Skip to main content
Erschienen in: Medical Oncology 4/2020

01.04.2020 | Review Article

Laparoscopic thermoablation for hepatocellular carcinoma in patients with liver cirrhosis: an effective procedure for tricky tumors

verfasst von: Roberto Santambrogio, Matteo Barabino, Valentina D’Alessandro, Elisa Galfrascoli, Marco Antonio Zappa, Gaetano Piccolo, Massimo Zuin, Enrico Opocher

Erschienen in: Medical Oncology | Ausgabe 4/2020

Einloggen, um Zugang zu erhalten

Abstract

The optimal treatment for hepatocellular carcinoma (HCC) is surgical resection. However, only a small percentage of patients are amenable to this option. Percutaneous radiofrequency interstitial thermal ablation (TA) proved to be effective in the treatment of unresectable HCC. Recent advances in laparoscopic ultrasound have improved the accuracy in detecting small intrahepatic HCC nodules missed by pre-operative imaging techniques. Our objective was to evaluate an operative combination of laparoscopic ultrasound with laparoscopic thermoablation (LTA) in the treatment of HCC not amenable to liver resection. The aim of our review was to evaluate the advantages and limits of the laparoscopic approach according the criteria of the evidence-based medicine. LTA of HCC proved to be a safe and effective technique both in the short- and long-term follow-up period. This technique may be indicated in selected cases when the percutaneous approach to the lesion is very difficult or contraindicated.
Literatur
1.
Zurück zum Zitat Lencioni R, Cioni D, Bartolozzi C. Percutaneous radiofrequency thermal ablation of liver malignancies: techniques, indications, imaging findings, and clinical results. Abdom Imaging. 2001;26:345–60.PubMed Lencioni R, Cioni D, Bartolozzi C. Percutaneous radiofrequency thermal ablation of liver malignancies: techniques, indications, imaging findings, and clinical results. Abdom Imaging. 2001;26:345–60.PubMed
2.
Zurück zum Zitat Livraghi T, Meloni F, Di Stasi M, Rolle E, Solbiati L, Tinelli C, Rossi S. Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice? Hepatology. 2008;47:82–9.PubMed Livraghi T, Meloni F, Di Stasi M, Rolle E, Solbiati L, Tinelli C, Rossi S. Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice? Hepatology. 2008;47:82–9.PubMed
3.
Zurück zum Zitat Santambrogio R, Bianchi P, Pasta A, Palmisano A, Montorsi M. Ultrasound-guided interventional procedures of the liver during laparoscopy technical considerations. Surg Endosc. 2002;16:349–54.PubMed Santambrogio R, Bianchi P, Pasta A, Palmisano A, Montorsi M. Ultrasound-guided interventional procedures of the liver during laparoscopy technical considerations. Surg Endosc. 2002;16:349–54.PubMed
4.
Zurück zum Zitat Ido K, Isoda N, Kawamoto C, Hozumu M, Suzuki T, Nagamine N, Nakazawa Y, Ono K, Hirota N, Hyodoh H, Kimura K. Laparoscopic microwave coagulation therapy for solitary hepatocellular carcinoma performed under laparoscopic ultrasonography. Gastrointest Endosc. 1997;45:415–20.PubMed Ido K, Isoda N, Kawamoto C, Hozumu M, Suzuki T, Nagamine N, Nakazawa Y, Ono K, Hirota N, Hyodoh H, Kimura K. Laparoscopic microwave coagulation therapy for solitary hepatocellular carcinoma performed under laparoscopic ultrasonography. Gastrointest Endosc. 1997;45:415–20.PubMed
5.
Zurück zum Zitat Ito T, Niiyama G, Kawanaka M, et al. Laparoscopic microwave coagulation for the treatment of hepatocellular carcinoma. Dig Endosc. 1999;11:137–43. Ito T, Niiyama G, Kawanaka M, et al. Laparoscopic microwave coagulation for the treatment of hepatocellular carcinoma. Dig Endosc. 1999;11:137–43.
6.
