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28.11.2017 | Short Communication

Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

verfasst von: Petra Borilova Linhartova, Tereza Deissova, Kristina Musilova, Lenka Zackova, Martina Kukletova, Lubomir Kukla, Lydie Izakovicova Holla

Erschienen in: Clinical Oral Investigations | Ausgabe 4/2018

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Abstract

Objectives

The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children.

Materials and methods

This study comprised 905 Czech children. Totally, 187 children aged 2–6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft ≥ 1)] were included in this case-control study. In addition, 177 subjects aged 13–15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT ≥ 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method.

Results

No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions.

Conclusions

Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected.

Clinical relevance

Although ENAM is considered as a candidate gene for dental caries, the presence of the ENAM variant (rs12640848) cannot be used as a risk factor of this multifactorial disease in the Czech population.

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Titel: Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children
verfasst von: Petra Borilova Linhartova
Tereza Deissova
Kristina Musilova
Lenka Zackova
Martina Kukletova
Lubomir Kukla
Lydie Izakovicova Holla
Publikationsdatum: 28.11.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 4/2018
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-017-2280-2

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Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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