santisteban, Patricia Martin, Leire Zubiri, José I Echeveste, Ignacio Gil-Bazo

Open Access Research

eNOS polymorphisms as predictors of efficacy of bevacizumab-based chemotherapy in metastatic colorectal cancer: data from a randomized clinical trial

Paola Ulivi, Emanuela Scarpi, Alessandro Passardi, Giorgia Marisi, Daniele Calistri, Wainer Zoli, Marzia Del Re, Giovanni Luca Frassineti, Davide Tassinari, Stefano Tamberi, Bernadette Vertogen, Dino Amadori

Open Access Research

Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells

Min Ding, Jiang Li, Yong Yu, Hui Liu, Zi Yan, Jinghan Wang, Qijun Qian

Open Access Research

Discordant circulating fetal DNA and subsequent cytogenetics reveal false negative, placental mosaic, and fetal mosaic cfDNA genotypes

Roger V Lebo, Robert W Novak, Katherine Wolfe, Melonie Michelson, Haynes Robinson, Melissa S Mancuso

Open Access Research

Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis

Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Gyongyi Szabo

Open Access Review

Expression of miR-296-5p as predictive marker for radiotherapy resistance in early-stage laryngeal carcinoma

Danielle Maia, Ana Carolina de Carvalho, Maria Aderuza Horst, André Lopes Carvalho, Cristovam Scapulatempo-Neto, Andre Luiz Vettore

Open Access Research

Strong founder effect of p.P240L in CDH23 in Koreans and its significant contribution to severe-to-profound nonsyndromic hearing loss in a Korean pediatric population

So Young Kim, Ah Reum Kim, Nayoung K D Kim, Min Young Kim, Eun-Hee Jeon, Bong Jik Kim, Young Eun Han, Mun Young Chang, Woong-Yang Park, Byung Yoon Choi

Open Access Research

Polymorphism in COMT is associated with IgG3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome

Madlen Löbel, Agnes Anna Mooslechner, Sandra Bauer, Sabrina Günther, Anne Letsch, Leif G Hanitsch, Patricia Grabowski, Christian Meisel, Hans-Dieter Volk, Carmen Scheibenbogen

Open Access Review

Translating clinical trials from human to veterinary oncology and back

Irene Fürdös, Judit Fazekas, Josef Singer, Erika Jensen-Jarolim

Open Access Research

Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock

Petr Ostadal, Mikulas Mlcek, Andreas Kruger, Pavel Hala, Stanislav Lacko, Martin Mates, Dagmar Vondrakova, Tomas Svoboda, Matej Hrachovina, Marek Janotka, Hana Psotova, Svitlana Strunina, Otomar Kittnar, Petr Neuzil

Open Access Research

Platelets, gender and acute cerebral infarction

Petter Järemo, Marie Eriksson-Franzen, Micha Milovanovic

Open Access Research

CD4+CD25−Foxp3+ T cells play a role in tuberculous hydrothorax rather than malignant hydrothorax

Ying Tang, Li-Ping Peng, Gui-Xiang Qin, Jing-Ting Sun, Li-Jun Xu, Yan-Fang Jiang

Open Access Research

Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres

Rajesh Mukthavaram, Xiao Ouyang, Rohit Saklecha, Pengfei Jiang, Natsuko Nomura, Sandeep C Pingle, Fang Guo, Milan Makale, Santosh Kesari

Open Access Research

Identification of apoptosis-related microRNAs and their target genes in myocardial infarction post-transplantation with skeletal myoblasts

Qi Liu, Guo Qing Du, Zhi Tao Zhu, ChunYang Zhang, Xiao Wei Sun, Jing Jin Liu, Xia Li, Yong Shun Wang, Wen Juan Du

Open Access Research

MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8

MingHua Li, LinLi Tian, Hui Ren, XiaoXue Chen, Yu Wang, JingChun Ge, ShuLiang Wu, YaNan Sun, Ming Liu, Hui Xiao

Open Access Review

Complement mediators: key regulators of airway tissue remodeling in asthma

Mohammad Afzal Khan, Abdullah Mohammed Assiri, Dieter Clemens Broering

Open Access Review

Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases

Yichun Zhu, William Wang, Xiangdong Wang

Open Access Review

Gut microbiota and allogeneic transplantation

Weilin Wang, Shaoyan Xu, Zhigang Ren, Jianwen Jiang, Shusen Zheng

Open Access Methodology

Correlation between μCT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis

Cedo M. Bagi, David E. Zakur, Edwin Berryman, Catharine J. Andresen, Dean Wilkie

Open Access Research

Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer

Naoyuki Sakamoto, Takeshi Ishikawa, Satoshi Kokura, Tetsuya Okayama, Kaname Oka, Mitsuko Ideno, Fumiyo Sakai, Akiko Kato, Masashige Tanabe, Tatsuji Enoki, Junichi Mineno, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa

