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Erschienen in: Clinical Orthopaedics and Related Research® 4/2017

15.10.2016 | Symposium: 2016 Bernese Hip Symposium

Labral Reattachment in Femoroacetabular Impingement Surgery Results in Increased 10-year Survivorship Compared With Resection

verfasst von: Helen Anwander, MD, Klaus A. Siebenrock, MD, Moritz Tannast, MD, Simon D. Steppacher, MD

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 4/2017

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Abstract

Background

Since the importance of an intact labrum for normal hip function has been shown, labral reattachment has become the standard method for open or arthroscopic treatment of hips with femoroacetabular impingement (FAI). However, no long-term clinical results exist evaluating the effect of labral reattachment. A 2-year followup comparing open surgical treatment of FAI with labral resection versus reattachment was previously performed at our clinic. The goal of this study was to report a concise followup of these patients at a minimum of 10 years.

Questions/purposes

We asked if patients undergoing surgical hip dislocation for the treatment of mixed-type FAI with labral reattachment compared with labral resection had (1) improved hip pain and function based on the Merle d’Aubigné-Postel score; and (2) improved survival at 10-year followup.

Methods

Between June 1999 and July 2002, we performed surgical hip dislocation with femoral neck osteoplasty and acetabular rim trimming in 52 patients (60 hips) with mixed-type FAI. In the first 20 patients (25 hips) until June 2001, a torn labrum or a detached labrum in the area of acetabular rim resection was resected. In the next 32 patients (35 hips), reattachment of the labrum was performed. The same indications were used to perform both procedures during the periods in question. Of the 20 patients (25 hips) in the first group, 19 patients (95%) (24 hips [96%]) were available for clinical and/or radiographic followup at a minimum of 10 years (mean, 13 years; range, 12–14 years). Of the 32 patients (35 hips) in the second group, 29 patients (91%) (32 hips [91%]) were available for clinical and/or radiographic followup at a minimum of 10 years (mean, 12 years; range, 10–13 years). We used the anterior impingement test to assess pain. Function was assessed using the Merle d’Aubigné- Postel score and ROM. Survivorship calculation was performed using the method of Kaplan-Meier with failure defined as conversion to THA, progression of osteoarthritis (of one grade or more on the Tönnis score), and a Merle d’Aubigné-Postel score < 15.

Results

At the 10-year followup, hip pain in hips with labral reattachment was slightly improved for the postoperative Merle d’Aubigné-Postel pain subscore (5.0 ± 1.0 [3–6] versus 3.9 ± 1.7 [0–6]; p = 0.017). No difference existed for the prevalence of hip pain assessed using the anterior impingement test with the numbers available (resection group 52% [11 of 21 hips] versus reattachment group 27% [eight of 30 hips]; odds ratio, 3.03; 95% confidence interval [CI], 0.93–9.83; p = 0.062). Function was slightly better in the reattachment group for the overall Merle d’Aubigné-Postel score (16.7 ± 1.5 [13–18] versus 15.3 ± 2.4 [9–18]; p = 0.028) and hip abduction (45° ± 13° [range, 30°–70°] versus 38° ± 8° [range, 25°–45°]; p = 0.001). Hips with labral reattachment showed a better survival rate at 10 years than did hips that underwent labral resection (78%; 95% CI, 64%–92% versus 46%, 95% CI, 26%–66%; p = 0.009) with the endpoints defined as conversion to THA, progression of osteoarthritis, and a Merle d’Aubigné-Postel score < 15. With isolated endpoints, survival at 10 years was increased for labral reattachment and the endpoint Merle d’Aubigné score < 15 (83%, 95% CI, 70%–97% versus 48%, 95% CI, 28%–69%; p = 0.009) but did not differ for progression of osteoarthritis (83%, 95% CI, 68%–97% versus 81%, 95% CI, 63%–98%; p = 0.957) or conversion to THA (94%, 95% CI, 86%–100% versus 87%, 95% CI, 74%–100%; p = 0.366).

Conclusions

The current results suggest the importance of preserving the labrum and show that resection may put the hip at risk for early deterioration. At 10-year followup, hips with labral reattachment less frequently had a decreased Merle d’Aubigné score but no effect on progression of osteoarthritis or conversion to THA could be shown.

