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Journal of Natural Medicines
Erschienen in:

06.09.2022 | Original Paper

Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation

verfasst von: Yukiko Matsuo, Takuya Fujii, Hironao Kato, Kazuki Tomizawa, Haruhiko Fukaya, Katsunori Miyake, Minpei Kuroda, Yoshihiro Mimaki

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2023

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Abstract

The MeOH extract of the flower heads of Coreopsis lanceolata L. (Asteraceae) exhibited aldose reductase (AR) inhibitory activity (IC50 8.36 µg/mL). Bioassay-guided fractionation of the extract resulted in the isolation of a new biflavanone-named Lanceolanone A (1) and a chalcone glucoside (6), along with 12 known compounds (2–5 and 7–14), of which 4, 7, 9, 10, and 12 were isolated from C. lanceolata for the first time. The structures of the new compounds (1 and 6) were determined by extensive spectroscopic analysis, including two-dimensional (2D) NMR, and ECD calculation method. Compounds 2, 4, 11, 13, and 14 exhibited AR inhibitory activities with IC50 values between 2.40 and 9.99 µM. Furthermore, 8–13 at 1.0 mM activated AMPK expression in HepG2 human hepatoma cells compared to the control.

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Metadaten
Titel
Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation
verfasst von
Yukiko Matsuo
Takuya Fujii
Hironao Kato
Kazuki Tomizawa
Haruhiko Fukaya
Katsunori Miyake
Minpei Kuroda
Yoshihiro Mimaki
Publikationsdatum
06.09.2022
Verlag
Springer Nature Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2023
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-022-01651-0

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