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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey

Zeitschrift:
BMC Endocrine Disorders > Ausgabe 1/2015
Autoren:
Andy Menke, Sarah Casagrande, Catherine C. Cowie
Wichtige Hinweise

Competing interest

The authors declare that they have no competing interest.

Authors’ contributions

AM designed the study, conducted the statistical analysis, and drafted the manuscript. SC and CCC guided the statistical analysis and critically revised the manuscript for important intellectual content. All authors read and approved the final manuscript.

Authors’ information

Not applicable.

Availability of data and materials

Not applicable.

Abstract

Background

Studies investigating the association between telomere length and diabetes have been inconsistent, and there are few data available investigating the associations of telomere length with diabetes duration and control. We evaluated the relationship of leukocyte telomere length with diabetes, and the relationship of leukocyte telomere length with diabetes duration and poor glucose control among people with diabetes.

Methods

We used data from the 1999–2002 National Health and Nutrition Examination Survey, a representative sample of the US civilian non-institutionalized population. In 3921 participants, leukocyte telomere length was measured and diabetes status was determined based on a previous diagnosis, hemoglobin A1c ≥6.5 %, or fasting glucose ≥126 mg/dL.

Results

The odds ratios (95 % confidence intervals) of diabetes associated with the first, second, and third quartile of leukocyte telomere length, compared to the highest quartile, was 2.09 (1.46–2.98), 1.74 (1.30–2.31), and 1.08 (0.76–1.54), respectively (p-trend < 0.01), in unadjusted models and 0.74 (0.48–1.14), 0.91 (0.61–1.34), and 0.87 (0.59–1.29), respectively (p-trend = 0.20), in multivariable adjusted models. Among participants with diabetes, unadjusted and adjusted leukocyte telomere length was not associated with diabetes duration or glucose control based on an hemoglobin A1c <7 or <8 % (all p > 0.05).

Conclusions

In this study of the US general population, leukocyte telomere length was not associated with diabetes status, diabetes duration, or diabetes control.
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