Open Access Research

Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters

Xiao-Yang Li, Zhen-Xiong Zhao, Min Huang, Ru Feng, Chi-Yu He, Chao Ma, Shi-Heng Luo, Jie Fu, Bao-Ying Wen, Long Ren, Jia-Wen Shou, Fang Guo, Yangchao Chen, Xin Gao, Yan Wang, Jian-Dong Jiang

Open Access Research

Loss of tapasin correlates with diminished CD8+ T-cell immunity and prognosis in colorectal cancer

Lena Sokol, Viktor H. Koelzer, Tilman T. Rau, Eva Karamitopoulou, Inti Zlobec, Alessandro Lugli

Open Access Research

YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells

Wen G. Jiang, Lin Ye, Fiona Ruge, Sioned Owen, Tracey Martin, Ping-Hui Sun, Andrew J. Sanders, Jane Lane, Lucy Satherley, Hoi P. Weeks, Yong Gao, Cong Wei, Yiling Wu, Malcolm D. Mason

Open Access Research

Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33

Jenny Calvén, Hamid Akbarshahi, Mandy Menzel, Cemil Korcan Ayata, Marco Idzko, Leif Bjermer, Lena Uller

Open Access Research

Activation of MET pathway predicts poor outcome to cetuximab in patients with recurrent or metastatic head and neck cancer

Juan Madoz-Gúrpide, Sandra Zazo, Cristina Chamizo, Victoria Casado, Cristina Caramés, Eduardo Gavín, Ion Cristóbal, Jesús García-Foncillas, Federico Rojo

Open Access Research

Association of levels of antibodies against citrullinated cyclic peptides and citrullinated α-enolase in chronic and aggressive periodontitis as a risk factor of Rheumatoid arthritis: a case control study

Stefan Reichert, Wolfgang Schlumberger, Cornelia Dähnrich, Nora Hornig, Wolfgang Altermann, Hans-Günter Schaller, Susanne Schulz

Open Access Research

Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complete Freund’s Adjuvant-induced mice: roles of dynorphin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel

Chao Wang, Danni Sun, Chunfang Liu, Chunyan Zhu, Xianghong Jing, Shuping Chen, Cuiling Liu, Kai Zhi, Tengfei Xu, Hui Wang, Junling Liu, Ying Xu, Zhiqiang Liu, Na Lin

Open Access Research

Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer

Manish Kumar, Ajay Matta, Olena Masui, Gunjan Srivastava, Jatinder Kaur, Alok Thakar, Nootan Kumar Shukla, Ajoy RoyChoudhury, Meherchand Sharma, Paul G. Walfish, K. W. Michael Siu, Shyam Singh Chauhan, Ranju Ralhan

Open Access Research

The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study

Maria L. Mansego, Griselda De Marco, Carmen Ivorra, Raúl Lopez-Izquierdo, Sonsoles Morcillo, Gemma Rojo-Martínez, Verónica González-Albert, Fernando Martinez, Federico Soriguer, Juan C. Martín-Escudero, Josep Redon, F. Javier Chaves

Open Access Research

The Italian external quality assessment for RAS testing in colorectal carcinoma identifies methods-related inter-laboratory differences

Nicola Normanno, Carmine Pinto, Francesca Castiglione, Francesca Fenizia, Massimo Barberis, Antonio Marchetti, Gabriella Fontanini, Gaetano De Rosa, Gian Luigi Taddei

Open Access Research

Immunomodulatory activity of pidotimod administered with standard antibiotic therapy in children hospitalized for community-acquired pneumonia

Susanna Esposito, Micaela Garziano, Veronica Rainone, Daria Trabattoni, Mara Biasin, Laura Senatore, Paola Marchisio, Marta Rossi, Nicola Principi, Mario Clerici

Open Access Research

MicroRNA-195-5p, a new regulator of Fra-1, suppresses the migration and invasion of prostate cancer cells

Jian Wu, Alin Ji, Xiao Wang, Yi Zhu, Yasai Yu, Yiwei Lin, Yunfu Liu, Shiqi Li, Zhen Liang, Xin Xu, Xiangyi Zheng, Liping Xie

Open Access Research

Serum apelin is associated with left ventricular hypertrophy in untreated hypertension patients

Lijun Ye, Fenghua Ding, Liang Zhang, Anna Shen, Huaguo Yao, Liehua Deng, Yuanlin Ding

Open Access Research

Assessment of ten trace elements in umbilical cord blood and maternal blood: association with birth weight

