The online version of this article (https://doi.org/10.1007/s12020-018-1609-1) contains supplementary material, which is available to authorized users.
To evaluate the temporal coupling between spontaneous kisspeptin and luteinizing hormone (LH) pulsatile releases in polycystic ovary syndrome (PCOS) patients.
We examined 71 patients diagnosed with PCOS. A 2 h pulsatility study was performed to evaluate serum kisspeptin and LH pulse frequency and concentration, sampled every 10 min; baseline follicle-stimulating hormone (FSH), estradiol (E2), prolactin (PRL), cortisol, 17-hydroksy-progesterone (17OHP), testosterone (T), free testosterone index (FTI, and insulin levels were also measured. Detect and Specific Concordance (SC) algorithms were used to evaluate the temporal coupling associations between spontaneous episodic secretion of kisspeptin and LH.
All PCOS patients demonstrated LH and kisspeptin pulsatile secretions. When the SC index was calculated across the sample of PCOS patients (n = 71), no temporal coupling was observed between kisspeptin and LH pulses. When PCOS patients were subdivided according to their menstrual cyclicity, oligomenorrheic patients demonstrated elevated kisspeptin pulse frequency. Additionally, the SC index reveled a temporal coupling between kisspeptin and LH secretory peaks only in eumenorrheic patients (n = 30, intermenstrual interval < 45 days). Oligomenorrheic PCOS patients (intermenstrual interval > 45 days) did not demonstrate temporal coupling between kisspeptin and LH secretory peaks.
The study of the endogenous kisspeptin and LH pulsatile release revealed the temporal coupling of kisspeptin with LH secretory pulses only in eumenorrheic. This data supports the hypothesis that neuroendocrine impairments in PCOS affect the coupling of kisspeptin with LH pulses and potentially worsen as the disease progresses, becoming unequivocally evident in oligomenorrheic PCOS patients.
J. Young, J.T. George, J.A. Tello, B. Francou, J. Bouligand, A. Guiochon-Mantel et al. Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications. Neuroendocrinology 97(2), 193–202 (2013) CrossRefPubMed
A.D. Genazzani, F. Petraglia, C. Volpogni, G. d’Ambrogio, F. Facchinetti, A.R. Genazzani, FSH secretory pattern and degree of concordance with LH in amenorrheic, fertile and postmenopausal women. Am. J. Physiol. 264, E776–E781 (1993) PubMed
A.D. Genazzani, F. Ricchieri, C. Lanzoni, Use of metformin in the treatment of polycystic ovary syndrome. Women’s Health (Lond.) 6(4), 577–593 (2010) CrossRef
A.D. Genazzani, D. Rodbard, Use of receiver operating characteristic curve to evaluate sensitivity, specificity, and accuracy of methods for detection of peaks in hormone time series. Acta Endocrinol. (Copenh) 124(3), 295–306 (1991) CrossRef
S. Osuka, A. Iwase, T. Nakahara, M. Kondo, A. Saito, Bayasula et al. Kisspeptin in the hypothalamus of two rat models of polycystic ovary syndrome. Endocrinology 158(2), 367–377 (2017) PubMed
- Kisspeptin and LH pulsatile temporal coupling in PCOS patients
Alessandro D. Genazzani
- Springer US
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