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European Archives of Psychiatry and Clinical Neuroscience

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08.11.2017 | Short Communication

Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress

verfasst von: Ji-chun Zhang, Wei Yao, Chao Dong, Mei Han, Yukihiko Shirayama, Kenji Hashimoto

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 8/2018

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Abstract

The transcription factor Keap1–Nrf2 signaling plays a key role in the oxidative stress which is involved in psychiatric disorders. In the learned helplessness (LH) paradigm, protein levels of Keap1 and Nrf2 in the prefrontal cortex and dentate gyrus of hippocampus from LH (susceptible) rats were lower than control and non-LH (resilience) rats. Furthermore, protein expressions of Keap1 and Nrf2 in the parietal cortex from major depressive disorder, schizophrenia, and bipolar disorder were lower than controls. These results suggest that Keap1–Nrf2 signaling might contribute to stress resilience which plays a key role in the pathophysiology of psychiatric disorders.

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Titel: Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress
verfasst von: Ji-chun Zhang
Wei Yao
Chao Dong
Mei Han
Yukihiko Shirayama
Kenji Hashimoto
Publikationsdatum: 08.11.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 8/2018
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-017-0848-0

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Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress

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