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Erschienen in: Rheumatology International 3/2010

01.01.2010 | Letter to the editor

Level of circulating CD4+ 28null cells in chronic inflammatory diseases: an important marker in predicting acute coronary events?

verfasst von: Satish M. Rachapalli

Erschienen in: Rheumatology International | Ausgabe 3/2010

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Excerpt

Emerging and established evidence in the last decade has clearly established that atherosclerosis is an inflammatory disease. Inflammation not only plays an important role in the development of the atherosclerotic plaque but also in the rupture of the plaque leading to critical ischaemia [1]. There is an increasing interest in identifying the immunological mediators that play an important role in plaque rupture. A subset of CD4 T cells lacking the surface expression of CD28 (CD4+ 28null cells) has been identified as potential culprits in driving this process. …
Literatur
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Zurück zum Zitat Vallejo AN, Schirmer M, Weyand CM, Goronzy JJ (2000) Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways. J Immunol 165(11):6301–6307PubMed Vallejo AN, Schirmer M, Weyand CM, Goronzy JJ (2000) Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways. J Immunol 165(11):6301–6307PubMed
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Zurück zum Zitat Pawlik A, Ostanek L, Brzosko I et al (2003) The expansion of CD4+CD28− T cells in patients with rheumatoid arthritis. Arthritis Res Ther 5(4):R210–R213. doi:10.1186/ar766 CrossRefPubMed Pawlik A, Ostanek L, Brzosko I et al (2003) The expansion of CD4+CD28 T cells in patients with rheumatoid arthritis. Arthritis Res Ther 5(4):R210–R213. doi:10.​1186/​ar766 CrossRefPubMed
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Metadaten
Titel
Level of circulating CD4+ 28null cells in chronic inflammatory diseases: an important marker in predicting acute coronary events?
verfasst von
Satish M. Rachapalli
Publikationsdatum
01.01.2010
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 3/2010
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-009-1028-y

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