Lorena Bermúdez, Consuelo García-Vicent, Jorge López, Maria Isabel Torró, Empar Lurbe

Open Access Research

T1ρ MRI of healthy and fibrotic human livers at 1.5 T

Anup Singh, Damodar Reddy, Mohammad Haris, Kejia Cai, K. Rajender Reddy, Hari Hariharan, Ravinder Reddy

Open Access Research

STAT1 modification improves therapeutic effects of interferons on lung cancer cells

Junjie Chen, Jialu Zhao, Lefu Chen, Nian Dong, Zhaojian Ying, Zhenzhen Cai, Dongxiang Ji, Yong Zhang, Li Dong, Yuping Li, Lei Jiang, Michael J. Holtzman, Chengshui Chen

Open Access Research

Effect of treatment with a JAK2-selective inhibitor, fedratinib, on bone marrow fibrosis in patients with myelofibrosis

Catriona Jamieson, Robert Hasserjian, Jason Gotlib, Jorge Cortes, Richard Stone, Moshe Talpaz, Jürgen Thiele, Scott Rodig, Olga Pozdnyakova

Open Access Research

The tumor area occupied by Tbet+ cells in deeply invading cervical cancer predicts clinical outcome

Arko Gorter, Frans Prins, Merel van Diepen, Simone Punt, Sjoerd H. van der Burg

Open Access Research

Downregulation of PHEX in multibacillary leprosy patients: observational cross-sectional study

Sandra R. Boiça Silva, Ximena Illarramendi, Antonio J. Tempone, Pedro H. L. Silva, José A. C. Nery, Alexandra M. V. Monteiro, Maria Cristina V. Pessolani, Edson Boasquevisque, Euzenir N. Sarno, Geraldo M. B. Pereira, Danuza Esquenazi

Open Access Research

Metabolomic approach to profile functional and metabolic changes in heart failure

Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Emanuela Locci, Luigi Barberini, Federica Torri, Federica Ascedu, Luigi Atzori, Giuseppe Mercuro

Open Access Research

Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis

Bota Cui, Pan Li, Lijuan Xu, Youquan Zhao, Huiquan Wang, Zhaoyuan Peng, Hai’e Xu, Jie Xiang, Zhi He, Ting Zhang, Yongzhan Nie, Kaichun Wu, Daiming Fan, Guozhong Ji, Faming Zhang

Open Access Research

Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients

Sharni Lee Hardcastle, Ekua Weba Brenu, Samantha Johnston, Thao Nguyen, Teilah Huth, Sandra Ramos, Donald Staines, Sonya Marshall-Gradisnik

Open Access Erratum

Erratum to: A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting

Imran Khan, Mohammad Khalid Zakaria, Mukesh Kumar, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar, Subrata Sinha

Open Access Research

PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression

Xiaohan Qu, Jinlu Liu, Xinwen Zhong, Xi Li, Qigang Zhang

Open Access Research

A modified experimental model of malignant pleural disease induced by lung Lewis carcinoma (LLC) cells

Milena Marques Pagliarelli Acencio, Juliana Puka, Evaldo Marchi, Leila Antonangelo, Ricardo Mingarini Terra, Francisco Suso Vargas, Vera Luiza Capelozzi, Lisete Ribeiro Teixeira

Open Access Research

Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day food-frequency questionnaire

Luigi Barrea, Paolo Emidio Macchia, Giovanni Tarantino, Carolina Di Somma, Elena Pane, Nicola Balato, Maddalena Napolitano, Annamaria Colao, Silvia Savastano

Open Access Research

Identification of serum proteome signatures of locally advanced and metastatic gastric cancer: a pilot study

Agata Abramowicz, Anna Wojakowska, Agnieszka Gdowicz-Klosok, Joanna Polanska, Pawel Rodziewicz, Pawel Polanowski, Agnieszka Namysl-Kaletka, Monika Pietrowska, Jerzy Wydmanski, Piotr Widlak

Open Access Research

Nutritional parameters predicting pressure ulcers and short-term mortality in patients with minimal conscious state as a result of traumatic and non-traumatic acquired brain injury

Tiziana Montalcini, Marta Moraca, Yvelise Ferro, Stefano Romeo, Sebastiano Serra, Maria Girolama Raso, Francesco Rossi, Walter G. Sannita, Giuliano Dolce, Arturo Pujia

Open Access Research

Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma

Jennifer Johnson, Maria Libera Ascierto, Sandeep Mittal, David Newsome, Liang Kang, Michael Briggs, Kirk Tanner, Francesco M. Marincola, Michael E. Berens, George F. Vande Woude, Qian Xie

Open Access Research

Comparative study of anti-angiogenic activities of luteolin, lectin and lupeol biomolecules