Zurück zum Zitat Goletti O, Lencioni R, Armillotta N, Puglisi A, Lippolis PV, Lorenzetti L, Cioni D, Musco B, Bartolozzi C, Cavina E. Laparoscopic radiofrequency thermal ablation of hepatocarcinoma: preliminary experience. Surg Laparosc Endosc Percutan Tech. 2000;10:284–90.PubMed Goletti O, Lencioni R, Armillotta N, Puglisi A, Lippolis PV, Lorenzetti L, Cioni D, Musco B, Bartolozzi C, Cavina E. Laparoscopic radiofrequency thermal ablation of hepatocarcinoma: preliminary experience. Surg Laparosc Endosc Percutan Tech. 2000;10:284–90.PubMed
7.
Zurück zum Zitat Podnos YD, Henry G, Ortiz JA, Ji P, Cooke J, Cao S, Imagawa DK. Laparoscopic ultrasound with radiofrequency ablation in cirrhotic patients with hepatocellular carcinoma: technique and technical considerations. Am Surg. 2001;67:1181–4.PubMed Podnos YD, Henry G, Ortiz JA, Ji P, Cooke J, Cao S, Imagawa DK. Laparoscopic ultrasound with radiofrequency ablation in cirrhotic patients with hepatocellular carcinoma: technique and technical considerations. Am Surg. 2001;67:1181–4.PubMed
8.
Zurück zum Zitat Hsieh CB, Chang HM, Chen TW, et al. Comparison of transcatheter arterial chemoembolization, laparoscopic radiofrequency, and conservative treatment for decompensated cirrhotic patients with hepatocellular carcinoma. World J Gastroenterol. 2004;10:505–8.PubMedPubMedCentral Hsieh CB, Chang HM, Chen TW, et al. Comparison of transcatheter arterial chemoembolization, laparoscopic radiofrequency, and conservative treatment for decompensated cirrhotic patients with hepatocellular carcinoma. World J Gastroenterol. 2004;10:505–8.PubMedPubMedCentral
9.
Zurück zum Zitat Ballem N, Berber E, Pitt T, Siperstein A. Laparoscopic radiofrequency ablation of unresectable hepatocellular carcinoma: long-term follow-up. HPB. 2008;10:315–20.PubMedPubMedCentral Ballem N, Berber E, Pitt T, Siperstein A. Laparoscopic radiofrequency ablation of unresectable hepatocellular carcinoma: long-term follow-up. HPB. 2008;10:315–20.PubMedPubMedCentral
10.
Zurück zum Zitat Casaccia M, Adorno E, Nardi I, et al. Laparoscopic US-guided radiofrequency ablation of unresectable hepatocellular carcinoma in liver cirrhosis: feasibility and clinical outcome. J Laparoendosc Adv Surg Tech. 2008;18:797–801. Casaccia M, Adorno E, Nardi I, et al. Laparoscopic US-guided radiofrequency ablation of unresectable hepatocellular carcinoma in liver cirrhosis: feasibility and clinical outcome. J Laparoendosc Adv Surg Tech. 2008;18:797–801.
11.
Zurück zum Zitat Hirooka M, Kisaka Y, Uehara T, et al. Efficacy of laparoscopic radiofrequency ablation for hepatocellular carcinoma compared to percutaneous radiofrequency ablation with artificial ascites. Dig Endosc. 2009;21:82–6.PubMed Hirooka M, Kisaka Y, Uehara T, et al. Efficacy of laparoscopic radiofrequency ablation for hepatocellular carcinoma compared to percutaneous radiofrequency ablation with artificial ascites. Dig Endosc. 2009;21:82–6.PubMed
12.
Zurück zum Zitat Panaro F, Piardi T, Audet M, et al. Laparoscopic ultrasound-guided radiofrequency ablation as a bridge to liver transplantation for hepatocellular carcinoma: preliminary results. Transplant Proc. 2010;42(4):1179–81.PubMed Panaro F, Piardi T, Audet M, et al. Laparoscopic ultrasound-guided radiofrequency ablation as a bridge to liver transplantation for hepatocellular carcinoma: preliminary results. Transplant Proc. 2010;42(4):1179–81.PubMed
13.
