Skip to main content
Erschienen in: Der Hautarzt 3/2017

03.02.2017 | Humane Papillomviren | Leitthema

Kondylome bei HIV-Infizierten

verfasst von: Prof. Dr. U. Wieland, Prof. Dr. A. Kreuter

Erschienen in: Die Dermatologie | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Zusammenfassung

Kondylome sind bei HIV-infizierten Patienten wesentlich häufiger als bei HIV-negativen Personen. Kondylome HIV-Positiver unterscheiden sich von denen HIV-Negativer in der Ausdehnung, im Auftreten an ungewöhnlicheren Lokalisationen, im HPV (humane Papillomviren)-Typenspektrum, in der Rezidivneigung sowie im Entartungsrisiko. Etwa 18–56 % der Kondylome HIV-positiver Patienten enthalten hochgradige Dysplasien. Aus diesem Grund sollten Kondylome bei HIV-Infizierten vorzugsweise ablativ entfernt und histopathologisch evaluiert werden. Durch die geschlechtsneutrale prophylaktische HPV-Impfung von HPV-naiven Jungen und Mädchen könnte zukünftig eine deutliche Reduktion von Kondylomen auch in dieser Patientengruppe erreicht werden.
Literatur
1.
Zurück zum Zitat Abramowitz L, Benabderrahmane D, Ravaud P et al (2007) Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men, homosexual men and women: Prevalence and associated factors. AIDS 21:1457–1465CrossRefPubMed Abramowitz L, Benabderrahmane D, Ravaud P et al (2007) Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men, homosexual men and women: Prevalence and associated factors. AIDS 21:1457–1465CrossRefPubMed
2.
Zurück zum Zitat Ali H, Donovan B, Wand H et al (2013) Genital warts in young Australians five years into national human papillomavirus vaccination programme: National surveillance data. BMJ 346:f2032CrossRefPubMed Ali H, Donovan B, Wand H et al (2013) Genital warts in young Australians five years into national human papillomavirus vaccination programme: National surveillance data. BMJ 346:f2032CrossRefPubMed
4.
Zurück zum Zitat Braun SA, Jansen TM, Homey B et al (2015) Successful therapy of condylomata acuminata with ingenol mebutate. Hautarzt 66:223–225CrossRefPubMed Braun SA, Jansen TM, Homey B et al (2015) Successful therapy of condylomata acuminata with ingenol mebutate. Hautarzt 66:223–225CrossRefPubMed
5.
Zurück zum Zitat Chirgwin KD, Feldman J, Augenbraun M et al (1995) Incidence of venereal warts in human immunodeficiency virus-infected and uninfected women. J Infect Dis 172:235–238CrossRefPubMed Chirgwin KD, Feldman J, Augenbraun M et al (1995) Incidence of venereal warts in human immunodeficiency virus-infected and uninfected women. J Infect Dis 172:235–238CrossRefPubMed
6.
Zurück zum Zitat Coskuner ER, Ozkan TA, Karakose A et al (2014) Impact of the quadrivalent HPV vaccine on disease recurrence in men exposed to HPV Infection: A randomized study. J Sex Med 11:2785–2791CrossRefPubMed Coskuner ER, Ozkan TA, Karakose A et al (2014) Impact of the quadrivalent HPV vaccine on disease recurrence in men exposed to HPV Infection: A randomized study. J Sex Med 11:2785–2791CrossRefPubMed
7.
Zurück zum Zitat De Camargo CC, Tasca KI, Mendes MB et al (2014) Prevalence of anogenital warts in men with HIV/AIDS and associated factors. Open AIDS J 8:25–30CrossRefPubMedPubMedCentral De Camargo CC, Tasca KI, Mendes MB et al (2014) Prevalence of anogenital warts in men with HIV/AIDS and associated factors. Open AIDS J 8:25–30CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Dinleyici M, Saracoglu N, Eren M et al (2015) Giant Condyloma Acuminate due to human Papillomavirus type 16 in an infant successfully treated with topical Imiquimod therapy. Dermatol Reports 7:6134CrossRefPubMedPubMedCentral Dinleyici M, Saracoglu N, Eren M et al (2015) Giant Condyloma Acuminate due to human Papillomavirus type 16 in an infant successfully treated with topical Imiquimod therapy. Dermatol Reports 7:6134CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Drolet M, Benard E, Boily MC et al (2015) Population-level impact and herd effects following human papillomavirus vaccination programmes: A systematic review and meta-analysis. Lancet Infect Dis 15:565–580CrossRefPubMedPubMedCentral Drolet M, Benard E, Boily