Ausgabe Sonderheft 2/2011
6th European Workshop on Immune-Mediated Inflammatory Diseases
Inhalt (86 Artikel)
Coeliac disease: the showcase of interaction between genes, environment and immunology in chronic tissue inflammation
Ludvig M Sollid
Central nervous system effects of tumor necrosis factor alpha blockade
Georg Schett
Epigenetic alterations in autoimmune disease
Esteban Ballestar, Biola M Javierre, Lorenzo de la Rica, David Gómez-Cabrero, Jesper Tegnér, Carmen Gomez-Vaquero, Javier Narvaez, Henar Hernando, Virginia C Rodriguez, Roser Vento, Laura Ciudad, Javier Rodriguez-Ubreva
Development of Foxp3+ regulatory T cell: epigenetics and more…
Jochen Hühn
IL-1 blockade in inherited fever syndromes - what have we learnt?
Helen J Lachmann
Biological ageing is a key determinant in systemic sclerosis
Paul G Shiels, JCA Broen, LM McGlynn, J Thomson, MM Chee, R Madhok, TRDJ Radstake
Immune-mediated muscle wasting and cell survival - the tale of a curious gene
James A Ross
Therapeutic inhibition of proteasomes in systemic lupus erythematosus
Falk Hiepe, Bimba Hoyer, Tobias Alexander, Adriano Taddeo, Reinhard Voll, Andreas Radbruch
Regulation of early B cell tolerance checkpoints in humans
Eric Meffre
IL-10 secreting regulatory B cells are potent arbiters of autoimmunity in both mouse and man
Claudia Mauri, Fabian Flores-Borja, Paul A Blair, Natalie A Carter
Breakdown of antimicrobial host defense barrier as trigger of chronic inflammatory bowel diseases
Jan Wehkamp
Anti-inflammatory and immune modulatory properties of mesenchymal stromal cells
Willem E Fibbe
Regulatory T cells for the control of physiological and pathological immune responses
Shimon Sakaguchi
Identification of robust and disease-specific stromal alterations in spondyloarthritis synovitis
Nataliya Yeremenko, Troy Noordenbos, Gemma Rigter, Juan Cañete, Paul-Peter Tak, Dominique Baeten
Characterization of recent thymic emigrants (RTEs), transitional B and Th17 cells in multiple sclerosis (MS)
Aina Teniente-Serra, Laia Grau-López, María Jesús Martínez-Arconada, Marco Fernández-Sanmartín, Cristina Ramo-Tello, Ricardo Pujol-Borrell, Eva Martínez-Cáceres
Reverse signalling of membrane TNF in human natural killer cells: a comparison of the effect of certolizumab pegol and other anti-TNF agents
Gianluca Fossati, Andrew M Nesbitt
A rare polymorphism in Toll Like Receptor 2 is associated with systemic sclerosis phenotype and increases production of inflammatory mediators
Jasper CA Broen, Lara Bossini-Castillo, Lenny van Bon, Madelon C Vonk, Hanneke Knaapen, Lorenzo Beretta, Blanca Rueda, Roger Hesselstrand, Ariane Herrick, Jane Worthington, Nicholas Hunzelmann, Christopher Denton, Carmen Fonseca, Gabriela Riemekasten, Hans Kiener, Raffaella Scorza, Carmen P Simeon, Norberto Ortego-Centeno, Miguel A Gonzalez-Gay, Paolo Airo’, Marieke JH Coenen, Javier Martin, Timothy RDJ Radstake
Immunosuppressive role of fibrinogen-like protein 2 (FGL2) in CD8+regulatory T cells-mediated long-term graft survival
Séverine Bézie, Séverine Ménoret, Laurent Tesson, Xian-Liang Li, Claire Usal, Ignacio Anegon, Lise Caron
Role of CD5/CD5L interactions in the homeostasis of regulatory lymphocyte subpopulations and the control of autoimmune disorders
Rafael Fenutría, Vanesa G Martinez, Victor Gil, Jordi Sintes, Ines Simôes, Jesús Merino, Ramón Merino, Manel Ramos-Casals, Chander Raman, Pablo Engel, Francisco Lozano
The anti-microbial peptide rCRAMP is strongly upregulated during experimental arthritis in the rat
Markus H Hoffmann, Martin Herrmann, Birgitta Agerberth, Rikard Holmdahl