Zurück zum Zitat Tesche LJ, Newton KN, Unger J, Semelka RC, Gerber DA. Efficacy and tolerability of laparoscopic-assisted radiofrequency ablation of hepatocellular carcinoma in patients above 60 years of age. Surg Laparosc Endosc Percutan Tech. 2010;20:404–9.PubMed Tesche LJ, Newton KN, Unger J, Semelka RC, Gerber DA. Efficacy and tolerability of laparoscopic-assisted radiofrequency ablation of hepatocellular carcinoma in patients above 60 years of age. Surg Laparosc Endosc Percutan Tech. 2010;20:404–9.PubMed
14.
Zurück zum Zitat Simo KA, Sereika SE, Newton KN, Gerber DA. Laparoscopic-assisted microwave ablation for hepatocellular carcinoma: safety and efficacy in comparison with radiofrequency ablation. J Surg Oncol. 2011;104:822–9.PubMed Simo KA, Sereika SE, Newton KN, Gerber DA. Laparoscopic-assisted microwave ablation for hepatocellular carcinoma: safety and efficacy in comparison with radiofrequency ablation. J Surg Oncol. 2011;104:822–9.PubMed
15.
Zurück zum Zitat Yoon YS, Han HS, Cho JY, Yoon CJ, Kim JH. Laparoscopic approach for treatment of multiple hepatocellular Carcinomas. Surg Endosc. 2012;26(11):3133–40.PubMed Yoon YS, Han HS, Cho JY, Yoon CJ, Kim JH. Laparoscopic approach for treatment of multiple hepatocellular Carcinomas. Surg Endosc. 2012;26(11):3133–40.PubMed
16.
Zurück zum Zitat Seleem MI, Gerges SS, Elkhouly A, El-wakeel B, Hassany M. Laparoscopic radiofrequency thermal ablation of hepatocellular carcinoma in liver cirrhosis patients. Gastroenterol Res. 2012;5:232–5. Seleem MI, Gerges SS, Elkhouly A, El-wakeel B, Hassany M. Laparoscopic radiofrequency thermal ablation of hepatocellular carcinoma in liver cirrhosis patients. Gastroenterol Res. 2012;5:232–5.
17.
Zurück zum Zitat Herbold T, Wahba R, Bangard C, et al. The laparoscopic approach for radiofrequency ablation of hepatocellular carcinoma-indication, technique and results. Langenbecks Arch Surg. 2013;398:47–53.PubMed Herbold T, Wahba R, Bangard C, et al. The laparoscopic approach for radiofrequency ablation of hepatocellular carcinoma-indication, technique and results. Langenbecks Arch Surg. 2013;398:47–53.PubMed
18.
Zurück zum Zitat Swan RZ, Sindram D, Martinie JB, Iannitti DA. Operative microwave ablation for hepatocellular carcinoma: complications, recurrence, and long-term outcomes. J Gastrointest Surg. 2013;17:719–29.PubMed Swan RZ, Sindram D, Martinie JB, Iannitti DA. Operative microwave ablation for hepatocellular carcinoma: complications, recurrence, and long-term outcomes. J Gastrointest Surg. 2013;17:719–29.PubMed
19.
Zurück zum Zitat Iida H, Aihara T, Ikuta S, Yamanaka N. A comparative study of therapeutic effect between laparoscopic microwave coagulation and laparoscopic radiofrequency ablation. Hepatogastroenterology. 2013;60:22–5. Iida H, Aihara T, Ikuta S, Yamanaka N. A comparative study of therapeutic effect between laparoscopic microwave coagulation and laparoscopic radiofrequency ablation. Hepatogastroenterology. 2013;60:22–5.
20.
Zurück zum Zitat Jiang K, Zhang W, Su M, et al. Laparoscopic radiofrequency ablation of solitary small hepatocellular carcinoma in the caudate lobe. EJSO. 2013;39:1236–42.PubMed Jiang K, Zhang W, Su M, et al. Laparoscopic radiofrequency ablation of solitary small hepatocellular carcinoma in the caudate lobe. EJSO. 2013;39:1236–42.PubMed
21.
