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Erschienen in: Current Allergy and Asthma Reports 8/2019

01.08.2019 | Autoimmunity (TK Tarrant, Section Editor)

Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease

verfasst von: Victoria A. Wickenheisser, Emilia Marta Zywot, Emily Mary Rabjohns, Hyun Ho Lee, David S. Lawrence, Teresa Kathleen Tarrant

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 8/2019

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Abstract

Purpose of Review

The goal of this review is to summarize the field to date and to discuss strengths and limitations of low-level laser (light) therapy (LLLT) for the future investigation as a treatment of inflammatory disease.

Recent Findings

LLLT is a promising therapeutic, particularly for those diseases of skin and joints because they are most accessible to treatment. Indeed, the known mechanisms of LLLT support its use for anti-inflammatory purposes, as well as stimulation of tissue growth and repair. Although the standard of care for the majority of inflammatory diseases is immunosuppressive agents such as corticosteroids with undesirable toxicities, LLLT offers a unique approach by being non-invasive and incurring minimal side effects. It is also relatively inexpensive and accessible and even has the possibility to be patient directed at home.

Summary

There is evidence that LLLT is able to modulate the immune system at the skin and joint, and it has been shown to be efficacious in humans by affecting bacterial colonization as it may pertain to chronic rhinosinusitis. However, there is variability in the methods of laser application as well as a lack of evidence for laser type, dose-ranging studies, and wavelength selection that create barriers to the implementation of LLLT without further more rigorous and standardized study. The heterogeneity makes it difficult to draw strong conclusions about the efficacy of LLLT and its mechanisms.
Literatur
3.
Zurück zum Zitat Lupton JR, Alster TS. Laser scar revision. Dermatol Clin. 2002;20(1):55–65.CrossRef Lupton JR, Alster TS. Laser scar revision. Dermatol Clin. 2002;20(1):55–65.CrossRef
6.
Zurück zum Zitat Poyton RO, Ball KA. Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase. Discov Med. 2011;11(57):154–9.PubMed Poyton RO, Ball KA. Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase. Discov Med. 2011;11(57):154–9.PubMed
12.
Zurück zum Zitat Bashiri H. Evaluation of low level laser therapy in reducing diabetic polyneuropathy related pain and sensorimotor disorders. Acta Med Iran. 2013;51(8):543–7.PubMed Bashiri H. Evaluation of low level laser therapy in reducing diabetic polyneuropathy related pain and sensorimotor disorders. Acta Med Iran. 2013;51(8):543–7.PubMed
17.
Zurück zum Zitat Dima R, Tieppo Francio V, Towery C, Davani S. Review of literature on low-level laser therapy benefits for nonpharmacological pain control in chronic pain and osteoarthritis. Altern Ther Health Med. 2017. Dima R, Tieppo Francio V, Towery C, Davani S. Review of literature on low-level laser therapy benefits for nonpharmacological pain control in chronic pain and osteoarthritis. Altern Ther Health Med. 2017.
19.
Zurück zum Zitat Todd KH, Funk JP. The minimum clinically important difference in physician-assigned visual analog pain scores. Acad Emerg Med. 1996;3(2):142–6.CrossRef Todd KH, Funk JP. The minimum clinically important difference in physician-assigned visual analog pain scores. Acad Emerg Med. 1996;3(2):142–6.CrossRef
20.
Zurück zum Zitat Gallagher EJ, Bijur PE, Latimer C, Silver W. Reliability and validity of a visual analog scale for acute abdominal pain in the ED. Am J Emerg Med. 2002;20(4):287–90.CrossRef Gallagher EJ, Bijur PE, Latimer C, Silver W. Reliability and validity of a visual analog scale for acute abdominal pain in the ED. Am J Emerg Med. 2002;20(4):287–90.CrossRef