Rashmi K. Ambasta, Saurabh Kumar Jha, Dhiraj Kumar, Renu Sharma, Niraj Kumar Jha, Pravir Kumar

Open Access Research

LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

Dongdong Ti, Haojie Hao, Chuan Tong, Jiejie Liu, Liang Dong, Jingxi Zheng, Yali Zhao, Huiling Liu, Xiaobing Fu, Weidong Han

Open Access Research

Diffuse reflectance spectroscopy accurately quantifies various degrees of liver steatosis in murine models of fatty liver disease

Andrie C. Westerkamp, Vishnu V. Pully, Golnar Karimian, Fernanda Bomfati, Zwanida J. Veldhuis, Janneke Wiersema-Buist, Benno H. W. Hendriks, Ton Lisman, Robert J. Porte

Open Access Research

HMGB1/RAGE induces IL-17 expression to exaggerate inflammation in peripheral blood cells of hepatitis B patients

JooYeon Jhun, SeungHoon Lee, HeeYeon Kim, Yang-Mi Her, Jae Kyeong Byun, Eun-Kyung Kim, Soon Kyu Lee, Mi-La Cho, Jong Young Choi

Open Access Research

A scaling aneurysm model-based approach to assessing the role of flow pattern and energy loss in aneurysm rupture prediction

Yunling Long, Jingru Zhong, Hongyu Yu, Huagang Yan, Zhizheng Zhuo, Qianqian Meng, Xinjian Yang, Haiyun Li

Open Access Research

Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals

Trine Pagh Ludvigsen, Rikke Kaae Kirk, Berit Østergaard Christoffersen, Henrik Duelund Pedersen, Torben Martinussen, Jonas Kildegaard, Peter M. H. Heegaard, Jens Lykkesfeldt, Lisbeth Høier Olsen

Open Access Review

Molecular magnetic resonance imaging in cancer

Mohammad Haris, Santosh K. Yadav, Arshi Rizwan, Anup Singh, Ena Wang, Hari Hariharan, Ravinder Reddy, Francesco M. Marincola

Open Access Research

Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy

Lu Fang, Andris H. Ellims, Xiao-lei Moore, David A. White, Andrew J. Taylor, Jaye Chin-Dusting, Anthony M. Dart

Open Access Research

In vitro migration and proliferation (“wound healing”) potential of mesenchymal stromal cells generated from human CD271+ bone marrow mononuclear cells

Hatixhe Latifi-Pupovci, Zyrafete Kuçi, Sibylle Wehner, Halvard Bönig, Ralf Lieberz, Thomas Klingebiel, Peter Bader, Selim Kuçi

Open Access Research

PEP-1-MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice

Yao Wu, Guanghui Xie, Yanyong Xu, Li Ma, Chuanfeng Tong, Daping Fan, Fen Du, Hong Yu

Open Access Research

Development and validation of new glomerular filtration rate predicting models for Chinese patients with type 2 diabetes

Jinxia Chen, Hua Tang, Hui Huang, Linsheng Lv, Yanni Wang, Xun Liu, Tanqi Lou

Open Access Research

Tumor associated PD-L1 expression pattern in microscopically tumor positive sentinel lymph nodes in patients with melanoma

Ahmad A. Tarhini, Haris Zahoor, Jennifer H. Yearley, Christopher Gibson, Zahra Rahman, Rachel Dubner, Uma N. M. Rao, Cindy Sander, John M. Kirkwood

Open Access Research

Relationship between ITPA polymorphisms and hemolytic anemia in HCV-infected patients after ribavirin-based therapy: a meta-analysis

Daniel Pineda-Tenor, Mónica García-Álvarez, María A. Jiménez-Sousa, Sonia Vázquez-Morón, Salvador Resino

Open Access Research

SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma

Xiao-Bin Cui, Yao-yuan Shen, Ting-ting Jin, Su Li, Ting-ting Li, Shu-mao Zhang, Hao Peng, Chun-xia Liu, Shu-gang Li, Lan Yang, Na Li, Jian-ming Hu, Jin-Fang Jiang, Man Li, Wei-hua Liang, Yong Li, Yu-tao Wei, Zhen-zhu Sun, Chuan-yue Wu, Yun-Zhao Chen, Feng Li

Open Access Research

Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology

Santosh K. Yadav, Rakesh K. Gupta, Vivek A. Saraswat, Murali Rangan, Michael A. Thomas, Sergio Rutella, Silvio Danese, Ena Wang, Francesco M. Marincola, Mohammad Haris