Zurück zum Zitat Jiang K, Su M, Zhao X, et al. ‘‘One-off’’ complete radiofrequency ablation of hepatocellular carcinoma adjacent to the gallbladder by a novel laparoscopic technique without gallbladder isolation. Cell Biochem Biophys. 2014;69:605–17.PubMed Jiang K, Su M, Zhao X, et al. ‘‘One-off’’ complete radiofrequency ablation of hepatocellular carcinoma adjacent to the gallbladder by a novel laparoscopic technique without gallbladder isolation. Cell Biochem Biophys. 2014;69:605–17.PubMed
22.
Zurück zum Zitat De la Serna S, Vilana R, SanchezCabus S, Calatayud D, Ferre J, Molina V, Fondevila C, Bruix J, Fuster J, Garcia Valdecasas JC. Results of laparoscopic radiofrequency ablation for HCC Could the location of the tumour influence a complete response to treatment? A single European Centre Experience. HPB. 2015;17:387–93.PubMed De la Serna S, Vilana R, SanchezCabus S, Calatayud D, Ferre J, Molina V, Fondevila C, Bruix J, Fuster J, Garcia Valdecasas JC. Results of laparoscopic radiofrequency ablation for HCC Could the location of the tumour influence a complete response to treatment? A single European Centre Experience. HPB. 2015;17:387–93.PubMed
23.
Zurück zum Zitat Murakami K, Naka S, Shiomi H, et al. Initial experiences with MR Image-guided laparoscopic microwave coagulation therapy for hepatic tumors. Surg Today. 2015;45:1173–8.PubMed Murakami K, Naka S, Shiomi H, et al. Initial experiences with MR Image-guided laparoscopic microwave coagulation therapy for hepatic tumors. Surg Today. 2015;45:1173–8.PubMed
24.
Zurück zum Zitat Tang Z, Zhu Y, Tang K, et al. Laparoscopic combined with percutaneous ablation for hepatocellular carcinoma under liver capsule: a single Chinese center experience of thirty patients. J Cancer Res Ther. 2016;12:143–7. Tang Z, Zhu Y, Tang K, et al. Laparoscopic combined with percutaneous ablation for hepatocellular carcinoma under liver capsule: a single Chinese center experience of thirty patients. J Cancer Res Ther. 2016;12:143–7.
25.
Zurück zum Zitat Baker EH, Thompson K, McKillop IH, et al. Operative microwave ablation for hepatocellular carcinoma: a single center retrospective review of 219 patients. J Gastrointest Oncol. 2017;8:337–46.PubMedPubMedCentral Baker EH, Thompson K, McKillop IH, et al. Operative microwave ablation for hepatocellular carcinoma: a single center retrospective review of 219 patients. J Gastrointest Oncol. 2017;8:337–46.PubMedPubMedCentral
26.
Zurück zum Zitat Santambrogio R, Barabino M, Bruno S, Costa M, Pisani Ceretti A, Angiolini MR, Zuin M, Meloni F, Opocher E. Long-term outcome of laparoscopic ablation therapies for unresectable hepatocellular carcinoma: a single European center experience of 426 patients. Surg Endosc. 2016;30:2103–13.PubMed Santambrogio R, Barabino M, Bruno S, Costa M, Pisani Ceretti A, Angiolini MR, Zuin M, Meloni F, Opocher E. Long-term outcome of laparoscopic ablation therapies for unresectable hepatocellular carcinoma: a single European center experience of 426 patients. Surg Endosc. 2016;30:2103–13.PubMed
27.
Zurück zum Zitat Gruttadauria S, Pagano D, Tropea A, Cintorino D, Castellana L, Bonsignore P, Ricotta C, Vizzini G, Luca A. Laparoscopic approach for thermoablation microwave in the treatment of hepatocellular carcinoma: a single center experience. J Laparosc Adv Surg Tech. 2016;26(10):808–11. Gruttadauria S, Pagano D, Tropea A, Cintorino D, Castellana L, Bonsignore P, Ricotta C, Vizzini G, Luca A. Laparoscopic approach for thermoablation microwave in the treatment of hepatocellular carcinoma: a single center experience. J Laparosc Adv Surg Tech. 2016;26(10):808–11.