Level of Evidence

Level III, therapeutic study.
Literatur
1.
Zurück zum Zitat Beaulé PE, Le Duff MJ, Zaragoza E. Quality of life following femoral head-neck osteochondroplasty for femoroacetabular impingement. J Bone Joint Surg Am. 2007;89:773–779.PubMed Beaulé PE, Le Duff MJ, Zaragoza E. Quality of life following femoral head-neck osteochondroplasty for femoroacetabular impingement. J Bone Joint Surg Am. 2007;89:773–779.PubMed
2.
Zurück zum Zitat Beck M, Kalhor M, Leunig M, Ganz R. Hip morphology influences the pattern of damage to the acetabular cartilage: femoroacetabular impingement as a cause of early osteoarthritis of the hip. J Bone Joint Surg Br. 2005;87:1012–1018.CrossRefPubMed Beck M, Kalhor M, Leunig M, Ganz R. Hip morphology influences the pattern of damage to the acetabular cartilage: femoroacetabular impingement as a cause of early osteoarthritis of the hip. J Bone Joint Surg Br. 2005;87:1012–1018.CrossRefPubMed
3.
Zurück zum Zitat Beck M, Leunig M, Parvizi J, Boutier V, Wyss D, Ganz R. Anterior femoroacetabular impingement: part II. Midterm results of surgical treatment. Clin Orthop Relat Res. 2004;418:67–73.CrossRef Beck M, Leunig M, Parvizi J, Boutier V, Wyss D, Ganz R. Anterior femoroacetabular impingement: part II. Midterm results of surgical treatment. Clin Orthop Relat Res. 2004;418:67–73.CrossRef
4.
Zurück zum Zitat Byrd JW, Jones KS. Arthroscopic management of femoroacetabular impingement: minimum 2-year follow-up. Arthroscopy. 2011;27:1379–1388.CrossRefPubMed Byrd JW, Jones KS. Arthroscopic management of femoroacetabular impingement: minimum 2-year follow-up. Arthroscopy. 2011;27:1379–1388.CrossRefPubMed
5.
Zurück zum Zitat Cetinkaya S, Toker B, Ozden VE, Dikmen G, Taser O. Arthroscopic labral repair versus labral debridement in patients with femoroacetabular impingement: a minimum 2.5 year follow-up study. Hip Int. 2016;26:20–24.CrossRefPubMed Cetinkaya S, Toker B, Ozden VE, Dikmen G, Taser O. Arthroscopic labral repair versus labral debridement in patients with femoroacetabular impingement: a minimum 2.5 year follow-up study. Hip Int. 2016;26:20–24.CrossRefPubMed
6.
Zurück zum Zitat Chiron P, Espié A, Reina N, Cavaignac E, Molinier F, Laffosse JM. Surgery for femoroacetabular impingement using a minimally invasive anterolateral approach: analysis of 118 cases at 2.2-year follow-up. Orthop Traumatol Surg Res. 2012;98:30–38.CrossRefPubMed Chiron P, Espié A, Reina N, Cavaignac E, Molinier F, Laffosse JM. Surgery for femoroacetabular impingement using a minimally invasive anterolateral approach: analysis of 118 cases at 2.2-year follow-up. Orthop Traumatol Surg Res. 2012;98:30–38.CrossRefPubMed
7.
Zurück zum Zitat D’Aubigne RM, Postel M. Functional results of hip arthroplasty with acrylic prosthesis. J Bone Joint Surg Am. 1954;36:451–475.CrossRefPubMed D’Aubigne RM, Postel M. Functional results of hip arthroplasty with acrylic prosthesis. J Bone Joint Surg Am. 1954;36:451–475.CrossRefPubMed
8.
Zurück zum Zitat Espinosa N, Rothenfluh DA, Beck M, Ganz R, Leunig M. Treatment of femoro-acetabular impingement: preliminary results of labral refixation. J Bone Joint Surg Am. 2006;88:925–935.CrossRefPubMed Espinosa N, Rothenfluh DA, Beck M, Ganz R, Leunig M. Treatment of femoro-acetabular impingement: preliminary results of labral refixation. J Bone Joint Surg Am. 2006;88:925–935.CrossRefPubMed
9.