Open Access Research

Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells

Quan-zhen Wang, Hai-qing Gao, Ying Liang, Jun Zhang, Jian Wang, Jie Qiu

Open Access Research

Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines

Silvia Boero, Anna Morabito, Barbara Banelli, Barbara Cardinali, Beatrice Dozin, Gianluigi Lunardi, Patrizia Piccioli, Sonia Lastraioli, Roberta Carosio, Sandra Salvi, Alessia Levaggi, Francesca Poggio, Alessia D’Alonzo, Massimo Romani, Lucia Del Mastro, Alessandro Poggi, Maria Pia Pistillo

Open Access Research

Monocytes/macrophages activation contributes to b-gamma-glutamyltransferase accumulation inside atherosclerotic plaques

Eugenia Belcastro, Maria Franzini, Silvana Cianchetti, Evelina Lorenzini, Silvia Masotti, Vanna Fierabracci, Angela Pucci, Alfonso Pompella, Alessandro Corti

Open Access Research

Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome

J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche, U. Muñoz

Open Access Review

Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review

G. Banderali, A. Martelli, M. Landi, F. Moretti, F. Betti, G. Radaelli, C. Lassandro, E. Verduci

Open Access Research

Bcl-2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose-dependent toxicity and resistance

Gina Leisching, Benjamin Loos, Matthys Botha, Anna-Mart Engelbrecht

Open Access Research

Wnt signaling in age-related macular degeneration: human macular tissue and mouse model

Jingsheng Tuo, Yujuan Wang, Rui Cheng, Yichao Li, Mei Chen, Fangfang Qiu, Haohua Qian, Defen Shen, Rosana Penalva, Heping Xu, Jian-Xing Ma, Chi-Chao Chan

Open Access Research

Understanding the molecular aspects of oriental obesity pattern differentiation using DNA microarray

Sun Woo Hong, Jae-Wook Yoo, Shambhunath Bose, Jung-Hyun Park, Kyungsun Han, Soyoun Kim, Chi-Yeon Lim, Hojun Kim, Dong-ki Lee

Open Access Research

Tumor size, stage and grade alterations of urinary peptidome in RCC

Clizia Chinello, Marta Cazzaniga, Gabriele De Sio, Andrew James Smith, Angelica Grasso, Bernardo Rocco, Stefano Signorini, Marco Grasso, Silvano Bosari, Italo Zoppis, Giancarlo Mauri, Fulvio Magni

Open Access Research

Anti-cytokine autoantibodies in postherpetic neuralgia

Ahmad Bayat, Peter D. Burbelo, Sarah K. Browne, Mark Quinlivan, Bianca Martinez, Steven M. Holland, Asokumar Buvanendran, Jeffrey S. Kroin, Andrew J. Mannes, Judith Breuer, Jeffrey I. Cohen, Michael J. Iadarola

Open Access Research

Identification of novel mutations by targeted exome sequencing and the genotype-phenotype assessment of patients with achromatopsia

Fen-Fen Li, Xiu-Feng Huang, Jie Chen, Xu-Dong Yu, Mei-Qin Zheng, Fan Lu, Zi-Bing Jin, De-Kang Gan

Open Access Research

DCIS in BRCA1 and BRCA2 mutation carriers: prevalence, phenotype, and expression of oncodrivers C-MET and HER3

Rachel L. Yang, Rosemarie Mick, Kathreen Lee, Holly L. Graves, Katherine L. Nathanson, Susan M. Domchek, Rachel R. Kelz, Paul J. Zhang, Brian J. Czerniecki

Open Access Research

Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model

Fabio Stellari, Angelo Sala, Francesca Ruscitti, Chiara Carnini, Prisco Mirandola, Marco Vitale, Maurizio Civelli, Gino Villetti

Open Access Research

Expression of CD147 and matrix metalloproteinase-11 in colorectal cancer and their relationship to clinicopathological features

Xiuyun Tian, Chunxiang Ye, Yongyong Yang, Xiaoya Guan, Bin Dong, Min Zhao, Chunyi Hao

Open Access Research

Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients

Yuehua Liao, Ying Xue, Lin Zhang, Xinwei Feng, Wanli Liu, Ge Zhang

Open Access Research

B cell epitopes on infliximab identified by oligopeptide microarray with unprocessed patient sera

Arne Homann, Niels Röckendorf, Arno Kromminga, Andreas Frey, Uta Jappe

Open Access Review

Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique?