MC et al (2015) Population-level impact and herd effects following human papillomavirus vaccination programmes: A systematic review and meta-analysis. Lancet Infect Dis 15:565–580CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Esser S, Kreuter A, Oette M et al (2015) German-Austrian guidelines on anal dysplasia and anal cancer in HIV-positive individuals: Prevention, diagnosis, and treatment. J Dtsch Dermatol Ges 13:1302–1319CrossRefPubMed Esser S, Kreuter A, Oette M et al (2015) German-Austrian guidelines on anal dysplasia and anal cancer in HIV-positive individuals: Prevention, diagnosis, and treatment. J Dtsch Dermatol Ges 13:1302–1319CrossRefPubMed
13.
Zurück zum Zitat Fuchs W, Wieland U, Skaletz-Rorowski A et al (2016) The male ScreenING Study: Prevalence of HPV-related genital and anal lesions in an urban cohort of HIV-positive men in Germany. J Eur Acad Dermatol Venereol 30:995–1001CrossRefPubMed Fuchs W, Wieland U, Skaletz-Rorowski A et al (2016) The male ScreenING Study: Prevalence of HPV-related genital and anal lesions in an urban cohort of HIV-positive men in Germany. J Eur Acad Dermatol Venereol 30:995–1001CrossRefPubMed
14.
Zurück zum Zitat Giuliano AR, Palefsky JM, Goldstone S et al (2011) Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males. N Engl J Med 364:401–411CrossRefPubMedPubMedCentral Giuliano AR, Palefsky JM, Goldstone S et al (2011) Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males. N Engl J Med 364:401–411CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Gormley RH, Kovarik CL (2012) Human papillomavirus-related genital disease in the immunocompromised host: Part I. J Am Acad Dermatol 66(867):e861–e814 Gormley RH, Kovarik CL (2012) Human papillomavirus-related genital disease in the immunocompromised host: Part I. J Am Acad Dermatol 66(867):e861–e814
16.
Zurück zum Zitat Gormley RH, Kovarik CL (2012) Human papillomavirus-related genital disease in the immunocompromised host: Part II. J Am Acad Dermatol 66(883):e881–e817 Gormley RH, Kovarik CL (2012) Human papillomavirus-related genital disease in the immunocompromised host: Part II. J Am Acad Dermatol 66(883):e881–e817
17.
Zurück zum Zitat Grussendorf-Conen EI (1997) Anogenital premalignant and malignant tumors (including Buschke-Lowenstein tumors). Clin Dermatol 15:377–388CrossRefPubMed Grussendorf-Conen EI (1997) Anogenital premalignant and malignant tumors (including Buschke-Lowenstein tumors). Clin Dermatol 15:377–388CrossRefPubMed
18.
Zurück zum Zitat Hernandez-Suarez G, Pineros M, Vargas JC et al (2013) Human papillomavirus genotypes in genital warts in Latin America: a cross-sectional study in Bogota, Colombia. Int J STD AIDS 24:567–572CrossRefPubMed Hernandez-Suarez G, Pineros M, Vargas JC et al (2013) Human papillomavirus genotypes in genital warts in Latin America: a cross-sectional study in Bogota, Colombia. Int J STD AIDS 24:567–572CrossRefPubMed
19.
Zurück zum Zitat Hildesheim A, Gonzalez P, Kreimer AR et al (2016) Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment. Am J Obstet Gynecol 215:212CrossRefPubMed Hildesheim A, Gonzalez P, Kreimer AR et al (2016) Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment. Am J Obstet Gynecol 215:212CrossRefPubMed
20.
Zurück zum Zitat Jiamton S, Leeyaphan C, Maneeprasopchoke P et al (2014) Prevalence and clinical manifestations of male patients with Anogenital warts attending a sexually transmitted disease clinic prior Hpv vaccine recommendation. Southeast Asian J Trop Med Public Health 45:1337–1343PubMed Jiamton S, Leeyaphan C, Maneeprasopchoke P et al (2014) Prevalence and clinical manifestations of male patients with Anogenital warts attending a sexually transmitted disease clinic prior Hpv vaccine recommendation. Southeast Asian J Trop Med Public Health 45:1337–1343PubMed
21.
Zurück zum Zitat Komlos KF, Kocjan BJ, Kosorok P et al (2012) Tumor-specific and gender-specific pre-vaccination distribution of human papillomavirus types 6 and 11 in anogenital warts and laryngeal papillomas: A study on 574 tissue specimens. J Med Virol 84:1233–1241CrossRefPubMed Komlos KF, Kocjan BJ, Kosorok P et al (2012) Tumor-specific and gender-specific pre-vaccination distribution of human papillomavirus types 6 and 11 in anogenital warts and laryngeal papillomas: A study on 574 tissue specimens. J Med Virol 84:1233–1241CrossRefPubMed
