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Erschienen in: Der Radiologe 3/2017

10.02.2017 | Schwannom | Leitthema

Tumoren der peripheren Nerven

verfasst von: Michael Ho, MD, Amelie M. Lutz, MD

Erschienen in: Die Radiologie | Ausgabe 3/2017

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Zusammenfassung

Hintergrund

Die Unterscheidung zwischen malignen und benignen Tumoren der peripheren Nerven ist im initialen Stadium schwierig. Die Früherkennung der malignen Tumoren ist aufgrund ihrer ungünstigen Prognose jedoch wichtig.

Fragestellungen

Möglichkeiten der MR-Neurographie zur Detektion, Artdiagnostik und klinischem Management von Tumoren der peripheren Nerven anhand bildmorphologischer Charakteristika.

Material und Methode

Zusammenschau der Studienlage mittels PubMed- bzw. MEDLINE-Recherche. Zusätzlich Darlegung teils unveröffentlichter Erkenntnisse aus der eigenen klinischen Beobachtung.

Ergebnisse

Wenn auch nicht pathognomonisch, existieren verschiedene Bildgebungszeichen zur möglichen Unterscheidung verschiedener Tumoren der peripheren Nerven.

Schlussfolgerungen

Die MR-Neurographie ist ein geeignetes bildgebendes Verfahren zur Detektion und ersten Differenzialdiagnose von Tumoren der peripheren Nerven. Zudem kommt ihr besondere Bedeutung bei der Verlaufskontrolle, der gezielten Biopsie und der operativen Planung zu.
Literatur
1.
Zurück zum Zitat Murphey MD, Smith WS, Smith SE et al (1999) From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics 19(5):1253–1280CrossRefPubMed Murphey MD, Smith WS, Smith SE et al (1999) From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics 19(5):1253–1280CrossRefPubMed
2.
Zurück zum Zitat Chhabra A, Soldatos T, Durand DJ et al (2011) The role of magnetic resonance imaging in the diagnostic evaluation of malignant peripheral nerve sheath tumors. Indian J Cancer 48(3):328–334CrossRefPubMed Chhabra A, Soldatos T, Durand DJ et al (2011) The role of magnetic resonance imaging in the diagnostic evaluation of malignant peripheral nerve sheath tumors. Indian J Cancer 48(3):328–334CrossRefPubMed
3.
Zurück zum Zitat Soldatos T, Fisher S, Karri S et al (2015) Advanced MR imaging of peripheral nerve sheath tumors including diffusion imaging. Semin Musculoskelet Radiol 19(2):179–190CrossRefPubMed Soldatos T, Fisher S, Karri S et al (2015) Advanced MR imaging of peripheral nerve sheath tumors including diffusion imaging. Semin Musculoskelet Radiol 19(2):179–190CrossRefPubMed
4.
Zurück zum Zitat Mauermann ML, Amrami KK, Kuntz NL et al (2009) Longitudinal study of intraneural perineurioma – a benign, focal hypertrophic neuropathy of youth. Brain 132(Pt 8):2265–2276CrossRefPubMedPubMedCentral Mauermann ML, Amrami KK, Kuntz NL et al (2009) Longitudinal study of intraneural perineurioma – a benign, focal hypertrophic neuropathy of youth. Brain 132(Pt 8):2265–2276CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Kransdorf MJ (1995) Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR Am J Roentgenol 164(2):395–402CrossRefPubMed Kransdorf MJ (1995) Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR Am J Roentgenol 164(2):395–402CrossRefPubMed
6.
Zurück zum Zitat Kransdorf MJ (1995) Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol 164(1):129–134CrossRefPubMed Kransdorf MJ (1995) Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol 164(1):129–134CrossRefPubMed
7.
Zurück zum Zitat Hornick JL, Fletcher CD (2005) Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol 29(7):859–865CrossRefPubMed Hornick JL, Fletcher CD (2005) Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol 29(7):859–865CrossRefPubMed
8.
Zurück zum Zitat Woertler K (2010) Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol 14(5):547–558CrossRefPubMed Woertler K (2010) Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol 14(5):547–558CrossRefPubMed