Antibiotics induced commensal flora disruption favours escherichia coli AIEC colonization and mesenteric translocation in NOD2 knock-out mice
Maryline Drouet, Cécile Vignal, Elisabeth Singer, Luc Dubreuil, Pierre Desreumaux, Christel Neut
Immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10
Carmen Ambarus, Lenny Geurts-van Bon, Mark Wenink, Paul Peter Tak, Timothy Radstake, Dominique Baeten
A subset of dendritic cells as a major and constitutive source of IL-22BP
Jérôme Martin, Gaelle Bériou, Michèle Heslan, Céline Bossard, Anne-Chantal Knol, Brigitte Dréno, Simon Milling, Miriam Merad, Régis Josien
CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
Nicolas Glaichenhaus, Cyrille Mionnet, Valérie Julia
The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vß repertoire but with an unmodified phenotype
Nicolas Degauque, Françoise Boeffard, Yohann Foucher, Caroline Ballet, Jean-Paul Soulillou, Sophie Brouard
12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance
Stefan Uderhardt, Martin Herrmann, Olga Oskolkova, Reinhard Voll, Falk Nimmerjahn, Valery Bochkov, Georg Schett, Gerhard Kroenke
Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients
Nuno Costa, Ana E Pires, Ana M Gabriel, Luiz F Goulart, Clara Pereira, Barbara Leal, Ana C Queiros, Wahiba Chaara, Maria F Moraes-Fontes, Carlos Vasconcelos, Carlos Ferreira, Jorge Martins, Marina Bastos, Maria J Santos, Maria A Pereira, Berta Martins, Margarida Lima, Cristina João, Adrien Six, Jocelyne Demengeot, Constantin Fesel
A SNP in intron 1 of TSHR controls its thymic expression and susceptibility to Graves’ disease suggesting central tolerance failure in pathogenesis
Maria del Pilar Armengol, Rosa Faner, Lars-Olivier Tykocinski, Anna Lucas-Martin, Marta Ruiz-Riol, Manel Juan, Bruno Kyewski, Ricardo Pujol-Borrell, Roger Colobran
Monocyte, macrophage and mast cell-derived PDGF control inflammation, tissue remodelling and autoimmunity in the pathophysiology of Graves’ ophthalmpathy
Leendert van Steensel, Dion Paridaens, P Martin van Hagen, Robert WAM Kuijpers, Willem A van den Bosch, Hemmo A Drexhage, Herbert Hooijkaas, Willem A Dik
Somatostatin receptor scintigraphy in sarcoidosis
Lieke SJ Kamphuis, Dik J Kwekkeboom, Jan AM van Laar, Paul LA van Daele, G Seerp Baarsma, P Martin van Hagen
MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma
Tarak Dhaouadi, Imen Sfar, Hajer Aounallah-Skhiri, Saloua Jendoubi-Ayed, Mohamed Amri, Hend Bouacha, Taieb Ben Abdallah, Khaled Ayed, Yousr Gorgi
Differential regulation of IL-22BP in Crohn’s disease versus ulcerative colitis
Jérôme Martin, Céline Bossard, Arnaud Boureille, Régis Josien
Case series: rituximab in the treatment of refractory sight-threatening scleritis
Kiki van Bilsen, P Martin van Hagen, Tom Missotten, Seerp G Baarsma, Robert W Kuijpers, Jan AM van Laar
Synthesis and characterization of non-viral liposomal carriers for the local application of siRNA molecules and anti-miRNAs in the therapeutic treatment of psoriasis
Stefanie Bracke, Barbara Geusens, Peter Dynoodt, Mireille Van Gele, Reinhart Speeckaert, Joost Schalkwijk, Sandra Tjabringa, Jo Lambert
Cutaneous adverse events associated with long-term immunomodulating therapy in multiple sclerosis
Deepak MW Balak, Gerald JD Hengstman, Raymond Hupperts, H Bing Thio
Treatment of lupus erythematosus with fumaric acid ester derivatives: two case-reports
Deepak MW Balak, H Bing Thio
Alitretinoin – molecular and cellular mechanisms of action