Zurück zum Zitat Ferguson SJ, Bryant JT, Ganz R, Ito K. The influence of the acetabular labrum on hip joint cartilage consolidation: a poroelastic finite element model. J Biomech. 2000;33:953–960.CrossRefPubMed Ferguson SJ, Bryant JT, Ganz R, Ito K. The influence of the acetabular labrum on hip joint cartilage consolidation: a poroelastic finite element model. J Biomech. 2000;33:953–960.CrossRefPubMed
10.
Zurück zum Zitat Ferguson SJ, Bryant JT, Ganz R, Ito K. An in vitro investigation of the acetabular labral seal in hip joint mechanics. J Biomech. 2003;36:171–178.CrossRefPubMed Ferguson SJ, Bryant JT, Ganz R, Ito K. An in vitro investigation of the acetabular labral seal in hip joint mechanics. J Biomech. 2003;36:171–178.CrossRefPubMed
11.
Zurück zum Zitat Ganz R, Gill TJ, Gautier E, Ganz K, Krügel N, Berlemann U. Surgical dislocation of the adult hip a technique with full access to the femoral head and acetabulum without the risk of avascular necrosis. J Bone Joint Surg Br. 2001;83:1119–1124.CrossRefPubMed Ganz R, Gill TJ, Gautier E, Ganz K, Krügel N, Berlemann U. Surgical dislocation of the adult hip a technique with full access to the femoral head and acetabulum without the risk of avascular necrosis. J Bone Joint Surg Br. 2001;83:1119–1124.CrossRefPubMed
12.
Zurück zum Zitat Holm I, Bolstad B, Lütken T, Ervik A, Røkkum M, Steen H. Reliability of goniometric measurements and visual estimates of hip ROM in patients with osteoarthrosis. Physiother Res Int. 2000;5:241–248.CrossRefPubMed Holm I, Bolstad B, Lütken T, Ervik A, Røkkum M, Steen H. Reliability of goniometric measurements and visual estimates of hip ROM in patients with osteoarthrosis. Physiother Res Int. 2000;5:241–248.CrossRefPubMed
13.
Zurück zum Zitat Hufeland M, Krüger D, Haas NP, Perka C, Schröder JH. Arthroscopic treatment of femoroacetabular impingement shows persistent clinical improvement in the mid-term. Arch Orthop Trauma Surg. 2016;136:687–691.CrossRefPubMed Hufeland M, Krüger D, Haas NP, Perka C, Schröder JH. Arthroscopic treatment of femoroacetabular impingement shows persistent clinical improvement in the mid-term. Arch Orthop Trauma Surg. 2016;136:687–691.CrossRefPubMed
14.
Zurück zum Zitat Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481.CrossRef Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481.CrossRef
15.
Zurück zum Zitat Larson CM, Giveans MR. Arthroscopic débridement versus refixation of the acetabular labrum associated with femoroacetabular impingement. Arthroscopy. 2009;25:369–376.CrossRefPubMed Larson CM, Giveans MR. Arthroscopic débridement versus refixation of the acetabular labrum associated with femoroacetabular impingement. Arthroscopy. 2009;25:369–376.CrossRefPubMed
16.
Zurück zum Zitat Larson CM, Giveans MR, Stone RM. Arthroscopic débridement versus refixation of the acetabular labrum associated with femoroacetabular impingement: mean 3.5-year follow-up. Am J Sports Med. 2012;40:1015–1021.CrossRefPubMed Larson CM, Giveans MR, Stone RM. Arthroscopic débridement versus refixation of the acetabular labrum associated with femoroacetabular impingement: mean 3.5-year follow-up. Am J Sports Med. 2012;40:1015–1021.CrossRefPubMed
17.
Zurück zum Zitat Laude F, Sariali E. [Treatment of FAI via a minimally invasive ventral approach with arthroscopic assistance. Technique and midterm results] [in German]. Orthopade. 2009;38:419–428.CrossRefPubMed Laude F, Sariali E. [Treatment of FAI via a minimally invasive ventral approach with arthroscopic assistance. Technique and midterm results] [in German]. Orthopade. 2009;38:419–428.CrossRefPubMed