22.
Zurück zum Zitat Kraut AA, Schink T, Schulze-Rath R et al (2010) Incidence of anogenital warts in Germany: A population-based cohort study. BMC Infect Dis 10:360CrossRefPubMedPubMedCentral Kraut AA, Schink T, Schulze-Rath R et al (2010) Incidence of anogenital warts in Germany: A population-based cohort study. BMC Infect Dis 10:360CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Kreuter A, Siorokos C, Oellig F et al (2016) High-grade Dysplasia in anogenital warts of HIV-positive men. JAMA Dermatol 152:1225–1230CrossRefPubMed Kreuter A, Siorokos C, Oellig F et al (2016) High-grade Dysplasia in anogenital warts of HIV-positive men. JAMA Dermatol 152:1225–1230CrossRefPubMed
24.
Zurück zum Zitat Kreuter A, Wieland U (2013) Lack of efficacy in treating condyloma acuminata and preventing recurrences with the recombinant quadrivalent human papillomavirus vaccine in a case series of immunocompetent patients. J Am Acad Dermatol 68:179–180CrossRefPubMed Kreuter A, Wieland U (2013) Lack of efficacy in treating condyloma acuminata and preventing recurrences with the recombinant quadrivalent human papillomavirus vaccine in a case series of immunocompetent patients. J Am Acad Dermatol 68:179–180CrossRefPubMed
25.
Zurück zum Zitat Maniar KP, Ronnett BM, Vang R et al (2013) Coexisting high-grade vulvar intraepithelial neoplasia (VIN) and condyloma acuminatum: Independent lesions due to different HPV types occurring in immunocompromised patients. Am J Surg Pathol 37:53–60CrossRefPubMedPubMedCentral Maniar KP, Ronnett BM, Vang R et al (2013) Coexisting high-grade vulvar intraepithelial neoplasia (VIN) and condyloma acuminatum: Independent lesions due to different HPV types occurring in immunocompromised patients. Am J Surg Pathol 37:53–60CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Mccloskey JC, Metcalf C, French MA et al (2007) The frequency of high-grade intraepithelial neoplasia in anal/perianal warts is higher than previously recognized. Int J STD AIDS 18:538–542CrossRefPubMed Mccloskey JC, Metcalf C, French MA et al (2007) The frequency of high-grade intraepithelial neoplasia in anal/perianal warts is higher than previously recognized. Int J STD AIDS 18:538–542CrossRefPubMed
27.
28.
Zurück zum Zitat Pimenoff VN, Felez-Sanchez M, Tous S et al (2015) Disagreement in high-grade/low-grade intraepithelial neoplasia and high-risk/low-risk HPV infection: Clinical implications for anal cancer precursor lesions in HIV-positive and HIV-negative MSM. Clin Microbiol Infect 21(605):e611–e609 Pimenoff VN, Felez-Sanchez M, Tous S et al (2015) Disagreement in high-grade/low-grade intraepithelial neoplasia and high-risk/low-risk HPV infection: Clinical implications for anal cancer precursor lesions in HIV-positive and HIV-negative MSM. Clin Microbiol Infect 21(605):e611–e609
29.
Zurück zum Zitat Richel O, Hallensleben ND, Kreuter A et al (2013) High-resolution anoscopy: Clinical features of anal intraepithelial neoplasia in HIV-positive men. Dis Colon Rectum 56:1237–1242CrossRefPubMed Richel O, Hallensleben ND, Kreuter A et al (2013) High-resolution anoscopy: Clinical features of anal intraepithelial neoplasia in HIV-positive men. Dis Colon Rectum 56:1237–1242CrossRefPubMed
30.
Zurück zum Zitat Robert-Koch-Institut (2016) Anwendung des neunvalenten Impfstoffs gegen Humane Papillomviren (HPV). Epidemiol Bull 16:137 Robert-Koch-Institut (2016) Anwendung des neunvalenten Impfstoffs gegen Humane Papillomviren (HPV). Epidemiol Bull 16:137
31.
Zurück zum Zitat Robert Koch-Institut (2016) Empfehlungen der Ständigen Impfkommission (STIKO) am Robert Koch-Institut. Epidemiol Bull 34:312 Robert Koch-Institut (2016) Empfehlungen der Ständigen Impfkommission (STIKO) am Robert Koch-Institut. Epidemiol Bull 34:312
32.
