Erschienen in:
30.01.2019 | Guide Line
JSH Practical Guidelines for Hematological Malignancies, 2018: II. Lymphoma-8. Adult T-cell leukemia–lymphoma
verfasst von:
Kunihiro Tsukasaki, Takuya Fukushima
Erschienen in:
International Journal of Hematology
|
Ausgabe 3/2019
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Excerpt
Adult T-cell leukemia–lymphoma (ATL) is a disease concept first described by Uchiyama and Takatsuki et al. in 1977 as a T-cell neoplasm endemic to southwestern Japan, primarily the Kyushu region and Okinawa [1]. Human T-cell leukemia virus type 1 (HTLV-1) was discovered as the causative virus in the early 1980s [2–5]. In the 2017 WHO Classification, ATL is defined as a peripheral T-cell neoplasm caused by HTLV-1 that is composed of lymphocytes with high-grade nuclear atypia [6]. …