18.
Zurück zum Zitat Laude F, Sariali E, Nogier A. Femoroacetabular impingement treatment using arthroscopy and anterior approach. Clin Orthop Relat Res. 2009;467:747–752.CrossRefPubMed Laude F, Sariali E, Nogier A. Femoroacetabular impingement treatment using arthroscopy and anterior approach. Clin Orthop Relat Res. 2009;467:747–752.CrossRefPubMed
19.
Zurück zum Zitat Martin RL, Sekiya JK. The interrater reliability of 4 clinical tests used to assess individuals with musculoskeletal hip pain. J Orthop Sports Phys Ther. 2008;38:71–77.CrossRefPubMed Martin RL, Sekiya JK. The interrater reliability of 4 clinical tests used to assess individuals with musculoskeletal hip pain. J Orthop Sports Phys Ther. 2008;38:71–77.CrossRefPubMed
20.
Zurück zum Zitat McWhirk LB, Glanzman AM. Within-session inter-rater realiability of goniometric measures in patients with spastic cerebral palsy. Pediatr Phys Ther. 2006;18:262–265.CrossRefPubMed McWhirk LB, Glanzman AM. Within-session inter-rater realiability of goniometric measures in patients with spastic cerebral palsy. Pediatr Phys Ther. 2006;18:262–265.CrossRefPubMed
21.
Zurück zum Zitat Murphy S, Tannast M, Kim YJ, Buly R, Millis MB. Débridement of the adult hip for femoroacetabular impingement: indications and preliminary clinical results. Clin Orthop Relat Res. 2004;429:178–181.CrossRef Murphy S, Tannast M, Kim YJ, Buly R, Millis MB. Débridement of the adult hip for femoroacetabular impingement: indications and preliminary clinical results. Clin Orthop Relat Res. 2004;429:178–181.CrossRef
22.
Zurück zum Zitat Murphy SB, Ganz R, Müller ME. The prognosis in untreated dysplasia of the hip. A study of radiographic factors that predict the outcome. J Bone Joint Surg Am. 1995;77:985–989.CrossRefPubMed Murphy SB, Ganz R, Müller ME. The prognosis in untreated dysplasia of the hip. A study of radiographic factors that predict the outcome. J Bone Joint Surg Am. 1995;77:985–989.CrossRefPubMed
23.
Zurück zum Zitat Naal FD, Miozzari HH, Schär M, Hesper T, Nötzli HP. Midterm results of surgical hip dislocation for the treatment of femoroacetabular impingement. Am J Sports Med. 2012;40:1501–1510.CrossRefPubMed Naal FD, Miozzari HH, Schär M, Hesper T, Nötzli HP. Midterm results of surgical hip dislocation for the treatment of femoroacetabular impingement. Am J Sports Med. 2012;40:1501–1510.CrossRefPubMed
24.
Zurück zum Zitat Naal FD, Miozzari HH, Wyss TF, Nötzli HP. Surgical hip dislocation for the treatment of femoroacetabular impingement in high-level athletes. Am J Sports Med. 2011;39:544–550.CrossRefPubMed Naal FD, Miozzari HH, Wyss TF, Nötzli HP. Surgical hip dislocation for the treatment of femoroacetabular impingement in high-level athletes. Am J Sports Med. 2011;39:544–550.CrossRefPubMed
25.
Zurück zum Zitat Nepple JJ, Philippon MJ, Campbell KJ, Dornan GJ, Jansson KS, LaPrade RF, Wijdicks CA. The hip fluid seal–Part II: The effect of an acetabular labral tear, repair, resection, and reconstruction on hip stability to distraction. Knee Surg Sports Traumatol Arthrosc. 2014;22:730–736.CrossRefPubMed Nepple JJ, Philippon MJ, Campbell KJ, Dornan GJ, Jansson KS, LaPrade RF, Wijdicks CA. The hip fluid seal–Part II: The effect of an acetabular labral tear, repair, resection, and reconstruction on hip stability to distraction. Knee Surg Sports Traumatol Arthrosc. 2014;22:730–736.CrossRefPubMed
26.