Andreas Kislat, Stephan Meller, Rodrigo Mota, Peter A Gerber, Bettina A Buhren, Erich Bünemann, Ulrike Wiesner, Thomas Ruzicka, Bernhard Homey
Immunostimulatory effects on B cells by the chemotherapeutic drug Doxorubicin
Johan M Kinn, Ali Zirakzadeh, Jin Hu, Ola Winqvist
Lyoplate-based multiparameter flow cytometry for the analysis of T cell subsets in human immuno-monitoring studies
Federica Villanova, Paola Di Meglio, Susanne Heck, Margaret Inokuma, Ryan Brinkman, Esperanza Perucha, Maria Hernandez Fuentes, Graham Lord, Skip Maino, Frank O Nestle
Longitudinal immunomonitoring following Tocilizumab in rheumatoid arthritis
Yves-Marie Pers, Pascale Louis-Plence, Pierre Portales, Julie Quentin, Sylvie Fabre, Jean-François Eliaou, Christian Jorgensen
Flow cytometry immunophenotyping of peripheral blood circulating B-cell subset: comparison of osteoarthritis, chronic lymphocytic leukemia patients and normal donors
Artjoms Spaks, Irina Spaka, Alla Rivkina
Drugs that simultaneously down-regulate IL-1β and TNF secretion significantly reduce inflammation in a rat model of antigen-induced arthritis
Rita Cascão, Bruno Vidal, Helena Raquel, Vineet Gupta, João E Fonseca, Luis F Moita
The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways
Nicolas Glaichenhaus, Valérie Julia
Regulation of chemokine and chemokine receptor expression by PPARG in adipocytes and macrophages
MT Audrey Nguyen, Ai Chen, Wendell J Lu, WuQiang Fan, Ping-Ping Li, Dayoung Oh, David Patsouris
Identification of an osteoclastogenic CD4+ T cell population producing IL-17 and TNFα
Thomas Ciucci, Eléonore Birgy-Barelli, Jérôme Pene, Grazia Abou-Ezzi, Nadia Arab, Xavier Hébuterne, Hans Yssel, Claudine Blin-Wakkach, Abdelilah Wakkach
Loss of IL-10 secretion by regulatory B lymphocytes in multiple sclerosis patients
Laure Michel, Nicolas Degauque, Alexandra Garcia, Marion Salou, Annie Elong Ngono, Jean-Paul Soulillou, David Laplaud, Sophie Brouard
Natalizumab alters the TCR repertoire after one year of treatment in four MS patients
Laure Michel, Marion Salou, Alexandra Garcia, Nicolas Degauque, Anne Salmon, Annie Elong Ngono, Arnaud Nicot, Sandrine Wiertlewski, Jean-Paul Soulillou, Sophie Brouard, David Laplaud
Tranilast, an analogue of tryptophan catabolites, induces allograft tolerance by CD161+ cells
Séverine Ménoret, Séverine Bézie, Xian-Liang Li, Claire Usal, Lise Caron, Ignacio Anegon
Single-cell gene profiling of human regulatory T cell subsets in human graft-versus-host disease
Shen Dong, Sylvie Maiella, Aliénor Xhaard, Yuanyu Pang, Christophe Becavin, Arndt Benecke, Gérard Socié, Elisabetta Bianchi, Lars Rogge
Alloantigenic recognition properties of CD8+ regulatory T cells
Elodie Picarda, Ignacio Anegon, Carole Guillonneau
Low serum mannose-binding lectin are associated with inflammation, new-onset diabetes mellitus and subclinical rejection after renal transplantation
Francesc Moreso, Meritxell Ibernon, José M Fernández-Real, Wifredo Ricart, Daniel Seron
PD1/PD-L1 dependent immunosuppression by huiPS-derived cell population
Jonathan Pini, Arieh Moussaieff, Emilie Murris, Reuven Shalom-Feuerstein, Isabelle Petit, Daniel Aberdam, Matthieu Rouleau
CCR9-expressing CD14+HLA-DRhi blood monocytes promote intestinal inflammation in IBD
Ludvig Linton, Mats Karlsson, Jeanette Grundström, Per Marits, Annelie Lindberg, Per Karlen, Ola Winqvist, Michael Eberhardson
Synovial lymphoid neogenesis is associated with IL-23 expression and disease activity in rheumatoid arthritis
Juan D Cañete, Raquel Celis, Julio Ramírez, Sara Marsal, Gabriela Ávila, Raimón Sanmartí, José L Pablos
