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Erschienen in: Breast Cancer Research 2/2005

01.06.2005 | Poster Presentation

Large-scale single nucleotide polymorphism analysis of candidates for low-penetrance breast cancer genes

verfasst von: A Vega, A Salas, C Phillips, B Sobrino, B Carracedo, C Ruíz-Ponte, R Rodríguez-López, G Rivas, J Benítez, A Carracedo

Erschienen in: Breast Cancer Research | Sonderheft 2/2005

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Excerpt

BRCA1 and BRCA2 are high-penetrance genes that account for around 25% of families with hereditary breast cancer [1]. Given that no additional high-penetrance susceptibility genes have been found to be involved in breast cancer, it has been proposed that different genetic backgrounds due to the combination of low-penetrance genes (polygenic mechanism) could explain the remaining familial breast cancer risk [2]. Hence there is much interest in the search for low-penetrance gene/variants for breast cancer, which exist with high prevalence in the general population. …
Literatur
1.
Zurück zum Zitat Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, et al: Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Breast Cancer Linkage Consortium. Am J Hum Genet. 1998, 62: 676-689. 10.1086/301749.CrossRefPubMedPubMedCentral Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, et al: Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Breast Cancer Linkage Consortium. Am J Hum Genet. 1998, 62: 676-689. 10.1086/301749.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Pharoah PD, Antoniou A, Bobrow M, Zimmern RL, Easton DF, Ponder BA: Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet. 2002, 31: 33-36. 10.1038/ng853.CrossRefPubMed Pharoah PD, Antoniou A, Bobrow M, Zimmern RL, Easton DF, Ponder BA: Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet. 2002, 31: 33-36. 10.1038/ng853.CrossRefPubMed
3.
Zurück zum Zitat Kruglyak L: Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 1999, 22: 139-144. 10.1038/9642.CrossRefPubMed Kruglyak L: Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 1999, 22: 139-144. 10.1038/9642.CrossRefPubMed
4.
Zurück zum Zitat Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al: The sequence of the human genome. Science. 2001, 291: 1304-1351. 10.1126/science.1058040.CrossRefPubMed Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al: The sequence of the human genome. Science. 2001, 291: 1304-1351. 10.1126/science.1058040.CrossRefPubMed
Metadaten
Titel
Large-scale single nucleotide polymorphism analysis of candidates for low-penetrance breast cancer genes
verfasst von
A Vega
A Salas
C Phillips
B Sobrino
B Carracedo
C Ruíz-Ponte
R Rodríguez-López
G Rivas
J Benítez
A Carracedo
Publikationsdatum
01.06.2005
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 2/2005
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1101

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