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Erschienen in:
24.04.2015 | Sine qua non Radiology-Pathology
Langerhans Cell Histiocytosis of the Temporal Bone
Erschienen in: Head and Neck Pathology | Ausgabe 2/2016
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Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology–pathology correlation article.