28.
Zurück zum Zitat Na BG, Kim JM, Oh DK, et al. Clinical outcomes of laparoscopic radiofrequency ablation of single primary or recurrent hepatocellular carcinoma (≤3 cm). Ann Surg Treat Res. 2017;92:355–60.PubMedPubMedCentral Na BG, Kim JM, Oh DK, et al. Clinical outcomes of laparoscopic radiofrequency ablation of single primary or recurrent hepatocellular carcinoma (≤3 cm). Ann Surg Treat Res. 2017;92:355–60.PubMedPubMedCentral
29.
Zurück zum Zitat Ding H, Su M, Zhu C, Wang L, Zheng Q, Wan Y. CT-guided versus laparoscopic radiofrequency ablation in recurrent small hepatocellular carcinoma against the diaphragmatic dome. Sci Rep. 2017;7:44583.PubMedPubMedCentral Ding H, Su M, Zhu C, Wang L, Zheng Q, Wan Y. CT-guided versus laparoscopic radiofrequency ablation in recurrent small hepatocellular carcinoma against the diaphragmatic dome. Sci Rep. 2017;7:44583.PubMedPubMedCentral
30.
Zurück zum Zitat Eun HS, Lee BS, Kwon IS, et al. Advantages of laparoscopic radiofrequency ablation over percutaneous radiofrequency ablation in hepatocellular carcinoma. Dig Dis Sci. 2017;62:2586–600.PubMed Eun HS, Lee BS, Kwon IS, et al. Advantages of laparoscopic radiofrequency ablation over percutaneous radiofrequency ablation in hepatocellular carcinoma. Dig Dis Sci. 2017;62:2586–600.PubMed
31.
Zurück zum Zitat Wang T, Zhang XY, Lu X, Zhai B. Laparoscopic microwave ablation of hepatocellular carcinoma at liver surface: technique effectiveness and long-term outcomes. Technol Cancer Res Treat. 2019;18:1–9. Wang T, Zhang XY, Lu X, Zhai B. Laparoscopic microwave ablation of hepatocellular carcinoma at liver surface: technique effectiveness and long-term outcomes. Technol Cancer Res Treat. 2019;18:1–9.
32.
Zurück zum Zitat Cillo U, Bertacco A, Fasolo E, et al. Videolaparoscopic microwave ablation in patients with HCC at a European high-volume center: results of 815 procedures. J Surg Oncol. 2019;120:956–65.PubMed Cillo U, Bertacco A, Fasolo E, et al. Videolaparoscopic microwave ablation in patients with HCC at a European high-volume center: results of 815 procedures. J Surg Oncol. 2019;120:956–65.PubMed
33.
Zurück zum Zitat Lo CM, Lai ECS, Liu CL, Fan ST, Wong J. Laparoscopy and laparoscopic ultrasonography avoid exploratory laparotomy in patients with hepatocellular carcinoma. Ann Surg. 1998;227:527–32.PubMedPubMedCentral Lo CM, Lai ECS, Liu CL, Fan ST, Wong J. Laparoscopy and laparoscopic ultrasonography avoid exploratory laparotomy in patients with hepatocellular carcinoma. Ann Surg. 1998;227:527–32.PubMedPubMedCentral
34.
Zurück zum Zitat Kokudo N, Bandai Y, Imanishi H, et al. Management of new hepatic nodules detected by intraoperative ultrasonography during hepatic resection for hepatocellular carcinoma. Surgery. 1996;119:634–40.PubMed Kokudo N, Bandai Y, Imanishi H, et al. Management of new hepatic nodules detected by intraoperative ultrasonography during hepatic resection for hepatocellular carcinoma. Surgery. 1996;119:634–40.PubMed
35.
