Erschienen in:
01.06.2005 | Poster Presentation
Large-scale single nucleotide polymorphism analysis of candidates for low-penetrance breast cancer genes
verfasst von:
A Vega, A Salas, C Phillips, B Sobrino, B Carracedo, C Ruíz-Ponte, R Rodríguez-López, G Rivas, J Benítez, A Carracedo
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2005
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Excerpt
BRCA1 and
BRCA2 are high-penetrance genes that account for around 25% of families with hereditary breast cancer [
1]. Given that no additional high-penetrance susceptibility genes have been found to be involved in breast cancer, it has been proposed that different genetic backgrounds due to the combination of low-penetrance genes (polygenic mechanism) could explain the remaining familial breast cancer risk [
2]. Hence there is much interest in the search for low-penetrance gene/variants for breast cancer, which exist with high prevalence in the general population. …