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Erschienen in: Der Diabetologe 7/2012

01.11.2012 | Leitthema

Klinische Befunde und rationelle Differenzialdiagnostik der diabetischen Dyslipidämie

verfasst von: Prof. Dr. A. von Eckardstein

Erschienen in: Die Diabetologie | Ausgabe 7/2012

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Zusammenfassung

Insbesondere der Typ-2-Diabetes begünstigt die Manifestation von Dyslipidämien, die wiederum das Risiko für makro- und mikrovaskuläre Komplikationen, aber auch für akute Pankreatitis beeinflussen. Diese Arbeit beschreibt die Charakteristika der diabetischen Dyslipidämie und diskutiert die diagnostische sowie prognostische Wertigkeit klassischer und neuer Laborparameter für ihre Charakterisierung. Außerdem werden die primären und die sekundären Ursachen ausgeprägter Dyslipidämien erörtert.
Literatur
1.
Zurück zum Zitat Fioretto P, Dodson PM, Ziegler D, Rosenson RS (2010) Residual microvascular risk in diabetes: unmet needs and future directions. Nat Rev Endocrinol 6:19–25PubMedCrossRef Fioretto P, Dodson PM, Ziegler D, Rosenson RS (2010) Residual microvascular risk in diabetes: unmet needs and future directions. Nat Rev Endocrinol 6:19–25PubMedCrossRef
2.
Zurück zum Zitat Cholesterol Treatment Trialists‘ (CTT) Collaborators, Kearney PM, Blackwell L et al (2008) Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 371:117–125CrossRef Cholesterol Treatment Trialists‘ (CTT) Collaborators, Kearney PM, Blackwell L et al (2008) Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 371:117–125CrossRef
3.
Zurück zum Zitat Cholesterol Treatment Trialists‘ (CTT) Collaboration, Baigent C, Blackwell L et al (2010) Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376:1670–1681CrossRef Cholesterol Treatment Trialists‘ (CTT) Collaboration, Baigent C, Blackwell L et al (2010) Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376:1670–1681CrossRef
4.
Zurück zum Zitat European Association for Cardiovascular Prevention & Rehabilitation, Reiner Z, Catapano AL et al (2011) ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 32:1769–1818CrossRef European Association for Cardiovascular Prevention & Rehabilitation, Reiner Z, Catapano AL et al (2011) ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 32:1769–1818CrossRef
5.
Zurück zum Zitat Jun M, Foote C, Lv J et al (2010) Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 375:1875–1884PubMedCrossRef Jun M, Foote C, Lv J et al (2010) Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 375:1875–1884PubMedCrossRef
6.
Zurück zum Zitat ACCORD Study Group; ACCORD Eye Study Group, Chew EY et al (2011) Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med 363:233–244 [Epub 2010 Jun 29. Erratum in: N Engl J Med. 2011 Jan 13;364:190] ACCORD Study Group; ACCORD Eye Study Group, Chew EY et al (2011) Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med 363:233–244 [Epub 2010 Jun 29. Erratum in: N Engl J Med. 2011 Jan 13;364:190]
7.
Zurück zum Zitat Sacks FM, Carey VJ, Fruchart JC (2010) Combination lipid therapy in type 2 diabetes. N Engl J Med 363:692–694PubMedCrossRef Sacks FM, Carey VJ, Fruchart JC (2010) Combination lipid therapy in type 2 diabetes. N Engl J Med 363:692–694PubMedCrossRef
8.
Zurück zum Zitat Bruckert E, Baccara-Dinet M, Eschwege E (2007) Low HDL-cholesterol is common in European type 2 diabetic patients receiving treatment for dyslipidaemia: data from a pan-European survey. Diabet Med 24:388–391PubMedCrossRef Bruckert E, Baccara-Dinet M, Eschwege E (2007) Low HDL-cholesterol is common in European type 2 diabetic patients receiving treatment for dyslipidaemia: data from a pan-European survey. Diabet Med 24:388–391PubMedCrossRef
9.
