Langzeiterfahrungen mit Tiefer Hirnstimulation

Morbus Parkinson

Zeitschrift:: NeuroTransmitter > Ausgabe 3/2013

Autor:: Dr. med. Niels Allert

Die meisten Patienten mit Morbus Parkinson können ihre Erkrankung gut mit medikamentösen Therapien kontrollieren. Mit zunehmender Therapiedauer über Jahre können aber Wirkungsschwankungen und unwillkürliche Überbewegungen auftreten, die auch mit pharmakologischen Kombinationstherapien nicht mehr zufriedenstellend behandelt werden können. Mit der „Tiefen Hirnstimulation“ steht für diese Patienten eine Behandlungsalternative zur Verfügung.

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Poewe W, Antonini A, Zijlmans JC, Burkhard PR, Vingerhoets F. Levodopa in the treatment of Parkinson’s disease: an old drug still going strong. Clin Interv Aging 2010;5:229–238PubMed
Benabid AL, Pollak P, Gervason C, Hoffmann D, Gao DM, Hommel M, Perret JE, de Rougemont J. Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 1991;337:403–406PubMedView Article
Siegfried J, Lippitz B. Bilateral chronic electrostimulation of ventroposterolateral pallidum: a new therapeutic approach for alleviating all parkinsonian symptoms. Neurosurgery 1994;35:1126–1129PubMedView Article
Pollak P, Benabid AL, Gross C, Gao DM, Laurent A, Benazzouz A, Hoffmann D, Gentil M, Perret J. [Effects of the stimulation of the subthalamic nucleus in Parkinson disease]. Rev Neurol (Paris) 1993;149:175–176
Voges J, Hilker R, Bötzel K, Kiening KL, Kloss M, Kupsch A, Schnitzler A, Schneider GH, Steude, Deuschl G, Pinsker MO. Thirty days complication rate following surgery performed for deep-brain-stimulation. Mov Disord 2007;22:1486–1489PubMedView Article
Bhatia R, Balton A, Richards M, Hopkins C, Aziz T, Nandi D. The incidence of deep brain stimulator hardware infection: the effect of change in antibiotic prophylaxis regimen and review of the literature. Br J Neurosurg 2011;25:625–631PubMedView Article
Lanotte M, Verna G, Panciani PP, Taveggia A, Zibetti M, Lopiano L, Ducati A. Management of skin erosion following deep brain stimulation. Neurosurgical Review 2009;32:111–114PubMedView Article
Sixel-Döring F, Trenkwalder C, Kappus C, Hellwig D. Skin complications in deep brain stimulation for Parkinson’s disease: frequency, time course, and risk factors. Acta Neurochirurgica (Wien) 2010;152:195–200View Article
Hamani C, Lozano AM. Hardware-related complications of deep brain stimulation: a review of the published literature. Stereotact Funct Neurosurg 2006;84:248–251PubMedView Article
Allert N, Markou M, Miskiewicz AA, Nolden L, Karbe H. Electrode dysfunctions in patients with deep brain stimulation: a clinical retrospective study. Acta Neurochir (Wien) 2011;153:2343–2349View Article
Hariz MI, Krack P, Alesch F, Augustinsson LE, Bosch A, Ekberg R, Johansson F, Johnels B, Meyerson BA, N’Guyen JP, Pinter M, Pollak P, von Raison F, Rehncrona S, Speelman JD, Sydow O, Benabid AL. Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up. J Neurol Neurosurg Psychiatry 2008;79:694–699PubMedView Article
Pahwa R, Lyons KE, Wilkinson SB, Simpson RK Jr, Ondo WG, Tarsy D, Norregaard T, Hubble JP, Smith DA, Hauser RA, Jankovic J. Long-term evaluation of deep brain stimulation of the thalamus. J Neurosurg 2006;104:506–512PubMedView Article
Volkmann J, Allert N, Voges J, Sturm V, Schnitzler A, Freund HJ. Long-term results of bilateral pallidal stimulation in Parkinson’s disease. Ann Neurol 2004;55:871–875PubMedView Article
Follett KA, Weaver FM, Stern M, Hur K, Harris CL, Luo P, Marks WJ Jr, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, Starr PA, Simpson R, Baltuch G, De Salles A, Huang GD, Reda DJ; CSP 468 Study Group. Pallidal versus subthalamic deep-brain stimulation for Parkinson’s disease. N Engl J Med 2010; 362: 2077–2091PubMedView Article
Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ Jr, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR. Arch Neurol 2011;68:165PubMedView Article
Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C, Koudsie A, Limousin PD, Benazzouz A, LeBas JF, Benabid AL, Pollak P. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 2003;349:1925–1934PubMedView Article
Fasano A, Romito LM, Daniele A, Piano C, Zinno M, Bentivoglio AR, Albanese A. Motor and cognitive outcome in patients with Parkinson’s disease 8 years after subthalamic implants. Brain 2010;133:2664–2676PubMedView Article
Moro E, Lozano AM, Pollak P, Agid Y, Rehncrona S, Volkmann J, Kulisevsky J, Obeso JA, Albanese A, Hariz MI, Quinn NP, Speelman JD, Benabid AL, Fraix V, Mendes A, Welter ML, Houeto JL, Cornu P, Dormont D, Tornqvist AL, Ekberg R, Schnitzler A, Timmermann L, Wojtecki L, Gironell A, Rodriguez-Oroz MC, Guridi J, Bentivoglio AR, Contarino MF, Romito L, Scerrati M, Janssens M, Lang AE. Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson’s disease. Mov Disord 2010;25:578–586PubMedView Article
St George RJ, Nutt JG, Burchiel KJ, Horak FB. A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD. Neurology 2010;75:1292–1299PubMedView Article
Frost E, Tripoliti E, Hariz MI, Pring T, Limousin P. Self-perception of speech changes in patients with Parkinson’s disease following deep brain stimulation of the subthalamic nucleus. Int J Speech Lang Pathol 2010;12:399–404PubMedView Article
Tripoliti E, Zrinzo L, Martinez-Torres I, Frost E, Pinto S, Foltynie T, Holl E, Petersen E, Roughton M, Hariz MI, Limousin P. Effects of subthalamic stimulation on speech of consecutive patients with Parkinson disease. Neurology 2011;76:80–86PubMedView Article
Wojtecki L, Timmermann L, Jörgens S, Südmeyer M, Maarouf M, Treuer H, Gross J, Lehrke R, Koulousakis A, Voges J, Sturm V, Schnitzler A. Frequency-dependent reciprocal modulation of verbal fluency and motor functions in subthalamic deep brain stimulation. Arch Neurol 2006;63:1273–1276PubMedView Article
Parsons TD, Rogers SA, Braaten AJ, Woods SP, Troster AI. Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson’s disease: a meta-analysis. Lancet Neurol 2006;5:578–588PubMedView Article
Witt K, Daniels C, Reiff J, Krack P, Volkmann J, Pinsker MO, Krause M, Tronnier V, Kloss M, Schnitzler A, Wojtecki L, Bötzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G. Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson’s disease: a randomised, multicentre study. Lancet Neurol 2008;7:605–614PubMedView Article
Saint-Cyr JA, Trépanier LL, Kumar R, Lozano AM, Lang AE. Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson’s disease. Brain 2000;123:2091–2108PubMedView Article
Hely MA, Morris JG, Reid WG, Trafficante R. Sydney Multicenter Study of Parkinson’s disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord 2005;20:190–199PubMedView Article
Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG. The Sydney multicenter study of Parkinson’s disease: the inevitability of dementia at 20 years. Mov Disord 2008; 23: 837–844PubMedView Article
Kleiner-Fisman G, Herzog J, Fisman DN, Tamma F, Lyons KE, Pahwa R, Lang AE, Deuschl G. Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes. Mov Disord 2006;21:290–304View Article
Temel Y, Kessels A, Tan S, Topdag A, Boon P, Visser-Vandewalle V. Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: a systematic review. Parkinsonism Relat Disord 2006;12:265–272.PubMedView Article
Voon V, Krack P, Lang AE, Lozano AM, Dujardin K, Schüpbach M, D’Ambrosia J, Thobois S, Tamma F, Herzog J, Speelman JD, Samanta J, Kubu C, Rossignol H, Poon YY, Saint-Cyr JA, Ardouin C, Moro E. A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson’s disease. Brain 2008;131:2720–2728PubMedView Article