9.
Zurück zum Zitat Stark AM, Hugo HH, Buhl R et al (2002) Tumoren peripherer Nerven. Dtsch Arztebl 99(14):A–928 Stark AM, Hugo HH, Buhl R et al (2002) Tumoren peripherer Nerven. Dtsch Arztebl 99(14):A–928
10.
Zurück zum Zitat Abreu E, Aubert S, Wavreille G et al (2013) Peripheral tumor and tumor-like neurogenic lesions. Eur J Radiol 82(1):38–50CrossRefPubMed Abreu E, Aubert S, Wavreille G et al (2013) Peripheral tumor and tumor-like neurogenic lesions. Eur J Radiol 82(1):38–50CrossRefPubMed
11.
Zurück zum Zitat Le LQ, Liu C, Shipman T (2001) Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. AJR Am J Roentgenol 176(1):75–82CrossRef Le LQ, Liu C, Shipman T (2001) Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. AJR Am J Roentgenol 176(1):75–82CrossRef
12.
Zurück zum Zitat Lin J, Martel W (2001) Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonography. AJR Am J Roentgenol 176(1):75–82CrossRefPubMed Lin J, Martel W (2001) Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonography. AJR Am J Roentgenol 176(1):75–82CrossRefPubMed
13.
Zurück zum Zitat Ahlawat S, Chhabra A, Blakely J (2014) Magnetic resonance neurography of peripheral nerve tumors and tumorlike conditions. Neuroimaging Clin N Am 24(1):171–192CrossRefPubMed Ahlawat S, Chhabra A, Blakely J (2014) Magnetic resonance neurography of peripheral nerve tumors and tumorlike conditions. Neuroimaging Clin N Am 24(1):171–192CrossRefPubMed
14.
Zurück zum Zitat Macarenco RS, Ellinger F, Oliveira AM (2007) Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med 131(4):625–636PubMed Macarenco RS, Ellinger F, Oliveira AM (2007) Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med 131(4):625–636PubMed
15.
Zurück zum Zitat Woodruff JM (1993) The pathology and treatment of peripheral nerve tumors and tumor-like conditions. CA Cancer J Clin 43(5):290–308CrossRefPubMed Woodruff JM (1993) The pathology and treatment of peripheral nerve tumors and tumor-like conditions. CA Cancer J Clin 43(5):290–308CrossRefPubMed
16.
Zurück zum Zitat Roux A, Tréguier C, Bruneau B et al (2012) Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings. Pediatr Radiol 42(8):952–958CrossRefPubMed Roux A, Tréguier C, Bruneau B et al (2012) Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings. Pediatr Radiol 42(8):952–958CrossRefPubMed
17.
Zurück zum Zitat Ogose A, Hotta T, Morita T et al (1999) Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis. Skeletal Radiol 28(4):183–188CrossRefPubMed Ogose A, Hotta T, Morita T et al (1999) Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis. Skeletal Radiol 28(4):183–188CrossRefPubMed
18.
Zurück zum Zitat Jee WH, Oh SN, McCauley T et al (2004) Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol 183(3):629–633CrossRefPubMed Jee WH, Oh SN, McCauley T et al (2004) Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol 183(3):629–633CrossRefPubMed
19.
Zurück zum Zitat Li CS, Huang GS, Wu HD et al (2008) Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging. Clin Imaging 32(2):121–127CrossRefPubMed Li CS, Huang GS, Wu HD et al (2008) Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging. Clin Imaging 32(2):121–127CrossRefPubMed
20.
Zurück zum Zitat Isobe K, Shimizu T, Akahane T et al (2004) Imaging of ancient schwannoma. AJR Am J Roentgenol 183(2):331–336CrossRefPubMed Isobe K, Shimizu T, Akahane T et al (2004) Imaging of ancient schwannoma. AJR Am J Roentgenol 183(2):331–336CrossRefPubMed
21.
Zurück zum Zitat Chhabra A, Thakkar RS, Andreisek G et al (2013) Anatomic MR imaging and functional diffusion tensor imaging of peripheral nerve tumors and tumorlike conditions. AJNR Am J Neuroradiol 34(4):802–807CrossRefPubMed Chhabra A, Thakkar RS, Andreisek G et al (2013) Anatomic MR imaging and functional diffusion tensor imaging of peripheral nerve tumors and tumorlike conditions. AJNR Am J Neuroradiol 34(4):802–807CrossRefPubMed