Samuel C. Wagner, Thomas E. Ichim, Hong Ma, Julia Szymanski, Jesus A. Perez, Javier Lopez, Vladimir Bogin, Amit N. Patel, Francisco M. Marincola, Santosh Kesari

Open Access Research

Autologous immuno magnetically selected CD133+ stem cells in the treatment of no-option critical limb ischemia: clinical and contrast enhanced ultrasound assessed results in eight patients

Vittorio Arici, Cesare Perotti, Calliada Fabrizio, Claudia Del Fante, Franco Ragni, Francesco Alessandrino, Gianluca Viarengo, Michele Pagani, Alessia Moia, Carmine Tinelli, Antonio Bozzani

Open Access Research

Information maximizing component analysis of left ventricular remodeling due to myocardial infarction

Xingyu Zhang, Bharath Ambale-Venkatesh, David A. Bluemke, Brett R. Cowan, J. Paul Finn, Alan H. Kadish, Daniel C. Lee, Joao A. C. Lima, William G. Hundley, Avan Suinesiaputra, Alistair A. Young, Pau Medrano-Gracia

Open Access Protocol

Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study

Marlies E. J. Reinders, Geertje J. Dreyer, Jonna R. Bank, Helene Roelofs, Sebastiaan Heidt, Dave L. Roelen, Maarten L. Zandvliet, Volkert A. L. Huurman, Wim E. Fibbe, Cees van Kooten, Frans H. J. Claas, Ton J. Rabelink, Johan W. de Fijter

Open Access Editorial

You’ll be a clinician-scientist, my son

Pierre R. Smeesters

Open Access Research

Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis

Ruben Magni, Benjamin H. Espina, Ketul Shah, Benjamin Lepene, Christine Mayuga, Temple A. Douglas, Virginia Espina, Sally Rucker, Ross Dunlap, Emanuel F. III Petricoin, Mary Frekko Kilavos, Donald M. Poretz, Gilbert R. Irwin, Samuel M. Shor, Lance A. Liotta, Alessandra Luchini

Open Access Protocol

HALT & REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation

Eva A. H. Lanters, Denise M. S. van Marion, Charles Kik, Herman Steen, Ad J. J. C. Bogers, Maurits A. Allessie, Bianca J. J. M. Brundel, Natasja M. S. de Groot

Open Access Protocol

The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results

Cristian Pattaro, Martin Gögele, Deborah Mascalzoni, Roberto Melotti, Christine Schwienbacher, Alessandro De Grandi, Luisa Foco, Yuri D’Elia, Barbara Linder, Christian Fuchsberger, Cosetta Minelli, Clemens Egger, Lisa S. Kofink, Stefano Zanigni, Torsten Schäfer, Maurizio F. Facheris, Sigurður V. Smárason, Alessandra Rossini, Andrew A. Hicks, Helmuth Weiss, Peter P. Pramstaller

Open Access Research

Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin

Baolai Zhang, Shuhong Dong, Zhongxin Li, Li Lu, Su Zhang, Xue Chen, Xiaobo Cen, Yongjie Wu

Open Access Research

Open-label, multicenter, single-arm phase II DeCOG-study of ipilimumab in pretreated patients with different subtypes of metastatic melanoma

Lisa Zimmer, Thomas K. Eigentler, Felix Kiecker, Jan Simon, Jochen Utikal, Peter Mohr, Carola Berking, Eckhart Kämpgen, Edgar Dippel, Rudolf Stadler, Axel Hauschild, Michael Fluck, Patrick Terheyden, Rainer Rompel, Carmen Loquai, Zeinab Assi, Claus Garbe, Dirk Schadendorf

Open Access Research

High glucose induces renal tubular epithelial injury via Sirt1/NF-kappaB/microR-29/Keap1 signal pathway

Ling Zhou, De-yu Xu, Wen-gang Sha, Lei Shen, Guo-yuan Lu, Xia Yin, Ming-jun Wang

Open Access Research

Early outgrowth cells versus endothelial colony forming cells functions in platelet aggregation

Lara Bou Khzam, Olivier Bouchereau, Rahma Boulahya, Ahmed Hachem, Younes Zaid, Haissam Abou-Saleh, Yahye Merhi

Open Access Research

Mechanical fibrinogen-depletion supports heparin-free mesenchymal stem cell propagation in human platelet lysate

Sandra Laner-Plamberger, Thomas Lener, Doris Schmid, Doris A. Streif, Tina Salzer, Michaela Öller, Cornelia Hauser-Kronberger, Thorsten Fischer, Volker R. Jacobs, Katharina Schallmoser, Mario Gimona, Eva Rohde

Open Access Research

Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway

Cheng Yang, Ye Cao, Yi Zhang, Long Li, Ming Xu, Yaqiu Long, Ruiming Rong, Tongyu Zhu

Open Access Research

Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related molecules

Tingzhun Zhu, Xiaoming Li, Lihan Luo, Xiaogang Wang, Zhiqing Li, Peng Xie, Xu Gao, Zhenquan Song, Jingyuan Su, Guobiao Liang

