The authors declare that they have no competing interests.
PU, LCL, CT and JGM wrote the manuscript. CT provided the photomicrographs. All authors read and approved the final manuscript.
Accurate staging is critical for decision-making for the treatment of malignant conditions. Fluoro-deoxy-glucose positron emission tomography-computed tomography (FDG PET-CT) is a highly sensitive imaging modality for the assessment of distant metastases; however false positive results are possible due to its lower specificity with detection of other hypermetabolic pathologies.
A patient with high-risk thigh melanoma was staged with FDG PET-CT. Four ipsilateral inguinal nodes (three superficial, one deep) demonstrated intense hypermetabolic activity. Metastatic melanoma was confirmed in the largest superficial inguinal node with ultrasound-guided fine needle aspiration. Histopathology demonstrated metastatic melanoma in one superficial node and histiocytic necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease in five deep inguinal nodes.
This case illustrates a false positive FDG PET-CT due to coincidental, synchronous melanoma and Kikuchi-Fujimoto disease in the same draining lymph node basin.
Dosi RV, Ambaliya A, Patel JS, Bhambhani YS, Patell RD. A fatal case of Kikuchi-Fujimoto disease. J Indian Med Assoc. 2012;110(1):53–4. PubMed
National Comprehensive Cancer Network. Melanoma 2.2014. Accessed 20/11/2013. [ www.nccn.org]
Schröer-Günther MA, Wolff RF, Westwood ME, Scheibler FJ, Schumann C, Baumert BG, et al. F-18-fluoro-2-deoxyglucose positron emission tomography (PET) and PET/computed tomography imaging in primary staging of patients with malignant melanoma: a systematic review. Syst Rev. 2012;1:62. CrossRefPubMedPubMedCentral
- Kikuchi-Fujimoto lymphadenitis imitating metastatic melanoma on positron emission tomography: a case report
Carolin J Teman
J Gregory McKinnon
- BioMed Central
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