Selective blockade of TGFbeta in the mice model of collagen-induced arthritis
Elena Gonzalo, Gabriel Criado, Begoña Santiago, Jose Luis Pablos, Maria Galindo
Therapeutic responses and prognosis in Korean adult-onset Still’s disease
Hyoun-Ah Kim, Jeong-Mi An, Chang-Hee Suh
B cell depletion by Rituximab severely reduces immunoglobulin levels in patients with ANCA-associated vasculitis previously treated with cyclophosphamide
Jens Thiel, Nora M Effelsberg, Klaus Warnatz, Michael Schlesier, Hans Hartmut Peter, Reinhard E Voll, Nils Venhoff
Serum biomarkers to predict clinical response in proof-of-concept trials in spondyloarthritis
Maureen Turina, Nataliya Yeremenko, Jacqueline Paramarta, Bernard Vandooren, Paul Peter Tak, Leen De Rycke, Dominique Baeten
Targeted delivery to inflammatory monocytes for efficient RNAi-mediated immuno-intervention in auto-immune arthritis
Jessy Présumey, Gabriel Courties, Louis-Marie Charbonnier, Virginie Escriou, Daniel Scherman, Yves-Marie Pers, Pascale Louis-Plence, Diego Kyburz, Steffen Gay, Christian Jorgensen, Florence Apparailly
Interleukin-6 receptor in the recent-onset rheumatoid arthritis
Marco Antonio Montes-Cano, Sonsoles Reneses, Jose Raul García-Lozano, Fuensanta Torrecillas, Cristina Abad-Molina, Alicia García, Antonio Núñez Roldán, Maria Francisca González-Escribano
The AIRE gene and susceptibility to rheumatoid arthritis in the Spanish population
Belen Torres, Jose Raul García-Lozano, Marco Antonio Montes-Cano, Alicia García, Antonio Núñez-Roldán, Maria Francisca González-Escribano
Triggering of viral RNA sensors induces CD55 expression on synovial fibroblasts
Olga N Karpus, Kirstin M Heutinck, Paul JM Wijnker, Paul Peter Tak, Jorg Hamann
Extensive natural killer cell receptor phenotyping on NK and T cells discloses differences in RA and PsA, potentially mirroring diverse immunoregulatory functions
Sandra TA van Bijnen, Marta Cossu, Frank Preijers, Jan Spanholtz, Harry Dolstra, Timothy RDJ Radstake
Mapping the certolizumab pegol epitope on TNF and comparison with infliximab, adalimumab and etanercept
Alistair I Henry, Haiping Gong, Andrew M Nesbitt
Effectiveness of dose reduction of etanercept and adalimumab in patients with rheumatoid arthritis
Rosalía Martínez-Pérez, Sergio Rodríguez-Montero, Alejandro Muñoz, Julia Uceda, Mario León, Francisco Gallo, Maria Luisa Velloso, José Luis Marenco
Adipocytes from the infrapatellar fat pad of OA patients modulate CD4+ T cell cytokine production
Andreea Ioan-Facsinay, Joanneke C Kwekkeboom, Margreet Kloppenburg, Rene EM Toes
Clinical and functional effectiveness of anti-TNF therapy in patients with rheumatoid arthritis
Rosalia Martínez-Pérez, Julia Uceda, Mario León, Sergio Rodríguez, Alejandro Muñoz, Francisco Gallo, Maria Luisa Velloso, Jose Luis Marenco
IL-17 producing mast cells contribute to synovial inflammation in non-psoriatic and psoriatic spondyloarthritis
Troy Noordenbos, Nataliya Yeremenko, Ioana Gofita, Paul Peter Tak, Juan Cañete, Dominique Baeten
Unique circulating cytokine profile of rheumatoid arthritis patients with nodules
Bridget Hodkinson, Pieter WA Meyer, Eustatius Musenge, Mahmood Ally, Ronlad Anderson, Mohammed Tikly
Flt3 inhibition leads to decreased production of IL-6 by synovial biopsies and fibroblast-like synoviocytes by reducing NFKb activity
M Inês Ramos, Olexandr Korchynskyi, Saida Aarrass, Paul Peter Tak, M Cristina Lebre
Non-canonical NF-κB signaling in endothelial cells may enhance synovial inflammation by stimulating angiogenesis