Schüpbach M, Gargiulo M, Welter ML, Mallet L, Béhar C, Houeto JL, Maltête D, Mesnage V, Agid Y. Neurosurgery in Parkinson disease: a distressed mind in a repaired body? Neurology 2006;66:1811–1816PubMedView Article
Houeto JL, Mallet L, Mesnage V, Tezenas du Montcel S, Béhar C, Gargiulo M, Torny F, Pelissolo A, Welter ML, Agid Y. Subthalamic stimulation in Parkinson disease: behavior and social adaptation. Arch Neurol 2006; 63: 1090–1095PubMedView Article
Thobois S, Ardouin C, Lhommée E, Klinger H, Lagrange C, Xie J, Fraix V, Coelho Braga MC, Hassani R, Kistner A, Juphard A, Seigneuret E, Chabardes S, Mertens P, Polo G, Reilhac A, Costes N, LeBars D, Savasta M, Tremblay L, Quesada JL, Bosson JL, Benabid AL, Broussolle E, Pollak P, Krack P. Non-motor dopamine withdrawal syndrome after surgery for Parkinson’s disease: predictors and underlying mesolimbic denervation. Brain 2010;133:1111–1127PubMedView Article
Czernecki V, Schüpbach M, Yaici S, Lévy R, Bardinet E, Yelnik J, Dubois B, Agid Y. Apathy following subthalamic stimulation in Parkinson disease: a dopamine responsive symptom. Mov Disord 2008;23:964–969PubMedView Article
Chopra A, Tye SJ, Lee KH, Sampson S, Matsumoto J, Adams A, Klassen B, Stead M, Fields JA, Frye MA. Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson’s disease: a review of the literature. J Neuropsychiatry Clin Neurosci 2012;24:102–110PubMedView Article
Ulla M, Thobois S, Llorca PM, Derost P, Lemaire JJ, Chereau-Boudet I, de Chazeron I, Schmitt A, Ballanger B, Broussolle E, Durif F. Contact dependent reproducible hypomania induced by deep brain stimulation in Parkinson’s disease: clinical, anatomical and functional imaging study. J Neurol Neurosurg Psychiatry 2011;82:607–614PubMedView Article
Coenen VA, Honey CR, Hurwitz T, Rahman AA, McMaster J, Bürgel U, Mädler B. Medial forebrain bundle stimulation as a pathophysiological mechanism for hypomania in subthalamic nucleus deep brain stimulation for Parkinson’s disease. Neurosurgery 2009;64:1106–1114PubMedView Article
Foubert-Samier A, Maurice S, Hivert S, Guelh D, Rigalleau V, Burbaud P, Cuny E, Meissner W, Tison F. A long-term follow-up of weight changes in subthalamic nucleus stimulated Parkinson’s disease patients. Rev Neurol (Paris) 2012;168:173–176View Article
Deuschl G, Schade-Brittinger C, Krack P, Volkmann J, Schafer H, Botzel K, Daniels C, Deutschlander A, Dillmann U, Eisner W, Gruber D, Hamel W, Herzog J, Hilker R, Klebe S, Klos M, Koy J, Krause M, Kupsch A, Lorenz D, Lorenzl S, Mehdorn HM, Moringlane JR, Oertel W, Pinsker MO, Reichmann H, Reus A, Schneider GH, Schnitzler A, Steude U, Sturm V, Timmermann L, Tronnier V, Trottenberg T, Wojtecki L, Wolf E, Poewe W, Voges J. A Randomized Trial of Deep-Brain Stimulation for Parkinson’s Disease. N Engl J Med 2006; 355: 896–908PubMedView Article
Volkmann J, Albanese A, Kulisevsky J, Tornqvist AL, Houeto JL, Pidoux B, Bonnet AM, Mendes A, Benabid AL, Fraix V, Van Blercom N, Xie J, Obeso J, Rodriguez-Oroz MC, Guridi J, Schnitzler A, Timmermann L, Gironell AA, Molet J, Pascual-Sedano B, Rehncrona S, Moro E, Lang AC, Lozano AM, Bentivoglio AR, Scerrati M, Contarino MF, Romito L, Janssens M, Agid Y. Long-term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson’s disease. Mov Disord 2009;24:1154–1161PubMedView Article
Derost PP, Ouchchane L, Morand D, Ulla M, Llorca PM, Barget M, Debilly B, Lemaire JJ, Durif F. Is DBS-STN appropriate to treat severe Parkinson disease in an elderly population? Neurology 2007;68:1345–1355PubMedView Article

Titel: Langzeiterfahrungen mit Tiefer Hirnstimulation
Morbus Parkinson
Autor:: Dr. med. Niels Allert
Publikationsdatum: 19.03.2013
DOI: https://doi.org/10.1007/s15016-013-0123-1
Verlag: Urban and Vogel
Zeitschrift: NeuroTransmitter
Ausgabe 3/2013
Print ISSN: 1436-123X
Elektronische ISSN: 2196-6397