Zurück zum Zitat Schiller JT, Lowy DR (2012) Understanding and learning from the success of prophylactic human papillomavirus vaccines. Nat Rev Microbiol 10:681–692CrossRefPubMed Schiller JT, Lowy DR (2012) Understanding and learning from the success of prophylactic human papillomavirus vaccines. Nat Rev Microbiol 10:681–692CrossRefPubMed
33.
Zurück zum Zitat Schiller JT, Müller M (2015) Next generation prophylactic human papillomavirus vaccines. Lancet Oncol 16:e217–e225CrossRefPubMed Schiller JT, Müller M (2015) Next generation prophylactic human papillomavirus vaccines. Lancet Oncol 16:e217–e225CrossRefPubMed
34.
Zurück zum Zitat Schopf RE (2016) Ingenol mebutate gel is effective against anogenital warts – a case series in 17 patients. J Eur Acad Dermatol Venereol 30:1041–1043CrossRefPubMed Schopf RE (2016) Ingenol mebutate gel is effective against anogenital warts – a case series in 17 patients. J Eur Acad Dermatol Venereol 30:1041–1043CrossRefPubMed
35.
Zurück zum Zitat Siegenbeek Van Heukelom ML, Richel O, De Vries HJ et al (2016) Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men who have sex with men. Br J Dermatol 175:735–743CrossRefPubMed Siegenbeek Van Heukelom ML, Richel O, De Vries HJ et al (2016) Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men who have sex with men. Br J Dermatol 175:735–743CrossRefPubMed
36.
Zurück zum Zitat Snoeck R, Bossens M, Parent D et al (2001) Phase II double-blind, placebo-controlled study of the safety and efficacy of cidofovir topical gel for the treatment of patients with human papillomavirus infection. Clin Infect Dis 33:597–602CrossRefPubMed Snoeck R, Bossens M, Parent D et al (2001) Phase II double-blind, placebo-controlled study of the safety and efficacy of cidofovir topical gel for the treatment of patients with human papillomavirus infection. Clin Infect Dis 33:597–602CrossRefPubMed
38.
Zurück zum Zitat Stier EA, Goldstone SE, Einstein MH et al (2013) Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. AIDS 27:545–551CrossRefPubMedPubMedCentral Stier EA, Goldstone SE, Einstein MH et al (2013) Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. AIDS 27:545–551CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Sturegard E, Johansson H, Ekstrom J et al (2013) Human papillomavirus typing in reporting of condyloma. Sex Transm Dis 40:123–129PubMed Sturegard E, Johansson H, Ekstrom J et al (2013) Human papillomavirus typing in reporting of condyloma. Sex Transm Dis 40:123–129PubMed
40.
Zurück zum Zitat Swedish KA, Factor SH, Goldstone SE (2012) Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis 54:891–898CrossRefPubMed Swedish KA, Factor SH, Goldstone SE (2012) Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis 54:891–898CrossRefPubMed
41.
Zurück zum Zitat Wieland U, Kreuter A (2011) HPV vaccine against HPV infection and disease in males. N Engl J Med 364:2163CrossRefPubMed Wieland U, Kreuter A (2011) HPV vaccine against HPV infection and disease in males. N Engl J Med 364:2163CrossRefPubMed
42.
Zurück zum Zitat Wikstrom A, Vassilaki I, Hedblad MA et al (2013) The spectrum of genital human papillomavirus infection among men attending a Swedish sexually-transmitted infections clinic: Human papillomavirus typing and clinical presentation of histopathologically benign lesions. Acta Derm Venereol 93:223–227CrossRefPubMed Wikstrom A, Vassilaki I, Hedblad MA et al (2013) The spectrum of genital human papillomavirus infection among men attending a Swedish sexually-transmitted infections clinic: Human papillomavirus typing and clinical presentation of histopathologically benign lesions. Acta Derm Venereol 93:223–227CrossRefPubMed
44.
Zurück zum Zitat Workowski KA, Bolan GACDC (2015) Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 64:1–137CrossRefPubMed Workowski KA, Bolan GACDC (2015) Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 64:1–137CrossRefPubMed
Metadaten
Titel
Kondylome bei HIV-Infizierten
verfasst von
Prof. Dr. U. Wieland
Prof. Dr. A. Kreuter
Publikationsdatum
03.02.2017
Verlag
Springer Medizin
Erschienen in
Die Dermatologie / Ausgabe 3/2017
Print ISSN: 2731-7005
Elektronische ISSN: 2731-7013
DOI
https://doi.org/10.1007/s00105-017-3938-z

