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Die Ophthalmologie
Erschienen in: Die Ophthalmologie 8/2017

15.02.2017 | Keratoplastik | Übersichten

Korneale Zelltherapie – Eine Übersicht

verfasst von: Dr. M. Fuest, G. Hin-Fai Yam, G. Swee-Lim Peh, P. Walter, N. Plange, J. S. Mehta

Erschienen in: Die Ophthalmologie | Ausgabe 8/2017

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Zusammenfassung

Die Kultivierung und Expansion von primären kornealen Zellen verzeichnet große Fortschritte in den letzten Jahren. Die Transplantation von kultivierten limbalen Epithelzellen ist bereits eine etablierte, erfolgreiche Therapie der okulären Oberfläche. Kultivierte korneale Endothelzellen werden derzeit in einer klinischen Studie in Japan getestet. Stromale Keratozyten können in vitro expandiert werden. Auch andere Stammzellgruppen können zu kornealen Zellen differenzieren und werden in Tiermodellen auf ihre Eignung überprüft. Bis zu ihrem klinischen Einsatz müssen allerdings noch Prozesse optimiert und vereinheitlicht, die Differenzierungseffizienz gesteigert und ethische Probleme adressiert werden. In diesem Übersichtsartikel fassen wir die aktuellen Entwicklungen im Bereich der kornealen Zelltherapie zusammen.
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Metadaten
Titel
Korneale Zelltherapie – Eine Übersicht
verfasst von
Dr. M. Fuest
G. Hin-Fai Yam
G. Swee-Lim Peh
P. Walter
N. Plange
J. S. Mehta
Publikationsdatum
15.02.2017
Verlag
Springer Medizin
Erschienen in
Die Ophthalmologie / Ausgabe 8/2017
Print ISSN: 2731-720X
Elektronische ISSN: 2731-7218
DOI
https://doi.org/10.1007/s00347-017-0454-6

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