Zurück zum Zitat Eckardstein A von, Schulte H, Assmann G (2000) Risk for diabetes mellitus in middle-aged Caucasian male participants of the PROCAM study: implications for the definition of impaired fasting glucose by the American Diabetes Association. Prospective Cardiovascular Münster. J Clin Endocrinol Metab 85:3101–3108CrossRef Eckardstein A von, Schulte H, Assmann G (2000) Risk for diabetes mellitus in middle-aged Caucasian male participants of the PROCAM study: implications for the definition of impaired fasting glucose by the American Diabetes Association. Prospective Cardiovascular Münster. J Clin Endocrinol Metab 85:3101–3108CrossRef
10.
Zurück zum Zitat Glaser NS, Geller DH, Haqq A et al (2011) Detecting and treating hyperlipidemia in children with type 1 diabetes mellitus: are standard guidelines applicable to this special population? Pediatr Diab 12(4 Pt 2):442–459CrossRef Glaser NS, Geller DH, Haqq A et al (2011) Detecting and treating hyperlipidemia in children with type 1 diabetes mellitus: are standard guidelines applicable to this special population? Pediatr Diab 12(4 Pt 2):442–459CrossRef
11.
Zurück zum Zitat Contois JH, Warnick GR, Sniderman AD (2011) Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement. J Clin Lipidol 5:264–272PubMedCrossRef Contois JH, Warnick GR, Sniderman AD (2011) Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement. J Clin Lipidol 5:264–272PubMedCrossRef
12.
Zurück zum Zitat Ramjee V, Sperling LS, Jacobson TA (2011) Non-high-density lipoprotein cholesterol versus apolipoprotein B in cardiovascular risk stratification: do the math. J Am Coll Cardiol 58:457–463PubMedCrossRef Ramjee V, Sperling LS, Jacobson TA (2011) Non-high-density lipoprotein cholesterol versus apolipoprotein B in cardiovascular risk stratification: do the math. J Am Coll Cardiol 58:457–463PubMedCrossRef
13.
Zurück zum Zitat Davidson MH, Ballantyne CM, Jacobson TA et al (2011) Clinical utility of inflammatory markers and advanced lipoprotein testing: advice from an expert panel of lipid specialists. J Clin Lipidol 5:338–367PubMedCrossRef Davidson MH, Ballantyne CM, Jacobson TA et al (2011) Clinical utility of inflammatory markers and advanced lipoprotein testing: advice from an expert panel of lipid specialists. J Clin Lipidol 5:338–367PubMedCrossRef
14.
Zurück zum Zitat Deventer HE van, Miller WG, Myers GL et al (2011) Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population. Clin Chem 57:490–501PubMedCrossRef Deventer HE van, Miller WG, Myers GL et al (2011) Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population. Clin Chem 57:490–501PubMedCrossRef
15.
Zurück zum Zitat Lund SS, Petersen M, Frandsen M et al (2011) Agreement between fasting and postprandial LDL cholesterol measured with 3 methods in patients with type 2 diabetes mellitus. Clin Chem 57:298–308 [Epub 2010 Oct 14. Erratum in: Clin Chem. 2011 May;57:782] Lund SS, Petersen M, Frandsen M et al (2011) Agreement between fasting and postprandial LDL cholesterol measured with 3 methods in patients with type 2 diabetes mellitus. Clin Chem 57:298–308 [Epub 2010 Oct 14. Erratum in: Clin Chem. 2011 May;57:782]
16.
Zurück zum Zitat Miller WG, Myers GL, Sakurabayashi I et al (2010) Seven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures. Clin Chem 56:977–986PubMedCrossRef Miller WG, Myers GL, Sakurabayashi I et al (2010) Seven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures. Clin Chem 56:977–986PubMedCrossRef
17.
Zurück zum Zitat Sniderman A, Couture P, Graaf J de (2010) Diagnosis and treatment of apolipoprotein B dyslipoproteinemias. Nat Rev Endocrinol 6:335–346PubMedCrossRef Sniderman A, Couture P, Graaf J de (2010) Diagnosis and treatment of apolipoprotein B dyslipoproteinemias. Nat Rev Endocrinol 6:335–346PubMedCrossRef
18.