Zurück zum Zitat Nötzli HP, Wyss TF, Stoecklin CH, Schmid MR, Treiber K, Hodler J. The contour of the femoral head-neck junction as a predictor for the risk of anterior impingement. J Bone Joint Surg Br. 2002;84:556–560.CrossRefPubMed Nötzli HP, Wyss TF, Stoecklin CH, Schmid MR, Treiber K, Hodler J. The contour of the femoral head-neck junction as a predictor for the risk of anterior impingement. J Bone Joint Surg Br. 2002;84:556–560.CrossRefPubMed
27.
Zurück zum Zitat Palmer DH, Ganesh V, Comfort T, Tatman P. Midterm outcomes in patients with cam femoroacetabular impingement treated arthroscopically. Arthroscopy. 2012;28:1671–1681.CrossRefPubMed Palmer DH, Ganesh V, Comfort T, Tatman P. Midterm outcomes in patients with cam femoroacetabular impingement treated arthroscopically. Arthroscopy. 2012;28:1671–1681.CrossRefPubMed
28.
Zurück zum Zitat Peters CL, Schabel K, Anderson L, Erickson J. Open treatment of femoroacetabular impingement is associated with clinical improvement and low complication rate at short-term followup. Clin Orthop Relat Res. 2010;468:504–510.CrossRefPubMed Peters CL, Schabel K, Anderson L, Erickson J. Open treatment of femoroacetabular impingement is associated with clinical improvement and low complication rate at short-term followup. Clin Orthop Relat Res. 2010;468:504–510.CrossRefPubMed
29.
Zurück zum Zitat Philippon MJ, Briggs KK, Yen YM, Kuppersmith DA. Outcomes following hip arthroscopy for femoroacetabular impingement with associated chondrolabral dysfunction: minimum two-year follow-up. J Bone Joint Surg Br. 2009;91:16–23.CrossRefPubMed Philippon MJ, Briggs KK, Yen YM, Kuppersmith DA. Outcomes following hip arthroscopy for femoroacetabular impingement with associated chondrolabral dysfunction: minimum two-year follow-up. J Bone Joint Surg Br. 2009;91:16–23.CrossRefPubMed
30.
Zurück zum Zitat Philippon MJ, Nepple JJ, Campbell KJ, Dornan GJ, Jansson KS, LaPrade RF, Wijdicks CA. The hip fluid seal–Part I: the effect of an acetabular labral tear, repair, resection, and reconstruction on hip fluid pressurization. Knee Surg Sports Traumatol Arthrosc. 2014;22:722–729.CrossRefPubMed Philippon MJ, Nepple JJ, Campbell KJ, Dornan GJ, Jansson KS, LaPrade RF, Wijdicks CA. The hip fluid seal–Part I: the effect of an acetabular labral tear, repair, resection, and reconstruction on hip fluid pressurization. Knee Surg Sports Traumatol Arthrosc. 2014;22:722–729.CrossRefPubMed
31.
Zurück zum Zitat Polesello GC, Lima FR, Guimaraes RP, Ricioli W, Queiroz MC. Arthroscopic treatment of femoroacetabular impingement: minimum five-year follow-up. Hip Int. 2014;24:381–386.CrossRefPubMed Polesello GC, Lima FR, Guimaraes RP, Ricioli W, Queiroz MC. Arthroscopic treatment of femoroacetabular impingement: minimum five-year follow-up. Hip Int. 2014;24:381–386.CrossRefPubMed
32.
Zurück zum Zitat Reynolds D, Lucas J, Klaue K. Retroversion of the acetabulum. A cause of hip pain. J Bone Joint Surg Br. 1999;81:281–288.CrossRefPubMed Reynolds D, Lucas J, Klaue K. Retroversion of the acetabulum. A cause of hip pain. J Bone Joint Surg Br. 1999;81:281–288.CrossRefPubMed
33.
Zurück zum Zitat Schilders E, Dimitrakopoulou A, Bismil Q, Marchant P, Cooke C. Arthroscopic treatment of labral tears in femoroacetabular impingement: a comparative study of refixation and resection with a minimum two-year follow-up. J Bone Joint Surg Br. 2011;93:1027–1032.CrossRefPubMed Schilders E, Dimitrakopoulou A, Bismil Q, Marchant P, Cooke C. Arthroscopic treatment of labral tears in femoroacetabular impingement: a comparative study of refixation and resection with a minimum two-year follow-up. J Bone Joint Surg Br. 2011;93:1027–1032.CrossRefPubMed
