Large Cell Transformation of Oral Mycosis Fungoides
- 24.07.2017
- Sine qua non Clinicopathologic Correlation
Erschienen in:
- Verfasst von
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Ahmed S. Sultan
Korrespondierender Autor Ahmed S. Sultan
- Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, 21201, Baltimore, USA
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Behzad Mostoufi
Behzad Mostoufi
- Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Maryland, 21201, Baltimore, USA
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John C. Papadimitriou
John C. Papadimitriou
- Department of Pathology, University of Maryland School of Medicine, 21201, Baltimore, USA
-
Rima Koka
Rima Koka
- Department of Pathology, University of Maryland School of Medicine, 21201, Baltimore, USA
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John Basile
John Basile
- Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, 21201, Baltimore, USA
- University of Maryland Greenebaum Cancer Center, 21201, Baltimore, USA
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Rania H. Younis
Rania H. Younis
- Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, 21201, Baltimore, USA
- University of Maryland Greenebaum Cancer Center, 21201, Baltimore, USA
- Erschienen in
- Head and Neck Pathology | Ausgabe 2/2018
Abstract
Mycosis fungoides (MF) accounts for approximately 50% of all primary cutaneous lymphomas. MF occurrence in the oral cavity is extremely rare with approximately 45 cases reported to date. We present a case of a 68 year-old man with a raised nodular lesion of the ventral tongue with clinical impression of irritational fibroma. Histopathologic and immunohistochemical (IHC) examination revealed a phenotype consistent with MF with large cell transformation in the context of Sezary syndrome. The histological diagnosis of oral MF requires a high index of suspicion and IHC panel to rule out large cell transformation. To our knowledge, only four cases of large cell transformation of oral MF have been reported in the English literature. The clinical and histopathologic features of a rare case of intra-oral MF with large cell transformation are exemplified in this article.
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- Titel
- Large Cell Transformation of Oral Mycosis Fungoides
- Verfasst von
-
Ahmed S. Sultan
Behzad Mostoufi
John C. Papadimitriou
Rima Koka
John Basile
Rania H. Younis
- Publikationsdatum
- 24.07.2017
- Verlag
- Springer US
- Erschienen in
-
Head and Neck Pathology / Ausgabe 2/2018
Elektronische ISSN: 1936-0568 - DOI
- https://doi.org/10.1007/s12105-017-0840-z
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