Zurück zum Zitat Takigawa Y, Sugawara Y, Yamamoto J, Shimada K, Yamasaki S, Kosuge T, Makuuchi M. New lesions detected by introperative ultrasound during liver resection for hepatocellular carcinoma. Ultrasound Med Biol. 2001;27:151–6.PubMed Takigawa Y, Sugawara Y, Yamamoto J, Shimada K, Yamasaki S, Kosuge T, Makuuchi M. New lesions detected by introperative ultrasound during liver resection for hepatocellular carcinoma. Ultrasound Med Biol. 2001;27:151–6.PubMed
36.
Zurück zum Zitat Torzilli G, Olivari N, Moroni E, et al. Contrast-enhanced intraoperative ultrasonography in surgery for hepatocellular carcinoma in cirrhosis. Liver Transpl. 2004;10:S34–S3838.PubMed Torzilli G, Olivari N, Moroni E, et al. Contrast-enhanced intraoperative ultrasonography in surgery for hepatocellular carcinoma in cirrhosis. Liver Transpl. 2004;10:S34–S3838.PubMed
37.
Zurück zum Zitat Lai ECH, Tang CN, Ha JPY, Tsui DKK, Li MKW. The evolving influence of laparoscopy and laparoscopic ultrasonography on patients with hepatocellular carcinoma. Am J Surg. 2008;196:736–40.PubMed Lai ECH, Tang CN, Ha JPY, Tsui DKK, Li MKW. The evolving influence of laparoscopy and laparoscopic ultrasonography on patients with hepatocellular carcinoma. Am J Surg. 2008;196:736–40.PubMed
38.
Zurück zum Zitat Ido K, Nakazawa Y, Isoda N, et al. The role of laparoscopic US and laparoscopic US-guided aspiration biopsy in the diagnosis of multicentric hepatocellular carcinoma. Gastrointest Endosc. 1999;50:523–6.PubMed Ido K, Nakazawa Y, Isoda N, et al. The role of laparoscopic US and laparoscopic US-guided aspiration biopsy in the diagnosis of multicentric hepatocellular carcinoma. Gastrointest Endosc. 1999;50:523–6.PubMed
39.
Zurück zum Zitat Klegar EK, Marcus SG, Newman E, Hiotis SP. Diagnostic laparoscopy in the evaluation of the viral hepatitis patient with potentially resectable hepatocellular carcinoma. HPB. 2005;7:204–7.PubMedPubMedCentral Klegar EK, Marcus SG, Newman E, Hiotis SP. Diagnostic laparoscopy in the evaluation of the viral hepatitis patient with potentially resectable hepatocellular carcinoma. HPB. 2005;7:204–7.PubMedPubMedCentral
40.
Zurück zum Zitat Reddy MS, Smith L, Jaques BC, et al. Do laparoscopy and intraoperative ultrasound have a role in the assessment of patients with end-stage liver disease and hepatocellular carcinoma for liver transplantation? Transpl Proc. 2007;39:1474–6. Reddy MS, Smith L, Jaques BC, et al. Do laparoscopy and intraoperative ultrasound have a role in the assessment of patients with end-stage liver disease and hepatocellular carcinoma for liver transplantation? Transpl Proc. 2007;39:1474–6.
41.
Zurück zum Zitat Brunello F, Cantamessa A, Gaia S, Carucci P, Rolle E, Castiglione A, Ciccone G, Rizzetto M. Radiofrequency ablation: technical and clinical long-term outcomes for single hepatocellular carcinoma up to 30 mm. Eur J Gastroenterol Hepatol. 2013;25:842–9.PubMed Brunello F, Cantamessa A, Gaia S, Carucci P, Rolle E, Castiglione A, Ciccone G, Rizzetto M. Radiofrequency ablation: technical and clinical long-term outcomes for single hepatocellular carcinoma up to 30 mm. Eur J Gastroenterol Hepatol. 2013;25:842–9.PubMed
42.
Zurück zum Zitat Lee DH, Lee JM, Lee JY, Kim SH, Yoon JH, Kim YJ, Han JK, Choi BI. Radiofrequency ablation of hepatocellular carcinoma as first-line treatment: long-term results and prognostic factors in 162 patients with cirrhosis. Radiology. 2014;270:900–9.PubMed Lee DH, Lee JM, Lee JY, Kim SH, Yoon JH, Kim YJ, Han JK, Choi BI. Radiofrequency ablation of hepatocellular carcinoma as first-line treatment: long-term results and prognostic factors in 162 patients with cirrhosis. Radiology. 2014;270:900–9.PubMed
43.