Open Access Research

PDL regeneration via cell homing in delayed replantation of avulsed teeth

Wenting Zhu, Qian Zhang, Yang Zhang, Lian Cen, Jun Wang

Open Access Review

Genetic testing and genomic analysis: a debate on ethical, social and legal issues in the Arab world with a focus on Qatar

Hatem El Shanti, Lotfi Chouchane, Ramin Badii, Imed Eddine Gallouzi, Paolo Gasparini

Open Access Research

Autophagy biomarkers in CSF correlates with infarct size, clinical severity and neurological outcome in AIS patients

Honghong Li, Shuwei Qiu, Xiangpen Li, Mei Li, Ying Peng

Open Access Commentary

Alliance Against Cancer, the network of Italian cancer centers bridging research and care

Paolo De Paoli, Gennaro Ciliberto, Manlio Ferrarini, PierGiuseppe Pelicci, Paolo Dellabona, Francesco De Lorenzo, Alberto Mantovani, Pellegrino Musto, Giuseppe Opocher, Piero Picci, Walter Ricciardi, Ruggero De Maria

Open Access Review

Granulocyte transfusions in children and adults with hematological malignancies: benefits and controversies

Chiara Cugno, Sara Deola, Perla Filippini, David F. Stroncek, Sergio Rutella

Open Access Research

MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo

Quanlu Duan, Chen Chen, Lei Yang, Ni Li, Wei Gong, Sheng Li, Dao Wen Wang

Open Access Research

Value of the prognostic nutritional index and weight loss in predicting metastasis and long-term mortality in nasopharyngeal carcinoma

Xiao-Jing Du, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Ying Sun, Ai-Hua Lin, Jun Ma

Open Access Research

Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma

Bing Zhu, Nan Lin, Min Zhang, Yong Zhu, Huanhuan Cheng, Shuxian Chen, Yunbiao Ling, Weidong Pan, Ruiyun Xu

Open Access Research

Anti-tumor enhancement of Fei-Liu-Ping ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse model

Rui Liu, Honggang Zheng, Weidong Li, Qiujun Guo, Shulin He, Yoshiro Hirasaki, Wei Hou, Baojin Hua, Conghuang Li, Yanju Bao, Yebo Gao, Xin Qi, Yingxia Pei, Yun Zhang

Open Access Research

Gene methylation of human ovarian carcinoma stromal progenitor cells promotes tumorigenesis

Chih-Ming Ho, Daniel Tzu-bi Shih, Chih-Chiang Hsiao, Shih-Hung Huang, Shwu-Fen Chang, Wen-Fang Cheng

Open Access Research

Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria

Fabien Herbert, Nicolas Tchitchek, Devendra Bansal, Julien Jacques, Sulabha Pathak, Christophe Bécavin, Constantin Fesel, Esther Dalko, Pierre-André Cazenave, Cristian Preda, Balachandran Ravindran, Shobhona Sharma, Bidyut Das, Sylviane Pied

Open Access Research

Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative

Hanna-Mari Koskimaa, Anna Paaso, Marij J. P. Welters, Seija Grénman, Kari Syrjänen, Sjoerd H. van der Burg, Stina Syrjänen

Open Access Research

Differential urinary glycoproteome analysis of type 2 diabetic nephropathy using 2D-LC–MS/MS and iTRAQ quantification

Zhengguang Guo, Xuejiao Liu, Menglin Li, Chen Shao, Jianling Tao, Wei Sun, Mingxi Li

Open Access Research

Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

Eduardo García-Fuentes, Concepción Santiago-Fernández, Carolina Gutiérrez-Repiso, María D. Mayas, Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Juan Alcaide, Luis Ocaña-Wilhelmi, Joan Vendrell, Francisco J. Tinahones, Lourdes Garrido-Sánchez

Open Access Meeting report

Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”: Napoli, December 3rd–6th 2014

Paolo A. Ascierto, Michael Atkins, Carlo Bifulco, Gerardo Botti, Alistair Cochran, Michael Davies, Sandra Demaria, Reinhard Dummer, Soldano Ferrone, Silvia Formenti, Thomas F. Gajewski, Claus Garbe, Samir Khleif, Rolf Kiessling, Roger Lo, Paul Lorigan, Grant Mc Arthur, Giuseppe Masucci, Ignacio Melero, Martin Mihm, Giuseppe Palmieri, Giorgio Parmiani, Igor Puzanov, Pedro Romero, Bastian Schilling, Barbara Seliger, David Stroncek, Janis Taube, Sara Tomei, Hassane M. Zarour, Alessandro Testori, Ena Wang, Jérôme Galon, Gennaro Ciliberto, Nicola Mozzillo, Francesco M. Marincola, Magdalena Thurin

