Background
Methods
Study group
Data source
Analysis of language and cognition
Statistics
Results
Onset and diagnosis
First symptoms | Late-infantile (n = 23) | Juvenile (n = 36) | p | ||
---|---|---|---|---|---|
n | % | n | % | ||
Gait disturbance | 16 | 70% | 25 | 69% | 0.9922 |
Pain | 6 | 26% | 5 | 14% | 0.2447 |
Abnormal movement patterns | 14 | 61% | 25 | 69% | 0.5011 |
Impaired fine motor skills | 4 | 17% | 22 | 61% | 0.0011 |
Restlessness/irritability | 4 | 17% | 10 | 28% | 0.3645 |
Weakness | 10 | 43% | 13 | 36% | 0.5748 |
Problems in concentration | 0 | 0% | 23 | 64% | 0.0001 |
Behavioural problems | 3 | 13% | 20 | 56% | 0.0012 |
Developmental regression in general | 14 | 61% | 19 | 53% | 0.5449 |
Language acquisition
Regression of language and cognitive abilities
a) Age [Months] | Late-infantile | Juvenile | p | ||||
---|---|---|---|---|---|---|---|
P25 | Median | P75 | P25 | Median | P75 | ||
Loss of complete sentences | 28 | 30 | 31 | 84 | 132 | - - - | <0,0001 |
Loss of two-word-sentences | 30 | 32 | 36 | 90 | 174 | - - - | <0,0001 |
Loss of single meaningful words | 31 | 32 | 36 | 98 | - - - | - - - | <0,0001 |
First language decline | 26 | 30 | 31 | 69 | 98 | 192 | <0,0001 |
Complete loss of expressive language | 28 | 32 | 36 | 87 | 153 | - - - | <0,0001 |
Problems in concentration | 31 | - - - | - - - | 62 | 84 | 113 | 0,0808 |
Behavioural problems | 28 | 31 | - - - | 78 | 142 | 192 | <0,0001 |
Decline in reading, writing and calculating | - - - | - - - | - - - | 87 | 128 | 180 | - - - |
Loss of any communication | 48 | 51 | - - - | 192 | - - - | - - - | 0,0011 |
b) Time after onset [Months]
|
Late-infantile
|
Juvenile
|
p
| ||||
P25
|
Median
|
P75
|
P25
|
Median
|
P75
| ||
Loss of complete sentences | 11 | 17 | 19 | 12 | 72 | - - - | 0,0409 |
Loss of two-word-sentences | 12 | 17 | 20 | 38 | 96 | - - - | 0,0056 |
Loss of single meaningful words | 11 | 17 | 20 | 43 | - - - | - - - | 0,0002 |
First language decline | 9 | 12 | 16 | 5 | 24 | 72 | 0,0445 |
Complete loss of expressive language | 12 | 15 | 20 | 16 | 72 | - - - | <0,0001 |
Problems in concentration | 16 | - - - | - - - | 0 | 6 | 14 | <0,0001 |
Behavioural problems | 9 | 18 | 21 | 6 | 32 | - - - | 0,4415 |
Decline in reading, writing and calculating | - - - | - - - | - - - | 12 | 48 | 70 | - - - |
Loss of any communication | 30 | 33 | - - - | - - - | - - - | - - - | 0,0332 |