27.
Zurück zum Zitat Sack U, Kinne RW, Marx T, Heppt P, Bender S, Emmrich F. Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis. Rheumatol Int. 1993;13(2):45–51.CrossRef Sack U, Kinne RW, Marx T, Heppt P, Bender S, Emmrich F. Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis. Rheumatol Int. 1993;13(2):45–51.CrossRef
30.
Zurück zum Zitat Hyrich KL, Lunt M, Watson KD, Symmons DP, Silman AJ, British Society for Rheumatology Biologics R. Outcomes after switching from one anti-tumor necrosis factor alpha agent to a second anti-tumor necrosis factor alpha agent in patients with rheumatoid arthritis: results from a large UK national cohort study. Arthritis Rheum 2007;56(1):13–20. doi:https://doi.org/10.1002/art.22331.CrossRef Hyrich KL, Lunt M, Watson KD, Symmons DP, Silman AJ, British Society for Rheumatology Biologics R. Outcomes after switching from one anti-tumor necrosis factor alpha agent to a second anti-tumor necrosis factor alpha agent in patients with rheumatoid arthritis: results from a large UK national cohort study. Arthritis Rheum 2007;56(1):13–20. doi:https://​doi.​org/​10.​1002/​art.​22331.CrossRef
31.
Zurück zum Zitat Nuki G, Bresnihan B, Bear MB, McCabe D, European Group Of Clinical I. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002;46(11):2838–2846. doi:https://doi.org/10.1002/art.10578.CrossRef Nuki G, Bresnihan B, Bear MB, McCabe D, European Group Of Clinical I. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002;46(11):2838–2846. doi:https://​doi.​org/​10.​1002/​art.​10578.CrossRef
35.
Zurück zum Zitat Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg. 2013;32(1):41–52.PubMedPubMedCentral Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg. 2013;32(1):41–52.PubMedPubMedCentral
39.
Zurück zum Zitat Sadick NS. Handheld LED array device in the treatment of acne vulgaris. J Drugs Dermatol. 2008;7(4):347–50.PubMed Sadick NS. Handheld LED array device in the treatment of acne vulgaris. J Drugs Dermatol. 2008;7(4):347–50.PubMed
40.
43.
Zurück zum Zitat Tartar D, Bhutani T, Huynh M, Berger T, Koo J. Update on the immunological mechanism of action behind phototherapy. J Drugs Dermatol. 2014;13(5):564–8.PubMed Tartar D, Bhutani T, Huynh M, Berger T, Koo J. Update on the immunological mechanism of action behind phototherapy. J Drugs Dermatol. 2014;13(5):564–8.PubMed
44.
Zurück zum Zitat Pittelkow MR, Perry HO, Muller SA, Maughan WZ, O'Brien PC. Skin cancer in patients with psoriasis treated with coal tar. A 25-year follow-up study. Arch Dermatol. 1981;117(8):465–8.CrossRef Pittelkow MR, Perry HO, Muller SA, Maughan WZ, O'Brien PC. Skin cancer in patients with psoriasis treated with coal tar. A 25-year follow-up study. Arch Dermatol. 1981;117(8):465–8.CrossRef
55.
Zurück zum Zitat Mester E, Szende B, Gartner P. The effect of laser beams on the growth of hair in mice. Radiobiol Radiother (Berl). 1968;9(5):621–6. Mester E, Szende B, Gartner P. The effect of laser beams on the growth of hair in mice. Radiobiol Radiother (Berl). 1968;9(5):621–6.
58.
Zurück zum Zitat Yamazaki M, Miura Y, Tsuboi R, Ogawa H. Linear polarized infrared irradiation using Super Lizer is an effective treatment for multiple-type alopecia areata. Int J Dermatol. 2003;42(9):738–40.CrossRef Yamazaki M, Miura Y, Tsuboi R, Ogawa H. Linear polarized infrared irradiation using Super Lizer is an effective treatment for multiple-type alopecia areata. Int J Dermatol. 2003;42(9):738–40.CrossRef
60.