Open Access Research

Comparison of hemostatic dressings for superficial wounds using a new spectrophotometric coagulation assay

Julian-Dario Rembe, Julia K. Böhm, Carolin Fromm-Dornieden, Nadine Schäfer, Marc Maegele, Matthias Fröhlich, Ewa K. Stuermer

Open Access Research

Interactions of tumour-derived micro(nano)vesicles with human gastric cancer cells

Małgorzata Stec, Rafał Szatanek, Monika Baj-Krzyworzeka, Jarosław Baran, Maria Zembala, Jakub Barbasz, Agnieszka Waligórska, Jurek W. Dobrucki, Bożenna Mytar, Antoni Szczepanik, Maciej Siedlar, Grażyna Drabik, Barbara Urbanowicz, Marek Zembala

Open Access Research

Lack of integrase inhibitors associated resistance mutations among HIV-1C isolates

Andargachew Mulu, Melanie Maier, Uwe Gerd Liebert

Open Access Research

HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma

Feng Xue, Brandon W. Higgs, Jiaqi Huang, Chris Morehouse, Wei Zhu, Xin Yao, Philip Brohawn, Zhan Xiao, Yinong Sebastian, Zheng Liu, Yun Xia, Dong Shen, Mike Kuziora, Zhengwei Dong, Hulin Han, Yi Gu, Jianren Gu, Qiang Xia, Yihong Yao

Open Access Research

Nerve detection with optical spectroscopy for regional anesthesia procedures

Benno H. W. Hendriks, Andrea J. R. Balthasar, Gerald W. Lucassen, Marjolein van der Voort, Manfred Mueller, Vishnu V. Pully, Torre M. Bydlon, Christian Reich, Arnold T. M. H. van Keersop, Jeroen Kortsmit, Gerrit C. Langhout, Geert-Jan van Geffen

Open Access Research

IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production

Xiangmao Bu, Tenglong Zhang, Chunhong Wang, Tao Ren, Zhenke Wen

Open Access Research

Chronic, not acute, skin-specific inflammation promotes thrombosis in psoriasis murine models

Jackelyn B. Golden, Yunmei Wang, Yi Fritz, Doina Diaconu, Xiufen Zhang, Sara M. Debanne, Daniel I. Simon, Thomas S. McCormick, Nicole L. Ward

Open Access Research

Radiation treatment monitoring using multimodal functional imaging: PET/CT (18F-Fluoromisonidazole & 18F-Fluorocholine) and DCE-US

Natalia Arteaga-Marrero, Cecilie Brekke Rygh, Jose F. Mainou-Gomez, Tom C. H. Adamsen, Nataliya Lutay, Rolf K. Reed, Dag R. Olsen

Open Access Research

Impaired Toll-like receptor 2-mediated Th1 and Th17/22 cytokines secretion in human peripheral blood mononuclear cells from patients with atopic dermatitis

Yangyang Yu, Yarui Zhang, Jie Zhang, Xia Dou, Hong Yang, Yong Shao, Kepeng Wang, Bo Yu, Wei Zhang, Hang Yung Alaster Lau

Open Access Research

Brain mediators of systemic oxidative stress on perceptual impairments in Parkinson’s disease

Wei-Che Lin, Kun-Hsien Chou, Pei-Lin Lee, Yung-Cheng Huang, Nai-Wen Tsai, Hsiu-Ling Chen, Kuei-Yueh Cheng, Hung-Chen Wang, Tsu-Kung Lin, Shau-Hsuan Li, Meng-Hsiang Chen, Cheng-Hsien Lu, Ching-Po Lin

Open Access Research

Low 25(OH) D serum levels are related with hip fracture in postmenopausal women: a matched case–control study

Xing-Mao Fu, Shao-Guang Fan, Shu-Liang Li, Yi-Sheng Chen, Hai Wu, Yan-Long Guo

Open Access Research

Chronic administration of the probiotic kefir improves the endothelial function in spontaneously hypertensive rats

Andreia G. F. Friques, Clarisse M. Arpini, Ieda C. Kalil, Agata L. Gava, Marcos A. Leal, Marcella L. Porto, Breno V. Nogueira, Ananda T. Dias, Tadeu U. Andrade, Thiago Melo C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro, Elisardo C. Vasquez

Open Access Research

Differential impact of two doses of antithymocyte globulin conditioning on lymphocyte recovery upon haploidentical hematopoietic stem cell transplantation

Jiangying Liu, Lan-Ping Xu, Zhilei Bian, Ying-Jun Chang, Yu Wang, Xiao-Hui Zhang, Xiao-Jun Huang

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