22.
Zurück zum Zitat Demehri S, Belzberg A, Blakeley J et al (2014) Conventional and functional MR imaging of peripheral nerve sheath tumors: initial experience. AJNR Am J Neuroradiol 35(8):1615–1620CrossRefPubMedPubMedCentral Demehri S, Belzberg A, Blakeley J et al (2014) Conventional and functional MR imaging of peripheral nerve sheath tumors: initial experience. AJNR Am J Neuroradiol 35(8):1615–1620CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Zou C, Smith KD, Liu J et al (2009) Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg 249(6):1014–1022CrossRefPubMed Zou C, Smith KD, Liu J et al (2009) Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg 249(6):1014–1022CrossRefPubMed
24.
Zurück zum Zitat Porter DE, Prasad V, Foster L et al (2009) Survival in malignant peripheral nerve sheath tumours: a comparison between sporadic and neurofibromatosis type 1‑associated tumours. Sarcoma 2009:756395CrossRefPubMedPubMedCentral Porter DE, Prasad V, Foster L et al (2009) Survival in malignant peripheral nerve sheath tumours: a comparison between sporadic and neurofibromatosis type 1‑associated tumours. Sarcoma 2009:756395CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Descamps MJ, Barrett L, Groves M et al (2006) Primary sciatic nerve lymphoma: a case report and review of the literature. J Neurol Neurosurg Psychiatr 77(9):1087–1089CrossRefPubMedPubMedCentral Descamps MJ, Barrett L, Groves M et al (2006) Primary sciatic nerve lymphoma: a case report and review of the literature. J Neurol Neurosurg Psychiatr 77(9):1087–1089CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Bakst R, Jakubowski A, Yahalom J (2011) Recurrent neurotropic chloroma: report of a case and review of the literature. Adv Hematol 2011:854240CrossRefPubMed Bakst R, Jakubowski A, Yahalom J (2011) Recurrent neurotropic chloroma: report of a case and review of the literature. Adv Hematol 2011:854240CrossRefPubMed
27.
Zurück zum Zitat Kim DH, Murovic JA, Tiel RL et al (2005) A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg 102(2):256–266CrossRefPubMed Kim DH, Murovic JA, Tiel RL et al (2005) A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg 102(2):256–266CrossRefPubMed
28.
Zurück zum Zitat Manenti G, Raguso M, D’Onofrio S (2013) Pancoast tumor: the role of magnetic resonance imaging. Case Rep Radiol 2013(2013):479120PubMedPubMedCentral Manenti G, Raguso M, D’Onofrio S (2013) Pancoast tumor: the role of magnetic resonance imaging. Case Rep Radiol 2013(2013):479120PubMedPubMedCentral
29.
Zurück zum Zitat Weishaupt D, Treiber K, Kundert HP et al (2003) Morton neuroma: MR imaging in prone, supine, and upright weight-bearing body positions. Radiology 226(3):849–856CrossRefPubMed Weishaupt D, Treiber K, Kundert HP et al (2003) Morton neuroma: MR imaging in prone, supine, and upright weight-bearing body positions. Radiology 226(3):849–856CrossRefPubMed
30.
Zurück zum Zitat Zanetti M, Strehle JK, Kundert HP et al (1999) Morton neuroma: effect of MR imaging findings on diagnostic thinking and therapeutic decisions. Radiology 213(2):583–588CrossRefPubMed Zanetti M, Strehle JK, Kundert HP et al (1999) Morton neuroma: effect of MR imaging findings on diagnostic thinking and therapeutic decisions. Radiology 213(2):583–588CrossRefPubMed
Metadaten
Titel
Tumoren der peripheren Nerven
verfasst von
Michael Ho, MD
Amelie M. Lutz, MD
Publikationsdatum
10.02.2017
Verlag
Springer Medizin
Erschienen in
Die Radiologie / Ausgabe 3/2017
Print ISSN: 2731-7048
Elektronische ISSN: 2731-7056
DOI
https://doi.org/10.1007/s00117-017-0215-1

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