Ae-Ri Noort, Katinka PM van Zoest, Paul Peter Tak, Sander W Tas
Diagnostic value of different anti-citrullinated peptides antibodies in rheumatoid arthritis
Estíbaliz Ruiz-Ortiz de Arrizabaleta, Dolors Grados-Cánovas, Aina Teniente-Serra, Virginia García-López, Bibiana Quirant-Sánchez, Susana Holgado, Alejandro Olivé, Ricardo Pujol-Borrell, Eva Martínez-Cáceres
Characterization of patients with anti-modified citrullinated vimentin antibodies (MCVA)
Estíbaliz Ruiz-Ortiz de Arrizabaleta, Dolors Grados-Cánovas, Aina Teniente-Serra, Iñaki Salvador-Corres, Ana Marín, Melania Martínez-Morillo, Susana Holgado, Alejandro Olivé, Ricardo Pujol-Borrell, Eva Martínez-Cáceres
Rheumatoid arthritis is associated with increased DKK1 expression and disturbances in the bone turnover regulating genes
Joana Caetano-Lopes, Ana Rodrigues, Ana Lopes, Ana C Vale, Michael A Pitts-Kiefer, Bruno Vidal, Inês P Perpétuo, Jacinto Monteiro, Yrjö T Konttinen, Maria F Vaz, Ara Nazarian, Helena Canhão, João E Fonseca
Apolipoprotein E and undercaboxylated osteocalcin are associated with bone fragility but not with bone mineral density in osteoarthritis patients
Ana Rodrigues, Joana Caetano-Lopes, Ana Lopes, Ana C Vale, Inês Aleixo, Inês P Perpétuo, Ana S Pena, Alexandra Faustino, Alexandre Sepriano, Joaquim Polido-Pereira, Elsa Vieira-Sousa, Bruno Vidal, José C Romeu, Pedro M Amaral, Luís G Rosa, José A Pereira da Silva, Jacinto Monteiro, Maria F Vaz, João E Fonseca, Helena Canhão
Predictors of response and anti-TNF drugs comparative efficacy
Helena Canhão, Ana F Mourão, Fernando Martins, Maria J Santos, Canas Silva, Joaquim Pereira, JA Pereira Silva, José Costa, Domingos Araujo, Candida Silva, Eugenia Simões, Catia Duarte, José Antonio P Silva, Fernando Pimentel, Jaime Branco, João E Fonseca
Osteoclasts modulate the balance between immunosuppression and inflammation through antigen presentation and interactions with CD4+ T cells
Grazia Abou Ezzi, Thomas Ciucci, Vanessa Amiot, Abdelilah Wakkach, Claudine Blin-Wakkach
Relationship between the sialylation level of anti-proteinase 3 antibodies and the activity of granulomatosis with polyangiitis (Wegener’s disease)
Philippe Guilpain, Cécile Espy, Willy Morelle, Niloufar Kavian, Christian Pagnoux, Jean-Claude Michalski, Loïc Guillevin, Bernard Weill, Frédéric Batteux
Impaired dendritic cell proinflammatory cytokine production in psoriatic arthritis
Mark H Wenink, Kim CM Santegoets, John Butcher, Lenny van Bon, Femke GM Lamers-Karnebeek, Wim B van den Berg, Piet LCM van Riel, Iain B McInnes, Timothy RDJ Radstake
Macrophage dysfunction in Psoriatic Arthritis
Mark H Wenink, Kim CM Santegoets, Lenny van Bon, John Butcher, Wim B van den Berg, Piet LCM van Riel, Iain B McInnes, Timothy RDJ Radstake
The expression of CXCR4/CXCL12 determines subsets of patients in systemic lupus erythematosus
Philippe Guilpain, Andrew Wang, Benjamin F Chong, Sandrine Chouzenoux, Loic Guillevin, Xin J Zhou, Fangming Lin, Anna-Marie Fairhurst, Christopher Boudreaux, Christian Roux, Edward K Wakeland, Laurie Davis, Frederic Batteux, Chandra Mohan
Genetic markers in clinical subtypes of juvenile idiopathic arthritis
Pierre Le Blay, Catherine Ludwig, Cécile Rittore, Stéphane Soler, Gabriel Tejedor, Vincent Daïen, Nicolas Molinari, Yves-Marie Pers, Jean-David Cohen, Michel Rodiere, Christian Jorgensen, Isabelle Touitou
CD4+CD45RA+ T-cells from early diffuse systemic sclerosis patients produce high levels of interleukin-17
Lenny van Bon, Marta Cossu, Wim van den Berg, Madelon Vonk, Hans Koenen, Timothy Radstake