Zurück zum Zitat Chinnaratha MA, Chuang MA, Fraser RJ, Woodman RJ, Wigg AJ. Percutaneous thermal ablation for primary hepatocellular carcinoma: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2016;45:1230–5. Chinnaratha MA, Chuang MA, Fraser RJ, Woodman RJ, Wigg AJ. Percutaneous thermal ablation for primary hepatocellular carcinoma: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2016;45:1230–5.
44.
Zurück zum Zitat Poulou LS, Botsa E, Thanou I, Ziakas PD, Thanos L. Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma. World J Hepatol. 2015;7:1054–63.PubMedPubMedCentral Poulou LS, Botsa E, Thanou I, Ziakas PD, Thanos L. Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma. World J Hepatol. 2015;7:1054–63.PubMedPubMedCentral
45.
Zurück zum Zitat Kim JW, Shin SS, Heo SH, Hong JH, Lim HS, Seon HJ, Hur YH, Park CH, Jeong YY, Kang HK. Ultrasound-guided percutaneous radiofrequency ablation of liver tumors: how we do it safely and completely. Korean J Radiol. 2015;16:1226–399.PubMedPubMedCentral Kim JW, Shin SS, Heo SH, Hong JH, Lim HS, Seon HJ, Hur YH, Park CH, Jeong YY, Kang HK. Ultrasound-guided percutaneous radiofrequency ablation of liver tumors: how we do it safely and completely. Korean J Radiol. 2015;16:1226–399.PubMedPubMedCentral
46.
Zurück zum Zitat Montorsi M, Santambrogio R, Bianchi P, Dapri G, Spinelli A, Podda M. Perspectives and drawbacks of minimally invasive surgery for hepatocellular carcinoma. Hepatogastroenterology. 2002;49:56–61.PubMed Montorsi M, Santambrogio R, Bianchi P, Dapri G, Spinelli A, Podda M. Perspectives and drawbacks of minimally invasive surgery for hepatocellular carcinoma. Hepatogastroenterology. 2002;49:56–61.PubMed
47.
Zurück zum Zitat Mulier S, Mulier P, Ni Y, et al. Complications of radiofrequency coagulation of liver tumors. Br J Surg. 2002;89:1206–22.PubMed Mulier S, Mulier P, Ni Y, et al. Complications of radiofrequency coagulation of liver tumors. Br J Surg. 2002;89:1206–22.PubMed
48.
Zurück zum Zitat Gillams AR. Radiofrequency ablation in the management of liver tumors. EJSO. 2003;29:9–16.PubMed Gillams AR. Radiofrequency ablation in the management of liver tumors. EJSO. 2003;29:9–16.PubMed
49.
Zurück zum Zitat Montorsi M, Santambrogio R, Bianchi P, et al. Laparoscopy with laparoscopic ultrasound (L-LUS) for the pre-treatment staging of hepatocellular carcinoma: a prospective study. Gastrointestinal Surg. 2001;5:312–5. Montorsi M, Santambrogio R, Bianchi P, et al. Laparoscopy with laparoscopic ultrasound (L-LUS) for the pre-treatment staging of hepatocellular carcinoma: a prospective study. Gastrointestinal Surg. 2001;5:312–5.
Metadaten
Titel
Laparoscopic thermoablation for hepatocellular carcinoma in patients with liver cirrhosis: an effective procedure for tricky tumors
verfasst von
Roberto Santambrogio
Matteo Barabino
Valentina D’Alessandro
Elisa Galfrascoli
Marco Antonio Zappa
Gaetano Piccolo
Massimo Zuin
Enrico Opocher
Publikationsdatum
01.04.2020
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 4/2020
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-020-1342-5

Weitere Artikel der Ausgabe 4/2020

Medical Oncology 4/2020 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.