Weitere Artikel der Ausgabe 3/2017

Der Hautarzt 3/2017 Zur Ausgabe

Passend zum Thema

ANZEIGE

IPD-Fallzahlen & Pneumokokken-Impfung bei Kindern in Deutschland

Das Niveau der postpandemischen Fallzahlen für invasive Pneumokokken-Erkrankungen (IPD) ist aus Sicht des Referenz-Zentrums für Streptokokken in Aachen alarmierend [1]. Wie sich die monatlichen IPD-Fallzahlen bei Kindern und Jugendlichen von Juli 2015 bis März 2023 entwickelt haben, lesen Sie hier.

ANZEIGE

HPV-Impfung: Auch für junge Erwachsene sinnvoll und wichtig

Auch nach dem 18. Lebensjahr kann eine HPV-Impfung sinnvoll und wichtig sein. Viele gesetzliche Krankenkassen übernehmen die Kosten auch zu einem späteren Zeitpunkt noch.

ANZEIGE

Impfstoffe – Krankheiten vorbeugen, bevor sie entstehen

Seit mehr als 130 Jahren entwickelt und produziert MSD Impfstoffe für alle Altersgruppen. Hier finden Sie nützliche Informationen und Praxismaterialien rund um das Thema Impfen.

MSD Sharp & Dohme GmbH