Background
Methods
Study population
Data collection
Statistical methods
Results
LTL | LTL | LTL | LTL | ||
---|---|---|---|---|---|
<0.87 | 0.87–1.01 | 1.02–1.19 | ≥1.20 | p-trend | |
Age, years | 55.4 (0.7) | 48.5 (1.1) | 42.4 (1.0) | 37.9 (1.0) | <0.01 |
Non-Hispanic white, % | 77.9 (3.1) | 75.9 (2.5) | 72.7 (2.9) | 66.7 (2.9) | <0.01 |
Non-Hispanic black, % | 7.7 (1.2) | 8.6 (1.6) | 8.7 (1.3) | 13.2 (2.3) | 0.01 |
Mexican-American, % | 6.0 (1.3) | 7.1 (1.2) | 7.9 (1.2) | 6.5 (1.2) | 0.76 |
Women, % | 45.3 (1.6) | 53.0 (2.1) | 51.2 (2.3) | 51.7 (2.1) | 0.04 |
<High school education, % | 26.7 (1.4) | 21.4 (1.5) | 19.9 (1.8) | 18.0 (1.6) | <0.01 |
High school education, % | 25.3 (1.9) | 28.9 (2.5) | 25.6 (2.3) | 27.6 (2.4) | 0.67 |
>High school education, % | 47.9 (2.0) | 49.7 (2.6) | 54.4 (2.7) | 54.4 (2.7) | 0.03 |
Household income < $20,000, % | 26.5 (1.7) | 21.2 (1.6) | 21.9 (2.3) | 26.8 (3.0) | 0.81 |
Current smokers, % | 22.1 (1.6) | 26.1 (2.3) | 24.6 (2.3) | 26.6 (2.4) | 0.22 |
Former smokers, % | 32.9 (1.7) | 28.6 (2.4) | 23.4 (1.8) | 21.1 (1.9) | <0.01 |
Never smokers, % | 45.1 (2.0) | 45.4 (1.8) | 52.0 (2.4) | 52.3 (3.1) | <0.01 |
Pack years smoked, mean years | 29.5 (1.6) | 25.2 (1.1) | 19.5 (1.1) | 14.5 (1.2) | <0.01 |
Consume alcohol, % | 68.9 (1.6) | 73.7 (2.9) | 74.1 (3.1) | 76.0 (3.4) | 0.10 |
Body mass index, kg/m2 | 28.6 (0.3) | 28.4 (0.3) | 27.6 (0.3) | 27.4 (0.3) | <0.01 |
C-reactive protein ≥1 mg/dL, % | 12.9 (1.3) | 10.1 (1.0) | 7.8 (1.0) | 8.7 (1.3) | 0.04 |
Diabetes, % | 12.9 (0.8) | 11.0 (0.9) | 7.1 (0.8) | 6.6 (0.8) | <0.01 |
A1c, mean % | 5.6 (0.03) | 5.5 (0.03) | 5.4 (0.03) | 5.3 (0.03) | <0.01 |
A1c, mean mmol/mol | 34 (0.3) | 37 (0.3) | 36 (0.3) | 34 (0.3) | <0.01 |
LTL | LTL | LTL | LTL | ||
---|---|---|---|---|---|
<0.87 | 0.87–1.01 | 1.02–1.19 | ≥1.20 | p-trend | |
Unadjusted | 2.09 (1.46–2.98) | 1.74 (1.30–2.31) | 1.08 (0.76–1.54) | 1.00 | <0.01 |
Age, race-ethnicity, and sex adjusted | 0.89 (0.63–1.26) | 1.08 (0.80–1.47) | 0.86 (0.62–1.19) | 1.00 | 0.73 |
Multivariable adjustedb | 0.74 (0.48–1.14) | 0.91 (0.61–1.34) | 0.87 (0.59–1.29) | 1.00 | 0.20 |
Unadjusted | Age, race-ethnicity, and sex adjusted | Multivariable adjustedb | |
---|---|---|---|
Diabetes status | p < 0.01 | p = 0.68 | p = 0.11 |
Normal | 1.045 (1.010–1.082) | 1.012 (0.979–1.046) | 1.000 (0.967–1.034) |
Prediabetes | 0.970 (0.937–1.006) | 1.010 (0.974–1.048) | 1.009 (0.970–1.050) |
Diabetes | 0.946 (0.918–0.974) | 1.020 (0.989–1.053) | 1.032 (0.996–1.069) |
Duration among those with diabetes | p = 0.44 | p = 0.90 | p = 0.57 |
Undiagnosed | 0.970 (0.937–1.006) | 0.965 (0.932–0.999) | 0.957 (0.921–0.994) |
Duration 0–2 years | 0.977 (0.916–1.041) | 0.966 (0.901–1.035) | 0.983 (0.917–1.055) |
Duration 3–5 years | 0.969 (0.920–1.022) | 0.984 (0.938–1.032) | 0.971 (0.909–1.037) |
Duration 6–10 years | 0.950 (0.889–1.015) | 0.974 (0.918–1.033) | 0.974 (0.904–1.050) |
Duration ≥11 years | 0.927 (0.884–0.972) | 0.982 (0.938–1.028) | 0.989 (0.940–1.041) |
Control among diagnosed diabetes (7 %) | p = 0.43 | p = 0.65 | p = 0.43 |
A1c <7 % (53 mmol/mol) | 0.943 (0.909–0.978) | 0.954 (0.918–0.992) | 0.955 (0.911–1.001) |
A1c ≥7 % (53 mmol/mol) | 0.956 (0.920–0.993) | 0.947 (0.913–0.982) | 0.939 (0.904–0.976) |
Control among diagnosed diabetes (8 %) | p = 0.80 | p = 0.12 | p = 0.20 |
A1c <8 % (64 mmol/mol) | 0.948 (0.915–0.983) | 0.961 (0.927–0.997) | 0.957 (0.918–0.999) |
A1c ≥8 % (64 mmol/mol) | 0.953 (0.912–0.997) | 0.930 (0.891–0.971) | 0.926 (0.882–0.973) |