Zurück zum Zitat Custodis F, Laufs U (2011) Hypertricglyceridemia: prognostic impact and treatment. Dtsch Med Wochenschr 136:1533–1542PubMedCrossRef Custodis F, Laufs U (2011) Hypertricglyceridemia: prognostic impact and treatment. Dtsch Med Wochenschr 136:1533–1542PubMedCrossRef
19.
Zurück zum Zitat Johansen CT, Wang J, Lanktree MB et al (2010) Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 42:684–687PubMedCrossRef Johansen CT, Wang J, Lanktree MB et al (2010) Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 42:684–687PubMedCrossRef
20.
Zurück zum Zitat Carpentier AC, Frisch F, Labbé SM et al (2012) Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients. J Clin Endocrinol Metab 97:1635–1644PubMedCrossRef Carpentier AC, Frisch F, Labbé SM et al (2012) Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients. J Clin Endocrinol Metab 97:1635–1644PubMedCrossRef
21.
Zurück zum Zitat Mahley RW, Huang Y, Rall SC Jr (1999) Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes. J Lipid Res 40:1933–1949PubMed Mahley RW, Huang Y, Rall SC Jr (1999) Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes. J Lipid Res 40:1933–1949PubMed
22.
Zurück zum Zitat Haase A, Goldberg AC (2012) Identification of people with heterozygous familial hypercholesterolemia. Curr Opin Lipidol 23:282–289PubMedCrossRef Haase A, Goldberg AC (2012) Identification of people with heterozygous familial hypercholesterolemia. Curr Opin Lipidol 23:282–289PubMedCrossRef
23.
Zurück zum Zitat Bender R, Bell DA, Hooper AJ et al (2012) Screening for familial hypercholesterolaemia. Pathology 44:122–128PubMedCrossRef Bender R, Bell DA, Hooper AJ et al (2012) Screening for familial hypercholesterolaemia. Pathology 44:122–128PubMedCrossRef
24.
Zurück zum Zitat Parks JS, Chung S, Shelness GS (2012) Hepatic ABC transporters and triglyceride metabolism. Curr Opin Lipidol 23:196–200PubMedCrossRef Parks JS, Chung S, Shelness GS (2012) Hepatic ABC transporters and triglyceride metabolism. Curr Opin Lipidol 23:196–200PubMedCrossRef
25.
Zurück zum Zitat Chapman MJ, Ginsberg HN, Amarenco P et al (2011) Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 32:1345–1361PubMedCrossRef Chapman MJ, Ginsberg HN, Amarenco P et al (2011) Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 32:1345–1361PubMedCrossRef
26.
Zurück zum Zitat Eckardstein A von (2006) Differential diagnosis of familial high density lipoprotein deficiency syndromes. Atherosclerosis 186:231–239CrossRef Eckardstein A von (2006) Differential diagnosis of familial high density lipoprotein deficiency syndromes. Atherosclerosis 186:231–239CrossRef
27.
Zurück zum Zitat Frikke-Schmidt R, Nordestgaard BG, Stene MC et al (2008) Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA 299:2524–2532PubMedCrossRef Frikke-Schmidt R, Nordestgaard BG, Stene MC et al (2008) Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA 299:2524–2532PubMedCrossRef
28.
Zurück zum Zitat Rowczenio D, Dogan A, Theis JD et al (2011) Amyloidogenicity and clinical phenotype associated with five novel mutations in apolipoprotein A-I. Am J Pathol 179:1978–1987PubMedCrossRef Rowczenio D, Dogan A, Theis JD et al (2011) Amyloidogenicity and clinical phenotype associated with five novel mutations in apolipoprotein A-I. Am J Pathol 179:1978–1987PubMedCrossRef
29.
Zurück zum Zitat Kunnen S, Van Eck M (2012) Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis? J Lipid Res 53:1783–1799PubMedCrossRef Kunnen S, Van Eck M (2012) Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis? J Lipid Res 53:1783–1799PubMedCrossRef
Metadaten
Titel
Klinische Befunde und rationelle Differenzialdiagnostik der diabetischen Dyslipidämie
verfasst von
Prof. Dr. A. von Eckardstein
Publikationsdatum
01.11.2012
Verlag
Springer-Verlag
Erschienen in
Die Diabetologie / Ausgabe 7/2012
Print ISSN: 2731-7447
Elektronische ISSN: 2731-7455
DOI
https://doi.org/10.1007/s11428-012-0890-5

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