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Erschienen in: Rheumatology International 6/2012

01.06.2012 | Short Communication

Juvenile diffuse systemic sclerosis/systemic lupus erythematosus overlap syndrome—a case report

verfasst von: Heng-Kuei Lin, Jiaan-Der Wang, Lin-Shien Fu

Erschienen in: Rheumatology International | Ausgabe 6/2012

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Abstract

We report a rare case of diffuse systemic sclerosis (SSc) evolving into diffuse SSc/systemic lupus erythematosus (SLE) overlap syndrome. A 15-year-old boy was diagnosed as diffuse SSc with initial presentations of Raynaud’s phenomenon and skin tightening. He underwent Chinese herbal treatment and clinical symptoms deteriorated in the following 3 years. On admission to our ward, serositis with pleural effusion, severe pulmonary fibrosis with moderate pulmonary hypertension, swallowing difficulty, and polyarthritis were observed. Autoantibody profiles revealed concurrence of anti-double-stranded DNA, anti-Smith, anti-topoisomerase I, and anti-ribonucleoprotein antibodies. The patient fulfills the criteria for both diffuse SSc and SLE. After drainage for pleural effusion accompanied by oral prednisolone and sildenafil, there were improvement of respiratory distress, swallowing difficulty, and pulmonary hypertension. In conclusion, connective tissue diseases may overlap with each other during the disease course. Serial follow-up for clinical symptoms as well as serological changes is recommended.
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Metadaten
Titel
Juvenile diffuse systemic sclerosis/systemic lupus erythematosus overlap syndrome—a case report
verfasst von
Heng-Kuei Lin
Jiaan-Der Wang
Lin-Shien Fu
Publikationsdatum
01.06.2012
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 6/2012
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-011-1937-4

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