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Erschienen in: Inflammation 6/2014

01.12.2014

Lack of Association Between TESPA1 Gene Polymorphisms (rs1801876, rs2171497, rs4758994, and rs997173) and Ankylosing Spondylitis in a Chinese Population

verfasst von: Si Liu, Li Liu, Shanshan Wu, Ting Yang, Faming Pan, Laura Laslett, Guo Xia, Yanting Hu, Dazhi Fan, Ning Ding, Shengqian Xu, Guoqi Cai, Li Wang, Lihong Xin

Erschienen in: Inflammation | Ausgabe 6/2014

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Abstract

We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497, rs4758994, and rs997173) in the TESPA1 gene. We found no evidence of association between these SNPs and AS susceptibility, and between their haplotypes and the disease. But, patients with rs1801876 GA, GG, and AA genotypes had significantly different Bath Ankylosing Spondylitis Functional Index (BASFI) scores (p = 0.023). There were significantly different visual analogue scale (VAS) night pain assessment scores (p = 0.040) and BASFI scores (p = 0.023) among different genotypes at rs2171497 locus. There were also significantly different chest expansion scores (p = 0.042) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores (p = 0.014) among different genotypes at rs997173 locus. For multiple testing, Bonferroni correction was performed. After Bonferroni correction, clinical characteristics of these three loci showed association between different genotype groups. These findings indicated that the TESPA1 gene is not involved in AS genetic predisposition in the Han Chinese population; however, it may play an important role in the clinical characteristics of AS.
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Metadaten
Titel
Lack of Association Between TESPA1 Gene Polymorphisms (rs1801876, rs2171497, rs4758994, and rs997173) and Ankylosing Spondylitis in a Chinese Population
verfasst von
Si Liu
Li Liu
Shanshan Wu
Ting Yang
Faming Pan
Laura Laslett
Guo Xia
Yanting Hu
Dazhi Fan
Ning Ding
Shengqian Xu
Guoqi Cai
Li Wang
Lihong Xin
Publikationsdatum
01.12.2014
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 6/2014
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-014-9936-8

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