nach oben

Indian Journal of Hematology and Blood Transfusion

Erschienen in:

11.12.2014 | Case Report

Leukemic Transformation of Severe Aplastic Anemia Following Matched Allogenic Stem Cell Transplantation, Transplanted Again in CR 1

verfasst von: Prabhu Manivannan, Abhishek Purohit, Venkatesan Somasundaram, Ankur Ahuja, Mukul Aggarwal, Rajiv Kumar, Pawan Kumar Singh, Hara Prasad Pati, Pravas Mishra, Tulika Seth, Manoranjan Mahapatra

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Sonderheft 1/2016

Einloggen, um Zugang zu erhalten

Abstract

Aplastic anemia (AA) is a life-threatening bone marrow failure disorder, if untreated, is associated with very high mortality. Allogenic bone marrow transplantation (BMT) is the standard of care for severe aplastic anemia (SAA) patients those who are younger than 40 years of age. The development of secondary malignancies in post-BMT setting for AA is a rare, however, well documented phenomenon. Among the secondary malignancies, development of acute myeloid leukemia is even rarer entity. Here we report a case of acute myeloid leukemia following human leucocyte antigen (HLA) matched sibling peripheral blood stem cell transplant (PBSCT) in a case of SAA. The patient achieved complete remission (CR) following chemotherapy and in CR1, a second HLA matched PBSCT from a different donor was offered. The patient is presently in remission at day +180 post-PBSCT.

Deeg HJ, Socié G, Schoch G et al (1996) Malignancies after marrow transplantation for aplastic anemia and Fanconi anemia: a joint Seattle and Paris analysis of results in 700 patients. Blood 87:386–392PubMed

Otero L, de Souza DC, de Cássia Tavares R et al (2012) Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature. Genet Mol Biol 35:734–736CrossRefPubMedPubMedCentral

Lawler M, Locasciulli A, Longoni D et al (2002) Leukemic transformation of donor cells in a patient receiving a second allogeneic bone marrow transplant for severe aplastic anemia. Bone Marrow Transpl 29:453–456CrossRef

Camitta BM, Rappeport JM, Parkman R et al (1975) Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood 45:355–363PubMed

Marsh JC, Ball SE, Cavenagh J et al (2009) British Committee for Standards in Haematology. Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol 147:43–70CrossRefPubMed

Kojima S, Ohara A, Tsuchida M, Japan Childhood Aplastic Anemia Study Group et al (2002) Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children. Blood 100:786–790CrossRefPubMed

Maciejewski JP, Risitano A, Sloand EM et al (2002) Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia. Blood 99:3129–3135CrossRefPubMed

Keung YK, Pettenati MJ, Cruz JM et al (2001) Bone marrow cytogenetic abnormalities of aplastic anemia. Am J Hematol 66:167–171CrossRefPubMed

Varma N, Varma S, Movafagh A et al (1995) Unusual clonal cytogenetic abnormalities in aplastic anemia. Am J Hematol 49:256–257CrossRefPubMed

10.

Klingemann HG, Storb R, Sanders J et al (1986) Acute lymphoblastic leukaemia after bone marrow transplantation for aplastic anaemia. Br J Haematol 63:47–50CrossRefPubMed

11.

Haltrich I, Müller J, Szabó J et al (2003) Donor-cell myelodysplastic syndrome developing 13 years after marrow grafting for aplastic anemia. Cancer Genet Cytogenet 142:124–128CrossRefPubMed

12.

Hashino S, Fujisawa F, Kondo T et al (2006) Donor-type myelodysplastic syndrome with t(2;3) and monosomy 7 after allogeneic peripheral blood stem cell transplantation and liver transplantation in a patient with severe-type aplastic anemia. Int J Hematol 84:363–366CrossRefPubMed

13.

Hughes RT, Milligan DW, Smith GM et al (1988) A second bone marrow transplant for acute myeloid leukaemia after transplantation for aplastic anaemia. Br J Haematol 68:391CrossRefPubMed

14.

Sevilla J, Querol S, Molines A et al (2006) Transient donor cell-derived myelodysplastic syndrome with monosomy 7 after unrelated cord blood transplantation. Eur J Haematol 77:259–263CrossRefPubMed

15.

Hamaki T, Kajiwara K, Kami M et al (2008) Donor cell-derived acute monoblastic leukemia involving MLL gene translocation in an adult patient who received umbilical cord blood transplantation. Bone Marrow Transplant 41:91–92CrossRefPubMed

16.

Browne PV, Lawler M, Humphries P et al (1991) Donor-cell leukemia after bone marrow transplantation for severe aplastic anemia. N Engl J Med 325:710–713CrossRefPubMed

17.

Tallman MS, Rowlings PA, Milone G et al (2000) Effect of post-remission chemotherapy prior to HLA-identicalsibling transplantation for acute myelogenous leukemia in first complete remission. Blood 96:1254–1258PubMed

18.

Rowe JM (2002) Therapy of secondary leukemia. Leukemia 16:748–750CrossRefPubMed

19.

Pagano L, Pulsoni A, Vignetti M et al (2005) Secondary acute myeloid leukaemia: results of conventional treatments. Experience of GIMEMA trials. Ann Oncol 16:228–233CrossRefPubMed

Titel: Leukemic Transformation of Severe Aplastic Anemia Following Matched Allogenic Stem Cell Transplantation, Transplanted Again in CR 1
verfasst von: Prabhu Manivannan
Abhishek Purohit
Venkatesan Somasundaram
Ankur Ahuja
Mukul Aggarwal
Rajiv Kumar
Pawan Kumar Singh
Hara Prasad Pati
Pravas Mishra
Tulika Seth
Manoranjan Mahapatra
Publikationsdatum: 11.12.2014
Verlag: Springer India
Erschienen in: Indian Journal of Hematology and Blood Transfusion / Ausgabe Sonderheft 1/2016
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-014-0484-z

Neu im Fachgebiet Onkologie

10.04.2024 | PSA-Screening | Nachrichten

Springer Medizin

Leukemic Transformation of Severe Aplastic Anemia Following Matched Allogenic Stem Cell Transplantation, Transplanted Again in CR 1

Abstract

Neu im Fachgebiet Onkologie

Einladung zum PSA-Screening senkt die Krebssterblichkeit

Chemotherapie mit Hindernissen

Das Ende der vollständigen axillären Lymphknotendissektion

Senkt Schlafapnoe das Überleben bei Lungenkrebs?

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Sonderheft 1/2016

Plasmablastic Lymphoma of Small Intestine: A Rare Case Report with Review of Literature

Dasatinib and Dysfunction of Platelets

Flow Cytometry in Diagnosis of Myelomatous Pleural Effusion: A Case Report

Gelatinous Transformation of Bone Marrow: A Prospective Tertiary Center Study, Indicating Varying Trends in Epidemiology and Pathogenesis

A Case Presenting with Splenic Infarct Diagnosed as Primary Bone Marrow CD5 Positive DLBCL: A Clinicopathological Correlation

Occurrence of Double Monoclonal Bands on Protein Electrophoresis: An Unusual Finding

Neu im Fachgebiet Onkologie

Einladung zum PSA-Screening senkt die Krebssterblichkeit

Chemotherapie mit Hindernissen

Das Ende der vollständigen axillären Lymphknotendissektion

Senkt Schlafapnoe das Überleben bei Lungenkrebs?

Update Onkologie