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European Archives of Oto-Rhino-Laryngology

Erschienen in:

27.02.2024 | Review Article

Late-onset, progressive sensorineural hearing loss in the paediatric population: a systematic review

verfasst von: Virginia Corazzi, Surina Fordington, Tamsin Holland Brown, Neil Donnelly, Jessica Bewick, Diana Ehsani, Stefano Pelucchi, Chiara Bianchini, Andrea Ciorba, Daniele Borsetto

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 7/2024

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Abstract

Purpose

To review possible risk factors for permanent delayed-onset, progressive sensorineural hearing loss (SNHL) in the paediatric population to recommend follow-up protocols for early detection.

Methods

PRISMA-compliant systematic review was performed, including observational studies on the paediatric population up to 16 years old who have passed the newborn hearing screening programme (NHSP), investigating the development of late-onset, progressive SNHL. Electronic searches were performed through Medline, Embase, Cochrane, and Emcare.

Results

37 studies were included. 21 showed an association between late-onset SNHL and congenital cytomegalovirus (cCMV) infection (age at hearing loss diagnosis 0.75 to 204 months, mean 45.6 ± 43.9), while 16 between late-onset SNHL and other congenital or perinatal factors, namely Neonatal Intensive Care Unit (NICU) stay, prematurity, neonatal respiratory failure, mechanical ventilation, extracorporeal membrane oxygenation (ECMO) support, hypocapnia, hypoxia, alkalosis, seizure activity, congenital diaphragmatic hernia (CDH), inner ear malformation, and gene mutations (age at hearing loss diagnosis 2.5 to 156 months, mean 38.7 ± 40.7).

Conclusions

cCMV infection may cause late-onset SNHL, which can be missed on standard NHSP. There is, therefore, evidence to support universal screening programmes to enable detection in even asymptomatic neonates. Ongoing audiological follow-up for all children with cCMV is advisable, to enable timely treatment. In the paediatric population presenting conditions such as NICU stay > 5 days, prematurity ≤ 34 weeks gestation, severe neonatal respiratory failure, mechanical ventilation, ECMO support, and CDH surgery, an audiological follow-up from 3 months of age up to at least 3–4 years of age, and at least annually, should be recommended.

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Titel: Late-onset, progressive sensorineural hearing loss in the paediatric population: a systematic review
verfasst von: Virginia Corazzi
Surina Fordington
Tamsin Holland Brown
Neil Donnelly
Jessica Bewick
Diana Ehsani
Stefano Pelucchi
Chiara Bianchini
Andrea Ciorba
Daniele Borsetto
Publikationsdatum: 27.02.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 7/2024
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-024-08527-x

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Late-onset, progressive sensorineural hearing loss in the paediatric population: a systematic review