34.
Zurück zum Zitat Steppacher SD, Anwander H, Zurmühle CA, Tannast M, Siebenrock KA. Eighty percent of patients with surgical hip dislocation for femoroacetabular impingement have a good clinical result without osteoarthritis progression at 10 years. Clin Orthop Relat Res. 2015;473:1333–1341.CrossRefPubMed Steppacher SD, Anwander H, Zurmühle CA, Tannast M, Siebenrock KA. Eighty percent of patients with surgical hip dislocation for femoroacetabular impingement have a good clinical result without osteoarthritis progression at 10 years. Clin Orthop Relat Res. 2015;473:1333–1341.CrossRefPubMed
35.
Zurück zum Zitat Steppacher SD, Huemmer C, Schwab JM, Tannast M, Siebenrock KA. Surgical hip dislocation for treatment of femoroacetabular impingement: factors predicting 5-year survivorship. Clin Orthop Relat Res. 2014;472:337–348.CrossRefPubMed Steppacher SD, Huemmer C, Schwab JM, Tannast M, Siebenrock KA. Surgical hip dislocation for treatment of femoroacetabular impingement: factors predicting 5-year survivorship. Clin Orthop Relat Res. 2014;472:337–348.CrossRefPubMed
36.
Zurück zum Zitat Tannast M, Hanke MS, Zheng G, Steppacher SD, Siebenrock KA. What are the radiographic reference values for acetabular under- and overcoverage? Clin Orthop Relat Res. 2015;473:1234–1246.CrossRefPubMed Tannast M, Hanke MS, Zheng G, Steppacher SD, Siebenrock KA. What are the radiographic reference values for acetabular under- and overcoverage? Clin Orthop Relat Res. 2015;473:1234–1246.CrossRefPubMed
37.
Zurück zum Zitat Tannast M, Siebenrock KA, Anderson SE. Femoroacetabular impingement: radiographic diagnosis—what the radiologist should know. AJR Am J Roentgenol. 2007;188:1540–1552.CrossRefPubMed Tannast M, Siebenrock KA, Anderson SE. Femoroacetabular impingement: radiographic diagnosis—what the radiologist should know. AJR Am J Roentgenol. 2007;188:1540–1552.CrossRefPubMed
38.
Zurück zum Zitat Tönnis D. General radiography of the hip joint. In: Tönnis D, ed. Congenital Dysplasia and Dislocation of the Hip. Heidelberg, Germany: Springer Verlag; 1987:100–142.CrossRef Tönnis D. General radiography of the hip joint. In: Tönnis D, ed. Congenital Dysplasia and Dislocation of the Hip. Heidelberg, Germany: Springer Verlag; 1987:100–142.CrossRef
39.
Zurück zum Zitat Wiberg G. The anatomy and roentgenographic appearance of a normal hip joint. Acta Chir Scand. 1939;83:7–38. Wiberg G. The anatomy and roentgenographic appearance of a normal hip joint. Acta Chir Scand. 1939;83:7–38.
40.
Zurück zum Zitat Wyss TF, Clark JM, Weishaupt D, Nötzli HP. Correlation between internal rotation and bony anatomy in the hip. Clin Orthop Relat Res. 2007;460:152–158.PubMed Wyss TF, Clark JM, Weishaupt D, Nötzli HP. Correlation between internal rotation and bony anatomy in the hip. Clin Orthop Relat Res. 2007;460:152–158.PubMed
Metadaten
Titel
Labral Reattachment in Femoroacetabular Impingement Surgery Results in Increased 10-year Survivorship Compared With Resection
verfasst von
Helen Anwander, MD
Klaus A. Siebenrock, MD
Moritz Tannast, MD
Simon D. Steppacher, MD
Publikationsdatum
15.10.2016
Verlag
Springer US
Erschienen in
Clinical Orthopaedics and Related Research® / Ausgabe 4/2017
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-016-5114-7

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