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Breast Cancer Research and Treatment

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10.07.2017 | Letter to the Editor

Letter to the editor: In response to “influence of clinical, societal, and treatment variables on racial difference in ER-/PR- breast cancer survival” by Roseland ME, Schwartz K, Ruterbusch JJ, Lamerato L, Krajenta R, Booza J, Simon MS

verfasst von: Constance Hilliard

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2017

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Excerpt

While I agree with this article that social determinants play an important role in explaining the higher mortality of Black women with triple-negative breast cancer, my research as an evolutionary historian, points to epigenetics as being an even more pivotal factor. The central actor is the TRPV6 gene, which has an “ancestral” variant carried by Africans and a “derived” haplotype found in Europeans and Asians. …

Hilliard CB (2016) High osteoporosis risk among East Africans linked to lactase persistence genotype. BoneKEy Rep. doi:10.1038/bonekey.2016.30 PubMedPubMedCentral

Fu S, Hirte H, Welch S et al (2017) First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors. Invest New Drugs 35:324CrossRefPubMedPubMedCentral

Jiang Y, Gou H, Zhu J, Tian S, Yu L (2016) Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation. Oncol Lett 12(2):1164–1170PubMedPubMedCentral

Titel: Letter to the editor: In response to “influence of clinical, societal, and treatment variables on racial difference in ER-/PR- breast cancer survival” by Roseland ME, Schwartz K, Ruterbusch JJ, Lamerato L, Krajenta R, Booza J, Simon MS
verfasst von: Constance Hilliard
Publikationsdatum: 10.07.2017
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 1/2017
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-017-4360-z

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23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Letter to the editor: In response to “influence of clinical, societal, and treatment variables on racial difference in ER-/PR- breast cancer survival” by Roseland ME, Schwartz K, Ruterbusch JJ, Lamerato L, Krajenta R, Booza J, Simon MS

Excerpt

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Excerpt

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