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01.12.2014 | Case report | Ausgabe 1/2014 Open Access

World Journal of Surgical Oncology 1/2014

Leukemoid reaction in sarcomatoid renal cell carcinoma: a two-case report

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2014
Autoren:
Weiping Huang, Feng Wang, Yeping Li, Feifei Duan, Zhixian Yu
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-12-100) contains supplementary material, which is available to authorized users.
Weiping Huang, Feng Wang contributed equally to this work.

Competing interest

The authors declare that there is no conflict of interest.

Authors’ contributions

WH: conception and design of the study, acquisition of data, and interpretation of data. WHFW: drafting the manuscript and revising it critically for important content. YL: drafting the manuscript and revising it critically for important content. FD: finished partial manuscript and translation. ZY: conception and coordination of the study. All authors have read and approved the final manuscript.

Abstract

Leukemoid reaction is defined as reactive leukocytosis exceeding 40 × 109/l, with a significant increase in early neutrophil precursors, and can be a paraneoplastic manifestation of various malignant tumors. Leukemoid reaction is a sign for poor prognosis in solid tumors so is sarcomatoid renal cell carcinoma (SRCC) when compared to more differentiated histologies. Here, we are reporting two cases of leukemoid reaction after radical nephrectomy, both of which were diagnosed as SRCC pathologically. The operations were successful: no complications were observed and the patients were discharged in good condition. However, a few weeks later, the white blood cell (WBC) count gradually increased. Even though routine management was done immediately, the count was still elevating. A diagnosis of a leukemoid reaction was established and both of them died shortly thereafter. Due to the poor prognosis of most patients with malignant leukemoid reaction, leukemoid reaction may be a predictor of prognosis in patients with SRCC, but more data are needed.
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