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Erschienen in: Virchows Archiv 2/2017

09.11.2016 | Brief Report

Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary

verfasst von: Alexandra Meurgey, Françoise Descotes, Eliane Mery-Lamarche, Mojgan Devouassoux-Shisheboran

Erschienen in: Virchows Archiv | Ausgabe 2/2017

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Abstract

Microcystic stromal tumors (MCST), first described in 2009 by Irving et al., are rare ovarian neoplasms. The entity was introduced into the 2014 WHO classification of tumors of female reproductive organs in the group of sex cord-stromal tumors, which is rather heterogeneous. We studied three cases of ovarian tumor with the characteristic morphological features and immunohistochemical marker profiles of MCST. The three tumors showed micro, and macrocystic patterns with solid areas, and were composed of small round to spindle-shaped cells, without atypia. The tumors diffusely and strongly expressed CD10, FOXL2, and nuclear β-catenin, but without immmunoreactivity for hormone receptors, calretinin, or inhibin. Genome analyses showed no somatic mutation of exon 1 of the FOXL2 gene and of exons 24 and 25 of DICER1 gene, the latter not having been reported previously. The patients are well, without evidence of tumor progression 1 to 10 years after diagnosis.
The absence of FOXL2 and DICER1 gene mutation, along with strong FOXL2 immunoreactivity provides additional evidence to place MCST within pure gonadal stromal rather than sex cord ovarian tumors.
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Metadaten
Titel
Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary
verfasst von
Alexandra Meurgey
Françoise Descotes
Eliane Mery-Lamarche
Mojgan Devouassoux-Shisheboran
Publikationsdatum
09.11.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Virchows Archiv / Ausgabe 2/2017
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-016-2038-2

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