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Intensive Care Medicine

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13.09.2019 | Less is more in Intensive Care

Less is more: catecholamine-sparing strategies in septic shock

verfasst von: Balasubramanian Venkatesh, Ashish K. Khanna, Jeremy Cohen

Erschienen in: Intensive Care Medicine | Ausgabe 12/2019

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Excerpt

Noradrenaline, a catecholamine, is the first line agent for the management of septic shock [1] and has been shown to be superior to dopamine [2] and equivalent to adrenaline [3] and vasopressin [4]. High doses of catecholamines are frequently required to reverse shock [5, 6]. While the presence of circulatory shock remains a strong and independent predictor of mortality [7], the use of catecholaminergic agents to reverse shock is associated with adverse events—tachyarrhythmias, thermogenic, metabolic and excess vasoconstriction resulting in tissue ischemia [2, 8]. These adverse effects have led to an interest in adjunctive therapies and catecholamine minimization strategies. …

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Titel: Less is more: catecholamine-sparing strategies in septic shock
verfasst von: Balasubramanian Venkatesh
Ashish K. Khanna
Jeremy Cohen
Publikationsdatum: 13.09.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 12/2019
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-019-05770-3

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Less is more: catecholamine-sparing strategies in septic shock

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