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Tumor Biology

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08.10.2015 | Original Article

KLF2 is downregulated in pancreatic ductal adenocarcinoma and inhibits the growth and migration of cancer cells

verfasst von: Dexiang Zhang, Yuedi Dai, Yuankun Cai, Tao Suo, Han Liu, Yueqi Wang, Zhijian Cheng, Houbao Liu

Erschienen in: Tumor Biology | Ausgabe 3/2016

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Abstract

Members of the Kruppel-like factor (KLF) family have been considered as the tumor suppressors for their inhibitory effects on cell proliferation. Dysregulation of KLF2, a member of KLF family, has been observed in various cancer types. However, its expression pattern and functions in the pancreatic ductal adenocarcinoma (PDAC) are unknown. In this study, we examined the expression of KLF2 in PDAC clinical samples and evaluated the functions of KLF2 in the progression of PDAC. KLF2 is shown to be downregulated in PDAC clinical samples and overexpression of KLF2 inhibits the growth, migration, and metastasis of PDAC cancer cells. KLF2 interacts with beta-catenin and negatively regulates the beta-catenin/TCF signaling. Taken together, this study suggests the suppressive functions of KLF2 in PDAC.

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Titel: KLF2 is downregulated in pancreatic ductal adenocarcinoma and inhibits the growth and migration of cancer cells
verfasst von: Dexiang Zhang
Yuedi Dai
Yuankun Cai
Tao Suo
Han Liu
Yueqi Wang
Zhijian Cheng
Houbao Liu
Publikationsdatum: 08.10.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 3/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-4053-3

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KLF2 is downregulated in pancreatic ductal adenocarcinoma and inhibits the growth and migration of cancer cells

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