Zurück zum Zitat Stich AN, Rosenkrantz WS, Griffin CE. Clinical efficacy of low-level laser therapy on localized canine atopic dermatitis severity score and localized pruritic visual analog score in pedal pruritus due to canine atopic dermatitis. Vet Dermatol. 2014;25(5):464–e74. https://doi.org/10.1111/vde.12144.CrossRefPubMed Stich AN, Rosenkrantz WS, Griffin CE. Clinical efficacy of low-level laser therapy on localized canine atopic dermatitis severity score and localized pruritic visual analog score in pedal pruritus due to canine atopic dermatitis. Vet Dermatol. 2014;25(5):464–e74. https://​doi.​org/​10.​1111/​vde.​12144.CrossRefPubMed
65.
Zurück zum Zitat Benninger MS, Ferguson BJ, Hadley JA, Hamilos DL, Jacobs M, Kennedy DW, et al. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg. 2003;129(3 Suppl):S1–32.CrossRef Benninger MS, Ferguson BJ, Hadley JA, Hamilos DL, Jacobs M, Kennedy DW, et al. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg. 2003;129(3 Suppl):S1–32.CrossRef
66.
Zurück zum Zitat Harvey RJ, Lund VJ. Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research. Rhinology. 2007;45(1):3–13.PubMed Harvey RJ, Lund VJ. Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research. Rhinology. 2007;45(1):3–13.PubMed
72.
Zurück zum Zitat Nikolic-Paterson DJ, Atkins RC. The role of macrophages in glomerulonephritis. Nephrol Dial Transplant. 2001;16(Suppl 5):3–7.CrossRef Nikolic-Paterson DJ, Atkins RC. The role of macrophages in glomerulonephritis. Nephrol Dial Transplant. 2001;16(Suppl 5):3–7.CrossRef
73.
Zurück zum Zitat Takemura T, Yoshioka K, Murakami K, Akano N, Okada M, Aya N, et al. Cellular localization of inflammatory cytokines in human glomerulonephritis. Virchows Arch. 1994;424(5):459–64.CrossRef Takemura T, Yoshioka K, Murakami K, Akano N, Okada M, Aya N, et al. Cellular localization of inflammatory cytokines in human glomerulonephritis. Virchows Arch. 1994;424(5):459–64.CrossRef
74.
Zurück zum Zitat Bremer V, Tojo A, Kimura K, Hirata Y, Goto A, Nagamatsu T, et al. Role of nitric oxide in rat nephrotoxic nephritis: comparison between inducible and constitutive nitric oxide synthase. J Am Soc Nephrol. 1997;8(11):1712–21.PubMed Bremer V, Tojo A, Kimura K, Hirata Y, Goto A, Nagamatsu T, et al. Role of nitric oxide in rat nephrotoxic nephritis: comparison between inducible and constitutive nitric oxide synthase. J Am Soc Nephrol. 1997;8(11):1712–21.PubMed
75.
Zurück zum Zitat Tesch GH, Yang N, Yu H, Lan HY, Foti R, Chadban SJ, et al. Intrinsic renal cells are the major source of interleukin-1 beta synthesis in normal and diseased rat kidney. Nephrol Dial Transplant. 1997;12(6):1109–15.CrossRef Tesch GH, Yang N, Yu H, Lan HY, Foti R, Chadban SJ, et al. Intrinsic renal cells are the major source of interleukin-1 beta synthesis in normal and diseased rat kidney. Nephrol Dial Transplant. 1997;12(6):1109–15.CrossRef
80.
91.
Zurück zum Zitat Shirasu N, Nam SO, Kuroki M. Tumor-targeted photodynamic therapy. Anticancer Res. 2013;33(7):2823–31.PubMed Shirasu N, Nam SO, Kuroki M. Tumor-targeted photodynamic therapy. Anticancer Res. 2013;33(7):2823–31.PubMed
92.
100.
Zurück zum Zitat Okada E, Delpy DT. Near-infrared light propagation in an adult head model. I. Modeling of low-level scattering in the cerebrospinal fluid layer. Appl Opt. 2003;42(16):2906–14.CrossRef Okada E, Delpy DT. Near-infrared light propagation in an adult head model. I. Modeling of low-level scattering in the cerebrospinal fluid layer. Appl Opt. 2003;42(16):2906–14.CrossRef
Metadaten
Titel
Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease
verfasst von
Victoria A. Wickenheisser
Emilia Marta Zywot
Emily Mary Rabjohns
Hyun Ho Lee
David S. Lawrence
Teresa Kathleen Tarrant
Publikationsdatum
01.08.2019
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 8/2019
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-019-0869-z

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